Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Ligands Medicine & Life Sciences
Histamine Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences
Chemokine Receptors Medicine & Life Sciences
Histamine Receptors Medicine & Life Sciences
Histamine H3 Receptors Medicine & Life Sciences
Cytochrome P-450 Enzyme System Medicine & Life Sciences
Rats Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Profiles

No photo of Ilze Adlere

Ilze Adlere

Person: Academic

No photo of Marta Arimont Segura

Marta Arimont Segura

Person: Academic

20182019
No photo of J.P. Bebelman

J.P. Bebelman

19972019
Photo of Maarten Bebelman

Maarten Bebelman

Person: Academic

20182018
No photo of Pierre Boronat

Pierre Boronat

Person: Academic

Research Output 1985 2019

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists

Adlere, I., Sun, S., Zarca, A., Roumen, L., Gozelle, M., Viciano Perpiñá, C., Caspar, B., Arimont, M., Bebelman, J. P., Briddon, S. J., Hoffmann, C., Hill, S. J., Smit, M. J., Vischer, H. F., Wijtmans, M., de Graaf, C., de Esch, I. J. P. & Leurs, R., 15 Jan 2019, In : European Journal of Medicinal Chemistry. 162, p. 631-649 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

CXCR4 Receptors
Quantitative Structure-Activity Relationship
Chemokine Receptors
Screening
Pharmacology

4-Hydroxypiperidines and their flexible 3-(amino)propyloxy analogues as non-imidazole histamine H3 receptor antagonist: Further structure-activity relationship exploration and in vitro and in vivo pharmacological evaluation

Olszewska, B., Stasiak, A., McNaught Flores, D., Fogel, W. A., Leurs, R. & Walczyński, K., Apr 2018, In : International Journal of Molecular Sciences. 19, p. 1-19 19 p., 1243.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine H3 Antagonists
Histamine H3 Receptors
histamines
Structure-Activity Relationship
Rats

Aminergic GPCR-Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data

Vass, M., Podlewska, S., De Esch, I. J. P., Bojarski, A. J., Leurs, R., Kooistra, A. J. & De Graaf, C., 17 Oct 2018, In : Journal of Medicinal Chemistry. 56 p.

Research output: Contribution to JournalArticleAcademicpeer-review

G-Protein-Coupled Receptors
Ligands
Mutation
Drug Discovery
Site-Directed Mutagenesis

A Structural Framework for GPCR Chemogenomics: What’s In a Residue Number?

Vass, M., Kooistra, A. J., Verhoeven, S., Gloriam, D., de Esch, I. J. P. & de Graaf, C., 2018, Computational Methods for GPCR Drug Discovery. Heifetz, A. (ed.). Humana Press Inc, p. 73-113 41 p. (Methods in Molecular Biology; vol. 1705).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

G-Protein-Coupled Receptors
Binding Sites
Ligands
Workflow
Mutation

Biogenesis and function of extracellular vesicles in cancer

Bebelman, M. P., Smit, M. J., Pegtel, D. M. & Baglio, S. R., Aug 2018, In : Pharmacology and Therapeutics. 188, p. 1-11 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Exosomes
Neoplasms
Biological Phenomena
Endosomes
Growth

Activities 1995 2013

  • 124 Lecture / Presentation

Knowledge Representation in Scientific Models and their Publications : a Case Study

M.G. de Vos (Speaker), W.R. van Hage (Speaker), J. Wielemaker (Speaker), A. Schreiber (Speaker)
2013

Activity: Lecture / PresentationAcademic

File

Design of the BiographyNet schema: Multiple views and provenance

C.J. Ockeloen (Speaker), A.S. Fokkens-Zwirello (Speaker), S. ter Braake (Speaker), P.T.J.M. Vossen (Speaker), S. Legene (Speaker), V. de Boer (Speaker), A.Th. Schreiber (Speaker)
28 Nov 2013

Activity: Lecture / PresentationAcademic

Recent developments in GPCR research; implecations for drug research,

R. Leurs (Speaker)
1999

Activity: Lecture / PresentationAcademic

Mutational analysis of the histamine H1 antagonist binding site

K. Wieland (Speaker)
1999

Activity: Lecture / PresentationAcademic

Prizes

FIGON DMD Poster Prize

T.S. Fan (Recipient), 2015

PrizeAcademic

KNCV Poster Prize

T.S. Fan (Recipient), 2015

PrizeAcademic