Projects per year
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Dive into the research topics where Medicinal chemistry is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Finished
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ONCORNET2.0: Horizon2020 ONCOgenic Receptor Network of Excellence and Training 2.0
van Muijlwijk-Koezen, J. & Smit, M.
1/02/20 → 31/01/24
Project: Research
Research output
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Probing the Histamine H1 Receptor Binding Site to Explore Ligand Binding Kinetics
Kuhne, S., Bosma, R., Kooistra, A. J., Riemens, R., Stroet, M. C. M., Vischer, H. F., de Graaf, C., Wijtmans, M., Leurs, R. & de Esch, I. J. P., 26 Dec 2024, (E-pub ahead of print) In: Journal of medicinal chemistry. 17 p.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Nanobody formats and conjugates detecting, modulating, and targeting CXCR4
Anbuhl, S. M., 10 Dec 2024, 244 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile60 Downloads (Pure) -
Modulation of non-canonical CXCR4 and ACKR3 functions
Perez Almeria, C. V., 18 Oct 2024, 185 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile61 Downloads (Pure) -
Pharmacological characterization of the zebrafish Hrh2a histamine H2 receptor
McNaught-Flores, D. A., Chen, Y. C., Arias-Montaño, J. A., Panula, P. & Leurs, R., 15 Oct 2024, In: European Journal of Pharmacology. 981, p. 1-12 12 p., 176870.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Multivalent CXCR4-targeting nanobody formats differently affect affinity, receptor clustering, and antagonism
Anbuhl, S. M., Dervillez, X., Neubacher, S., Schriek, A. I., Bobkov, V., de Taeye, S. W., Szpakowska, M., Siderius, M., Grossmann, T. N., Chevigné, A., Smit, M. J. & Heukers, R., Sept 2024, In: Biochemical Pharmacology. 227, 116457.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access
Activities
- 124 Lecture / Presentation
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Design of the BiographyNet schema: Multiple views and provenance
C.J. Ockeloen (Speaker), A.S. Fokkens-Zwirello (Speaker), S. ter Braake (Speaker), P.T.J.M. Vossen (Speaker), S. Legene (Speaker), V. de Boer (Speaker) & A.Th. Schreiber (Speaker)
28 Nov 2013Activity: Lecture / Presentation › Academic
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Knowledge Representation in Scientific Models and their Publications : a Case Study
M.G. de Vos (Speaker), W.R. van Hage (Speaker), J. Wielemaker (Speaker) & A. Schreiber (Speaker)
2013Activity: Lecture / Presentation › Academic
File -
Mutational analysis of the histamine H1 antagonist binding site
K. Wieland (Speaker)
1999Activity: Lecture / Presentation › Academic
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Qualitative structure-activity relationships for inverse agonism by H2 antagonists,
A.E. Alewijnse (Speaker)
1999Activity: Lecture / Presentation › Academic
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Changed insights in receptor mechanisms and the consequences for Medicine Research.
H. Timmerman (Speaker)
1999Activity: Lecture / Presentation › Academic
Prizes
Datasets
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Chemokine G protein-coupled receptor (GPCR) mutation data set
Smit, M. (Contributor), De Graaf, G. C. (Contributor) & Leurs, R. (Contributor), Zenodo, 2016
DOI: 10.5281/zenodo.58160, https://zenodo.org/record/58160
Dataset / Software: Dataset
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KLIFS: A Knowledge-Based Structural Database To Navigate Kinase–Ligand Interaction Space
de Esch, I. (Contributor), Kooistra, A. J. (Contributor), Leurs, R. (Contributor), van Linden, O. (Contributor) & de Graaf, C. (Contributor), Unknown Publisher, 13 Aug 2013
DOI: 10.5281/zenodo.45414, https://zenodo.org/record/45414
Dataset / Software: Dataset
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PDEStrIAn: A phosphodiesterase structure and ligand interaction annotated database as a tool for structure-based drug design
Jansen, C. (Contributor), Kooistra, A. J. (Contributor), Kanev, G. K. (Contributor), Leurs, R. (Contributor), de Esch, I. (Contributor) & De Graaf, C. (Contributor), Zenodo, 2016
DOI: 10.5281/zenodo.45774, https://zenodo.org/record/45774
Dataset / Software: Dataset
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Workshop Material - 3D-e-Chem Structural Cheminformatics Workflows for Computer-Aided Drug Discovery
Kooistra, A. J. (Contributor), Vass, M. (Contributor), McGuire, R. (Contributor), Verhoeven, S. (Contributor), de Graaf, C. (Contributor) & Ridder, L. (Contributor), Zenodo, 2018
DOI: 10.5281/zenodo.1187072, https://zenodo.org/record/1187072
Dataset / Software: Dataset
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Secretin-like class B G protein-coupled receptor (GPCR) mutation data set
De Graaf, C. (Contributor), Zenodo, 2016
DOI: 10.5281/zenodo.60790, https://zenodo.org/record/60790
Dataset / Software: Dataset