What does responsible research and innovation (RRI) in emerging in silico technologies look like, and why should it matter to researchers and scientists? In this presentation, we explore some of the ethical, legal, and social implications (ELSI) of new and emerging technologies (NEST), arguing that responsibility cannot be treated as an optional add-on but as a core component of innovation. We situate current debates within the history of RRI and Open Science, tracing how approaches such as the socio-technical integration (STIR) method seek to operationalize responsibility in practice. By asking not only why you should care but also whether you can afford not to, the discussion highlights how attention to responsibility shapes scientific credibility, public trust, and long-term sustainability.