https://studiegids.vu.nl/en/courses/2024-2025/XM_0067To obtain detailed knowledge of translational radiopharmaceutical sciencesRadiopharmaceutical sciences concern the development and evaluation of radiolabeled compounds, so-called radiopharmaceuticals or tracers. These radiopharmaceuticals can be either imaging agents for Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) or therapeutic agents. The stunning clinical successes of nuclear imaging and targeted radionuclide therapy have resulted in a rapid growth of the field of radiopharmaceutical sciences, a truly translational scientific discipline in which design, synthesis and application of radiopharmaceuticals is key. This course focusses on radiopharmaceutical design, including target validation with molecular biology techniques, chemistry and vector molecules, lead finding and optimization for radiopharmaceuticals, in vitro investigations, preclinical research including imaging and metabolism, radiopharmacy aspects like Good Manufacturing Practice, regulatory matters (eg Eudralex 4) and European Pharmacopea and finally an introduction to PET data analysis.The "Flipped classroom method" is used. An active participation and full time presence of the students is expected. Some lectures will be traditional classes where the theory is presented by the teacher, some will be presented by the students where they will present on basis of the theory described in the textbook. There will be several classes devoted to problem solving sessions and case studies.There will be several assignments, 2 practicals, and cases during the course which will account for 30% of the final grade. There will be a written or oral final examination, accounting for 70 % of the final grade.Radiopharmaceutical Chemistry, Lewis, Windhorst, Zeglis editors. Springer, 2019. ISBN 978-3-319-98946-4. Available as PDF via the VU library: https://link.springer.com/book/10.1007/978-3-319-98947-1mDDS, DD&S and D&IVUNetBasic knowledge about organic chemistry, eg organic chemistry I bachelor pharmaceutical sciences, chemistry or alike