Research Output 2002 2020

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2020

Facilities that make the PDB data collection more powerful

Lange, J., Baakman, C., Pistorius, A., Krieger, E., Hooft, R., Joosten, R. P. & Vriend, G., 1 Jan 2020, In : Protein Science. 29, 1, p. 330-344 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Databases
Computational Biology
Proteins
Bioinformatics
Software
2019

Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength

Price, C. E., Branco Dos Santos, F., Hesseling, A., Uusitalo, J. J., Bachmann, H., Benavente, V., Goel, A., Berkhout, J., Bruggeman, F. J., Marrink, S. J., Montalban-Lopez, M., De Jong, A., Kok, J., Molenaar, D., Poolman, B., Teusink, B. & Kuipers, O. P., 10 Jan 2019, In : BMC Evolutionary Biology. 19, 1, p. 1-15 15 p., 15.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
strength (mechanics)
glucose
mutation
chemostat
fitness

A genome-scale metabolic network of the aroma bacterium Leuconostoc mesenteroides subsp. cremoris

Özcan, E., Selvi, S. S., Nikerel, E., Teusink, B., Toksoy Öner, E. & Çakır, T., 1 Jan 2019, In : Applied Microbiology and Biotechnology.

Research output: Contribution to JournalArticleAcademicpeer-review

Metabolic Networks and Pathways
Citric Acid
Genome
Bacteria
phosphoketolase

A systematic assessment of current genome-scale metabolic reconstruction tools

Mendoza, S. N., Olivier, B. G., Molenaar, D. & Teusink, B., 7 Aug 2019, In : Genome Biology. 20, 1, 158.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Software
genome
Genome
software
Benchmarking

Finding functional differences between species in a microbial community: Case studies in wine fermentation and Kefir culture

Melkonian, C., Gottstein, W., Blasche, S., Kim, Y., Abel-Kistrup, M., Swiegers, H., Saerens, S., Edwards, N., Patil, K. R., Teusink, B. & Molenaar, D., 25 Jun 2019, In : Frontiers in Microbiology. 10, JUNE, p. 1-14 14 p., 01347.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Wine
Fermentation
Metagenomics
Gluconobacter
Pantoea

Impact of pathogenic mutations of the GLUT1 glucose transporter on channel dynamics using consdyn enhanced sampling: [version 1; peer review: 1 approved with reservations, 1 not approved]

Mouhib, H., Higuchi, A., Abeln, S., Yura, K. & Feenstra, K. A., 22 Mar 2019, (Accepted/In press) In : F1000Research. 8, 322.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Peer Review
Facilitative Glucose Transport Proteins
Sampling
Mutation
Glucose Transporter Type 1

Impact of pathogenic mutations of the GLUT1 glucose transporter on channel dynamics using ConsDYN enhanced sampling

Mouhib, H., Higuchi, A., Abeln, S., Yura, K. & Feenstra, K. A., 22 Mar 2019, In : F1000Research. 8, p. 322

Research output: Contribution to JournalArticleAcademic

Open Access
Facilitative Glucose Transport Proteins
Sampling
Mutation
Glucose Transporter Type 1
Molecular dynamics

SeRenDIP: SEquential REmasteriNg to DerIve profiles for fast and accurate predictions of PPI interface positions

Hou, Q., De Geest, P. F. G., Griffioen, C. J., Abeln, S., Heringa, J. & Feenstra, K. A., 15 Nov 2019, In : Bioinformatics. 35, 22, p. 4794-4796 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Web Server
Proteins
Protein
Prediction
Interaction

Tailor-made multiple sequence alignments using the PRALINE 2 alignment toolkit

Dijkstra, M. J. J., van der Ploeg, A. J., Feenstra, K. A., Fokkink, W. J., Abeln, S. & Heringa, J., 1 Aug 2019, In : Bioinformatics. p. 1-3 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Multiple Sequence Alignment
Workflow
Sequence Alignment
Work Flow
Alignment

The ability of transcription factors to differentially regulate gene expression is a crucial component of the mechanism underlying inversion, a frequently observed genetic interaction pattern

Amini, S., Jacobsen, A., Ivanova, O., Lijnzaad, P., Heringa, J., Holstege, F. C. P., Feenstra, K. A. & Kemmeren, P., 13 May 2019, In : PLoS Computational Biology. 15, 5, p. 1-27 27 p., e1007061.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Transcription factors
Transcription Factor
Gene expression
Gene Expression
gene expression

The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth

Dijk, E. V., Gils, J. H. M. V., Peduzzo, A., Hofmann, A., Groth, G., Mouhib, H., Otzen, D. E., Buell, A. K. & Abeln, S., 13 Jun 2019, In : arXiv.org. 25 p.

Research output: Contribution to JournalArticleAcademic

thermodynamics
protein
heat capacity
meta-analysis
hydrophobicity

The number of active metabolic pathways is bounded by the number of cellular constraints at maximal metabolic rates

de Groot, D. H., van Boxtel, C., Planque, R., Bruggeman, F. J. & Teusink, B., 11 Mar 2019, In : PLoS Computational Biology. 15, 3, p. 1-24 24 p., e1006858.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolic Networks and Pathways
biochemical pathways
Pathway
enzyme
Fluxes
2018

Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer

Jacobsen, A., Bosch, L. J. W., Martens-De Kemp, S. R., Carvalho, B., Sillars-Hardebol, A. H., Dobson, R. J., De Rinaldis, E., Meijer, G. A., Abeln, S., Heringa, J., Fijneman, R. J. A. & Feenstra, K. A., 14 May 2018, In : Scientific Reports. 8, 1, p. 7522 7522.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Aurora Kinase A
Colorectal Neoplasms
Cell Line
Protein Interaction Maps
Genes

Deep sequencing identifies hepatitis B virus core protein signatures in chronic hepatitis B patients

van der Ree, M. H., Jansen, L., Welkers, M. R. A., Reesink, H. W., Feenstra, K. A. & Kootstra, N. A., Oct 2018, In : Antiviral research. 158, p. 213-225 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Viral Core Proteins
High-Throughput Nucleotide Sequencing
Chronic Hepatitis B
Hepatitis B e Antigens
Hepatitis B virus

Dynamic elementary mode modelling of non-steady state flux data

Folch-Fortuny, A., Teusink, B., Hoefsloot, H. C. J., Smilde, A. K. & Ferrer, A., 18 Jun 2018, In : BMC Systems Biology. 12, p. 1-15 15 p., 71.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolic Flux Analysis
Fluxes
Discriminant Analysis
Metabolic Networks and Pathways
Modeling

Further elucidation of galactose utilization in Lactococcus lactis MG1363

Solopova, A., Bachmann, H., Teusink, B., Kok, J. & Kuipers, O. P., 3 Aug 2018, In : Frontiers in Microbiology. 9, AUGUST, p. 1-9 9 p., 1803.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
Galactose
Lactose
Lactococcus
Membrane Transport Proteins

Low affinity uniporter carrier proteins can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M. J., De La Torre Cortés, P. & Teusink, B., 3 Apr 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 5576.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Facilitated Diffusion
Facilitative Glucose Transport Proteins
Glycolysis
Saccharomyces cerevisiae
Carrier Proteins

Maintaining maximal metabolic flux by gene expression control

Planqué, R., Hulshof, J., Teusink, B., Hendriks, J. C. & Bruggeman, F. J., 20 Sep 2018, In : PLoS Computational Biology. 14, 9, p. 1-20 20 p., e1006412.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolites
Metabolic Networks and Pathways
Gene expression
Gene Expression
gene expression

Motif-Aware PRALINE: Improving the alignment of motif regions: Improving the alignment of motif regions

Dijkstra, M., Bawono, P., Abeln, S., Feenstra, K. A., Fokkink, W. & Heringa, J., 1 Nov 2018, In : PLoS Computational Biology. 14, 11, p. 1-19 19 p., e1006547.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Sequence Alignment
sequence alignment
Alignment
Multiple Sequence Alignment
Benchmarking

The characteristics of molten globule states and folding pathways strongly depend on the sequence of a protein

Dijkstra, M. J. J., Fokkink, W. J., Heringa, J., van Dijk, E. & Abeln, S., 17 Nov 2018, In : Molecular Physics. 116, 21-22, p. 3173-3180 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
globules
folding
Molten materials
Hot Temperature
proteins

Training for translation between disciplines: A philosophy for life and data sciences curricula

Anton Feenstra, K., Abeln, S., Westerhuis, J. A., Brancos Dos Santos, F., Molenaar, D., Teusink, B., Hoefsloot, H. C. J. & Heringa, J., 1 Jul 2018, In : Bioinformatics. 34, 13, p. i4-i12 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Understanding start-up problems in yeast glycolysis

Overal, G. B., Teusink, B., Bruggeman, F. J., Hulshof, J. & Planqué, R., May 2018, In : Mathematical Biosciences. 299, May, p. 117-126 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Glycolysis
Start-up
glycolysis
Yeast
Yeasts
2017

Both intrinsic substrate preference and network context contribute to substrate selection of classical tyrosine phosphatases

Palma, A., Tinti, M., Paoluzi, S., Santonico, E., Brandt, B. W., Hooft Van Huijsduijnen, R., Masch, A., Heringa, J., Schutkowski, M., Castagnoli, L. & Cesareni, G., 24 Mar 2017, In : Journal of Biological Chemistry. 292, 12, p. 4942-4958 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Phosphoric Monoester Hydrolases
Tyrosine
Phosphopeptides
Protein Tyrosine Phosphatases
Substrates

Detection of structural variants and recurrent breakpoint genes in colorectal adenoma-to-carcinoma progression

van den Broek, E., Dijkstra, M. J. J., Voorham, Q. J. M., Carvalho, B., van de Wiel, M. A., Abeln, S., Meijer, G. A. & Fijneman, R. J. A., Feb 2017, In : Cancer Research. 77

Research output: Contribution to JournalArticleAcademic

GeneBreak: detection of recurrent DNA copy number aberration-associated chromosomal breakpoints within genes

Fijneman, R. J. A., van den Broek, E., van Lieshout, S., Rausch, C., Ylstra, B., van de Wiel, M. A., Meijer, G. A. & Abeln, S., 6 Jul 2017, In : F1000Research. 5, p. 1-8 8 p., 2340.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Aberrations
Chromosome Aberrations
Genes
Genome
DNA

Low affinity membrane transporters can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M., de la Torre Cortés, P. & Teusink, B., 2 Nov 2017, In : bioRxiv.

Research output: Contribution to JournalArticleAcademic

Maintaining maximal metabolic rates by gene expression control

Planque, R., Hulshof, J., Teusink, B., Hendriks, J. C. & Bruggeman, F. J., 9 Mar 2017, In : bioRxiv.

Research output: Contribution to JournalArticleAcademicpeer-review

Model-based quantification of metabolic interactions from dynamic microbial-community data

Hanemaaijer, M., Olivier, B. G., Röling, W. F. M., Bruggeman, F. J. & Teusink, B., 1 Mar 2017, In : PLoS ONE. 12, 3, e0173183.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Microbial Interactions
Coculture Techniques
microbial communities
Hydrogen
Wolinella

Probing the genome-scale metabolic landscape of Bordetella pertussis, the causative agent of whooping cough

dos Santos, F. B., Olivier, B. G., Boele, J., Krumpochova, P., Klau, G. W., Giera, M. & Teusink, B., 1 Nov 2017, In : Applied and Environmental Microbiology. 83, 21

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Bordetella pertussis
whooping cough
Whooping Cough
thiosulfate
physiology

Revelation of the Genetic Basis for Convergent Innovative Anal Fin Pigmentation Patterns in Cichlid Fishes

Gu, L., Zhang, C. & Xia, C., 20 Jul 2017, (Submitted) In : bioRxiv.

Research output: Contribution to JournalArticleAcademic

pigmentation
fins
fish
genes
convergent evolution

Seeing the trees through the forest: sequence-based homo- and heteromeric protein-protein interaction sites prediction using random forest

Hou, Q., De Geest, P. F. G., Vranken, W. F., Heringa, J. & Feenstra, K. A., 15 May 2017, In : Bioinformatics. 33, 10, p. 1479-1487 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Random Forest
Protein-protein Interaction
Proteins
Prediction
Predictors

Systematically linking tranSMART, Galaxy and EGA for reusing human translational research data [version 1; referees: awaiting peer review]

Zhang, C., Bijlard, J., Staiger, C., Scollen, S., van Enckevort, D., Hoogstrate, Y., Senf, A., Hiltemann, S., Repo, S., Pipping, W., Bierkens, M., Payralbe, S., Stringer, B., Heringa, J., Stubbs, A., Bonino Da Silva Santos, LO., Belien, J. A. M., Weistra, W., Azevedo, R. V. D. M., van Bochove, K. & 6 othersMeijer, G., Boiten, J-W., Rambla, J., Fijneman, R. J., Spalding, JD. & Abeln, S., 16 Aug 2017, In : F1000Research. 6, 1488

Research output: Contribution to JournalArticleAcademic

Open Access

Systems biology of lactic acid bacteria: For food and thought

Teusink, B. & Molenaar, D., 1 Dec 2017, In : Current Opinion in Systems Biology. 6, p. 7-13 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Systems Biology
Lactic acid
Bacteria
Lactic Acid
Food
2016

BioASF: A framework for automatically generating executable pathway models specified in BioPAX

Haydarlou, R., Jacobsen, A., Bonzanni, N., Feenstra, K. A., Abeln, S. & Heringa, J., 15 Jun 2016, In : Bioinformatics. 32, 12, p. 60-69

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Pathway
Research Personnel
Catenins
Biological Models
Wnt Signaling Pathway

CLUB-MARTINI: Selecting favourable interactions amongst available candidates, a coarse-grained simulation approach to scoring docking decoys

Hou, Q., Lensink, M. F., Heringa, J. & Feenstra, K. A., 11 May 2016, In : PLoS ONE. 11, 5, e0155251.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Free energy
energy
Conformations
protein conformation
Benchmarking

ConBind: Motif-aware cross-species alignment for the identification of functional transcription factor binding sites

Lelieveld, S. H., Schütte, J., Dijkstra, M. J. J., Bawono, P., Kinston, S. J., Göttgens, B., Heringa, J. & Bonzanni, N., 5 May 2016, In : Nucleic Acids Research. 44, 8, p. e72

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Sequence Alignment
Transcription Factors
Nucleotides
Binding Sites
Nucleic Acid Regulatory Sequences

Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation

van Dijk, E., Varilly, P., Knowles, T. P. J., Frenkel, D. & Abeln, S., 19 Feb 2016, In : Physical Review Letters. 116, 7, p. 078101

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
biopolymer denaturation
hydrophobicity
proteins
solvation
specific heat

Construction and Experimental Validation of a Petri Net Model of Wnt/beta-Catenin Signaling

Jacobsen, A., Heijmans, N., Verkaar, F., Smit, M. J., Heringa, J., van Amerongen, R. & Feenstra, K. A., 2016, In : PLoS ONE. 11, 5, e0155743.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Catenins
beta Catenin
Petri nets
Stabilization
Wnt Signaling Pathway

ECCB 2016: The 15th European Conference on Computational Biology

Heringa, J., Reinders, M., Abeln, S. & de Ridder, J., 1 Sep 2016, In : Bioinformatics. 32, 17, p. 389-392

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Gene expression metaModules identifies key functional subnet- works in microbiome-related disease

May, A., Brandt, B. W., El-Kebir, M., Klau, G. W., Zaura, E., Crielaard, W., Heringa, J. & Abeln, S., 2016, In : Bioinformatics. 32, 11, p. 1678-1685

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Microbiota
Gene expression
Gene Expression
Pathway
Mouth Diseases

HapCol: Accurate and memory-efficient haplotype assembly from long reads

Pirola, Y., Zaccaria, S., Dondi, R., Klau, G. W., Pisanti, N. & Bonizzoni, P., 1 Jun 2016, In : Bioinformatics. 32, 11, p. 1610-1617 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Haplotype
Nucleotides
Polymorphism
Haplotypes
Sequencing

Integrating Candida albicans metabolism with biofilm heterogeneity by transcriptome mapping

Rajendran, R., May, A., Sherry, L., Kean, R., Williams, C., Jones, B. L., Burgess, K. V., Heringa, J., Abeln, S., Brandt, B. W., Munro, C. A. & Ramage, G., 21 Oct 2016, In : Scientific Reports. 6, July, p. 1-11 11 p., 35436.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Biofilms
Candida albicans
Transcriptome
Phenotype
Metabolic Networks and Pathways

Integration of EGA secure data access into Galaxy

Hoogstrate, Y., Zhang, C., Senf, A., Bijlard, J., Hiltemann, S., van Enckevort, D., Repo, S., Heringa, J., Jenster, G., Fijneman, R. J. A., Boiten, J-W., Meijer, G. A., Stubbs, A., Rambla, J., Spalding, D. & Abeln, S., 2016, In : F1000Research. 5, 2841.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Galaxies
Genes
Genome
Translational Medical Research
Workflow

Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy

Knijnenburg, T. A., Klau, G. W., Iorio, F., Garnett, M. J., McDermott, U., Shmulevich, I. & Wessels, L. F. A., 23 Nov 2016, In : Scientific Reports. 6, 36812.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Learning systems
Genes
Cells

Mechanical Unfolding of an Autotransporter Passenger Protein Reveals the Secretion Starting Point and Processive Transport Intermediates

Baclayon, M., van Ulsen, P., Mouhib, H., Hashemi Shabestari, M., Verzijden, T., Abeln, S., Roos, W. H. & Wuite, G. J. L., 2016, In : ACS Nano. 10, 6, p. 5710-5719

Research output: Contribution to JournalArticleAcademicpeer-review

protease
secretions
passengers
Hemoglobin
hemoglobin

On the Minimum Error Correction Problem for Haplotype Assembly in Diploid and Polyploid Genomes

Bonizzoni, P., Dondi, R., Klau, G. W., Pirola, Y., Pisanti, N. & Zaccaria, S., 1 Sep 2016, In : Journal of Computational Biology. 23, 9, p. 718-736 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Polyploidy
Haplotype
Error correction
Error Correction
Diploidy

SCRY: Extending SPARQL with custom data processing methods for the life sciences

Stringer, B., Meroño-peñuela, A., Abeln, S., van Harmelen, F. & Heringa, J., 2016, In : CEUR Workshop Proceedings. 1795, p. 1-10 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

The FAIR Guiding Principles for scientific data management and stewardship

Wilkinson, M. D., Dumontier, M., Aalbersberg, IJ. J., Appleton, G., Axton, M., Baak, A., Blomberg, N., Boiten, J-W., da Silva Santos, L. B., Bourne, P. E., Bouwman, J., Brookes, A. J., Clark, T., Crosas, M., Dillo, I., Dumon, O., Edmunds, S., Evelo, C. T., Finkers, R., Gonzalez-Beltran, A. & 33 othersGray, A. J. G., Groth, P. T., Goble, C., Grethe, J. S., Heringa, J., ’t Hoen, P. A. C., Hooft, R., Kuhn, T., Kok, R., Kok, J., Lusher, S. J., Martone, M. E., Mons, A., Packer, A. L., Persson, B., Rocca-Serra, P., Roos, M., van Schaik, R., Sansone, S-A., Schultes, E., Sengstag, T., Slater, T., Strawn, G., Swertz, M. A., Thompson, M., van der Lei, J., van Mulligen, E., Velterop, J., Waagmeester, A., Wittenburg, P., Wolstencroft, K., Zhao, J. & Mons, B., 15 Mar 2016, In : Scientific Data. 3, 160018.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Reusability
Data Management
Information management
management
Reuse
2015

Automatic classification of protein structure using the maximum contact map overlap metric

Andonov, R., Djidjev, H., Klau, G. W., Boudic-Jamin, M. L. & Wohlers, I., 2015, In : Algorithms. 8, 4, p. 850-869 20 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Protein Structure
Overlap
Contact
Proteins
Protein

CIDANE: Comprehensive isoform discovery and abundance estimation

Canzar, S., Andreotti, S., Weese, D., Reinert, K. & Klau, G. W., 2015, In : Lecture Notes in Computer Science. 9029, p. 60-61

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access