Environmental Bioanalytical Chemistry

Research Output 2003 2020

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2019

A Multiomics Study To Unravel the Effects of Developmental Exposure to Endosulfan in Rats: Molecular Explanation for Sex-Dependent Effects

Tarazona, S., Bernabeu, E., Carmona, H., Gómez-Giménez, B., García-Planells, J., Leonards, P. E. G., Jung, S., Conesa, A., Felipo, V. & Llansola, M., 16 Oct 2019, In : ACS Chemical Neuroscience. 10, 10, p. 4264-4279 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Endosulfan
Rats
Brain
Pesticides
Impurities

Brominated and organophosphorus flame retardants in South African indoor dust and cat hair

Brits, M., Brandsma, S. H., Rohwer, E. R., De Vos, J., Weiss, J. M. & de Boer, J., 1 Oct 2019, In : Environmental Pollution. 253, p. 120-129 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Flame Retardants
Flame retardants
Dust
Hair
Phosphates

Chlorinated Paraffins in Car Tires Recycled to Rubber Granulates and Playground Tiles

Brandsma, S. H., Brits, M., Groenewoud, Q. R., van Velzen, M. J. M., Leonards, P. E. G. & de Boer, J., 2 Jul 2019, In : Environmental Science and Technology. 53, 13, p. 7595-7603 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Chlorinated paraffins in indoor dust from Australia: Levels, congener patterns and preliminary assessment of human exposure

He, C., Brandsma, S. H., Jiang, H., O'Brien, J. W., van Mourik, L. M., Banks, A. P., Wang, X., Thai, P. K. & Mueller, J. F., 10 Sep 2019, In : Science of the Total Environment. 682, p. 318-323 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Paraffin
Paraffins
Dust
dust
alkane

Compound Identification Using Liquid Chromatography and High-Resolution Noncontact Fraction Collection with a Solenoid Valve

Jonker, W., de Vries, K., Althuisius, N., van Iperen, D., Janssen, E., ten Broek, R., Houtman, C., Zwart, N., Hamers, T., Lamoree, M. H., Ooms, B., Hidding, J., Somsen, G. W. & Kool, J., 1 Dec 2019, In : SLAS Technology. 24, 6, p. 543-555 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Solenoid valves
Liquid chromatography
Liquid Chromatography
Bioactivity
Flow rate

Early-life exposure to persistent organic pollutants (OCPs, PBDEs, PCBs, PFASs) and attention-deficit/hyperactivity disorder: A multi-pollutant analysis of a Norwegian birth cohort

Lenters, V., Iszatt, N., Forns, J., Čechová, E., Kočan, A., Legler, J., Leonards, P., Stigum, H. & Eggesbø, M., Apr 2019, In : Environment International. 125, p. 33-42 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
PBDE
PCB
sulfonate
confidence interval
hexachlorobenzene

First detection of short-chain chlorinated paraffins (SCCPs) in humpback whales (Megaptera novaeangliae) foraging in Antarctic waters

Casà, M. V., van Mourik, L. M., Weijs, L., Mueller, J. & Nash, S. B., Jul 2019, In : Environmental Pollution. 250, p. 953-959 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Humpback Whale
Whales
Paraffin
Paraffins
Water

Investigating predictive tools for refinery effluent hazard assessment using stream mesocosms

Cailleaud, K., Bassères, A., Gelber, C., Postma, J. F., ter Schure, A. T. M., Leonards, P. E. G., Redman, A. D., Whale, G. F., Spence, M. J. & Hjort, M., Mar 2019, In : Environmental toxicology and chemistry. 38, 3, p. 650-659 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Biota
Biomimetics
Poisons
Petroleum
hazard assessment

Occurrence of legacy and alternative plasticizers in indoor dust from various EU countries and implications for human exposure via dust ingestion and dermal absorption

Christia, C., Poma, G., Harrad, S., de Wit, C. A., Sjostrom, Y., Leonards, P., Lamoree, M. & Covaci, A., 1 Apr 2019, In : Environmental Research. 171, p. 204-212 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Skin Absorption
Plasticizers
phthalate
Dust
Eating

Review of the analysis of insecticide residues and their levels in different matrices in Ghana

Mohammed, S., Lamoree, M., Ansa-Asare, O. D. & de Boer, J., 30 Apr 2019, In : Ecotoxicology and Environmental Safety. 171, p. 361-372 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Ghana
Insecticides
Endosulfan
Lindane
DDT

Short-, medium-, and long-chain chlorinated paraffins in South African indoor dust and cat hair

Brits, M., de Boer, J., Rohwer, E. R., De Vos, J., Weiss, J. M. & Brandsma, S. H., 22 Aug 2019, In : Chemosphere. 238, p. 124643 124643.

Research output: Contribution to JournalArticleAcademicpeer-review

Dust
hair
Paraffin
Hair
Paraffins

The PFOA substitute GenX detected in the environment near a fluoropolymer manufacturing plant in the Netherlands

Brandsma, S. H., Koekkoek, J. C., van Velzen, M. J. M. & de Boer, J., 1 Apr 2019, In : Chemosphere. 220, p. 493-500 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
perfluorooctanoic acid
Fluorine containing polymers
Netherlands
manufacturing
Poaceae

The strength in numbers: comprehensive characterization of house dust using complementary mass spectrometric techniques

Rostkowski, P., Haglund, P., Aalizadeh, R., Alygizakis, N., Thomaidis, N., Arandes, J. B., Nizzetto, P. B., Booij, P., Budzinski, H., Brunswick, P., Covaci, A., Gallampois, C., Grosse, S., Hindle, R., Ipolyi, I., Jobst, K., Kaserzon, S. L., Leonards, P., Lestremau, F., Letzel, T. & 7 othersMagnér, J., Matsukami, H., Moschet, C., Oswald, P., Plassmann, M., Slobodnik, J. & Yang, C., 4 Mar 2019, In : Analytical and Bioanalytical Chemistry. p. 1-21 21 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Dust
Spectrometry
Spectrum Analysis
Screening
Gases

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

Viant, M. R., Ebbels, T. M. D., Beger, R. D., Ekman, D. R., Epps, D. J. T., Kamp, H., Leonards, P. E. G., Loizou, G. D., MacRae, J. I., van Ravenzwaay, B., Rocca-Serra, P., Salek, R. M., Walk, T. & Weber, R. J. M., 10 Jul 2019, In : Nature Communications. 10, p. 1-10 10 p., 3041.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
toxicology
Metabolomics
Practice Guidelines
Toxicology
2018

Development of a luminescent mutagenicity test for high-throughput screening of aquatic samples

Zwart, N., Lamoree, M. H., Houtman, C. J., de Boer, J., Kool, J. & Hamers, T., Feb 2018, In : Toxicology in Vitro. 46, p. 350-360 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mutagenicity Tests
Salmonella
Screening
Throughput
Mutagens

Effects of environmental pollutants on calcium release and uptake by rat cortical microsomes

Dusza, H. M., Cenijn, P. H., Kamstra, J. H., Westerink, R. H. S., Leonards, P. E. G. & Hamers, T., Dec 2018, In : Neurotoxicology. 69, p. 266-277 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Environmental Pollutants
Endosulfan
Microsomes
Rats
Diethylhexyl Phthalate
Flame Retardants
Flame retardants
Dust
Cleaning
Electronic equipment

High-Throughput Effect-Directed Analysis Using Downscaled in Vitro Reporter Gene Assays to Identify Endocrine Disruptors in Surface Water

Zwart, N., Nio, S. L., Houtman, C. J., De Boer, J., Kool, J., Hamers, T. & Lamoree, M. H., 3 Apr 2018, In : Environmental Science and Technology. 52, 7, p. 4367-4377 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Endocrine Disruptors
endocrine disruptor
Fractionation
Surface waters
Assays

Mass spectrometric identification of in vitro-generated metabolites of two emerging organophosphate flame retardants: V6 and BDP

Alves, A., Erratico, C., Lucattini, L., Cuykx, M., Ballesteros-Gómez, A., Leonards, P. E. G., Voorspoels, S. & Covaci, A., Dec 2018, In : Chemosphere. 212, p. 1047-1057 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Flame Retardants
Organophosphates
organophosphate
Flame retardants
Metabolites

Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts

Govarts, E., Iszatt, N., Trnovec, T., de Cock, M., Eggesbø, M., Palkovicova Murinova, L., van de Bor, M., Guxens, M., Chevrier, C., Koppen, G., Lamoree, M., Hertz-Picciotto, I., Lopez-Espinosa, M. J., Lertxundi, A., Grimalt, J. O., Torrent, M., Goñi-Irigoyen, F., Vermeulen, R., Legler, J. & Schoeters, G., Jun 2018, In : Environment International. 115, p. 267-278 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
hexachlorobenzene
smoking
pregnancy
DDE
PCB

The Arabidopsis GORK K+-channel is phosphorylated by calcium-dependent protein kinase 21 (CPK21), which in turn is activated by 14-3-3 proteins

van Kleeff, P. J. M., Gao, J., Mol, S., Zwart, N., Zhang, H., Li, K. W. & de Boer, A. H., Apr 2018, In : Plant Physiology and Biochemistry. 125, p. 219-231 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

14-3-3 Proteins
potassium channels
Arabidopsis
protein kinases
phosphorylation

Time-Integrative Passive sampling combined with TOxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment

Hamers, T., Legradi, J., Zwart, N., Smedes, F., de Weert, J., van den Brandhof, E. J., van de Meent, D. & de Zwart, D., Dec 2018, In : Environmental Toxicology and Pharmacology. 64, p. 48-59 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Water Quality
Rivers
Water quality
Toxicity
Sampling
2017
Flame Retardants
Dust
Hand
Phosphates
phosphate

Case Study on Screening Emerging Pollutants in Urine and Nails

Alves, A., Giovanoulis, G., Nilsson, U., Erratico, C., Lucattini, L., Haug, L. S., Jacobs, G., De Wit, C. A., Leonards, P. E. G., Covaci, A., Magner, J. & Voorspoels, S., 15 Mar 2017, In : Environmental Science and Technology. 51, 7, p. 4046-4053 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Nails
Metabolites
urine
metabolite
Screening

Continuous fraction collection of gas chromatographic separations with parallel mass spectrometric detection applied to cell-based bioactivity analysis

Jonker, W., Zwart, N., Stockl, J. B., de Koning, S., Schaap, J., Lamoree, M. H., Somsen, G. W., Hamers, T. & Kool, J., 2 Mar 2017, In : Talanta. 168, p. 162-167 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Determination of monoamine neurotransmitters in zebrafish (Danio rerio) by gas chromatography coupled to mass spectrometry with a two-step derivatization

Aragon, A., Legradi, J. B., Ballesteros-Gómez, A., Legler, J., van Velzen, M., de Boer, J. & Leonards, P., 15 Feb 2017, In : Analytical and Bioanalytical Chemistry. 409, 11, p. 2931-2939 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Zebrafish
Gas chromatography
Gas Chromatography
Mass spectrometry
Neurotransmitter Agents

Estimating human exposure to perfluoroalkyl acids via solid food and drinks: Implementation and comparison of different dietary assessment methods

Papadopoulou, E., Poothong, S., Koekkoek, J., Lucattini, L., Padilla-Sánchez, J. A., Haugen, M., Herzke, D., Valdersnes, S., Maage, A., Cousins, I. T., Leonards, P. E. G. & Småstuen Haug, L., 2017, In : Environmental Research. 158, p. 269-276 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

assessment method
Diet Records
Food
Acids
food

European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters

Tousova, Z., Oswald, P., Slobodnik, J., Blaha, L., Muz, M., Hu, M., Brack, W., Krauss, M., Di Paolo, C., Tarcai, Z., Seiler, T. B., Hollert, H., Koprivica, S., Ahel, M., Schollée, J. E., Hollender, J., Suter, M. J. F., Hidasi, A. O., Schirmer, K., Sonavane, M. & 17 othersAit-Aissa, S., Creusot, N., Brion, F., Froment, J., Almeida, A. C., Thomas, K., Tollefsen, K. E., Tufi, S., Ouyang, X., Leonards, P., Lamoree, M., Torrens, V. O., Kolkman, A., Schriks, M., Spirhanzlova, P., Tindall, A. & Schulze, T., 1 Dec 2017, In : Science of the Total Environment. 601-602, p. 1849-1868 20 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Organic pollutants
Surface waters
organic pollutant
Toxicity
Demonstrations

Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex

Dudok, J. J., Leonards, P. E. G. & Wijnholds, J., 5 May 2017, In : Brain sciences. 7, 5, 53.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cerebral Cortex
Molecular Biology
Brain
Genetic Techniques
Genetic Models

Improved androgen specificity of AR-EcoScreen by CRISPR based glucocorticoid receptor knockout

Zwart, N., Andringa, D., de Leeuw, W. J., Kojima, H., Iida, M., Houtman, C. J., de Boer, J., Kool, J., Lamoree, M. H. & Hamers, T., 1 Dec 2017, In : Toxicology in Vitro. 45, p. 1-9 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Glucocorticoid Receptors
Androgens
Glucocorticoids
Genes

Medium-Chain Chlorinated Paraffins (CPs) Dominate in Australian Sewage Sludge

Brandsma, S. H., van Mourik, L., O'Brien, J. W., Eaglesham, G., Leonards, P. E. G., de Boer, J., Gallen, C., Mueller, J., Gaus, C. & Bogdal, C., 20 Feb 2017, In : Environmental Science and Technology. 51, p. 3364-3372 9 p., 6.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Sewage
Paraffin
Weights and Measures
Atmospheric Pressure
Waste Water
canal
biota
river
sediment
plastic

Miniaturization of a transthyretin binding assay using a fluorescent probe for high throughput screening of thyroid hormone disruption in environmental samples

Ouyang, X., Froment, J., Leonards, P. E. G., Christensen, G., Tollefsen, K-E., de Boer, J., Thomas, K. V. & Lamoree, M. H., 2017, In : Chemosphere. 171, p. 722-728

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Miniaturization
Prealbumin
Thyroid Hormones
Fluorescent Dyes
hormone

Multigeneration toxicity of imidacloprid and thiacloprid to Folsomia candida

van Gestel, C. A. M., de Lima e Silva, C., Lam, T., Koekkoek, J. C., Lamoree, M. H. & Verweij, R. A., 1 Apr 2017, In : Ecotoxicology. 26, 3, p. 320-328 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
imidacloprid
Candida
Toxicity
Soil
toxicity

Thyroid stimulating hormone levels in newborns and early life exposure to endocrine disrupting chemicals - analysis of three European mother-child cohorts

de Cock, M., de Boer, M. R., Govarts, E., Iszatt, N., Palkovicova, L., Lamoree, M. H., Schoeters, G., Eggesbø, M., Trnovec, T., Legler, J. & van de Bor, M., 7 Jun 2017, In : Pediatric Research. 82, p. 429-437 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Endocrine Disruptors
Thyrotropin
Mothers
Newborn Infant
Polychlorinated Biphenyls
2016

Properties, performance and associated hazards of state-of-the-art durable water repellent (DWR) chemistry for textile finishing

Holmquist, H., Schellenberger, S., van der Veen, I., Peters, G., Leonards, P. E. G. & Cousins, I., 16 Mar 2016, In : Environment International. 91, p. 251-264 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

hazard
polymer
water
hydrocarbon
textile
2013

MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex

Dudok, J. J., Sanz, A. S., Lundvig, D. M. S. & Wijnholds, J., 8 May 2013, In : Journal of Neuroscience. 33, 19, p. 8518-8527 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Membrane Proteins
Adherens Junctions
Maintenance
Proteins
Stem Cells

MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Müller cells

Dudok, J. J., Sanz, A. S., Lundvig, D. M. S., Sothilingam, V., Garcia Garrido, M., Klooster, J., Seeliger, M. W. & Wijnholds, J., Oct 2013, In : Glia. 61, 10, p. 1629-1644 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Photoreceptor Cells
Retina
Retinal Degeneration
Electroretinography
Adherens Junctions

Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis

Pellissier, L. P., Alves, C. H., Quinn, P. M., Vos, R. M., Tanimoto, N., Lundvig, D. M. S., Dudok, J. J., Hooibrink, B., Richard, F., Beck, S. C., Huber, G., Sothilingam, V., Garcia Garrido, M., Le Bivic, A., Seeliger, M. W. & Wijnholds, J., 5 Dec 2013, In : PLoS Genetics. 9, 12

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Leber Congenital Amaurosis
retina
ablation
stem cells
Retina
2006

Perfluoroalkyl compounds in relation to life-history and reproductive parameters in bottlenose dolphins (Tursiops truncatus) from Sarasota Bay, Florida, U.S.A

Houde, M., Balmer, B. C., Brandsma, S., Wells, R. S., Rowles, T. K., Solomon, K. R. & Muir, D. C. G., Sep 2006, In : Environmental Toxicology and Chemistry. 25, 9, p. 2405-2412 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bottle-Nosed Dolphin
Reproductive History
Dolphins
dolphin
life history
2005

Accumulation of organochlorines and brominated flame retardants in estuarine and marine food chains: Field measurements and model calculations

Veltman, K., Hendriks, J., Huijbregts, M., Leonards, P., Van Den Heuvel-Greve, M. & Vethaak, D., Oct 2005, In : Marine Pollution Bulletin. 50, 10, p. 1085-1102 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

flame retardants
Birds
Flame retardants
food chain
organochlorine

Characterization of polychlorinated n-alkanes using comprehensive two-dimensional gas chromatography-electron-capture negative ionisation time-of-flight mass spectrometry

Korytár, P., Parera, J., Leonards, P. E. G., Santos, F. J., De Boer, J. & Brinkman, U. A. T., 9 Sep 2005, In : Journal of Chromatography A. 1086, 1-2, p. 71-82 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Alkanes
Chlorine
Gas chromatography
Gas Chromatography
Ionization

Comprehensive two-dimensional gas chromatography of polybrominated diphenyl ethers

Korytár, P., Covaci, A., Leonards, P. E. G., De Boer, J. & Brinkman, U. A. T., 30 Dec 2005, In : Journal of Chromatography A. 1100, 2, p. 200-207 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Halogenated Diphenyl Ethers
decabromobiphenyl ether
Gas chromatography
Gas Chromatography
Polybrominated Biphenyls

Quadrupole mass spectrometer operating in the electron-capture negative ion mode as detector for comprehensive two-dimensional gas chromatography

Korytár, P., Parera, J., Leonards, P. E. G., De Boer, J. & Brinkman, U. A. T., 4 Mar 2005, In : Journal of Chromatography A. 1067, 1-2, p. 255-264 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Mass spectrometers
Gas chromatography
Gas Chromatography
Negative ions
Electrons
2004

Baseline survey of concentrations of toxaphene congeners in fish from European waters

McHugh, B., McGovern, E., Nixon, E., Klungsøyr, J., Rimkus, G. G., Leonards, P. E. & de Boer, J., Aug 2004, In : Journal of Environmental Monitoring. 6, 8, p. 665-672 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Toxaphene
baseline survey
Fishes
Water
fish

Distribution and fate of HBCD and TBBPA brominated flame retardants in North Sea estuaries and aquatic food webs

Morris, S., Allchin, C. R., Zegers, B. N., Haftka, J. J. H., Boon, J. P., Belpaire, C., Leonards, P. E. G., Van Leeuwen, S. P. J. & De Boer, J., 1 Nov 2004, In : Environmental Science and Technology. 38, 21, p. 5497-5504 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Flame Retardants
Estuaries
Flame retardants
food web
Sediments
2003

Brominated flame retardants and endocrine disruption

Vos, J. G., Becher, G., Van Den Berg, M. & Leonards, P. E. G., Nov 2003, In : Pure and Applied Chemistry. 75, 11-12, p. 2039-2046 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Halogenated Diphenyl Ethers
Flame Retardants
Flame retardants
Ethers
Toxicity

Polybrominated diphenyl ethers in influents, suspended particulate matter, sediments, sewage treatment plant and effluents and biota from the Netherlands

De Boer, J., Wester, P. G., Van Der Horst, A. & Leonards, P. E. G., Mar 2003, In : Environmental Pollution. 122, 1, p. 63-74 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Halogenated Diphenyl Ethers
Sewage treatment plants
Biota
Particulate Matter
Sewage