Research Output 1993 2019

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2019

A Fast and Economical Sample Preparation Protocol for Interaction Proteomics Analysis

Gonzalez-Lozano, M. A., Koopmans, F., Paliukhovich, I., Smit, A. B. & Li, K. W., May 2019, In : Proteomics. 19, 9, p. 1-3 3 p., 1900027.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Immunoprecipitation
Proteomics
Proteins
Staphylococcal Protein A
Throughput

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

Klim, J. R., Williams, L. A., Limone, F., Guerra San Juan, I., Davis-Dusenbery, B. N., Mordes, D. A., Burberry, A., Steinbaugh, M. J., Gamage, K. K., Kirchner, R., Moccia, R., Cassel, S. H., Chen, K., Wainger, B. J., Woolf, C. J. & Eggan, K., Feb 2019, In : Nature Neuroscience. 22, 2, p. 167-179 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Amyotrophic Lateral Sclerosis
Motor Neurons
Regeneration
Growth
RNA

A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms

The EAGLE-ADHD Consortium, 18 Jan 2019, In : Behavior Genetics. p. 1-16 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Impulsive Behavior
Single Nucleotide Polymorphism
Meta-Analysis
signs and symptoms (animals and humans)
meta-analysis

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

Meijer, M., Rehbach, K., Brunner, J. W., Classen, J. A., Lammertse, H. C. A., van Linge, L. A., Schut, D., Krutenko, T., Hebisch, M., Cornelisse, L. N., Sullivan, P. F., Peitz, M., Toonen, R. F., Brüstle, O. & Verhage, M., 14 May 2019, In : Cell Reports. 27, 7, p. 2199-2211.e6

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neuronal Plasticity
Synaptic Transmission
Neurons
Plasticity
Synapses

Biallelic variants in LARS2 and KARS cause deafness and (ovario)leukodystrophy

Van Der Knaap, M. S., Bugiani, M., Mendes, M. I., Riley, L. G., Smith, D. E. C., Rudinger-Thirion, J., Frugier, M., Breur, M., Crawford, J., Van Gaalen, J., Schouten, M., Willems, M., Waisfisz, Q., Mau-Them, F. T., Rodenburg, R. J., Taft, R. J., Keren, B., Christodoulou, J., Depienne, C., Simons, C. & 2 othersSalomons, G. S. & Mochel, F., 12 Mar 2019, In : Neurology. 92, 11, p. E1225-E1237 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Deafness
Aminoacylation
Transfer RNA
Brain
Fibroblasts

Cell Replacement Therapy Improves Pathological Hallmarks in a Mouse Model of Leukodystrophy Vanishing White Matter

Dooves, S., Leferink, P. S., Krabbenborg, S., Breeuwsma, N., Bots, S., Hillen, A. E. J., Jacobs, G., van der Knaap, M. S. & Heine, V. M., 5 Mar 2019, In : Stem cell reports. 12, 3, p. 441-450 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Leukoencephalopathies
Cell- and Tissue-Based Therapy
Neuroglia
Stem Cells
Stem cells

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons

van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., Steenvoorden, E., Rynearson, K. D., Brouwers, J. F., Helms, J. B., Ovaa, H., Giera, M., Wagner, S. L., Bang, A. G. & Goldstein, L. S. B., 7 Mar 2019, In : Cell Stem Cell. 24, 3, p. 363-375.e9

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Induced Pluripotent Stem Cells
Cholesterol Esters
Amyloid
Alzheimer Disease
Cholesterol

Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Posthuma, D. & Willemsen, G., 5 Aug 2019, In : Biological Psychiatry. p. 1-12 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
HLA Antigens
Haplotypes
Alleles
Depression
Major Histocompatibility Complex

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Davies, G. E., Ehli, E. A., Fedko, I. O., Groen-Blokhuis, M. M., Hammerschlag, A. R., Hottenga, J. J., Hudziak, J., Ouwens, K. G. & ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Jan 2019, In : Nature Genetics. 51, 1, p. 63-75 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Genome
Genome-Wide Association Study
Meta-Analysis
Population

Fbxo41 Promotes Disassembly of Neuronal Primary Cilia

King, C. R., Ana, A. R., Chazeau, A., Saarloos, I., van der Graaf, A. J., Verhage, M. & Toonen, R. F., 1 Dec 2019, In : Scientific Reports. 9, 1, 8179.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cilia
Centrioles
Aurora Kinase A
Centrosome
Ubiquitin-Protein Ligases

Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

Forstner, A. J., Awasthi, S., Wolf, C., Maron, E., Erhardt, A., Czamara, D., Eriksson, E., Lavebratt, C., Allgulander, C., Friedrich, N., Becker, J., Hecker, J., Rambau, S., Conrad, R., Geiser, F., McMahon, F. J., Moebus, S., Hess, T., Buerfent, B. C., Hoffmann, P. & 55 othersHerms, S., Heilmann-Heimbach, S., Kockum, I., Olsson, T., Alfredsson, L., Weber, H., Alpers, G. W., Arolt, V., Fehm, L., Fydrich, T., Gerlach, A. L., Hamm, A., Kircher, T., Pané-Farré, C. A., Pauli, P., Rief, W., Ströhle, A., Plag, J., Lang, T., Wittchen, H-U., Mattheisen, M., Meier, S., Metspalu, A., Domschke, K., Reif, A., Hovatta, I., Lindefors, N., Andersson, E., Schalling, M., Mbarek, H., Milaneschi, Y., de Geus, E. J. C., Boomsma, D. I., Penninx, B. W. J. H., Thorgeirsson, T. E., Steinberg, S., Stefansson, K., Stefansson, H., Müller-Myhsok, B., Hansen, T. F., Børglum, A. D., Werge, T., Mortensen, P. B., Nordentoft, M., Hougaard, D. M., Hultman, C. M., Sullivan, P. F., Nöthen, M. M., Woldbye, D. P. D., Mors, O., Binder, E. B., Rück, C., Ripke, S., Deckert, J. & Schumacher, J., 11 Nov 2019, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Panic Disorder
Depression
Single Nucleotide Polymorphism
Genome

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk

Jansen, I. E., Savage, J. E., Watanabe, K., Bryois, J., Williams, D. M., Steinberg, S., Sealock, J., Karlsson, I. K., Hägg, S., Athanasiu, L., Voyle, N., Proitsi, P., Witoelar, A., Stringer, S., Aarsland, D., Almdahl, I. S., Andersen, F., Bergh, S., Bettella, F., Bjornsson, S. & 33 othersBrækhus, A., Bråthen, G., de Leeuw, C., Desikan, R. S., Djurovic, S., Dumitrescu, L., Fladby, T., Hohman, T. J., Jonsson, P. V., Kiddle, S. J., Rongve, A., Saltvedt, I., Sando, S. B., Selbæk, G., Shoai, M., Skene, N. G., Snaedal, J., Stordal, E., Ulstein, I. D., Wang, Y., White, L. R., Hardy, J., Hjerling-Leffler, J., Sullivan, P. F., van der Flier, W. M., Dobson, R., Davis, L. K., Stefansson, H., Stefansson, K., Pedersen, N. L., Ripke, S., Andreassen, O. A. & Posthuma, D., 1 Mar 2019, In : Nature Genetics. 51, 3, p. 404-413 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Meta-Analysis
Alzheimer Disease
Genome
Proxy
Genes

Leukoencephalopathy due to variants in GFPT1-associated congenital myasthenic syndrome

Helman, G., Sharma, S., Crawford, J., Patra, B., Jain, P., Bent, S. J., Urtizberea, J. A., Saran, R. K., Taft, R. J., van der Knaap, M. S. & Simons, C., 5 Feb 2019, In : Neurology. 92, 6, p. e587-e593 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Congenital Myasthenic Syndromes
Leukoencephalopathies
Mitochondrial Diseases
Muscle Weakness
Genome

Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory

Matos, M. R., Visser, E., Kramvis, I., van der Loo, R. J., Gebuis, T., Zalm, R., Rao-Ruiz, P., Mansvelder, H. D., Smit, A. B. & van den Oever, M. C., 24 May 2019, In : Nature Communications. 10, p. 1-11 11 p., 2315.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
fear
Long-Term Memory
Fear
Prefrontal Cortex
Data storage equipment

Spontaneous Activity Patterns Are Altered in the Developing Visual Cortex of the Fmr1 Knockout Mouse

Cheyne, J. E., Zabouri, N., Baddeley, D. & Lohmann, C., 26 Sep 2019, In : Frontiers in Neural Circuits. 13, September, p. 1-8 8 p., 57.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Fragile X Syndrome
Visual Cortex
Knockout Mice
Autistic Disorder
Rodentia

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., Hussain, N. K., Imig, C., de Jong, A. P. H., Jung, H., Kohansalnodehi, M., Kramarz, B., Lipstein, N., Lovering, R. C., MacGillavry, H., Mariano, V. & 53 othersMi, H., Ninov, M., Osumi-Sutherland, D., Pielot, R., Smalla, K. H., Tang, H., Tashman, K., Toonen, R. F. G., Verpelli, C., Reig-Viader, R., Watanabe, K., van Weering, J., Achsel, T., Ashrafi, G., Asi, N., Brown, T. C., De Camilli, P., Feuermann, M., Foulger, R. E., Gaudet, P., Joglekar, A., Kanellopoulos, A., Malenka, R., Nicoll, R. A., Pulido, C., de Juan-Sanz, J., Sheng, M., Südhof, T. C., Tilgner, H. U., Bagni, C., Bayés, À., Biederer, T., Brose, N., Chua, J. J. E., Dieterich, D. C., Gundelfinger, E. D., Hoogenraad, C., Huganir, R. L., Jahn, R., Kaeser, P. S., Kim, E., Kreutz, M. R., McPherson, P. S., Neale, B. M., O'Connor, V., Posthuma, D., Ryan, T. A., Sala, C., Feng, G., Hyman, S. E., Thomas, P. D., Smit, A. B. & Verhage, M., 17 Jul 2019, In : Neuron. 103, 2, p. 217-234.e4 22 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Knowledge Bases
Synapses
Genes
Gene Ontology
Molecular Sequence Annotation

Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons

van Ziel, A. M., Largo-Barrientos, P., Wolzak, K., Verhage, M. & Scheper, W., 7 Feb 2019, In : Scientific Reports. 9, 1, p. 1-12 12 p., 1567.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Unfolded Protein Response
Pharmacology
Neurons
Endoplasmic Reticulum Stress
Proteins
2018

A BDNF-Mediated Push-Pull Plasticity Mechanism for Synaptic Clustering

Niculescu, D., Michaelsen-Preusse, K., Güner, Ü., van Dorland, R., Wierenga, C. J. & Lohmann, C., 21 Aug 2018, In : Cell Reports. 24, 8, p. 2063-2074 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neuronal Plasticity
Brain-Derived Neurotrophic Factor
Plasticity
Cluster Analysis
Synapses

Adult mouse eIF2Bϵ Arg191His astrocytes display a normal integrated stress response in vitro

Wisse, L. E., Ter Braak, T. J., Van De Beek, M. C., Van Berkel, C. G. M., Wortel, J., Heine, V. M., Proud, C. G., Van Der Knaap, M. S. & Abbink, T. E. M., 28 Feb 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 3773.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Eukaryotic Initiation Factor-2B
Astrocytes
Mutation
White Matter
In Vitro Techniques

Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter

Leferink, P. S., Breeuwsma, N., Bugiani, M., van der Knaap, M. S. & Heine, V. M., Apr 2018, In : Glia. 66, 4, p. 862-873 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Leukoencephalopathies
Astrocytes
Spinal Cord
Pathology
Oligodendroglia

Axonal abnormalities in vanishing white matter

Klok, M. D., Bugiani, M., de Vries, S. I., Gerritsen, W., Breur, M., van der Sluis, S., Heine, V. M., Kole, M. H. P., Baron, W. & van der Knaap, M. S., 1 Apr 2018, In : Annals of Clinical and Translational Neurology. 5, 4, p. 429-444 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Astrocytes
Axons
Myelin Sheath
Prosencephalon
Coculture Techniques

Bergmann glia translocation: a new disease marker for vanishing white matter identifies therapeutic effects of Guanabenz treatment

Dooves, S., Bugiani, M., Wisse, L. E., Abbink, T. E. M., van der Knaap, M. S. & Heine, V. M., Jun 2018, In : Neuropathology and Applied Neurobiology. 44, 4, p. 391-403 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Guanabenz
Therapeutic Uses
Neuroglia
Pathology
Therapeutics

Bi-allelic Mutations in EPRS, Encoding the Glutamyl-Prolyl-Aminoacyl-tRNA Synthetase, Cause a Hypomyelinating Leukodystrophy

Mendes, M. I., Gutierrez Salazar, M., Guerrero, K., Thiffault, I., Salomons, G. S., Gauquelin, L., Tran, L. T., Forget, D., Gauthier, M. S., Waisfisz, Q., Smith, D. E. C., Simons, C., van der Knaap, M. S., Marquardt, I., Lemes, A., Mierzewska, H., Weschke, B., Koehler, W., Coulombe, B., Wolf, N. I. & 1 othersBernard, G., 5 Apr 2018, In : American Journal of Human Genetics. 102, 4, p. 676-684 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Amino Acyl-tRNA Synthetases
Mutation
Aminoacylation
Myelin Sheath
Inborn Genetic Diseases

Comparative Analyses of Data Independent Acquisition Mass Spectrometric Approaches: DIA, WiSIM-DIA, and Untargeted DIA

Koopmans, F., Ho, J. T. C., Smit, A. B. & Li, K. W., Jan 2018, In : Proteomics. 18, 1, p. 1-6 6 p., 1700304.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Data acquisition
Peptides
Ions
Proteomics
Synapses

Comparative Hippocampal Synaptic Proteomes of Rodents and Primates: Differences in Neuroplasticity-Related Proteins

Koopmans, F., Pandya, N. J., Franke, S. K., Phillippens, I. H. C. M. H., Paliukhovich, I., Li, K. W. & Smit, A. B., 2 Oct 2018, In : Frontiers in Molecular Neuroscience. 11, p. 1-14 14 p., 364.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neuronal Plasticity
Proteome
Primates
Rodentia
Synapses

Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B

Dominguez, N., van Weering, J. R. T., Borges, R., Toonen, R. F. G. & Verhage, M., Feb 2018, In : Journal of Neurochemistry. 144, 3, p. 241-254 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chromogranin B
Chromogranin A
Exocytosis
Secretory Vesicles
Neurons

Diffusion tensor imaging in metachromatic leukodystrophy

van Rappard, D. F., Königs, M., Steenweg, M. E., Boelens, J. J., Oosterlaan, J., van der Knaap, M. S., Wolf, N. I. & Pouwels, P. J. W., Mar 2018, In : Journal of Neurology. 265, 3, p. 659-668 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metachromatic Leukodystrophy
Diffusion Tensor Imaging
Cell Transplantation
Anisotropy
Sulfoglycosphingolipids

Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium (vol 84, pg 138, 2018)

Peyrot, W. J., Van der Auwera, S., Milaneschi, Y., Dolan, C. . V., Madden, P. A. F., Sullivan, P. F., Strohmaier, J., Ripke, S., Rietschel, M., Nivard, M. G., Mullins, N., Montgomery, G. W., Henders, A. K., Heat, A. C., Fisher, H. L., Dunn, E. C., Byrne, E. M., Air, T. A., Baune, B. T., Breen, G. & 8 othersLevinson, D. F., Lewis, C. M., Martin, N. G., Nelson, E. N., Boomsma, D. . I., Grabe, H. J., Wray, N. R. & Penninx, B. W. J. H., 1 Dec 2018, In : Biological Psychiatry. 84, 11, p. 857-857

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic defects disrupting glial ion and water homeostasis in the brain

Min, R. & van der Knaap, M. S., May 2018, In : Brain Pathology. 28, 3, p. 372-387 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neuroglia
Homeostasis
Ions
Water
Brain

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Savage, J. E., Jansen, P. R., Stringer, S., Watanabe, K., Bryois, J., de Leeuw, C. A., Nagel, M., Awasthi, S., Barr, P. B., Coleman, J. R. I., Grasby, K. L., Hammerschlag, A. R., Kaminski, J. A., Karlsson, R., Krapohl, E., Lam, M., Nygaard, M., Reynolds, C. A., Trampush, J. W., Young, H. & 97 othersZabaneh, D., Hägg, S., Hansell, N. K., Karlsson, I. K., Linnarsson, S., Montgomery, G. W., Muñoz-Manchado, A. B., Quinlan, E. B., Schumann, G., Skene, N. G., Webb, B. T., White, T., Arking, D. E., Avramopoulos, D., Bilder, R. M., Bitsios, P., Burdick, K. E., Cannon, T. D., Chiba-Falek, O., Christoforou, A., Cirulli, E. T., Congdon, E., Corvin, A., Davies, G., Deary, I. J., DeRosse, P., Dickinson, D., Djurovic, S., Donohoe, G., Conley, E. D., Eriksson, J. G., Espeseth, T., Freimer, N. A., Giakoumaki, S., Giegling, I., Gill, M., Glahn, D. C., Hariri, A. R., Hatzimanolis, A., Keller, M. C., Knowles, E., Koltai, D., Konte, B., Lahti, J., Le Hellard, S., Lencz, T., Liewald, D. C., London, E., Lundervold, A. J., Malhotra, A. K., Melle, I., Morris, D., Need, A. C., Ollier, W., Palotie, A., Payton, A., Pendleton, N., Poldrack, R. A., Räikkönen, K., Reinvang, I., Roussos, P., Rujescu, D., Sabb, F. W., Scult, M. A., Smeland, O. B., Smyrnis, N., Starr, J. M., Steen, V. M., Stefanis, N. C., Straub, R. E., Sundet, K., Tiemeier, H., Voineskos, A. N., Weinberger, D. R., Widen, E., Yu, J., Abecasis, G., Andreassen, O. A., Breen, G., Christiansen, L., Debrabant, B., Dick, D. M., Heinz, A., Hjerling-Leffler, J., Ikram, M. A., Kendler, K. S., Martin, N. G., Medland, S. E., Pedersen, N. L., Plomin, R., Polderman, T. J. C., Ripke, S., van der Sluis, S., Sullivan, P. F., Vrieze, S. I., Wright, M. J. & Posthuma, D., 1 Jul 2018, In : Nature Genetics. 50, 7, p. 912-919 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Intelligence
Meta-Analysis
Mendelian Randomization Analysis
Genes

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

23Andme Research Team, 1 Jul 2018, In : Nature Genetics. 50, 7, p. 920-927 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genetic Loci
Genome-Wide Association Study
Meta-Analysis
Mendelian Randomization Analysis
Psychiatry

MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission

He, E., Lozano, M. A. G., Stringer, S., Watanabe, K., Sakamoto, K., Oudsten, F. D., Koopmans, F., Giamberardino, S. N., Hammerschlag, A., Niels Cornelisse, L., Li, K. W., van Weering, J., Posthuma, D., Smit, A. B., Sullivan, P. F. & Verhage, M., 1 Jun 2018, In : Human Molecular Genetics. 27, 11, p. 1879-1891 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Internal-External Control
Synaptic Transmission
Synapses
Schizophrenia
Proteomics

Natural History of Vanishing White Matter

Hamilton, E. M. C., van der Lei, H. D. W., Vermeulen, G., Gerver, J. A. M., Lourenço, C. M., Naidu, S., Mierzewska, H., Gemke, R. J. B. J., de Vet, H. C. W., Uitdehaag, B. M. J., Lissenberg-Witte, B. I., Research Group, V. W. M. & van der Knaap, M. S., Aug 2018, In : Annals of Neurology. 84, 2, p. 274-288 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Natural History
Age of Onset
Leukoencephalopathies
Absence Epilepsy
Sex Characteristics

Pool size estimations for dense-core vesicles in mammalian CNS neurons

Persoon, C. M., Moro, A., Nassal, J. P., Farina, M., Broeke, J. H., Arora, S., Dominguez, N., van Weering, J. R. T., Toonen, R. F. & Verhage, M., 15 Oct 2018, In : EMBO Journal. 37, 20, p. 1-18 18 p., e99672.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Secretory Vesicles
Neurons
Axons
Electric fuses
Neuropeptides

Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy

Kovačević, J., Maroteaux, G., Schut, D., Loos, M., Dubey, M., Pitsch, J., Remmelink, E., Koopmans, B., Crowley, J., Cornelisse, L. N., Sullivan, P. F., Schoch, S., Toonen, R. F., Stiedl, O. & Verhage, M., 1 May 2018, In : Brain. 141, 5, p. 1350-1374 25 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Haploinsufficiency
Brain Diseases
Proteins
etiracetam
Electroencephalography

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

Verweij, F. J., Bebelman, M. P., Jimenez, C. R., Garcia-Vallejo, J. J., Janssen, H., Neefjes, J., Knol, J. C., de Goeij-de Haas, R., Piersma, S. R., Baglio, S. R., Verhage, M., Middeldorp, J. M., Zomer, A., van Rheenen, J., Coppolino, M. G., Hurbain, I., Raposo, G., Smit, M. J., Toonen, R. F. G., van Niel, G. & 1 othersPegtel, D. M., 5 Mar 2018, In : Journal of Cell Biology. 217, 3, p. 1129-1142 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Exosomes
Multivesicular Bodies
Membrane Fusion
Cell Membrane
Qa-SNARE Proteins

Secretory vesicle trafficking in awake and anaesthetized mice: differential speeds in axons versus synapses

Knabbe, J., Nassal, J. P., Verhage, M. & Kuner, T., 15 Aug 2018, In : Journal of Physiology. 596, 16, p. 3759-3773 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Secretory Vesicles
Synapses
Axons
Brain
Microtubules

Seizures and disturbed brain potassium dynamics in the leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts

Dubey, M., Brouwers, E., Hamilton, E. M. C., Stiedl, O., Bugiani, M., Koch, H., Kole, M. H. P., Boschert, U., Wykes, R. C., Mansvelder, H. D., van der Knaap, M. S. & Min, R., Mar 2018, In : Annals of Neurology. 83, 3, p. 636-649 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Potassium
Seizures
Brain
Astrocytes
Epilepsy

SICT: automated detection and supervised inspection of fast Ca2+ transients

Mancini, R., van der Bijl, T., Bourgeois-Jaarsma, Q., Lasabuda, R. & Groffen, A. J., 19 Oct 2018, In : Scientific Reports. 8, p. 1-13 13 p., 15523.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Signal-To-Noise Ratio
Motion Pictures
Caffeine
Quality Control
Neurons

The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity

Saeloh, D., Tipmanee, V., Jim, K. K., Dekker, M. P., Bitter, W., Voravuthikunchai, S. P., Wenzel, M. & Hamoen, L. W., 16 Feb 2018, In : Plos Pathogens. 14, 2, e1006876.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Membrane Proteins
Anti-Bacterial Agents
Membranes
Myrtus
Proteins

Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models

Deurloo, M. H. S., Turlova, E., Chen, W. L., Lin, Y. W., Tam, E., Tassew, N. G., Wu, M., Huang, Y. C., Crawley, J. N., Monnier, P. P., Groffen, A. J. A., Sun, H. S., Osborne, L. R. & Feng, Z. P., 17 Aug 2018, In : Molecular Neurobiology. p. 1-13 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Transcription Factors
Williams Syndrome
Calcium
Proteins
General Transcription Factors

Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly

Meijer, M., Dörr, B., Lammertse, H. C. A., Blithikioti, C., van Weering, J. R. T., Toonen, R. F. G., Söllner, T. H. & Verhage, M., 17 Jan 2018, In : EMBO Journal. 37, 2, p. 300-320 21 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
SNARE Proteins
Phosphorylation
src-Family Kinases
Synaptic Vesicles
Synaptic Transmission

VPS35 depletion does not impair presynaptic structure and function

Vazquez-Sanchez, S., Bobeldijk, S., Dekker, M. P., Van Keimpema, L. & Van Weering, J. R. T., 14 Feb 2018, In : Scientific Reports. 8, 1, p. 1-12 12 p., 2996.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synaptic Vesicles
Presynaptic Terminals
Neurons
Endosomes
Recycling

Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi

Emperador-Melero, J., Huson, V., van Weering, J., Bollmann, C., Fischer von Mollard, G., Toonen, R. F. & Verhage, M., 24 Aug 2018, In : Nature Communications. 9, p. 1-17 17 p., 3421.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
SNARE Proteins
secretions
Synaptic Vesicles
Secretory Vesicles
Protein Transport

Vti Proteins: Beyond Endolysosomal Trafficking

Emperador-Melero, J., Toonen, R. F. & Verhage, M., 22 Nov 2018, In : Neuroscience. p. 1-9 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
SNARE Proteins
Qb-SNARE Proteins
Intracellular Membranes
Membrane Fusion
Fungal Proteins
2017

AHCODA-DB: a data repository with web-based mining tools for the analysis of automated high-content mouse phenomics data

Koopmans, B., Smit, A. B., Verhage, M. & Loos, M., 4 Apr 2017, In : BMC Bioinformatics. 18, 1, p. 200

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Web-based
Repository
Mouse
Mining
Quality control

Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons

Heman-Ackah, S. M., Manzano, R., Hoozemans, J. J. M., Scheper, W., Flynn, R., Haerty, W., Cowley, S. A., Bassett, A. R. & Wood, M. J. A., 15 Nov 2017, In : Human Molecular Genetics. 26, 22, p. 4441-4450 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Unfolded Protein Response
Induced Pluripotent Stem Cells
alpha-Synuclein
Parkinson Disease
Synucleins

A one-week 5-choice serial reaction time task to measure impulsivity and attention in adult and adolescent mice

Remmelink, E., Chau, U., Smit, A. B., Verhage, M. & Loos, M., 15 Feb 2017, In : Scientific Reports. 7, p. 42519

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Impulsive Behavior
Reaction Time
Task Performance and Analysis
Psychiatry
Food Deprivation

CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons

van Keimpema, L., Kooistra, R., Toonen, R. F. & Verhage, M., 7 Sep 2017, In : Scientific Reports. 7, 1, p. 10817

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Transcription Factor AP-1
Exocytosis
Secretory Vesicles
Calmodulin
Neurons

Complex Genetics of Behavior: BXDs in the Automated Home-Cage

Loos, M., Verhage, M., Spijker, S. & Smit, A. B., 2017, In : Methods in Molecular Biology. 1488, p. 519-530 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Inbred Strains Mice
Automation
Dissection
Genome
Phenotype