They Came from the Dust: Indoor Endocrine Disruptors and Thyroid-Hormone Binding

Press/Media: Other

Description

House dust can contain complex mixtures of endocrine-disrupting compounds (EDCs),1,2 which can interfere with the synthesis, transport, or actions of thyroid hormones, including thyroxine (T4).2,3 In a recent study published in Environmental Health Perspectives,1 researchers assessed the ability of house dust contaminant mixtures to interfere with T4 binding to transthyretin (TTR), a protein involved in transporting the hormone to target tissues. Extrapolating in vitro results to in vivo binding potencies, the researchers estimated a slight but potentially meaningful decrease in T4 binding due to contaminant mixtures.

Period30 Jul 2020

Media coverage

1

Media coverage

  • TitleThey Came from the Dust: Indoor Endocrine Disruptors and Thyroid-Hormone Binding
    Degree of recognitionInternational
    Media name/outletEnvironmental Health Perspectives
    Media typePrint
    CountryUnited States
    Date30/07/20
    DescriptionHouse dust can contain complex mixtures of endocrine-disrupting compounds (EDCs),1,2 which can interfere with the synthesis, transport, or actions of thyroid hormones, including thyroxine (T4).2,3 In a recent study published in Environmental Health Perspectives,1 researchers assessed the ability of house dust contaminant mixtures to interfere with T4 binding to transthyretin (TTR), a protein involved in transporting the hormone to target tissues. Extrapolating in vitro results to in vivo binding potencies, the researchers estimated a slight but potentially meaningful decrease in T4 binding due to contaminant mixtures.
    Producer/AuthorJulia R. Barrett
    URLhttps://ehp.niehs.nih.gov/doi/10.1289/EHP7477
    PersonsTimo Hamers