Research Output 2002 2020

2020

Facilities that make the PDB data collection more powerful

Lange, J., Baakman, C., Pistorius, A., Krieger, E., Hooft, R., Joosten, R. P. & Vriend, G., 1 Jan 2020, In : Protein Science. 29, 1, p. 330-344 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Databases
Computational Biology
Proteins
Bioinformatics
Software

Microdroplet screening and selection for improved microbial production of extracellular compounds

van Tatenhove-Pel, R. J., Hernandez-Valdes, J. A., Teusink, B., Kuipers, O. P., Fischlechner, M. & Bachmann, H., Feb 2020, In : Current Opinion in Biotechnology. 61, p. 72-81 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Fermentation
Screening
Emulsions
Throughput
Industry
2019

Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength

Price, C. E., Branco Dos Santos, F., Hesseling, A., Uusitalo, J. J., Bachmann, H., Benavente, V., Goel, A., Berkhout, J., Bruggeman, F. J., Marrink, S. J., Montalban-Lopez, M., De Jong, A., Kok, J., Molenaar, D., Poolman, B., Teusink, B. & Kuipers, O. P., 10 Jan 2019, In : BMC Evolutionary Biology. 19, 1, p. 1-15 15 p., 15.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
strength (mechanics)
glucose
mutation
chemostat
fitness

A framework for exhaustive modelling of genetic interaction pattern using Petri nets

Jacobsen, A., Ivanova, O., Amini, S., Heringa, J., Kemmeren, P. & Feenstra, K. A., 17 Dec 2019, In : Bioinformatics.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Petri nets
Petri Nets
Genes
Phenotype
Biological Phenomena

A genome-scale metabolic network of the aroma bacterium Leuconostoc mesenteroides subsp. cremoris

Özcan, E., Selvi, S. S., Nikerel, E., Teusink, B., Toksoy Öner, E. & Çakır, T., 1 Jan 2019, In : Applied Microbiology and Biotechnology.

Research output: Contribution to JournalArticleAcademicpeer-review

Metabolic Networks and Pathways
Citric Acid
Genome
Bacteria
phosphoketolase

A systematic assessment of current genome-scale metabolic reconstruction tools

Mendoza, S. N., Olivier, B. G., Molenaar, D. & Teusink, B., 7 Aug 2019, In : Genome Biology. 20, 1, 158.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Software
genome
Genome
software
Benchmarking

Finding functional differences between species in a microbial community: Case studies in wine fermentation and Kefir culture

Melkonian, C., Gottstein, W., Blasche, S., Kim, Y., Abel-Kistrup, M., Swiegers, H., Saerens, S., Edwards, N., Patil, K. R., Teusink, B. & Molenaar, D., 25 Jun 2019, In : Frontiers in Microbiology. 10, JUNE, p. 1-14 14 p., 01347.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Wine
Fermentation
Metagenomics
Gluconobacter
Pantoea

Genome-Scale Metabolic Reconstruction of Acetobacter pasteurianus 386B, a Candidate Functional Starter Culture for Cocoa Bean Fermentation

Pelicaen, R., Gonze, D., Teusink, B., De Vuyst, L. & Weckx, S., 5 Dec 2019, In : Frontiers in Microbiology. 10, 2801.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Acetobacter
Fermentation
Genome
Growth
Genomics

Impact of pathogenic mutations of the GLUT1 glucose transporter on channel dynamics using consdyn enhanced sampling [version 1; peer review: 1 approved with reservations, 1 not approved]

Mouhib, H., Higuchi, A., Abeln, S., Yura, K. & Feenstra, K. A., 22 Mar 2019, In : F1000Research. 8, p. 1-14 14 p., 322.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Peer Review
Facilitative Glucose Transport Proteins
Sampling
Mutation
Glucose Transporter Type 1

Metabolomics: From Method Development to System Biology

Krumpochova, P., 2019, 215 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Reasoning about cell dynamics using network models

Jacobsen, A., 2019, 182 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

SeRenDIP: SEquential REmasteriNg to DerIve profiles for fast and accurate predictions of PPI interface positions

Hou, Q., De Geest, P. F. G., Griffioen, C. J., Abeln, S., Heringa, J. & Feenstra, K. A., 1 Nov 2019, In : Bioinformatics. 35, 22, p. 4794-4796 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Web Server
Proteins
Protein
Prediction
Interaction
computer vision
data analysis

Tailor-made multiple sequence alignments using the PRALINE 2 alignment toolkit

Dijkstra, M. J. J., van der Ploeg, A. J., Feenstra, K. A., Fokkink, W. J., Abeln, S. & Heringa, J., 15 Dec 2019, In : Bioinformatics (Oxford, England). 35, 24, p. 5315-5317 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Multiple Sequence Alignment
Workflow
Sequence Alignment
Work Flow
Alignment

The ability of transcription factors to differentially regulate gene expression is a crucial component of the mechanism underlying inversion, a frequently observed genetic interaction pattern

Amini, S., Jacobsen, A., Ivanova, O., Lijnzaad, P., Heringa, J., Holstege, F. C. P., Feenstra, K. A. & Kemmeren, P., 13 May 2019, In : PLoS Computational Biology. 15, 5, p. 1-27 27 p., e1007061.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Transcription factors
Transcription Factor
Gene expression
Gene Expression
gene expression

The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth

Dijk, E. V., Gils, J. H. M. V., Peduzzo, A., Hofmann, A., Groth, G., Mouhib, H., Otzen, D. E., Buell, A. K. & Abeln, S., 13 Jun 2019, In : arXiv.org. 25 p.

Research output: Contribution to JournalArticleAcademic

thermodynamics
protein
heat capacity
meta-analysis
hydrophobicity

The number of active metabolic pathways is bounded by the number of cellular constraints at maximal metabolic rates

de Groot, D. H., van Boxtel, C., Planque, R., Bruggeman, F. J. & Teusink, B., 11 Mar 2019, In : PLoS Computational Biology. 15, 3, p. 1-24 24 p., e1006858.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolic Networks and Pathways
biochemical pathways
Pathway
enzyme
Fluxes

The potential use of big data in oncology

Willems, S. M., Abeln, S., Feenstra, K. A., de Bree, R., van der Poel, E. F., Baatenburg de Jong, R. J., Heringa, J. & van den Brekel, M. W. M., Nov 2019, In : Oral Oncology. 98, p. 8-12 5 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Information Storage and Retrieval
Head and Neck Neoplasms
Netherlands
Neck
Head
2018

An integrated model quantitatively describing metabolism, growth and cell cycle in budding yeast

Palumbo, P., Vanoni, M., Papa, F., Busti, S., Wortel, M., Teusink, B. & Alberghina, L., 2018, Artificial Life and Evolutionary Computation - 12th Italian Workshop, WIVACE 2017, Revised Selected Papers. Springer/Verlag, p. 165-180 16 p. (Communications in Computer and Information Science; vol. 830).

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

Integrated Model
Cell Cycle
Metabolism
Yeast
Cells

Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer

Jacobsen, A., Bosch, L. J. W., Martens-De Kemp, S. R., Carvalho, B., Sillars-Hardebol, A. H., Dobson, R. J., De Rinaldis, E., Meijer, G. A., Abeln, S., Heringa, J., Fijneman, R. J. A. & Feenstra, K. A., 14 May 2018, In : Scientific Reports. 8, 1, p. 7522 7522.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Aurora Kinase A
Colorectal Neoplasms
Cell Line
Protein Interaction Maps
Genes

Constraint-based models of microbial physiology: Surprisingly versatile

Teusink, B., Planqué, B., Molenaar, D. & Bruggeman, F., 1 Jan 2018, 10th International Conference on Simulation and Modelling in the Food and Bio-Industry 2018, FOODSIM 2018. Eurosis, p. 5-10 6 p.

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

microbial physiology
Physiology
Fluxes
Microbiological Phenomena
Growth

Deep sequencing identifies hepatitis B virus core protein signatures in chronic hepatitis B patients

van der Ree, M. H., Jansen, L., Welkers, M. R. A., Reesink, H. W., Feenstra, K. A. & Kootstra, N. A., Oct 2018, In : Antiviral research. 158, p. 213-225 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Viral Core Proteins
High-Throughput Nucleotide Sequencing
Chronic Hepatitis B
Hepatitis B e Antigens
Hepatitis B virus

Dynamic elementary mode modelling of non-steady state flux data

Folch-Fortuny, A., Teusink, B., Hoefsloot, H. C. J., Smilde, A. K. & Ferrer, A., 18 Jun 2018, In : BMC Systems Biology. 12, p. 1-15 15 p., 71.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolic Flux Analysis
Fluxes
Discriminant Analysis
Metabolic Networks and Pathways
Modeling

Further elucidation of galactose utilization in Lactococcus lactis MG1363

Solopova, A., Bachmann, H., Teusink, B., Kok, J. & Kuipers, O. P., 3 Aug 2018, In : Frontiers in Microbiology. 9, AUGUST, p. 1-9 9 p., 1803.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
Galactose
Lactose
Lactococcus
Membrane Transport Proteins

Low affinity uniporter carrier proteins can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M. J., De La Torre Cortés, P. & Teusink, B., 3 Apr 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 5576.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Facilitated Diffusion
Facilitative Glucose Transport Proteins
Glycolysis
Saccharomyces cerevisiae
Carrier Proteins

Maintaining maximal metabolic flux by gene expression control

Planqué, R., Hulshof, J., Teusink, B., Hendriks, J. C. & Bruggeman, F. J., 20 Sep 2018, In : PLoS Computational Biology. 14, 9, p. 1-20 20 p., e1006412.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolites
Metabolic Networks and Pathways
Gene expression
Gene Expression
gene expression

Metabolite Depletion Affects Flux Profiling of Cell Lines

Nilsson, A., Haanstra, J. R., Teusink, B. & Nielsen, J., Jun 2018, In : Trends in Biochemical Sciences. 43, 6, p. 395-397 3 p.

Research output: Contribution to JournalShort surveyAcademicpeer-review

Metabolites
Cells
Fluxes
Cell Line
Growth

Motif-Aware PRALINE: Improving the alignment of motif regions: Improving the alignment of motif regions

Dijkstra, M., Bawono, P., Abeln, S., Feenstra, K. A., Fokkink, W. & Heringa, J., 1 Nov 2018, In : PLoS Computational Biology. 14, 11, p. 1-19 19 p., e1006547.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Sequence Alignment
sequence alignment
Alignment
Multiple Sequence Alignment
Benchmarking

Preface to Introduction to Structural Bioinformatics

Feenstra, K. A. & Abeln, S., 29 Jan 2018, Introduction to Structural Bioinformatics.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

File

Regulatory and metabolic networks

Sauer, U. & Teusink, B., Apr 2018, In : Current Opinion in Systems Biology. 8, p. iv-v 2 p.

Research output: Contribution to JournalEditorialAcademicpeer-review

The characteristics of molten globule states and folding pathways strongly depend on the sequence of a protein

Dijkstra, M. J. J., Fokkink, W. J., Heringa, J., van Dijk, E. & Abeln, S., 17 Nov 2018, In : Molecular Physics. 116, 21-22, p. 3173-3180 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
globules
folding
Molten materials
Hot Temperature
proteins

Training for translation between disciplines: A philosophy for life and data sciences curricula

Anton Feenstra, K., Abeln, S., Westerhuis, J. A., Brancos Dos Santos, F., Molenaar, D., Teusink, B., Hoefsloot, H. C. J. & Heringa, J., 1 Jul 2018, In : Bioinformatics. 34, 13, p. i4-i12 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Understanding start-up problems in yeast glycolysis

Overal, G. B., Teusink, B., Bruggeman, F. J., Hulshof, J. & Planqué, R., May 2018, In : Mathematical Biosciences. 299, May, p. 117-126 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Glycolysis
Start-up
glycolysis
Yeast
Yeasts
2017

Both intrinsic substrate preference and network context contribute to substrate selection of classical tyrosine phosphatases

Palma, A., Tinti, M., Paoluzi, S., Santonico, E., Brandt, B. W., Hooft Van Huijsduijnen, R., Masch, A., Heringa, J., Schutkowski, M., Castagnoli, L. & Cesareni, G., 24 Mar 2017, In : Journal of Biological Chemistry. 292, 12, p. 4942-4958 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Phosphoric Monoester Hydrolases
Tyrosine
Phosphopeptides
Protein Tyrosine Phosphatases
Substrates

Detection of structural variants and recurrent breakpoint genes in colorectal adenoma-to-carcinoma progression

van den Broek, E., Dijkstra, M. J. J., Voorham, Q. J. M., Carvalho, B., van de Wiel, M. A., Abeln, S., Meijer, G. A. & Fijneman, R. J. A., Feb 2017, In : Cancer Research. 77

Research output: Contribution to JournalArticleAcademic

GeneBreak: detection of recurrent DNA copy number aberration-associated chromosomal breakpoints within genes

Fijneman, R. J. A., van den Broek, E., van Lieshout, S., Rausch, C., Ylstra, B., van de Wiel, M. A., Meijer, G. A. & Abeln, S., 6 Jul 2017, In : F1000Research. 5, p. 1-8 8 p., 2340.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Aberrations
Chromosome Aberrations
Genes
Genome
DNA

Introduction to Protein Structure Prediction

Abeln, S., Heringa, J. & Feenstra, K. A., 1 Dec 2017, (Submitted) Introduction to Structural Bioinformatics.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

File
Proteins

Low affinity membrane transporters can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M., de la Torre Cortés, P. & Teusink, B., 2 Nov 2017, In : bioRxiv.

Research output: Contribution to JournalArticleAcademic

Maintaining maximal metabolic rates by gene expression control

Planque, R., Hulshof, J., Teusink, B., Hendriks, J. C. & Bruggeman, F. J., 9 Mar 2017, In : bioRxiv.

Research output: Contribution to JournalArticleAcademicpeer-review

Making sense of our microbes as they become data in our computers

May, A., 2017, 94 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Model-based quantification of metabolic interactions from dynamic microbial-community data

Hanemaaijer, M., Olivier, B. G., Röling, W. F. M., Bruggeman, F. J. & Teusink, B., 1 Mar 2017, In : PLoS ONE. 12, 3, e0173183.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Microbial Interactions
Coculture Techniques
microbial communities
Hydrogen
Wolinella

Multiple sequence alignment

Bawono, P., Dijkstra, M., Pirovano, W., Feenstra, A., Abeln, S. & Heringa, J., 2017, Methods in Molecular Biology: Volume I: Data, Sequence Analysis, and Evolution. Humana Press Inc, Vol. 1525. p. 167-189 23 p. (Methods in Molecular Biology; vol. 1525).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Sequence Alignment
Sequence Analysis
Proteins
Nucleotides
Research Personnel

Multi-Scale Investigation of Protein-Protein Interactions

Hou, Q., 2017, 139 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Probing the genome-scale metabolic landscape of Bordetella pertussis, the causative agent of whooping cough

dos Santos, F. B., Olivier, B. G., Boele, J., Krumpochova, P., Klau, G. W., Giera, M. & Teusink, B., 1 Nov 2017, In : Applied and Environmental Microbiology. 83, 21

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Bordetella pertussis
whooping cough
Whooping Cough
thiosulfate
physiology

Revelation of the Genetic Basis for Convergent Innovative Anal Fin Pigmentation Patterns in Cichlid Fishes

Gu, L., Zhang, C. & Xia, C., 20 Jul 2017, (Submitted) In : bioRxiv.

Research output: Contribution to JournalArticleAcademic

pigmentation
fins
fish
genes
convergent evolution

Seeing the trees through the forest: sequence-based homo- and heteromeric protein-protein interaction sites prediction using random forest

Hou, Q., De Geest, P. F. G., Vranken, W. F., Heringa, J. & Feenstra, K. A., 15 May 2017, In : Bioinformatics. 33, 10, p. 1479-1487 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Random Forest
Protein-protein Interaction
Proteins
Prediction
Predictors

Strategies for protein structure model generation

Abeln, S., Heringa, J. & Feenstra, K. A., 1 Dec 2017, (Submitted) Introduction to Structural Bioinformatics.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

File
Model structures
Proteins
Concretes

Systematically linking tranSMART, Galaxy and EGA for reusing human translational research data [version 1; referees: awaiting peer review]

Zhang, C., Bijlard, J., Staiger, C., Scollen, S., van Enckevort, D., Hoogstrate, Y., Senf, A., Hiltemann, S., Repo, S., Pipping, W., Bierkens, M., Payralbe, S., Stringer, B., Heringa, J., Stubbs, A., Bonino Da Silva Santos, LO., Belien, J. A. M., Weistra, W., Azevedo, R. V. D. M., van Bochove, K. & 6 othersMeijer, G., Boiten, J-W., Rambla, J., Fijneman, R. J., Spalding, JD. & Abeln, S., 16 Aug 2017, In : F1000Research. 6, 1488

Research output: Contribution to JournalArticleAcademic

Open Access

Systems biology of lactic acid bacteria: For food and thought

Teusink, B. & Molenaar, D., 1 Dec 2017, In : Current Opinion in Systems Biology. 6, p. 7-13 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Systems Biology
Lactic acid
Bacteria
Lactic Acid
Food

The role of hydrophobicity in protein folding and aggregation

Dijk, E., 2017, 133 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File