Environment and Health

Research Output 1992 2020

1992

Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?

van Dam, A. M., Brouns, M., Louisse, S. & Berkenbosch, F., 21 Aug 1992, In : Brain Research. 588, 2, p. 291-6 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Microglia
Interleukin-1
Endotoxins
Macrophages
Brain

Cytokines and inflammatory proteins in Alzheimer's disease

Berkenbosch, F., Biewenga, J., Brouns, M., Rozemuller, J. M., Strijbos, P. & van Dam, A. M., 1 Jul 1992, In : Research in immunology. 143, 6, p. 657-63 7 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

1993

Immunocytochemical detection of prostaglandin E2 in microvasculature and in neurons of rat brain after administration of bacterial endotoxin

Van Dam, A. M., Brouns, M., Man-A-Hing, W. & Berkenbosch, F., 11 Jun 1993, In : Brain Research. 613, 2, p. 331-6 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Microvessels
Dinoprostone
Endotoxins
Neurons
Brain
1995

Rat oxytocin receptor in brain, pituitary, mammary gland, and uterus: partial sequence and immunocytochemical localization

Adan, R. A., Van Leeuwen, F. W., Sonnemans, M. A., Brouns, M., Hoffman, G., Verbalis, J. G. & Burbach, J. P., Sep 1995, In : Endocrinology. 136, 9, p. 4022-8 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Oxytocin Receptors
Pituitary Gland
Human Mammary Glands
Uterus
Brain
1996

Skin and liver diseases induced in flounder (Platichthys flesus) after longterm exposure to contaminated sediments in large-scale mesocosms

Vethaak, A. D., Jol, J. G., Meijboom, A., Eggens, M. L., Rheinallt, T. A., Wester, P. W., Van De Zande, T., Bergman, A., Dankers, N., Ariese, F., Baan, R. A., Everts, J. M., Opperhuizen, A. & Marquenie, J. M., Oct 1996, In : Environmental Health Perspectives. 104, 11, p. 1218-1229 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

1998

Evidence for distinct mechanisms of transition state stabilization of GTPases by fluoride

Vincent, S., Brouns, M., Hart, M. J. & Settleman, J., 3 Mar 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 5, p. 2210-5 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

GTP Phosphohydrolases
Fluorides
GTPase-Activating Proteins
Guanine Nucleotides
Aluminum
1999

Determination of ruthenium in photographic emulsions - Development and comparison of different sample treatments and mass spectrometric methods

Krystek, P. & Heumann, K. G., 1999, In : Fresenius' Journal of Analytical Chemistry. 364, 1-2, p. 87-90 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Photographic emulsions
Ruthenium
Emulsions
Mass spectrometry
Mass Spectrometry
Iridium
Rhodium
Photographic emulsions
Inductively coupled plasma mass spectrometry
Dilution
2000

The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development

Brouns, M. R., Matheson, S. F., Hu, K. Q., Delalle, I., Caviness, V. S., Silver, J., Bronson, R. T. & Settleman, J., Nov 2000, In : Development (Cambridge). 127, 22, p. 4891-903 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Actins
Protein Kinase C
rho GTP-Binding Proteins
Neural Tube
Integrins
2001

p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation

Brouns, M. R., Matheson, S. F. & Settleman, J., Apr 2001, In : Nature Cell Biology. 3, 4, p. 361-7 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

src-Family Kinases
Nervous System
Actins
Brain
GTPase-Activating Proteins
2002

Determination of uranium in urine - Measurement of isotope ratios and quantification by use of inductively coupled plasma mass spectrometry

Krystek, P. & Ritsema, R., 24 Jul 2002, In : Analytical and Bioanalytical Chemistry. 374, 2, p. 226-229 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Inductively coupled plasma mass spectrometry
Uranium
Isotopes
Mass Spectrometry
Urine

Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development

Sordella, R., Classon, M., Hu, K. Q., Matheson, S. F., Brouns, M. R., Fine, B., Zhang, L., Takami, H., Yamada, Y. & Settleman, J., May 2002, In : Dev Cell. 2, 5, p. 553-65 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

rho GTP-Binding Proteins
Cell Size
Embryonic Development
Modulation
Defects
2003

Brominated flame retardants and endocrine disruption

Vos, J. G., Becher, G., Van Den Berg, M. & Leonards, P. E. G., Nov 2003, In : Pure and Applied Chemistry. 75, 11-12, p. 2039-2046 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Halogenated Diphenyl Ethers
Flame Retardants
Flame retardants
Ethers
Toxicity

Polybrominated diphenyl ethers in influents, suspended particulate matter, sediments, sewage treatment plant and effluents and biota from the Netherlands

De Boer, J., Wester, P. G., Van Der Horst, A. & Leonards, P. E. G., Mar 2003, In : Environmental Pollution. 122, 1, p. 63-74 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Halogenated Diphenyl Ethers
Sewage treatment plants
Biota
Particulate Matter
Sewage
2004

Analytical product study of germanium-containing medicine by different ICP-MS applications

Krystek, P. & Ritsema, R., 20 Aug 2004, In : Journal of Trace Elements in Medicine and Biology. 18, 1, p. 9-16 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Germanium
Inductively coupled plasma mass spectrometry
Medicine
Mass Spectrometry
Isotopes

Baseline survey of concentrations of toxaphene congeners in fish from European waters

McHugh, B., McGovern, E., Nixon, E., Klungsøyr, J., Rimkus, G. G., Leonards, P. E. & de Boer, J., Aug 2004, In : Journal of Environmental Monitoring. 6, 8, p. 665-672 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Toxaphene
baseline survey
Fishes
Water
fish

Determination of methylmercury and inorganic mercury in shark fillets

Krystek, P. & Ritsema, R., Dec 2004, In : Applied Organometallic Chemistry. 18, 12, p. 640-645 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Inductively coupled plasma mass spectrometry
Mercury
Gas chromatography
Fish
Atomic spectroscopy

Distribution and fate of HBCD and TBBPA brominated flame retardants in North Sea estuaries and aquatic food webs

Morris, S., Allchin, C. R., Zegers, B. N., Haftka, J. J. H., Boon, J. P., Belpaire, C., Leonards, P. E. G., Van Leeuwen, S. P. J. & De Boer, J., 1 Nov 2004, In : Environmental Science and Technology. 38, 21, p. 5497-5504 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Flame Retardants
Estuaries
Flame retardants
food web
Sediments

Synthetic musks in fish and other aquatic organisms

Leonards, P. E. G. & De Boer, J., 2004, Handbook of Environmental Chemistry. Springer/Verlag, Vol. 3. p. 49-84 36 p. (Handbook of Environmental Chemistry; vol. 3).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

musk xylene
Aquatic organisms
xylene
Xylene
aquatic organism
2005

Accumulation of organochlorines and brominated flame retardants in estuarine and marine food chains: Field measurements and model calculations

Veltman, K., Hendriks, J., Huijbregts, M., Leonards, P., Van Den Heuvel-Greve, M. & Vethaak, D., Oct 2005, In : Marine Pollution Bulletin. 50, 10, p. 1085-1102 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

flame retardants
Birds
Flame retardants
food chain
organochlorine

Characterization of polychlorinated n-alkanes using comprehensive two-dimensional gas chromatography-electron-capture negative ionisation time-of-flight mass spectrometry

Korytár, P., Parera, J., Leonards, P. E. G., Santos, F. J., De Boer, J. & Brinkman, U. A. T., 9 Sep 2005, In : Journal of Chromatography A. 1086, 1-2, p. 71-82 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Alkanes
Chlorine
Gas chromatography
Gas Chromatography
Ionization

Comprehensive two-dimensional gas chromatography of polybrominated diphenyl ethers

Korytár, P., Covaci, A., Leonards, P. E. G., De Boer, J. & Brinkman, U. A. T., 30 Dec 2005, In : Journal of Chromatography A. 1100, 2, p. 200-207 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Halogenated Diphenyl Ethers
decabromobiphenyl ether
Gas chromatography
Gas Chromatography
Polybrominated Biphenyls

Inhibition of transmethylation disturbs neurulation in chick embryos

Afman, L. A., Blom, H. J., Drittij, M-J., Brouns, M. R. & van Straaten, H. W. M., 8 Aug 2005, In : Developmental Brain Research. 158, 1-2, p. 59-65 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Neurulation
Homocysteine
Chick Embryo
Methionine Adenosyltransferase
Adenosylhomocysteinase
Inductively coupled plasma mass spectrometry
Atomic spectroscopy
Fluorescence Spectrometry
Fluorescence spectroscopy
Mercury

Monitoring metal speciation in the rivers meuse and rhine using DGT

Cleven, R., Nur, Y., Krystek, P. & Van Den Berg, G., Jul 2005, In : Water, Air and Soil Pollution. 165, 1-4, p. 249-263 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Rivers
Metals
Thin films
Monitoring
metal

Morphogenetic movements during cranial neural tube closure in the chick embryo and the effect of homocysteine

Brouns, M. R., Afman, L. A., Vanhauten, B. A. M., Hekking, J. W. M., Köhler, E. S. & van Straaten, H. W. M., Sep 2005, In : Anatomy and Embryology. 210, 2, p. 81-90 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Neural Tube
Homocysteine
Chick Embryo
Neural Crest
Cell Movement

Quadrupole mass spectrometer operating in the electron-capture negative ion mode as detector for comprehensive two-dimensional gas chromatography

Korytár, P., Parera, J., Leonards, P. E. G., De Boer, J. & Brinkman, U. A. T., 4 Mar 2005, In : Journal of Chromatography A. 1067, 1-2, p. 255-264 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Mass spectrometers
Gas chromatography
Gas Chromatography
Negative ions
Electrons

Toward positional cloning of the curly tail gene

Brouns, M. R., Peeters, M. C. E., Geurts, J. M., Merckx, D. M., Engelen, J. J., Hekking, J. W. M., Terwindt-Rouwenhorst, E. A. W., Oosterbaan, M. E. A. C., Geraedts, J. P. M. & van Straaten, H. W., Mar 2005, In : Birth Defects Research Part A-Clinical and Molecular Teratology. 73, 3, p. 154-61 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Tail
Organism Cloning
Genes
S 6
Chromosomes, Human, Pair 4
2006

Determination of Hg Species in Seafood

Krystek, P. & Ritsema, R., 17 Nov 2006, The Determination of Chemical Elements in Food: Applications for Atomic and Mass Spectrometry. John Wiley & Sons, Inc., p. 707-726 20 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Distinct but overlapping functions for the closely related p190 RhoGAPs in neural development

Matheson, S. F., Hu, K-Q., Brouns, M. R., Sordella, R., VanderHeide, J. D. & Settleman, J., 2006, In : Developmental Neuroscience. 28, 6, p. 538-50 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

rho GTP-Binding Proteins
Brain
GTPase-Activating Proteins
Corpus Callosum
Lateral Ventricles

Perfluoroalkyl compounds in relation to life-history and reproductive parameters in bottlenose dolphins (Tursiops truncatus) from Sarasota Bay, Florida, U.S.A

Houde, M., Balmer, B. C., Brandsma, S., Wells, R. S., Rowles, T. K., Solomon, K. R. & Muir, D. C. G., Sep 2006, In : Environmental Toxicology and Chemistry. 25, 9, p. 2405-2412 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bottle-Nosed Dolphin
Reproductive History
Dolphins
dolphin
life history
2007

Comparison of routine care self-reported and biometrical data on hypertension and diabetes: results of the Utrecht Health Project

Molenaar, E. A., Van Ameijden, E. J. C., Grobbee, D. E. & Numans, M. E., Apr 2007, In : European Journal of Public Health. 17, 2, p. 199-205 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Self Care
Hypertension
Health
Population Characteristics
Self Report

Monitoring of chromium species and 11 selected metals in emission and immission of airborne environment

Krystek, P. & Ritsema, R., 16 May 2007, In : International Journal of Mass Spectrometry. 265, 1, p. 23-29 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Chromium
chromium
Metals
Sampling
Inductively coupled plasma mass spectrometry
2008

Aanzienlijke comorbiditeit bij volwassenen met overgewicht: resultaten uit het 'Leidsche Rijn Gezondheidsproject'

Molenaar, E. A., Numans, M. E., van Ameijden, E. J. C. & Grobbee, D. E., 8 Nov 2008, In : Nederlands Tijdschrift voor Geneeskunde. 152, 45, p. 2457-63 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Comorbidity
Primary Health Care
Mental Health
Odds Ratio
Quality of Life
Uranium
Mass Spectrometry
Military Personnel
Inhalation
Nose

Burden and rates of treatment and control of cardiovascular disease risk factors in obesity: the Framingham Heart Study

Molenaar, E. A., Hwang, S-J., Vasan, R. S., Grobbee, D. E., Meigs, J. B., D'Agostino, R. B., Levy, D. & Fox, C. S., Jul 2008, In : Diabetes Care. 31, 7, p. 1367-72 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cardiovascular Diseases
Obesity
Weights and Measures
Therapeutics
Hypertension

Particle size-dependent organ distribution of gold nanoparticles after intravenous administration

De Jong, W. H., Hagens, W. I., Krystek, P., Burger, M. C., Sips, A. J. A. M. & Geertsma, R. E., 1 Feb 2008, In : Biomaterials. 29, 12, p. 1912-1919 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Particle Size
Gold
Intravenous Administration
Nanoparticles
Particle size
2009

Association of lifestyle factors with abdominal subcutaneous and visceral adiposity: the Framingham Heart Study

Molenaar, E. A., Massaro, J. M., Jacques, P. F., Pou, K. M., Ellison, R. C., Hoffmann, U., Pencina, K., Shadwick, S. D., Vasan, R. S., O'Donnell, C. J. & Fox, C. S., Mar 2009, In : Diabetes Care. 32, 3, p. 505-10 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Intra-Abdominal Fat
Adiposity
Life Style
Subcutaneous Fat
Nutrition Policy

Robust Identification of Coagulated Zebrafish Eggs using Image Processing and Classification Techniques

Alshut, R., Legradi, J. B., Yang, L., Strähle, U., Mikut, R. & Reischl, M., Jan 2009, In : Proc., 19. Workshop Computational Intelligence. 50, p. 9-21 13 p.

Research output: Contribution to JournalArticleAcademic

Inductively coupled plasma mass spectrometry
Groundwater
atomic absorption spectrometry
Mass Spectrometry
groundwater
2010

Effect of nutritional counselling and nutritional plus exercise counselling in overweight adults: a randomized trial in multidisciplinary primary care practice

Molenaar, E. A., van Ameijden, E. J. C., Vergouwe, Y., Grobbee, D. E. & Numans, M. E., Apr 2010, In : Family Practice. 27, 2, p. 143-50 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Counseling
Primary Health Care
Waist Circumference
Exercise
Nutritionists

Methods for Automated High-Throughput Toxicity Testing Using Zebrafish Embryos

Alshut, R., Legradi, J. B., Liebel, U., Yang, L., van Wezel, J., Straehle, U., Mikut, R. & Reischl, M., 2010, Ki 2010: Advances in Artificial Intelligence. Springer Berlin Heidelberg, Vol. 6359. p. 219-226 8 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

2012

A combined DNA-microarray and mechanism-specific toxicity approach with zebrafish embryos to investigate the pollution of river sediments

Kosmehl, T., Otte, J. C., Yang, L., Legradi, J. B., Bluhm, K., Zinsmeister, C., Keiter, S. H., Reifferscheid, G., Manz, W., Braunbeck, T., Strähle, U. & Hollert, H., 2 Feb 2012, In : Reproductive toxicology (Elmsford, N.Y.). 33, 2, p. 245-253 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bio-efficacy evaluation of nanoformulations of β-cyfluthrin against Callosobruchus maculatus (Coleoptera: Bruchidae)

Loha, K. M., Shakil, N. A., Kumar, J., Singh, M. K. & Srivastava, C., 1 Aug 2012, In : Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes. 47, 7, p. 687-691 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

cyfluthrin
Callosobruchus maculatus
Bruchidae
Beetles
Polyethylene glycols
2013

Gene Responses in the Central Nervous System of Zebrafish Embryos Exposed to the Neurotoxicant Methyl Mercury

Ho, N. Y., Yang, L., Legradi, J. B., Armant, O., Takamiya, M., Rastegar, S. & Strähle, U., 4 Mar 2013, In : Environmental science technology. 47, 7, p. 3316-3325 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos

Armant, O., März, M., Schmidt, R., Ferg, M., Diotel, N., Ertzer, R., Bryne, J. C., Yang, L., Baader, I., Reischl, M., Legradi, J. B., Mikut, R., Stemple, D., van Ijcken, W., van der Sloot, A., Lenhard, B., Strähle, U. & Rastegar, S., 14 May 2013, In : Developmental biology. 380, 2, p. 351-362 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex

Dudok, J. J., Sanz, A. S., Lundvig, D. M. S. & Wijnholds, J., 8 May 2013, In : Journal of Neuroscience. 33, 19, p. 8518-8527 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Membrane Proteins
Adherens Junctions
Maintenance
Proteins
Stem Cells

MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Müller cells

Dudok, J. J., Sanz, A. S., Lundvig, D. M. S., Sothilingam, V., Garcia Garrido, M., Klooster, J., Seeliger, M. W. & Wijnholds, J., Oct 2013, In : Glia. 61, 10, p. 1629-1644 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Photoreceptor Cells
Retina
Retinal Degeneration
Electroretinography
Adherens Junctions

Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis

Pellissier, L. P., Alves, C. H., Quinn, P. M., Vos, R. M., Tanimoto, N., Lundvig, D. M. S., Dudok, J. J., Hooibrink, B., Richard, F., Beck, S. C., Huber, G., Sothilingam, V., Garcia Garrido, M., Le Bivic, A., Seeliger, M. W. & Wijnholds, J., 5 Dec 2013, In : PLoS Genetics. 9, 12

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Leber Congenital Amaurosis
retina
ablation
stem cells
Retina