Data from: Renal imaging in 199 Dutch patients with Birt-Hogg-Dubé syndrome: screening compliance and outcome

  • Paul Johannesma (Contributor)
  • Irma Van De Beek (Contributor)
  • Lawrence Rozendaal (Contributor)
  • Marianne Jonker (Contributor)
  • Simon Horenblas (Contributor)
  • Tijmen Van Der Wel (Contributor)
  • Jeroen Van Moorselaar (Contributor)
  • Hanne Meijers-Heijboer (Contributor)
  • Theo Starink (Contributor)
  • Arjan Houweling (Contributor)
  • Rinze Reinhard (Contributor)
  • Hans Gille (Contributor)
  • Pieter Postmus (Contributor)
  • Jan Hein Van Waesberghe (Contributor)



Birt-Hogg-Dubé syndrome is associated with an increased risk for renal cell carcinoma. Surveillance is recommended, but the optimal imaging method and screening interval remain to be defined. The main aim of our study was to evaluate the outcomes of RCC surveillance to get insight in the safety of annual US in these patients. Surveillance data and medical records of 199 patients with Birt-Hogg-Dubé syndrome were collected retrospectively using medical files and a questionnaire. These patients were diagnosed in two Dutch hospitals and data were collected until June 2014. A first screening for renal cell carcinoma was performed in 172/199 patients (86%). Follow-up data were available from 121 patients. The mean follow-up period per patient was 4.2 years. Of the patients known to be under surveillance, 83% was screened at least annually and 94% at least every two years. Thirty-eight renal cell carcinomas had occurred in 23 patients. The mean age at diagnosis of the first tumour was 51. Eighteen tumours were visualized by ultrasound. Nine small tumours (7-27 mm) were visible on MRI or CT and not detected using ultrasound. Our data indicate that compliance to renal screening is relatively high. Furthermore, ultrasound might be a sensitive, cheap and widely available alternative for MRI or part of the MRIs for detecting clinically relevant renal tumours in BHD patients,but the limitations should be considered carefully. . Data from larger cohorts are necessary to confirm these observations.,Renal imaging data repositoryData used to calculate the mean age at initial screening and to make table 1.,
Date made available1 Mar 2019
PublisherUnknown Publisher

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