Amsterdam Neuroscience - Neurodegeneration

Research Output 2011 2019

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2019

A Fast and Economical Sample Preparation Protocol for Interaction Proteomics Analysis

Gonzalez-Lozano, M. A., Koopmans, F., Paliukhovich, I., Smit, A. B. & Li, K. W., May 2019, In : Proteomics. 19, 9, p. 1-3 3 p., 1900027.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Immunoprecipitation
Proteomics
Proteins
Staphylococcal Protein A
Throughput

A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms

The EAGLE-ADHD Consortium, 18 Jan 2019, In : Behavior Genetics. p. 1-16 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Impulsive Behavior
Single Nucleotide Polymorphism
Meta-Analysis
signs and symptoms (animals and humans)
meta-analysis

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons

van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., Steenvoorden, E., Rynearson, K. D., Brouwers, J. F., Helms, J. B., Ovaa, H., Giera, M., Wagner, S. L., Bang, A. G. & Goldstein, L. S. B., 7 Mar 2019, In : Cell Stem Cell. 24, 3, p. 363-375.e9

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Induced Pluripotent Stem Cells
Cholesterol Esters
Amyloid
Alzheimer Disease
Cholesterol

Comparative characterization of human induced pluripotent stem cells (hiPSC) derived from patients with schizophrenia and autism

Grunwald, L. M., Stock, R., Haag, K., Buckenmaier, S., Eberle, M. C., Wildgruber, D., Storchak, H., Kriebel, M., Weißgraeber, S., Mathew, L., Singh, Y., Loos, M., Li, K. W., Kraushaar, U., Fallgatter, A. J. & Volkmer, H., 1 Dec 2019, In : Translational Psychiatry. 9, 1, 179.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Induced Pluripotent Stem Cells
Autistic Disorder
Schizophrenia
Neurons
Gene Expression Profiling

Enhanced regeneration and reinnervation following timed GDNF gene therapy in a cervical ventral root avulsion

Eggers, R., de Winter, F., Arkenaar, C., Tannemaat, M. R. & Verhaagen, J., Nov 2019, In : Experimental Neurology. 321, p. 1-13 13 p., 113037.

Research output: Contribution to JournalArticleAcademicpeer-review

Glial Cell Line-Derived Neurotrophic Factor
Spinal Nerve Roots
Genetic Therapy
Axons
Regeneration

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

The 23andMe Research Team, Mar 2019, In : Nature Genetics. 51, 3, p. 394-403 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Sleep Initiation and Maintenance Disorders
Genome
Sleep
Genes
Neurons

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk

Jansen, I. E., Savage, J. E., Watanabe, K., Bryois, J., Williams, D. M., Steinberg, S., Sealock, J., Karlsson, I. K., Hägg, S., Athanasiu, L., Voyle, N., Proitsi, P., Witoelar, A., Stringer, S., Aarsland, D., Almdahl, I. S., Andersen, F., Bergh, S., Bettella, F., Bjornsson, S. & 33 othersBrækhus, A., Bråthen, G., de Leeuw, C., Desikan, R. S., Djurovic, S., Dumitrescu, L., Fladby, T., Hohman, T. J., Jonsson, P. V., Kiddle, S. J., Rongve, A., Saltvedt, I., Sando, S. B., Selbæk, G., Shoai, M., Skene, N. G., Snaedal, J., Stordal, E., Ulstein, I. D., Wang, Y., White, L. R., Hardy, J., Hjerling-Leffler, J., Sullivan, P. F., van der Flier, W. M., Dobson, R., Davis, L. K., Stefansson, H., Stefansson, K., Pedersen, N. L., Ripke, S., Andreassen, O. A. & Posthuma, D., 1 Mar 2019, In : Nature Genetics. 51, 3, p. 404-413 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Meta-Analysis
Alzheimer Disease
Genome
Proxy
Genes

Gpr158 Deficiency Impacts Hippocampal CA1 Neuronal Excitability, Dendritic Architecture, and Affects Spatial Learning

Çetereisi, D., Kramvis, I., Gebuis, T., van der Loo, R. J., Gouwenberg, Y., Mansvelder, H. D., Li, K. W., Smit, A. B. & Spijker, S., 25 Oct 2019, In : Frontiers in Cellular Neuroscience. 13, OCTOBER, p. 1-18 18 p., 465.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
G-Protein-Coupled Receptors
Hippocampus
Physiological Stress
Pyramidal Cells
Dendrites

Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex

Boggio, E. M., Ehlert, E. M., Lupori, L., Moloney, E. B., De Winter, F., Vander Kooi, C. W., Baroncelli, L., Mecollari, V., Blits, B., Fawcett, J. W., Verhaagen, J. & Pizzorusso, T., 31 Jan 2019, In : Molecular Neurobiology. p. 1-11 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

ocular Dominance
Visual Cortex
Immunoglobulin Fc Fragments
Parvalbumins
Interneurons

Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory

Matos, M. R., Visser, E., Kramvis, I., van der Loo, R. J., Gebuis, T., Zalm, R., Rao-Ruiz, P., Mansvelder, H. D., Smit, A. B. & van den Oever, M. C., 24 May 2019, In : Nature Communications. 10, p. 1-11 11 p., 2315.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
fear
Long-Term Memory
Fear
Prefrontal Cortex
Data storage equipment

The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour

Domínguez-Iturza, N., Lo, A. C., Shah, D., Armendáriz, M., Vannelli, A., Mercaldo, V., Trusel, M., Li, K. W., Gastaldo, D., Santos, A. R., Callaerts-Vegh, Z., D'Hooge, R., Mameli, M., Van der Linden, A., Smit, A. B., Achsel, T. & Bagni, C., 1 Aug 2019, In : Nature Communications. 10, 1, p. 1-13 13 p., 3454.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
schizophrenia
Autistic Disorder
brain
Brain
Schizophrenia

The Effects of Sindbis Viral Vectors on Neuronal Function

Uyaniker, S., van der Spek, S. J. F., Reinders, N. R., Xiong, H., Li, K. W., Bossers, K., Smit, A. B., Verhaagen, J. & Kessels, H. W., 8 Aug 2019, In : Frontiers in Cellular Neuroscience. 13, August, p. 1-12 12 p., 362.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neurons
Proteome
Transcriptome
Proteins
Injections

Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration

Eggers, R., De Winter, F., Hoyng, S. A., Hoeben, R. C., Malessy, M. J. A., Tannemaat, M. R. & Verhaagen, J., Feb 2019, In : Brain. 142, 2, p. 295-311 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Switch Genes
Glial Cell Line-Derived Neurotrophic Factor
Genetic Therapy
Axons
Regeneration

Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons

van Ziel, A. M., Largo-Barrientos, P., Wolzak, K., Verhage, M. & Scheper, W., 7 Feb 2019, In : Scientific Reports. 9, 1, p. 1-12 12 p., 1567.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Unfolded Protein Response
Pharmacology
Neurons
Endoplasmic Reticulum Stress
Proteins
2018

Comparative Analyses of Data Independent Acquisition Mass Spectrometric Approaches: DIA, WiSIM-DIA, and Untargeted DIA

Koopmans, F., Ho, J. T. C., Smit, A. B. & Li, K. W., Jan 2018, In : Proteomics. 18, 1, p. 1-6 6 p., 1700304.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Data acquisition
Peptides
Ions
Proteomics
Synapses

Comparative Hippocampal Synaptic Proteomes of Rodents and Primates: Differences in Neuroplasticity-Related Proteins

Koopmans, F., Pandya, N. J., Franke, S. K., Phillippens, I. H. C. M. H., Paliukhovich, I., Li, K. W. & Smit, A. B., 2 Oct 2018, In : Frontiers in Molecular Neuroscience. 11, p. 1-14 14 p., 364.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neuronal Plasticity
Proteome
Primates
Rodentia
Synapses

Integrins promote axonal regeneration after injury of the nervous system

Nieuwenhuis, B., Haenzi, B., Andrews, M. R., Verhaagen, J. & Fawcett, J. W., Aug 2018, In : Biological Reviews. 93, 3, p. 1339-1362 24 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Nervous System Trauma
integrins
Neurology
nervous system
Integrins

MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission

He, E., Lozano, M. A. G., Stringer, S., Watanabe, K., Sakamoto, K., Oudsten, F. D., Koopmans, F., Giamberardino, S. N., Hammerschlag, A., Niels Cornelisse, L., Li, K. W., van Weering, J., Posthuma, D., Smit, A. B., Sullivan, P. F. & Verhage, M., 1 Jun 2018, In : Human Molecular Genetics. 27, 11, p. 1879-1891 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Internal-External Control
Synaptic Transmission
Synapses
Schizophrenia
Proteomics

Neuropathology and cognitive performance in self-reported cognitively healthy centenarians

Ganz, A. B., Beker, N., Hulsman, M., Sikkes, S. A. M., Scheltens, P., Smit, A. B., Rozemuller, A. J. M., Hoozemans, J. J. M. & Holstege, H., 23 Jul 2018, In : Acta Neuropathologica Communications. 6, p. 1-13 13 p., 64.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Pathology
Neurodegenerative Diseases
Brain
Cerebral Amyloid Angiopathy
Lewy Bodies

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

Slagboom, J., Otvos, R. A., Cardoso, F. C., Iyer, J., Visser, J. C., van Doodewaerd, B. R., McCleary, R. J. R., Niessen, W. M. A., Somsen, G. W., Lewis, R. J., Kini, R. M., Smit, A. B., Casewell, N. R. & Kool, J., 15 Jun 2018, In : Toxicon. 148, p. 213-222 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Microfluidics
Venoms
Snake Venoms
Acetylcholine
Carrier Proteins

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Pandya, N. J., Seeger, C., Babai, N., Gonzalez-Lozano, M. A., Mack, V., Lodder, J. C., Gouwenberg, Y., Mansvelder, H. D., Danielson, U. H., Li, K. W., Heine, M., Spijker, S., Frischknecht, R. & Smit, A. B., 31 Jul 2018, In : Cell Reports. 24, 5, p. 1218-1230 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neurotransmitter Receptor
AMPA Receptors
Glutamate Receptors
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Plasticity

Proteomics of neurodegenerative diseases: analysis of human post-mortem brain

Li, K. W., Ganz, A. B. & Smit, A. B., 5 Oct 2018, In : Journal of Neurochemistry. p. 1-11 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neurodegenerative diseases
Neurodegenerative Diseases
Proteomics
Dementia
Brain

Stress vulnerability promotes an alcohol-prone phenotype in a preclinical model of sustained depression

Riga, D., Schmitz, L. J. M., van Mourik, Y., Hoogendijk, W. J. G., De Vries, T. J., Smit, A. B. & Spijker, S., 18 Dec 2018, In : Addiction Biology. p. 1-12 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Alcohols
Depression
Phenotype
Self Administration
Cues

The dorsal column lesion model of spinal cord injury and its use in deciphering the neuron-intrinsic injury response

Attwell, C. L., van Zwieten, M., Verhaagen, J. & Mason, M. R. J., 1 May 2018, In : Developmental Neurobiology. 2018, p. 1-26 26 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Spinal Cord Injuries
Neurons
Wounds and Injuries
Spinal Ganglia
Axotomy
2017

Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation

Groh, N., Bühler, A., Huang, C., Li, K. W., van Nierop, P., Smit, A. B., Fändrich, M., Baumann, F. & David, D. C., 2017, In : Frontiers in Aging Neuroscience. 9, p. 138

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Amyloid
Proteins
Neurodegenerative Diseases
Neurofibrillary Tangles
Amyloid Plaques

AHCODA-DB: a data repository with web-based mining tools for the analysis of automated high-content mouse phenomics data

Koopmans, B., Smit, A. B., Verhage, M. & Loos, M., 4 Apr 2017, In : BMC Bioinformatics. 18, 1, p. 200

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Web-based
Repository
Mouse
Mining
Quality control

A one-week 5-choice serial reaction time task to measure impulsivity and attention in adult and adolescent mice

Remmelink, E., Chau, U., Smit, A. B., Verhage, M. & Loos, M., 15 Feb 2017, In : Scientific Reports. 7, p. 42519

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Impulsive Behavior
Reaction Time
Task Performance and Analysis
Psychiatry
Food Deprivation

Complex Genetics of Behavior: BXDs in the Automated Home-Cage

Loos, M., Verhage, M., Spijker, S. & Smit, A. B., 2017, In : Methods in Molecular Biology. 1488, p. 519-530 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Inbred Strains Mice
Automation
Dissection
Genome
Phenotype

Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution

Pandya, N. J., Koopmans, F., Slotman, J. A., Paliukhovich, I., Houtsmuller, A. B., Smit, A. B. & Li, K. W., 21 Sep 2017, In : Scientific Reports. 7, 1, p. 12107

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Proteome
Brain
Proteins
AMPA Receptors
Cerebellum

Expression of a Mutant SEMA3A Protein with Diminished Signalling Capacity Does Not Alter ALS-Related Motor Decline, or Confer Changes in NMJ Plasticity after BotoxA-Induced Paralysis of Male Gastrocnemic Muscle

Moloney, E. B., Hobo, B., De Winter, F. & Verhaagen, J., 2017, In : PLoS ONE. 12, 1, p. e0170314

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Semaphorin-3A
Neuromuscular Junction
Amyotrophic Lateral Sclerosis
paralysis
Paralysis

Gene-set analysis shows association between FMRP targets and autism spectrum disorder

Jansen, A., Dieleman, G. C., Smit, A. B., Verhage, M., Verhulst, F. C., Polderman, T. J. C. & Posthuma, D., Jun 2017, In : European Journal of Human Genetics. 25, 7, p. 863-868 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Fragile X Mental Retardation Protein
Genes
Psychiatry
Exome
Fragile X Syndrome

High Content Analysis of Hippocampal Neuron-Astrocyte Co-cultures Shows a Positive Effect of Fortasyn Connect on Neuronal Survival and Postsynaptic Maturation

van Deijk, A-L. F., Broersen, L. M., Verkuyl, J. M., Smit, A. B. & Verheijen, M. H. G., 2017, In : Frontiers in Neuroscience. 11, p. 440

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Coculture Techniques
Astrocytes
Neurons
Synapses
Phospholipids

Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats

Riga, D., Kramvis, I., Koskinen, M. K., van Bokhoven, P., van der Harst, J. E., Heistek, T. S., Jaap Timmerman, A., van Nierop, P., van der Schors, R. C., Pieneman, A. W., de Weger, A., van Mourik, Y., Schoffelmeer, A. N. M., Mansvelder, H. D., Meredith, R. M., Hoogendijk, W. J. G., Smit, A. B. & Spijker, S., 20 Dec 2017, In : Science Translational Medicine. 9, 421

Research output: Contribution to JournalArticleAcademicpeer-review

Extracellular Matrix
Hippocampus
Long-Term Potentiation
Chondroitin ABC Lyase
Chondroitin Sulfate Proteoglycans

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

Nguyen, H. T., Bryois, J., Kim, A., Dobbyn, A., Huckins, L. M., Munoz-Manchado, A. B., Ruderfer, D. M., Genovese, G., Fromer, M., Xu, X., Pinto, D., Linnarsson, S., Verhage, M., Smit, A. B., Hjerling-Leffler, J., Buxbaum, J. D., Hultman, C., Sklar, P., Purcell, S. M., Lage, K. & 3 othersHe, X., Sullivan, P. F. & Stahl, E. A., 20 Dec 2017, In : Genome Medicine. 9, 1, p. 114

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Bayes Theorem
Schizophrenia
Genes
Protein Interaction Maps
Neurodevelopmental Disorders

Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

Mizee, M. R., Miedema, S. S. M., van der Poel, M., Adelia, Schuurman, K. G., van Strien, M. E., Melief, J., Smolders, J., Hendrickx, D. A., Heutinck, K. M., Hamann, J. & Huitinga, I., 17 Feb 2017, In : Acta Neuropathologica Communications. 5, 1, p. 16

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Microglia
Brain
Phenotype
Choroid Plexus
Density Gradient Centrifugation

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells

Nadadhur, A. G., Melero, J. E., Meijer, M., Schut, D., Jacobs, G., Wan Li, K., Hjorth, J. J. J., Meredith, R. M., Toonen, R. F., Van Kesteren, R. E., Smit, A. B., Verhage, M. & Heine, V. M., 1 Jun 2017, In : PLoS ONE. 12, 6, 0178533.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Confocal microscopy
Stem cells
Cell culture

Oligodendroglial myelination requires astrocyte-derived lipids

Camargo, N., Goudriaan, A., van Deijk, A. L. F., Otte, W. M., Brouwers, J. F., Lodder, H., Gutmann, D. H., Nave, K. A., Dijkhuizen, R. M., Mansvelder, H. D., Chrast, R., Smit, A. B. & Verheijen, M. H. G., 26 May 2017, In : PloS Biology. 15, 5, e1002605.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
myelination
astrocytes
Astrocytes
Oligodendroglia
Lipids

Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease

Korecka, J. A., Moloney, E. B., Eggers, R., Hobo, B., Scheffer, S., Ras-Verloop, N., Pasterkamp, R. J., Swaab, D. F., Smit, A. B., van Kesteren, R. E., Bossers, K. & Verhaagen, J., 27 Sep 2017, In : Journal of Neuroscience. 37, 39, p. 9361-9379 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Dopaminergic Neurons
Parkinson Disease
Substantia Nigra
Mesencephalon
Cues

Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS

Taskesen, E., Mishra, A., van der Sluis, S., Ferrari, R., Veldink, J. H., van Es, M. A., Smit, A. B., Posthuma, D. & Pijnenburg, Y., 21 Aug 2017, In : Scientific Reports. 7, 1, p. 8899

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Frontotemporal Dementia
Genome-Wide Association Study
DNA Methylation
Genes
Frontotemporal Dementia With Motor Neuron Disease

Temporal profiling of depression vulnerability in a preclinical model of sustained depression

Riga, D., Schmitz, L. J. M., Hoogendijk, W. J. G., Smit, A. B. & Spijker, S., 17 Aug 2017, In : Scientific Reports. 7, 1, p. 8570

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Depression
Motivation
Memory Disorders
Mental Disorders
Wistar Rats

The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory

Schmitz, L. J. M., Klaassen, R. V., Ruiperez-Alonso, M., Zamri, A. E., Stroeder, J., Rao-Ruiz, P., Lodder, J. C., van der Loo, R. J., Mansvelder, H. D., Smit, A. B. & Spijker, S., 4 Dec 2017, In : eLife. 6, p. 1-28 28 p., e24192.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
AMPA Receptors
Data storage equipment
Synapses
Proteins
Neuronal Plasticity

The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons

Leal, G., Comprido, D., de Luca, P., Morais, E., Rodrigues, L., Mele, M., Santos, A. R., Costa, R. O., Pinto, M. J., Patil, S., Berentsen, B., Afonso, P., Carreto, L., Li, K. W., Pinheiro, P., Almeida, R. D., Santos, M. A. S., Bramham, C. R. & Duarte, C. B., 20 Dec 2017, In : eNeuro. 4, 6

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Heterogeneous-Nuclear Ribonucleoprotein K
Neurotransmitter Receptor
RNA-Binding Proteins
Brain-Derived Neurotrophic Factor
N-Methyl-D-Aspartate Receptors

Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains

Geerts, C. J., Mancini, R., Chen, N., Koopmans, F. T. W., Li, K. W., Smit, A. B., van Weering, J. R. T., Verhage, M. & Groffen, A. J. A., 2017, In : PLoS ONE. 12, 7, p. e0180912

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
SNARE Proteins
secretory granules
Secretory Vesicles
Neurons
Synaptotagmin I
2016

Catalytically active tissue transglutaminase colocalises with Aβ pathology in Alzheimer's disease mouse models

Wilhelmus, M. M. M., Smit, A. B., Drukarch, B., de Jager, M. & Loo, R. J., 3 Feb 2016, In : Scientific Reports. 6, p. 20569

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Alzheimer Disease
Pathology
Astrocytes
transglutaminase 2
Serum Amyloid A Protein

Clinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesion

Eggers, R., Tannemaat, M. R., De Winter, F., Malessy, M. J. A. & Verhaagen, J., Feb 2016, In : European Journal of Neuroscience. 43, 3, p. 318-335

Research output: Contribution to JournalArticleAcademicpeer-review

Evaluation of five tests for sensitivity to functional deficits following cervical or thoracic dorsal column transection in the rat

Fagoe, N. D., Attwell, C. L., Eggers, R., Tuinenbreijer, L., Kouwenhoven, D., Verhaagen, J. & Mason, M. R. J., 1 Mar 2016, In : PLoS ONE. 11, 3, e0150141.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Ladders
chest
ladders
lesions (animal)
Rats

Individual and Familial Susceptibility to MPTP in a Common Marmoset Model for Parkinson's Disease

van Kesteren, R. E., Hofman, S., Wubben, J. A. M., Smit, A. B. & Philippens, I. H. C. H. M., 2016, In : Neurodegenerative Diseases. 16, 5-6, p. 293-303 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Callithrix
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Parkinson Disease
Genealogy and Heraldry
Disease Susceptibility

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

Middeldorp, J., Lehallier, B., Villeda, S. A., Miedema, S. S. M., Evans, E., Czirr, E., Zhang, H., Luo, J., Stan, T., Mosher, K. I., Masliah, E. & Wyss-Coray, T., 1 Nov 2016, In : JAMA Neurology. 73, 11, p. 1325-1333 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Alzheimer Disease
Parabiosis
Calbindins
Synaptophysin
Blood Circulation

Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease

Hondius, D., van Nierop, P., Li, K. W., Hoozemans, J. J. M., van der Schors, R. C., van Haastert, E. S., van der Vies, S. M., Rozemuller, A. J. M. & Smit, A. B., Jun 2016, In : Alzheimers & Dementia. 12, 6, p. 654-68 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Proteome
Hippocampus
Alzheimer Disease
Proteins
Laser Capture Microdissection

Progression and recovery of Parkinsonism in a chronic progressive MPTP-induction model in the marmoset without persistent molecular and cellular damage

Franke, S. K., van Kesteren, R. E., Wubben, J. A., Hofman, S., Paliukhovich, I., van der Schors, R. C., van Nierop, P., Smit, A. B. & Philippens, I. H. C. H. M., 2016, In : Neuroscience. 312, p. 247-259

Research output: Contribution to JournalArticleAcademicpeer-review

Callithrix
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Parkinsonian Disorders
Caudate Nucleus
Tyrosine 3-Monooxygenase