LaserLaB - Analytical Chemistry and Spectroscopy

Research Output 1986 2019

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2019

Inhibition of autotransporter biogenesis by small molecules

Steenhuis, M., Abdallah, A. M., de Munnik, S. M., Kuhne, S., Sterk, G. J., van den Berg van Saparoea, B., Westerhausen, S., Wagner, S., van der Wel, N. N., Wijtmans, M., van Ulsen, P., Jong, W. S. P. & Luirink, J., 1 Jul 2019, In : Molecular Microbiology. 112, 1, p. 81-98 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Membrane Proteins
Virulence Factors
Libraries
Hemoglobins
Peptide Hydrolases
2018

Comparing autotransporter β-domain configurations for their capacity to secrete heterologous proteins to the cell surface

Jong, W. S. P., Schillemans, M., ten Hagen-Jongman, C. M., Luirink, J. & van Ulsen, P., 7 Feb 2018, In : PLoS ONE. 13, 2, e0191622.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
IgA-specific serine endopeptidase
recombinant proteins
Membrane Proteins
Recombinant Proteins
Membranes

Exit-channel recoil resonances by imaging the photodissociation of single quantum-state-selected OCS molecules

Sofikitis, D., Suarez, J., Schmidt, J. A., Rakitzis, T. P., Farantos, S. C. & Janssen, M. H. M., 26 Sep 2018, In : Physical Review A. 98, 3, p. 1-11 11 p., 033417.

Research output: Contribution to JournalArticleAcademicpeer-review

photodissociation
molecules
velocity distribution
energy
photolysis

Ionophoric effects of the antitubercular drug bedaquiline

Hards, K., McMillan, D. G. G., Schurig-Briccio, L. A., Gennis, R. B., Lill, H., Bald, D. & Cook, G. M., 10 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. 7326-7331 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

File
bedaquiline
Antitubercular Agents
Adenosine Triphosphate
Escherichia coli
Proton-Motive Force

The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.

Lu, P., Asseri, A. H. O., Kremer, M., Maaskant, J., Ummels, R., Lill, H. & Bald, D., 8 Feb 2018, In : Scientific Reports. 8

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cytochromes
Electron Transport
Mycobacterium tuberculosis
Energy Metabolism
Mycobacterium smegmatis
2017

A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection.

Boot, M., JIm, K. K., Liu, T., Commandeur, S., Lu, P., Verboom, T., Lill, H., Bitter, W. & Bald, D., 2017, In : Scientific Reports. 7, 10665.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cytochromes
Fluorescence
Mycobacterium marinum
Infection
Oxidative Phosphorylation

Application of an E. coli signal sequence as a versatile inclusion body tag

Jong, W. S. P., Vikström, D., Houben, D., Berg van Saparoea, H. B., de Gier, J. W. & Luirink, J., 21 Mar 2017, In : Microbial Cell Factories. 16, 1, 50.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Inclusion Bodies
Protein Sorting Signals
Escherichia coli
Proteins
Fusion reactions

SRP, FtsY, DnaK and YidC Are Required for the Biogenesis of the E. coli Tail-Anchored Membrane Proteins DjlC and Flk

Peschke, M., Le Goff, M., Koningstein, G. M., Karyolaimos, A., de Gier, J. W., van Ulsen, P. & Luirink, J., 1 Jan 2017, (Accepted/In press) In : Journal of Molecular Biology.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Signal Recognition Particle
Membrane Proteins
Escherichia coli
Membranes
Hydrophobic and Hydrophilic Interactions

Targeting energy metabolism in Mycobacterium tuberculosis – a new paradigm in anti-mycobacterial drug discovery.

Bald, D., Villellas, C., Lu, P. & Koul, A., 2017, In : mBio. 8, 2, p. 1-11 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Oxidative Phosphorylation
Drug Discovery
Mycobacterium tuberculosis
Energy Metabolism
Drug Delivery Systems
2016

Cytochrome bd displays significant quinol peroxidase activity

Al-Attar, S., Yu, Y., Pinske, M., Hoeser, J., Friedrich, T., Bald, D. & de Vries, S., 2016, In : Scientific Reports. 6, 27631

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Hydroquinones
Cytochromes
Heme
Peroxidase
Oxidoreductases

Mechanical Unfolding of an Autotransporter Passenger Protein Reveals the Secretion Starting Point and Processive Transport Intermediates

Baclayon, M., van Ulsen, P., Mouhib, H., Hashemi Shabestari, M., Verzijden, T., Abeln, S., Roos, W. H. & Wuite, G. J. L., 2016, In : ACS Nano. 10, 6, p. 5710-5719

Research output: Contribution to JournalArticleAcademicpeer-review

protease
secretions
passengers
Hemoglobin
hemoglobin

Meningococcal two-partner secretion systems and their association with outcome in patients with meningitis.

Piet, J. R., van Ulsen, P., Ur Rahman, S., Bovenkerk, S., Bentley, S. D., van de Beek, S. & van der Ende, A., 2016, In : Infection and Immunity. 84, 9, p. 2534-2540

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

MreB-Dependent Organization of the E-coli Cytoplasmic Membrane Controls Membrane Protein Diffusion

Oswald, F., Varadarajan, A., Lill, H., Peterman, E. J. G. & Bollen, Y. J. M., 2016, In : Biophysical Journal. 110, 5, p. 1139-1149

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Prokaryotic Cells
Thymidine Monophosphate
Membrane Proteins
Cell Membrane
Escherichia coli

Synthesis, characterization and biological acitvity of fluorescently labeled bedaquiline analogues.

Rombouts, J. A., Veenboer, R. M. P., Villellas, C., Lu, P., Ehlers, A. W., Andries, K., Koul, A., Lill, H., Ruijter, E., Orru, R. V. A., Lammertsma, K., Bald, D. & Slootweg, J. C., 2016, In : RSC Advances. 6, p. 108708-108716

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2015

A new perspective: imaging the stereochemistry of molecular collisions

Aoiz, F. J., Brouard, M., Gordon, S. D. S., Nichols, B., Stolte, S. & Walpole, V., 2015, In : Physical Chemistry Chemical Physics - PCCP. 17, 45, p. 30210-30228

Research output: Contribution to JournalArticleAcademicpeer-review

molecular collisions
stereochemistry
collisions
inelastic collisions
inelastic scattering

A review on emerging diagnostic assay for viral detection: the case of avian influenza virus.

Roodbar Shojaei, T., Tabatabaei, M., Shawky, S., Salleh, M. A. M. & Bald, D., 2015, In : Molecular Biology Reports. 42, 1, p. 187-199

Research output: Contribution to JournalArticleAcademicpeer-review

Influenza in Birds
Orthomyxoviridae
Viruses
Biotechnology

Autotransporter-based antigen display in bacterial ghosts.

Hjelm, A., Söderström, B., Vikström, D., Jong, W. S. P., Luirink, S. & de Gier, J. W., Jan 2015, In : Applied and Environmental Microbiology. 81, 2, p. 726-735 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

lysis
antigen
vaccine
Escherichia coli
antigens

Bactericidal mode of action of bedaquiline.

Hards, K., Robson, J. R., Berney, M., Shaw, L., Bald, D., Koul, A., Andries, K. & Cook, G. M., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 7, p. 2028-2037

Research output: Contribution to JournalArticleAcademicpeer-review

bedaquiline
Adenosine Triphosphate
Proton-Motive Force
Mycobacterium
Oxygen Consumption

Cell age dependent concentration of Escherichia coli divisome proteins analyzed with ImageJ and ObjectJ.

Vischer, N. O., Verheul, J., Postma, M., van den Berg van Saparoea, H. B., Galli, E., Natale, P., Gerdes, K., Luirink, J., Vollmer, W., Vicente, M. & den Blaauwen, T., 2015, In : Frontiers in Microbiology. 11, p. 586 6.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Escherichia coli Proteins
Proteins
Cell Cycle
Spatio-Temporal Analysis
Cell Cycle Proteins

Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes

Brouwer, I., Giniatullina, A., Laurens, N., van Weering, J. R. T., Bald, D., Wuite, G. J. L. & Groffen, A. J. A., 2015, In : Nature Communications. 6, p. 8387 8387.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
membranes
Membranes
SNARE Proteins
secretions
Phosphatidylserines

Enantiomer-specific analysis of multi-component mixtures by correlated electron imaging-ion mass spectrometry

Rafiee Fanood, M. M., Ram, N. B., Lehmann, C. S., Powis, I. & Janssen, M. H. M., 2015, In : Nature Communications. 6, p. 7511 7511.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Camphor
Functional Laterality
Monoterpenes
Enantiomers
enantiomers

Enantioselective femtosecond laser photoionization spectrometry of limonene using photoelectron circular dichroism

Rafiee Fanood, M. M., Janssen, M. H. M. & Powis, I., 2015, In : Physical Chemistry Chemical Physics - PCCP. 17, 14, p. 8614-8617

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
dichroism
photoionization
photoelectrons
enantiomers
spectroscopy

Measurement of the density profile of pure and seeded molecular beams by femtosecond ion imaging

Meng, C. & Janssen, M. H. M., 2015, In : Review of Scientific Instruments. 86, 2, p. 023110 023110.

Research output: Contribution to JournalArticleAcademicpeer-review

Molecular beams
molecular beams
Imaging techniques
Ions
profiles

Of linkers and autochaperones: an unambiguous nomenclature to identify common and uncommon themes for autotransporter secretion.

Drobnak, I., Braselmann, E., Chaney, J. L., Leyton, D. L., Bernstein, H. D., Lithgow, T., Luirink, S., Nataro, J. P. & Clark, P. L., 2015, In : Molecular Microbiology. 95, 1, p. 1-16 1.

Research output: Contribution to JournalArticleAcademicpeer-review

Terminology
Conserved Sequence
Virulence
Proteins
Bacterial Translocation

Processing of cell-surface signalling anti-sigma factors prior to signal recognition is aconserved autoproteolytic mechanism that produces two functional domains.

Bastiaansen, K. C. J. T., Otero-Asman, J. R., Luirink, J., Bitter, W. & Llamas, M. A., 2015, In : Environmental Microbiology. 17, 9, p. 3263-3277

Research output: Contribution to JournalArticleAcademicpeer-review

sigma factors
Sigma Factor
cells
membrane
Pseudomonas

Review of multidimensional data processing approaches for Raman and infrared spectroscopy

Gautam, R., Vanga, S. & Ariese, F., 2015, In : EPJ Techniques and Instrumentation. 2, 1, p. 8 8.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Raman spectroscopy
Infrared spectroscopy
Molecules
Biological systems
Nucleic Acids

Rotational Orientation Effects in NO(X) plus Ar Inelastic Collisions

Brouard, M., Chadwick, H., Gordon, S. D. S., Hornung, B., Nichols, B., Aoiz, F. J. & Stolte, S., 2015, In : Journal of Physical Chemistry A. 119, 50, p. 12404-12416

Research output: Contribution to JournalArticleAcademicpeer-review

Angular momentum
inelastic collisions
angular momentum
collisions
energy

Salmonella outer membrane vesicles displaying high densities of pneumococcal antigen at the surface offer protection against colonization.

Kuipers, K., Daleke, M. H., Jong, W. S. P., ten Hagen-Jongman ten, C. M., van Opzeeland, F., Simonneti, E., Luirink, S. & de Jonge, M. I., 2015, In : Vaccine. 33, 17, p. 2022-2029

Research output: Contribution to JournalArticleAcademicpeer-review

Surface Antigens
Salmonella
antigens
Membranes
Antigens

Self-cleavage of the Pseudomonas aerugginosa cell-surface signaling anti-sigma factor FoxR occurs through an N-O acyl rearrangement.

Bastiaansen, K. C. J. T., van Ulsen, P., Wijtmans, M., Bitter, W. & Llamas, M. A., 2015, In : Journal of Biological Chemistry. 290, 19, p. 12237-12246

Research output: Contribution to JournalArticleAcademicpeer-review

Sigma Factor
Pseudomonas
Siderophores
Transcription
Pseudomonas aeruginosa

The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress.

Lu, P., Heineke, M. H., Koul, A., Andries, K., Cook, G. M., Lill, H., van Spanning, R. J. M. & Bald, D., 2015, In : Scientific Reports. 5, 10333.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mycobacterium smegmatis
Peroxides
Cytochromes
Anti-Bacterial Agents
bedaquiline

The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity.

Glas, M., van den Berg van Saparoea, H. B., Mclaughlin, S. H., Roseboom, W., Liu, F., Koningstein, G. M., Fish, A., den Blaauwen, T., Heck, A. J., de Jong, L. D., Bitter, W., de Esch, I. J. P. & Luirink, S., 2015, In : Journal of Biological Chemistry. 290, 35, p. 21498-21509

Research output: Contribution to JournalArticleAcademicpeer-review

Cell Division
Escherichia coli
Cells
Proteins
Membranes

Time and Space resolved Methods: general discussion

Zanni, M., Jemmis, E. D., Aravamudhan, S., Pallipurath, A., Arunan, E., Schnedermann, C., Mishra, A. K., Warren, M., Hirst, J. D., John, F., Pal, R., Helliwell, J. R., Moirangthem, K., Chakraborty, S., Dijkstra, A. G., Chowdhury, P. R., Ghiggino, K., Miller, R. J. D., Meech, S., Medhi, H. & 11 othersHariharan, M., Ariese, F., Edwards, A., Mallia, A. R., Umapathy, S., Nielsen, M. M., Hunt, N., Tian, Z. Y., Skelton, J., Sankar, G. & Goswami, D., 2015, In : Faraday Discussions. 177, p. 263-292

Research output: Contribution to JournalArticleAcademicpeer-review

2014

Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector.

van der Woude, A. D., Stoop, E. J. M., Stiess, M., Wang, Q., Ummels, R., van Stempvoort, G., Piersma, S. R., Cascioferro, A., Jimenez, C. R., Houben, E. N. G., Luirink, J., Pieters, J., van der Sar, A. M. & Bitter, W., 2014, In : Cellular Microbiology. 16, 2, p. 280-295

Research output: Contribution to JournalArticleAcademicpeer-review

Mycobacterium marinum
Cyclic GMP-Dependent Protein Kinases
Virulence
Mycobacterium
Virulence Factors

An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines.

Jong, W. S. P., Daleke, M. H., Vikstrom, D., ten Hagen-Jongman ten, C. M., de Punder, K., van der Wel, N. N., van de Sandt, C. E., Rimmelzwaan, G. F., Follman, F., Agger, E., Andersen, P., de Gier, J-W. & Luirink, J., 25 Nov 2014, In : Microbial Cell Factories. 13, p. 1-15 15 p., 162.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Bacterial Vaccines
Synthetic Vaccines
Vaccines
Hemoglobin
Hemoglobins

ATP synthase in mycobacteria: special features and implications for a function as drug target.

Lu, P., Lill, H. & Bald, D., 2014, In : Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1837, p. 1208-1218

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mycobacterium
Adenosine Triphosphate
Pharmaceutical Preparations
Energy Metabolism
Macrophages

Cryo-Electron Microscopic Structure of SecA Bound to the 70S Ribosome.

Singh, R., Kraft, C., Jaiswal, R., Sejwal, K., Kasaragod, V. B., Kuper, J., Berger, J., Mielke, T., Luirink, J. & Bhushan, S., 2014, In : Journal of Biological Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

Ribosomes
Bacteria
Tunnels
Electrons
Peptides

Decoration of outer membrane vesicles with multiple antigens using an autotransporter approach.

Daleke, M. H., Felix, T., Soprova, Z., ten Hagen-Jongman ten, C. M., Vikström, D., Majlessi, L., Beskers, J., Follman, F., de Punder, K., van der Wel, N. N., Baumgarten, T., Pham, T. V., Piersma, S. R., Jimenez, C. R., van Ulsen, P., de Gier, J. W., Leclerc, C., Jong, W. S. & Luirink, S., 2014, In : Applied and Environmental Microbiology. 80, 18, p. 5854-5864

Research output: Contribution to JournalArticleAcademicpeer-review

vesicle
antigen
membrane
antigens
Antigens

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

Koul, A., Vranckx, L., Dhar, N., Göhlmann, H., Özdemir, E., Neefs, J-M., Schulz, M., Lu, P., Mortz, E., McKinney, J. D., Andries, K. & Bald, D., 2014, In : Nature Communications. 5, 3369.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
bedaquiline
tuberculosis
adenosine triphosphate
metabolism
Mycobacterium tuberculosis

Fatal attraction in glycolysis: how Saccharomyces cerevisiae manages sudden transitions to high glucose.

van Heerden, J. H., Wortel, M. T., Bruggeman, F. J., Heijnen, J. J., Bollen, Y. J. M., Planque, R., Hulshof, J., O'Toole, T. G., Wahl, A. & Teusink, B., 2014, In : Microbial Cell. 1, 3, p. 103-106

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Fully quantum state-resolved inelastic scattering of NO(X) plus Kr: Differential cross sections and product rotational alignment

Brouard, M., Chadwick, H., Gordon, S. D. S., Hornung, B., Nichols, B., Klos, J., Aoiz, F. J. & Stolte, S., 2014, In : Journal of Chemical Physics. 141, 16, 164306.

Research output: Contribution to JournalArticleAcademicpeer-review

Krypton
Inelastic scattering
inelastic scattering
alignment
Electric fields

Imaging and quantification of trans-membrane protein diffusion in living bacteria.

Oswald, F., Bank, E., Bollen, Y. J. M. & Peterman, E. J. G., 2014, In : Physical Chemistry Chemical Physics - PCCP. 16, 25, p. 12625-12634

Research output: Contribution to JournalArticleAcademicpeer-review

Membrane Proteins
Bacteria
Fluorescence Microscopy
Thermal Diffusion
Cell Membrane

Inelastic Scattering of NO by Kr: Rotational Polarization over a Rainbow

Chadwick, H., Nichols, B., Gordon, S. D. S., Hornung, B., Squires, E., Brouard, M., Klos, J., Alexander, M. H., Aoiz, F. J. & Stolte, S., 2014, In : Journal of Physical Chemistry Letters. 5, 19, p. 3296-3301

Research output: Contribution to JournalArticleAcademicpeer-review

Inelastic scattering
rainbows
inelastic scattering
Polarization
parity

Lost in transition: start-up of glycolysis yields subpopulations of nongrowing cells.

van Heerden, J. H., Wortel, M. T., Bruggeman, F. J., Heijnen, J. J., Bollen, Y. J. M., Planque, R., Hulshof, J., O'Toole, T. G., Wahl, S. A. & Teusink, B., 2014, In : Science. 343, 6174, 1245114.

Research output: Contribution to JournalArticleAcademicpeer-review

Glycolysis
Substrate Cycling
Energy Metabolism
Hydrolysis
Adenosine Triphosphate

Opto-mechanical probe for combining atomic force microscopy and optical near-field surface analysis

van Hoorn, C. H., Chavan, D. C., Tiribilli, B., Margheri, G., Mank, A. J. G., Ariese, F. & Iannuzzi, D., 2014, In : Optics Letters. 39, 16, p. 4800-4803

Research output: Contribution to JournalArticleAcademicpeer-review

File
near fields
atomic force microscopy
scanning
probes
microscopy

The ATPsynthase inhibitor bedaquiline interferes with small-molecule efflux in Mycobacterium smegmatis.

Lu, P., Villelas, C., Koul, A., Andries, K., Lill, H. & Bald, D., 2014, In : The Journal of Antibiotics.

Research output: Contribution to JournalArticleAcademicpeer-review

The polypeptide transport-associated domains of TpsB transporters determine the system specificity of two-partner secretion systems.

Rahman, S., Arenas, J., Oztürk, H., Dekker, N. & van Ulsen, P., 2014, In : Journal of Biological Chemistry. 289, 28, p. 19799-19809

Research output: Contribution to JournalArticleAcademicpeer-review

Peptides
Periplasm
Neisseria meningitidis
Substrates
Substrate Specificity

Type V secretion: From biogenesis to biotechnology

van Ulsen, P., Rahman, S. U., Jong, W. S. P., Daleke, M. H. & Luirink, J., 2014, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1843, 8, p. 1592-1611

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Biotechnology
Membranes
Proteins
Membrane Proteins
Virulence Factors

Variable processing of the IgA protease autotransporter at the cell surface of Neisseria meningitidis

Roussel-Jazédé, V., Arenas, J., Langereis, J. D., Tommassen, J. & van Ulsen, P., 2014, In : Microbiology. 160, 11, p. 2421-2431 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

IgA-specific serine endopeptidase
Neisseria meningitidis
Peptides
Nuclear Localization Signals
Peptide Hydrolases
2013

Advances and strategies in discovery of new antibacterials for combating metabolically resting bacteria

Bald, D. & Koul, A., 2013, In : Drug Discovery Today. 18, p. 250-255

Research output: Contribution to JournalArticleAcademicpeer-review

Anti-Bacterial Agents
Bacteria
Bacterial Infections
Pharmaceutical Preparations

A general scaling rule for the collision energy dependence of a rotationally inelastic differential cross-section and its application to NO(X)+He.

Zhang, X., Eyles, C. J., Taatjes, C. A., Ding, D. & Stolte, S., 2013, In : Physical Chemistry Chemical Physics - PCCP. 15, 15, p. 5620-5635

Research output: Contribution to JournalArticleAcademicpeer-review

scaling
collisions
cross sections
scattering amplitude
energy