Genome-wide association study of polygenic risk score-defined phenotype suffers from inflated test-statistics

Simulation results from running the following script 100 times: https://github.com/euffelmann/paper-ad_prs_extremes/blob/main/scripts/ad_prs_extremes_simulation.R. These files can be used to reproduce tables and figures in: https://github.com/euffelmann/paper-ad_prs_extremes