https://studiegids.vu.nl/en/courses/2024-2025/XM_0111Deepening of the knowledge of the biochemical aspects of drug targets and their role in cellular signaling in health and disease, with the aim to understand their importance in modern pharmacology.This course is designed for students with a background in the field of pharmaceutical and life sciences (or have followed Principles of Pharmaceutical Sciences) and an interest in the biological and pharmacological aspects of drug discovery. The course will focus on biochemical properties, including structures, of the main families of drug targets and their involvement in cellular signaling networks in health and disease (e.g. CNS-related disorders, cancer). Different strategies to identify, validate and modulate drug targets (e.g. ‘omics’ approaches, siRNA, CRISPR/Cas9, biologicals) will be addressed. New concepts in the architecture of signaling networks and mechanisms of signal transfer will be discussed.Lectures and assignmentsWritten examination and assignmentsPrimary literature and handouts. 'Cell signaling', Authors: Wendell Lim, Bruce Mayer, Tony Pawson ISBN: 97808153424411DDS, 1BMS, MSc Bioinformatics and Systems Biology with Life Science background/BScBSc Pharmaceutical Sciences or equivalent or Principles of Pharmaceutical Sciences or BSc in Life Sciences