Chemistry and Pharmaceutical Sciences

Research Output 1977 2020

Filter
Review article
2019

Base Metal Catalyzed Isocyanide Insertions

Collet, J. W., Roose, T. R., Ruijter, E., Maes, B. U. W. & Orru, R. V. A., 9 Jul 2019, In : Angewandte Chemie - International Edition. 20 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Cyanides
Metals
Transition metals
Nucleophiles
Organometallics

CE-MS for metabolomics: Developments and applications in the period 2016–2018

Ramautar, R., Somsen, G. W. & de Jong, G. J., 1 Jan 2019, In : Electrophoresis. 40, 1, p. 165-179 15 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Metabolomics
Metabolites
Electrophoresis
Coatings

CE-SDS method development, validation and best practice - An overview

Sänger-van de Griend, C. E., 29 May 2019, In : Electrophoresis.

Research output: Contribution to JournalReview articleAcademicpeer-review

Licensure
Practice Guidelines
Industry
Proteins
Therapeutics

Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly

Jeganathan, S., Wendt, M., Kiehstaller, S., Brancaccio, D., Kuepper, A., Pospiech, N., Carotenuto, A., Novellino, E., Hennig, S. & Grossmann, T. N., 25 Nov 2019, In : Angewandte Chemie - International Edition. 58, 48, p. 17351-17358 8 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Transcription factors
Epitopes
Peptides
Transcription Factors
Conformations

Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays

Otvos, R. A., Still, K. B. M., Somsen, G. W., Smit, A. B. & Kool, J., 1 Mar 2019, In : SLAS Discovery. 24, 3, p. 362-385 24 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Nicotinic Receptors
Drug Discovery
Biological Products
Ion Channels
Libraries

Enlightening developments in 1,3-P,N-ligand-stabilized multinuclear complexes: A shift from catalysis to photoluminescence

Rong, M. K., Holtrop, F., Slootweg, J. C. & Lammertsma, K., 1 Mar 2019, In : Coordination Chemistry Reviews. 382, p. 57-68 12 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Catalysis
catalysis
Photoluminescence
Coinage
Metals

Increasing the functionalities of 3D printed microchemical devices by single material, multimaterial, and print-pause-print 3D printing

Li, F., Macdonald, N. P., Guijt, R. M. & Breadmore, M. C., 7 Jan 2019, In : Lab on a Chip. 19, 1, p. 35-49 15 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Fluidic devices
Printing
Equipment and Supplies
3D printers
Rapid prototyping

Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosis

Ferraz, C. R., Arrahman, A., Xie, C., Casewell, N. R., Lewis, R. J., Kool, J. & Cardoso, F. C., 1 Jan 2019, In : Frontiers in Ecology and Evolution. 7, JUN, 218.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
venom
venoms
snake
snakes
toxin

Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs

De Groof, T. W. M., Bobkov, V., Heukers, R. & Smit, M. J., 15 Mar 2019, In : Molecular and Cellular Endocrinology. 484, p. 15-24 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Single-Domain Antibodies
G-Protein-Coupled Receptors
Imaging techniques
Immunoglobulin Fragments
Antibodies

Nanobodies detecting and modulating GPCRs outside in and inside out

Heukers, R., De Groof, T. W. M. & Smit, M. J., 1 Apr 2019, In : Current Opinion in Cell Biology. 57, p. 115-122 8 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Single-Domain Antibodies
G-Protein-Coupled Receptors
Immunoglobulin Fragments
Physiological Phenomena
Drug Discovery

One-body reduced density-matrix functional theory in finite basis sets at elevated temperatures

Giesbertz, K. J. H. & Ruggenthaler, M., 12 Feb 2019, In : Physics Reports. p. 1-47 47 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
File
density functional theory
temperature
constrictions
bosons
interactions

Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft

Neubacher, S., Hennig, S. & Grossmann, T. N., 1 May 2019, In : BioSpektrum. 25, 3, p. 338-339 2 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Enzymes
Protein Engineering
Enzyme Stability
Cyclization
Proteins

Resurfacing halide perovskite nanocrystals Optoelectronic devices require tailored ligands that stabilize nanocrystals and promote charge transport

Almeida, G., Infante, I. & Manna, L., 1 Jan 2019, In : Science. 364, 6443, p. 833-834 2 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

RNA Structure and Cellular Applications of Fluorescent Light-Up Aptamers

Neubacher, S. & Hennig, S., 28 Jan 2019, In : Angewandte Chemie - International Edition. 58, 5, p. 1266-1279 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
RNA
Nucleotide Aptamers
Long Noncoding RNA
Blueprints
Untranslated RNA

The Landscape of Atypical and Eukaryotic Protein Kinases

Kanev, G. K., de Graaf, C., de Esch, I. J. P., Leurs, R., Würdinger, T., Westerman, B. A. & Kooistra, A. J., Nov 2019, In : Trends in Pharmacological Sciences. 40, 11, p. 818-832 15 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Protein Kinases
Phosphotransferases
Spine
Single Nucleotide Polymorphism
Tumors

The Nature of Hydrogen Bonds: A Delineation of the Role of Different Energy Components on Hydrogen Bond Strengths and Lengths

van der Lubbe, S. C. C. & Fonseca Guerra, C., 1 Jan 2019, In : Chemistry - An Asian Journal. 14, 16, p. 2760-2769 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Bond length
Static Electricity
Hydrogen
Hydrogen bonds
Coulomb interactions

Thiosulfonates as Emerging Reactants: Synthesis and Applications

Mampuys, P., McElroy, C. R., Clark, J. H., Orru, R. V. A. & Maes, B. U. W., 14 Oct 2019, In : Advanced Synthesis and Catalysis. p. 1-63 63 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Nucleophiles
Availability

Total Synthesis of Aspidosperma and Strychnos Alkaloids through Indole Dearomatization

Saya, J. M., Ruijter, E. & Orru, R. V. A., 5 Jul 2019, In : Chemistry - A European Journal. 25, 38, p. 8916-8935 20 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
File
Alkaloids
Secologanin Tryptamine Alkaloids
Indoles
indole
tryptamine
2018

Advances in Palladium-Catalyzed Cascade Cyclizations

Biemolt, J. & Ruijter, E., 18 Oct 2018, In : Advanced Synthesis and Catalysis. 360, 20, p. 3821-3871 51 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
File
Cyclization
Palladium
Functional groups
Molecules

Biogenesis and function of extracellular vesicles in cancer

Bebelman, M. P., Smit, M. J., Pegtel, D. M. & Baglio, S. R., Aug 2018, In : Pharmacology and Therapeutics. 188, p. 1-11 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Exosomes
Neoplasms
Biological Phenomena
Endosomes
Growth

Capillary Electrophoresis: Trends and Recent Advances

Voeten, R. L. C., Ventouri, I. K., Haselberg, R. & Somsen, G. W., 6 Feb 2018, In : Analytical Chemistry. 90, 3, p. 1464-1481 18 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access

Chemical Diversity in the G Protein-Coupled Receptor Superfamily

Vass, M., Kooistra, A. J., Yang, D., Stevens, R. C., Wang, M. W. & de Graaf, C., 1 May 2018, In : Trends in Pharmacological Sciences. 39, 5, p. 494-512 19 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

G-Protein-Coupled Receptors
Ligands
Cell signaling
Chemical compounds
Modulators

Comment on "nonuniqueness of algebraic first-order density-matrix functionals"

Gritsenko, O. V., 14 Feb 2018, In : Physical Review A. 97, 2, p. 1-2 2 p., 026501.

Research output: Contribution to JournalReview articleAcademicpeer-review

functionals
occupation
orbitals
symmetry
prototypes

Coordination chemistry of tris(azolyl)phosphines

Tazelaar, C. G. J., Slootweg, J. C. & Lammertsma, K., 1 Feb 2018, In : Coordination Chemistry Reviews. 356, p. 115-126 12 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
phosphine
Phosphines
phosphines
chemistry
Methane

Diagnostic accuracy of diagnostic imaging for lumbar disc herniation in adults with low back pain or sciatica is unknown; a systematic review

Kim, J-H., van Rijn, R. M., van Tulder, M. W., Koes, B. W., de Boer, M. R., Ginai, A. Z., Ostelo, R. W. G. J., van der Windt, D. A. M. W. & Verhagen, A. P., 2018, In : Chiropractic and Manual Therapies. 26, p. 37

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Sciatica
Myelography
Diagnostic Imaging
Low Back Pain
Tomography

Nucleophilic Substitution (SN2): Dependence on Nucleophile, Leaving Group, Central Atom, Substituents, and Solvent

Hamlin, T. A., Swart, M. & Bickelhaupt, F. M., 5 Jun 2018, In : ChemPhysChem. 19, 11, p. 1315-1330 16 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Potential energy surfaces
Nucleophiles
nucleophiles
Substitution reactions
potential energy

Optimizing separations in online comprehensive two-dimensional liquid chromatography

Pirok, B. W. J., Gargano, A. F. G. & Schoenmakers, P. J., 1 Jan 2018, In : Journal of Separation Science. 41, 1, p. 68-98 31 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Liquid chromatography
Mass spectrometry
Polymers
Molecular weight
Stereochemistry

The Therapeutic Potential of PTEN Modulation: Targeting Strategies from Gene to Protein

McLoughlin, N. M., Mueller, C. & Grossmann, T. N., 18 Jan 2018, In : Cell Chemical Biology. 25, 1, p. 19-29

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Tumors
Genes
Modulation
MicroRNAs
Phosphoric Monoester Hydrolases

When fragments link: a bibliometric perspective on the development of fragment-based drug discovery

Romasanta, A. K. S., van der Sijde, P., Hellsten, I., Hubbard, R. E., Keseru, G. M., van Muijlwijk-Koezen, J. & de Esch, I. J. P., Sep 2018, In : Drug Discovery Today. 23, 9, p. 1596-1609 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Bibliometrics
Drug Discovery
Authorship
Pharmaceutical Chemistry
Physics
2017

Analyzing Reaction Rates with the Distortion/Interaction-Activation Strain Model

Bickelhaupt, F. M. & Houk, K. N., 2017, In : Angewandte Chemie International Edition in English. 56, 34, p. 10070-10086 17 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Reaction rates
Chemical activation
Molecules
Cycloaddition
Organometallics

Extending the Structural View of Class B GPCRs

de Graaf, C., Song, G., Cao, C., Zhao, Q., Wang, M. W., Wu, B. & Stevens, R. C., 1 Dec 2017, In : Trends in Biochemical Sciences. 42, 12, p. 946-960 15 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

G-Protein-Coupled Receptors
GTP-Binding Proteins
Secretin
Chemical activation
Modulation

Fluorine-18 labelled building blocks for PET tracer synthesis

Van Der Born, D., Pees, A., Poot, A. J., Orru, R. V. A., Windhorst, A. D. & Vugts, D. J., 7 Aug 2017, In : Chemical Society Reviews. 46, 15, p. 4709-4773 65 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Positron emission tomography
Fluorine
Radioisotopes
Imaging techniques

From the Kohn-Sham band gap to the fundamental gap in solids. An integer electron approach

Baerends, E. J., 5 Jun 2017, In : Physical Chemistry Chemical Physics. 19, 24, p. 15639-15656 18 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

integers
Energy gap
Molecules
Electrons
Excitation energy

Functionalization of P4 through Direct P−C Bond Formation

Borger, J. E., Ehlers, A. W., Slootweg, J. C. & Lammertsma, K., 4 Sep 2017, In : Chemistry - A European Journal. 23, 49, p. 11738-11746 9 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Organophosphorus Compounds
Chlorine
Metals
carbene

Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise

Slagboom, J., Kool, J., Harrison, R. A. & Casewell, N. R., 1 Jun 2017, In : British Journal of Haematology. 177, 6, p. 947-959 13 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Snake Bites
Snake Venoms
Venoms
Pharmaceutical Preparations
Neglected Diseases

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

Schuetz, D. A., de Witte, W. E. A., Wong, Y. C., Knasmueller, B., Richter, L., Kokh, D. B., Sadiq, S. K., Bosma, R., Nederpelt, I., Heitman, L. H., Segala, E., Amaral, M., Guo, D., Andres, D., Georgi, V., Stoddart, L. A., Hill, S., Cooke, R. M., de Graaf, C., Leurs, R. & 6 othersFrech, M., Wade, R. C., de Lange, E. C. M., IJzerman, A. P., Müller-Fahrnow, A. & Ecker, G. F., 1 Jun 2017, In : Drug Discovery Today. 22, 6, p. 896-911 16 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Drug Industry
Drug Discovery
Pharmaceutical Preparations
Decision Making
Industry

New Modalities for Challenging Targets in Drug Discovery

Valeur, E., Guéret, S. M., Adihou, H., Gopalakrishnan, R., Lemurell, M., Waldmann, H., Grossmann, T. N. & Plowright, A. T., 21 Aug 2017, In : Angewandte Chemie International Edition in English. 56, p. 10294–10323

Research output: Contribution to JournalReview articleAcademicpeer-review

Proteins
Molecules
Oligonucleotides
Nucleic acids
Biological systems

Nitrilium ions-synthesis and applications

Van Dijk, T., Slootweg, J. C. & Lammertsma, K., 2017, In : Organic and Biomolecular Chemistry. 15, 48, p. 10134-10144 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Ions
synthesis
Organic Chemistry
organic chemistry
Synthetic Chemistry Techniques

Reversed-phase separation methods for glycan analysis

Vreeker, G. C. M. & Wuhrer, M., 1 Jan 2017, In : Analytical and Bioanalytical Chemistry. 409, 2, p. 359-378 20 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Chromatography
Phase separation
Polysaccharides
Reverse-Phase Chromatography
Hydrophobic and Hydrophilic Interactions

Structural Analysis of Chemokine Receptor-Ligand Interactions

Arimont, M., Sun, S-L., Leurs, R., Smit, M., De Esch, I. J. P. & de Graaf, C., 22 Jun 2017, In : Journal of Medicinal Chemistry. 60, 12, p. 4735-4779 45 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Chemokine Receptors
Ligands
Molecular Models
Structure-Activity Relationship
Site-Directed Mutagenesis

The clinical pharmacology of non-sedating antihistamines

Yanai, K., Yoshikawa, T., Yanai, A., Nakamura, T., Iida, T., Leurs, R. & Tashiro, M., 1 Oct 2017, In : Pharmacology and Therapeutics. 178, p. 148-156 9 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Clinical Pharmacology
Histamine Antagonists
Histamine H1 Antagonists
Histamine H1 Receptors
Hypnotics and Sedatives
2015

CE-MS for metabolomics: Developments and applications in the period 2012-2014

Ramautar, R., Somsen, G. W. & de Jong, G. J., 1 Jan 2015, In : Electrophoresis. 36, 1, p. 212-224 13 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Metabolomics
Electrophoresis
Micellar Electrokinetic Capillary Chromatography
Literature
Edible Plants

Generic GPCR residue numbers - Aligning topology maps while minding the gaps

Isberg, V., de Graaf, C., Bortolato, A., Cherezov, V., Katritch, V., Marshall, F. H., Mordalski, S., Pin, J. P., Stevens, R. C., Vriend, G. & Gloriam, D. E., 2015, In : Trends in Pharmacological Sciences. 36, 1, p. 22-31 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

G-Protein-Coupled Receptors
Topology
Constriction
Crystal structure
Databases

G Protein-Coupled Receptor Multimers: A Question Still Open Despite the Use of Novel Approaches

Vischer, H. F., Castro, M. & Pin, J. P., Sep 2015, In : Molecular Pharmacology. 88, 3, p. 561-71 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
G-Protein-Coupled Receptors
Fluorescence Microscopy

Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It

Hoffmann, R. C., Castro, M., Rinken, A., Leurs, R., Hill, S. J. & Vischer, H. F., Sep 2015, In : Molecular Pharmacology. 88, 3, p. 552-60 9 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

G-Protein-Coupled Receptors
Ligands
Pharmaceutical Preparations
Molecular Dynamics Simulation
Plasma Cells

Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors

de Munnik, S. M., Smit, M. J., Leurs, R. & Vischer, H. F., 2015, In : Frontiers in Pharmacology. 6, MAR, 40.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Herpesviridae
Viral Proteins
G-Protein-Coupled Receptors
Immune Evasion
Chemokine Receptors

The systemic control of circadian gene expression

Gerber, A., Saini, C., Curie, T., Emmenegger, Y., Rando, G., Gosselin, P., Gotic, I., Gos, P., Franken, P. & Schibler, U., 1 Sep 2015, In : Diabetes, Obesity and Metabolism. 17, S1, p. 23-32 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Suprachiasmatic Nucleus
Gene Expression
Serum Response Factor
Circadian Clocks
RNA-Binding Proteins
2013

Targeting tumors with nanobodies for cancer imaging and therapy

Oliveira, S., Heukers, R., Sornkom, J., Kok, R. J. & van Bergen En Henegouwen, P. M. P., 28 Dec 2013, In : Journal of Controlled Release. 172, 3, p. 607-17 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Single-Domain Antibodies
Neoplasms
Molecular Imaging
Therapeutics
Monoclonal Antibodies
2012

Capillary electrophoresis-mass spectrometry for the analysis of biopharmaceuticals

Haselberg, R., De Jong, G. J. & Somsen, G. W., Oct 2012, In : LC GC Europe. 25, 10, p. 551-562 12 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

2011

Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates

Orhan, H. & Vermeulen, N. P. E., May 2011, In : Current Drug Metabolism. 12, 4, p. 383-394 12 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Metabolites
Pharmaceutical Preparations
Biotransformation
Toxicity
Molecules