Environmental Health and Toxicology

Research Output 1992 2019

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2019

Compound Identification Using Liquid Chromatography and High-Resolution Noncontact Fraction Collection with a Solenoid Valve

Jonker, W., de Vries, K., Althuisius, N., van Iperen, D., Janssen, E., ten Broek, R., Houtman, C., Zwart, N., Hamers, T., Lamoree, M. H., Ooms, B., Hidding, J., Somsen, G. W. & Kool, J., 1 Dec 2019, In : SLAS Technology. 24, 6, p. 543-555 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Solenoid valves
Liquid chromatography
Liquid Chromatography
Bioactivity
Flow rate

GH3 and RC-4BC cell lines are not suitable as in vitro models to study prolactin modulation and AHR responsiveness in rat pituitary

van den Brand, A. D., Rubinstein, E., van den Berg, M. & van Duursen, M. B. M., 1 Oct 2019, In : Molecular and cellular endocrinology. 496, p. 1-7 7 p., 110520.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Aryl Hydrocarbon Receptors
Prolactin
Rats
Cells
Modulation

Imatinib mesylate does not counteract ovarian tissue fibrosis in postnatal rat ovary

Asadi-Azarbaijani, B., Braber, S., van Duursen, M., Jahnukainen, K., Santos, R. & Oskam, I., Jun 2019, In : Reproductive Biology. 19, 2, p. 133-138 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

fibrosis
Ovary
Fibrosis
rats
vimentin

Primary endometrial 3D co-cultures: A comparison between human and rat endometrium

van den Brand, A. D., Rubinstein, E., de Jong, P. C., van den Berg, M. & van Duursen, M. B. M., 1 Nov 2019, In : Journal of Steroid Biochemistry and Molecular Biology. 194, p. 1-9 9 p., 105458.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Endometrium
Coculture Techniques
Rats
Aryl Hydrocarbon Receptors
Gene expression
2018

Are Extremely Low Gestational Age Newborns Born to Obese Women at Increased Risk of Cerebral Palsy at 2 Years?

van der Burg, J. W., O’Shea, T. M., Kuban, K., Allred, E. N., Paneth, N., Dammann, O. & Leviton, A., Mar 2018, In : Journal of Child Neurology. 33, 3, p. 216-224 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cerebral Palsy
Gestational Age
Newborn Infant
Paresis
Logistic Models

Combining ex-ante LCA and EHS screening to assist green design: A case study of cellulose nanocrystal foam

Tan, L., Mandley, S. J., Peijnenburg, W., Waaijers-van der Loop, S. L., Giesen, D., Legradi, J. B. & Shen, L., 3 Jan 2018, In : Journal of Cleaner Production. 178, p. 494-506 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
health and safety
foam
Nanocrystals
Foams
cellulose

Comparison of in vitro and in vivo bioassays to measure thyroid hormone disrupting activity in water extracts

Leusch, F. D. L., Aneck-Hahn, N. H., Cavanagh, J. A. E., Du Pasquier, D., Hamers, T., Hebert, A., Neale, P. A., Scheurer, M., Simmons, S. O. & Schriks, M., Jan 2018, In : Chemosphere. 191, p. 868-875 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bioassay
Thyroid Hormones
Biological Assay
hormone
bioassay

Determinants of a dietary pattern linked with greater metabolic risk and its tracking during adolescence

Appannah, G., Pot, G. K., Oddy, W. H., Jebb, S. A. & Ambrosini, G. L., Apr 2018, In : Journal of Human Nutrition and Dietetics. 31, 2, p. 218-227 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Maternal Age
Dietary Fiber
Food
Pregnancy
Eating

Development of a luminescent mutagenicity test for high-throughput screening of aquatic samples

Zwart, N., Lamoree, M. H., Houtman, C. J., de Boer, J., Kool, J. & Hamers, T., Feb 2018, In : Toxicology in Vitro. 46, p. 350-360 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mutagenicity Tests
Salmonella
Screening
Throughput
Mutagens

Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive

Escher, B. I., Aїt-Aїssa, S., Behnisch, P. A., Brack, W., Brion, F., Brouwer, A., Buchinger, S., Crawford, S. E., Du Pasquier, D., Hamers, T., Hettwer, K., Hilscherová, K., Hollert, H., Kase, R., Kienle, C., Tindall, A. J., Tuerk, J., van der Oost, R., Vermeirssen, E. & Neale, P. A., Jul 2018, In : Science of the Total Environment. 628-629, July, p. 748-765 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bioassay
Surface waters
bioassay
surface water
Water

Effects of environmental pollutants on calcium release and uptake by rat cortical microsomes

Dusza, H. M., Cenijn, P. H., Kamstra, J. H., Westerink, R. H. S., Leonards, P. E. G. & Hamers, T., Dec 2018, In : Neurotoxicology. 69, p. 266-277 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Environmental Pollutants
Endosulfan
Microsomes
Rats
Diethylhexyl Phthalate
Flame Retardants
Flame retardants
Dust
Cleaning
Electronic equipment

Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature

Perrin, E. M., O'Shea, T. M., Skinner, A. C., Bose, C., Allred, E. N., Fichorova, R. N., van der Burg, J. W. & Leviton, A., 10 Jan 2018, In : Pediatric Research. 83, p. 1110-1119 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Obesity
Inflammation
Interleukin-6
Proteins
Odds Ratio

High-Throughput Effect-Directed Analysis Using Downscaled in Vitro Reporter Gene Assays to Identify Endocrine Disruptors in Surface Water

Zwart, N., Nio, S. L., Houtman, C. J., De Boer, J., Kool, J., Hamers, T. & Lamoree, M. H., 3 Apr 2018, In : Environmental Science and Technology. 52, 7, p. 4367-4377 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Endocrine Disruptors
endocrine disruptor
Fractionation
Surface waters
Assays

Organophosphate triesters and selected metabolites enhance binding of thyroxine to human transthyretin in vitro

Hill, K. L., Hamers, T., Kamstra, J. H., Willmore, W. G. & Letcher, R. J., 15 Mar 2018, In : Toxicology Letters. 285, p. 87-93 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Prealbumin
Organophosphates
Metabolites
Thyroxine
Esters

Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts

Govarts, E., Iszatt, N., Trnovec, T., de Cock, M., Eggesbø, M., Palkovicova Murinova, L., van de Bor, M., Guxens, M., Chevrier, C., Koppen, G., Lamoree, M., Hertz-Picciotto, I., Lopez-Espinosa, M. J., Lertxundi, A., Grimalt, J. O., Torrent, M., Goñi-Irigoyen, F., Vermeulen, R., Legler, J. & Schoeters, G., Jun 2018, In : Environment International. 115, p. 267-278 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
hexachlorobenzene
smoking
pregnancy
DDE
PCB

Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: A prospective cohort study

Lauritzen, H. B., Larose, T. L., Øien, T., Sandanger, T. M., Odland, J. O., Van De Bor, M. & Jacobsen, G. W., 18 Jan 2018, In : Environmental Health: A Global Access Science Source. 17, 1, p. 1-12 12 p., 9.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Pediatric Obesity
Cohort Studies
Prospective Studies
Mothers
Confidence Intervals

Sleep extension is a feasible lifestyle intervention in free-living adults who are habitually short sleepers: A potential strategy for decreasing intake of free sugars? A randomized controlled pilot study

Al Khatib, H. K., Hall, W. L., Creedon, A., Ooi, E., Masri, T., McGowan, L., Harding, S. V., Darzi, J. & Pot, G. K., 1 Jan 2018, In : American Journal of Clinical Nutrition. 107, 1, p. 43-53 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Life Style
Sleep
Control Groups
Obesity
Actigraphy

Soil-transmitted helminth infections and intestinal and systemic inflammation in schoolchildren

de Gier, B., Pita-Rodríguez, G. M., Campos-Ponce, M., van de Bor, M., Chamnan, C., Junco-Díaz, R., Doak, C. M., Fiorentino, M., Kuong, K., Angel-Núñez, F., Parker, M. E., Perignon, M., Rojas-Rivero, L., Berger, J., Polman, K. & Wieringa, F. T., Jun 2018, In : Acta Tropica. 182, June, p. 124-127 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
helminthiasis
school children
Helminths
Soil
inflammation

Time-Integrative Passive sampling combined with TOxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment

Hamers, T., Legradi, J., Zwart, N., Smedes, F., de Weert, J., van den Brandhof, E. J., van de Meent, D. & de Zwart, D., Dec 2018, In : Environmental Toxicology and Pharmacology. 64, p. 48-59 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Water Quality
Rivers
Water quality
Toxicity
Sampling
2017

An effective clean-up technique for GC/EI-HRMS determination of developmental neurotoxicants in human breast milk

Čechová, E., Seifertová, M., Kukučka, P., Vojta, Š., Quaak, I., de Cock, M., van de Bor, M. & Kočan, A., Feb 2017, In : Analytical and Bioanalytical Chemistry. 409, 5, p. 1311-1322 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Human Milk
Flame Retardants
Lipids
Pyrethrins
Dialysis

Bisphenol A alternatives in thermal paper from the Netherlands, Spain, Sweden and Norway. Screening and potential toxicity

Björnsdotter, M. K., Jonker, W., Legradi, J., Kool, J. & Ballesteros-Gómez, A., 1 Dec 2017, In : Science of the Total Environment. 601-602, p. 210-221 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Toxicity
Screening
Liquid chromatography
Impurities
toxicity

Breakfast consumption and nutrient intakes in 4-18-year-olds: UK National Diet and Nutrition Survey Rolling Programme (2008-2012)

Coulthard, J. D., Palla, L. & Pot, G. K., 17 Aug 2017, In : British Journal of Nutrition. 118, 4, p. 280-290 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Diet Surveys
Breakfast
Nutrition Surveys
Food
Micronutrients
Flame Retardants
Dust
Hand
Phosphates
phosphate

Continuous fraction collection of gas chromatographic separations with parallel mass spectrometric detection applied to cell-based bioactivity analysis

Jonker, W., Zwart, N., Stockl, J. B., de Koning, S., Schaap, J., Lamoree, M. H., Somsen, G. W., Hamers, T. & Kool, J., 2 Mar 2017, In : Talanta. 168, p. 162-167 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Determination of monoamine neurotransmitters in zebrafish (Danio rerio) by gas chromatography coupled to mass spectrometry with a two-step derivatization

Aragon, A., Legradi, J. B., Ballesteros-Gómez, A., Legler, J., van Velzen, M., de Boer, J. & Leonards, P., 15 Feb 2017, In : Analytical and Bioanalytical Chemistry. 409, 11, p. 2931-2939 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Zebrafish
Gas chromatography
Gas Chromatography
Mass spectrometry
Neurotransmitter Agents

Differential DNA methylation at conserved non-genic elements and evidence for transgenerational inheritance following developmental exposure to mono(2-ethylhexyl) phthalate and 5-azacytidine in zebrafish

Kamstra, J. H., Bastos Sales, L., Aleström, P. & Legler, J., 12 Apr 2017, In : Epigenetics and Chromatin. 10, 1, 20.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Azacitidine
Zebrafish
DNA Methylation
Larva
Embryonic Structures

Effects of Hydroxylated Polybrominated Diphenyl Ethers in Developing Zebrafish Are Indicative of Disruption of Oxidative Phosphorylation

Legradi, J. B., Pomeren, M. V., Dahlberg, A-K. & Legler, J., 3 May 2017, In : International Journal of Molecular Sciences. 18, 5

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Halogenated Diphenyl Ethers
phosphorylation
wildlife
Oxidative Phosphorylation
Zebrafish

Enhanced uptake of BPA in the presence of nanoplastics can lead to neurotoxic effects in adult zebrafish

Chen, Q., Yin, D., Jia, Y., Schiwy, S., Legradi, J., Yang, S. & Hollert, H., 7 Aug 2017, In : Science of the Total Environment. 609, dec 2017, p. 1312-1321 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Biomarkers
Neurology
Fish
Tissue
Plastics

Exposure to endocrine disrupting chemicals perturbs lipid metabolism and circadian rhythms

Kopp, R., Ozáez Martínez, Legradi, J. & Legler, J., 27 Oct 2017, In : Journal of Environmental Sciences (China). 62, dec 2017, p. 133-137 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Endocrine Disruptors
circadian rhythm
metabolism
lipid
Clocks

Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos

Hausen, J., Otte, J. C., Legradi, J., Yang, L., Strähle, U., Fenske, M., Hecker, M., Tang, S., Hammers-Wirtz, M., Hollert, H., Keiter, S. H. & Ottermanns, R., 8 Apr 2017, (Accepted/In press) In : Environmental Science and Pollution Research International. 25, 5, p. 4023-4036 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Zebrafish
Transcriptome
embryo
fishing
Embryonic Structures

Improved androgen specificity of AR-EcoScreen by CRISPR based glucocorticoid receptor knockout

Zwart, N., Andringa, D., de Leeuw, W. J., Kojima, H., Iida, M., Houtman, C. J., de Boer, J., Kool, J., Lamoree, M. H. & Hamers, T., 1 Dec 2017, In : Toxicology in Vitro. 45, p. 1-9 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Glucocorticoid Receptors
Androgens
Glucocorticoids
Genes

Legacy and alternative halogenated flame retardants in human milk in Europe: Implications for children's health

Čechová, E., Vojta, Š., Kukučka, P., Kočan, A., Trnovec, T., Murínová, Ľ. P., de Cock, M., van de Bor, M., Askevold, J., Eggesbø, M. & Scheringer, M., 1 Nov 2017, In : Environment International. 108, p. 137-145 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

child health
milk
PBDE
replacement
lipid

Main meal quality in Brazil and United Kingdom: Similarities and differences

Gorgulho, B. M., Pot, G. K., Sarti, F. M. & Marchioni, D. M., 1 Apr 2017, In : Appetite. 111, p. 151-157 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Brazil
Meals
Fast Foods
Nutritive Value
United Kingdom

Maternal obesity and attention-related symptoms in the preterm offspring

van der Burg, J. W., Jensen, E. T., van de Bor, M., Joseph, R. M., O'Shea, T. M., Kuban, K., Allred, E. N., Scott, M., Hunter, S., Hooper, S. R., Dammann, O. & Leviton, A., Aug 2017, In : Early Human Development. 115, p. 9-15 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Obesity
Mothers
Pregnancy
Odds Ratio
Confidence Intervals

Maternal serum levels of perfluoroalkyl substances and organochlorines and indices of fetal growth: A Scandinavian case-cohort study

Lauritzen, H. B., Larose, T. L., Oien, T., Sandanger, T. M., Odland, J. O., Van De Bor, M. & Jacobsen, G. W., 1 Jan 2017, In : Pediatric Research. 81, 1, p. 33-42 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Fetal Development
perfluorooctanoic acid
Cohort Studies
Mothers
Gestational Age

Mode of Action Assignment of Chemicals Using Toxicogenomics: A Case Study with Oxidative Uncouplers

Hawliczek-Ignarski, A., Cenijn, P. H., Legler, J., Segner, H. & Legradi, J., 29 Nov 2017, In : Frontiers of Environmental Science. 5, p. 1-14 14 p., 80.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Toxicogenetics
Pharmacologic Actions
Toxic Actions
Oxidative Phosphorylation
Narcotics

Optimization of an in vitro assay methodology for competitive binding of thyroidogenic xenobiotics with thyroxine on human transthyretin and albumin

Hill, K. L., Hamers, T., Kamstra, J. H., Willmore, W. G. & Letcher, R. J., 20 Oct 2017, In : MethodsX. 4, p. 404-412 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Prealbumin
Competitive Binding
Xenobiotics
Thyroxine
Thyroid Hormones

The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm

Jensen, E. T., van der Burg, J. W., O'Shea, T. M., Joseph, R. M., Allred, E. N., Heeren, T., Leviton, A., Kuban, K. C. K. & Extremely Low Gestational Age Newborns Study Investigators, Aug 2017, In : Journal of Pediatrics. 187, p. 50-57.e3

Research output: Contribution to JournalArticleAcademicpeer-review

Weight Gain
Body Mass Index
Mothers
Pregnancy
Weights and Measures

Thyroid stimulating hormone levels in newborns and early life exposure to endocrine disrupting chemicals - analysis of three European mother-child cohorts

de Cock, M., de Boer, M. R., Govarts, E., Iszatt, N., Palkovicova, L., Lamoree, M. H., Schoeters, G., Eggesbø, M., Trnovec, T., Legler, J. & van de Bor, M., 7 Jun 2017, In : Pediatric Research. 82, p. 429-437 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Endocrine Disruptors
Thyrotropin
Mothers
Newborn Infant
Polychlorinated Biphenyls

Toxicity profiling of marine surface sediments: a case study using rapid screening bioassays of exhaustive total extracts, elutriates and passive sampler extracts

Vethaak, A. D., Hamers, T., Martinez-Gomez, C., Kamstra, J. H., de Weert, J., Leonards, P. E. G. & Smedes, F., 1 Jan 2017, In : Marine Environmental Research. 124, -, p. 81-91 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bioassay
samplers
sampler
Toxicity
bioassay
2016
Open Access
Zebrafish
Locomotion
Larva
environmental factor
Photoperiod

Developmental neurotoxicants in human milk: Comparison of levels and intakes in three European countries

Čechová, E., Scheringer, M., Seifertová, M., Mikeš, O., Kroupová, K., Kuta, J., Forns, J., Eggesbø, M., Quaak, I., de Cock, M., van de Bor, M., Patayová, H., Palkovičová Murínová, Ľ. & Kočan, A., 25 Nov 2016, In : Science of the Total Environment. 579, p. 637-645 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Polychlorinated Biphenyls
Polychlorinated biphenyls
milk
Hexachlorobenzene
Chlorinated Hydrocarbons
2013

Gene Responses in the Central Nervous System of Zebrafish Embryos Exposed to the Neurotoxicant Methyl Mercury

Ho, N. Y., Yang, L., Legradi, J. B., Armant, O., Takamiya, M., Rastegar, S. & Strähle, U., 4 Mar 2013, In : Environmental science technology. 47, 7, p. 3316-3325 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos

Armant, O., März, M., Schmidt, R., Ferg, M., Diotel, N., Ertzer, R., Bryne, J. C., Yang, L., Baader, I., Reischl, M., Legradi, J. B., Mikut, R., Stemple, D., van Ijcken, W., van der Sloot, A., Lenhard, B., Strähle, U. & Rastegar, S., 14 May 2013, In : Developmental biology. 380, 2, p. 351-362 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2012

A combined DNA-microarray and mechanism-specific toxicity approach with zebrafish embryos to investigate the pollution of river sediments

Kosmehl, T., Otte, J. C., Yang, L., Legradi, J. B., Bluhm, K., Zinsmeister, C., Keiter, S. H., Reifferscheid, G., Manz, W., Braunbeck, T., Strähle, U. & Hollert, H., 2 Feb 2012, In : Reproductive toxicology (Elmsford, N.Y.). 33, 2, p. 245-253 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2010

Effect of nutritional counselling and nutritional plus exercise counselling in overweight adults: a randomized trial in multidisciplinary primary care practice

Molenaar, E. A., van Ameijden, E. J. C., Vergouwe, Y., Grobbee, D. E. & Numans, M. E., Apr 2010, In : Family Practice. 27, 2, p. 143-50 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Counseling
Primary Health Care
Waist Circumference
Exercise
Nutritionists
2009

Association of lifestyle factors with abdominal subcutaneous and visceral adiposity: the Framingham Heart Study

Molenaar, E. A., Massaro, J. M., Jacques, P. F., Pou, K. M., Ellison, R. C., Hoffmann, U., Pencina, K., Shadwick, S. D., Vasan, R. S., O'Donnell, C. J. & Fox, C. S., Mar 2009, In : Diabetes Care. 32, 3, p. 505-10 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Intra-Abdominal Fat
Adiposity
Life Style
Subcutaneous Fat
Nutrition Policy

Robust Identification of Coagulated Zebrafish Eggs using Image Processing and Classification Techniques

Alshut, R., Legradi, J. B., Yang, L., Strähle, U., Mikut, R. & Reischl, M., Jan 2009, In : Proc., 19. Workshop Computational Intelligence. 50, p. 9-21 13 p.

Research output: Contribution to JournalArticleAcademic

2008

Aanzienlijke comorbiditeit bij volwassenen met overgewicht: resultaten uit het 'Leidsche Rijn Gezondheidsproject'

Molenaar, E. A., Numans, M. E., van Ameijden, E. J. C. & Grobbee, D. E., 8 Nov 2008, In : Nederlands Tijdschrift voor Geneeskunde. 152, 45, p. 2457-63 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Comorbidity
Primary Health Care
Mental Health
Odds Ratio
Quality of Life