Research Output 1985 2019

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2018

A Structural Framework for GPCR Chemogenomics: What’s In a Residue Number?

Vass, M., Kooistra, A. J., Verhoeven, S., Gloriam, D., de Esch, I. J. P. & de Graaf, C., 2018, Computational Methods for GPCR Drug Discovery. Heifetz, A. (ed.). Humana Press Inc, p. 73-113 41 p. (Methods in Molecular Biology; vol. 1705).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

G-Protein-Coupled Receptors
Binding Sites
Ligands
Workflow
Mutation
2017

1.15 - Structural Chemogenomics Databases to Navigate Protein–Ligand Interaction Space

Kanev, G. K., Kooistra, A. J., de Esch, I. J. P. & de Graaf, C., 2017, 1.15 - Structural Chemogenomics Databases to Navigate Protein–Ligand Interaction Space. Comprehensive Medicinal Chemistry III ed. Elsvier, Vol. 1. p. 444-471

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Ligands
Proteins
Drug Combinations
Proteome
Bioactivity

Chemokine receptor oligomerization to tweak chemotactic responses

Vischer, H. F., 2017, G-Protein-Coupled Receptor Dimers. p. 233-272 (The Receptors; vol. 33).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Chemokine Receptors
Cell Movement
G-Protein-Coupled Receptors
Chemokines
Pharmacology

Kinase-Centric Computational Drug Development

Kooistra, A. J. & Volkamer, A., 1 Jan 2017, Annual Reports in Medicinal Chemistry. Academic Press Inc., Vol. 50. p. 197-236 (Annual Reports in Medicinal Chemistry; vol. 50).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Phosphotransferases
Pharmaceutical Preparations
Bioactivity
Drug Design
Sequence Analysis

Ligand-binding kinetics on histamine receptors

Bosma, R., Mocking, T. A. M., Leurs, R. & Vischer, H. F., 2017, Histamine receptors as drug targets. Humana Press, p. 115-155 (Methods in pharmacology and toxicology).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Histamine Receptors
Ligands
Pharmaceutical Preparations
Histamine Antagonists

Methods to study the molecular pharmacology of the histamine H4 receptor

Verweij, E. W. E., Leurs, R. & Vischer, H. F., 2017, Histamine receptors as drug targets. Humana Press, p. 157-181 (Methods in pharmacology and toxicology).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Histamine Receptors
Pharmacology
Ligands
Animal Disease Models
Drug Discovery
2016

Molecular Aspects of Histamine Receptors

Mocking, T., Bosma, R., Rahman, S. N., Verweij, E. W. E., McNaught-Flores, D. A., Vischer, H. F. & Leurs, R., 2016, Histamine Receptors. Preclinical and clinical aspects.. Blandina, P. & Passani, M. B. (eds.). Humana Press, p. 1-49 (The Receptors; no. 28).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

2014

From three-dimensional GPCR structure to rational ligand discovery

Kooistra, A. J., Leurs, R., De Esch, I. J. P. & de Graaf, C., 2014, G Protein-Coupled Receptors - Modeling and Simulation. Filizola, M. (ed.). Springer New York LLC, p. 129-157 29 p. (Advances in Experimental Medicine and Biology; vol. 796).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Ligands
Screening
Workflow
Structural Models
G-Protein-Coupled Receptors
2010

Chemokine Receptors as Drug Targets

Smit, M. J., Lira, SA. & Leurs, R., 2010, Methods and Principles in Medicinal Chemistry. Raimund Mannhold, R., Hugo Kubinyi, H. & Gerd Folkers, G. (eds.).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Chemokine Receptors in Inflammatory Diseases

Kraneveld, A. D., Braber, S., Overbeek, S., De Kruijf, P., Koelink, P. & Smit, M. J., 2010, Chemokine Receptors as Drug Targets. Martine Smit, M. J. & Sergio Lira, S. (eds.). germany: Wiley-VCH, p. 105-113 384 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Constitutively Active Viral Chemokine Receptors: Tools for Immune Subversion and Pathogenesis

Maussang Detaille, D. A. B., Bongers, G. M., Lira, SA. & Smit, M. J., 2010, Chemokine Receptors as Drug Targets. Martine Smit, M. J., Sergio Lira, S. A. & Rob Leurs, R. (eds.). Germany: Wiley-VCH, p. 177-189 384 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

CXCR4 as a Therapeutic Target

Chow, Y. C. K. & Bachelerie, F., 2010, Chemokine Receptors as Drug Targets.. Martine Smit, M. J., Sergio Lira, S. A. & Rob Leurs, R. (eds.). germany: Wiley-VCH, p. 239-256 384 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Molecular Pharmacology of the Four Histamine Receptors

Bongers, G., De Esch, I. J. & Leurs, R., 2010, HISTAMINE IN INFLAMMATION. Thurmond, R. L. (ed.). Vol. Springer. p. 709-711 3 p. (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Histamine Receptors
Ligands
Pharmaceutical Chemistry

Targeting Chemokine Receptor Dimers: Are there Two (or More) to Tango?

Vischer, H. F., Nijmeijer, S. & Parmentier, M., 2010, Chemokine Receptors as Drug Targets. Martine Smit, M. J., Sergio Lira, S. A. & Rob Leurs, R. (eds.). Germany: Wiley-VCH, p. 85-98 375 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Therapeutic Targeting of the CXCR3 Receptors

Wijtmans, M., De Esch, I. J. & Leurs, R., 2010, Chemokine Receptors as Drug Targets. Martine Smit, M. J., Sergio Lira, S. A. & Rob Leurs, R. (eds.). Germany: Wiley-VCH, p. 301-315 384 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

2008

Cytochrome P450 Protein Modeling and Ligand Docking

Feenstra, K. A., de Graaf, C. & Vermeulen, N. P. E., 2008, Drug-Drug Interactions. Rodrigues, A. D. (ed.). New York: Informa Healthcare USA, Inc., p. 435-470 (Drugs and the pharmaceutical sciences; no. 179).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

2002

Molecular modeling approaches to predicting drug metabolism and toxicity.

ter Laak, A. M., de Groot, M. J. & Vermeulen, N. P. E., 2002, Drug-drug interactions. Rodrigues, A. D. (ed.). New York: Marcel Dekker Inc., p. 505

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

1999

Telemetry to study the effect of protectors on the doxorubicin-induced cardiotoxicity in freely moving mice

Kramer, K., van Acker, F. A. A., van Acker, S. A. B. E., Grimbergen, J. A., van der Vijgh, W. J. F. & Bast, A., 1999, Humane Endpoints in Animal Experiments for Biomedical Research. Hendriksen, C. F. M. & Morton, D. B. (eds.). London, England: The Royal Society of Medicine Press Limited, p. 66-70

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Using telemetry to study the effect of protectors on doxorubicin-induced cardiotoxicity in freely moving mice.

van Acker, F. A. A., van Acker, S. A. B. E., Grimbergen, J. A., van der Vijgh, W. J. F., Bast, A. & Kramer, K., 1999, Humane Endpoints in Animal Experiments for Biomedical Research. Hendriksen, F. M. & Morton, D. B. (eds.). London: Royal Society of Medicine Press Limited, p. 66-70

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

1997

1,5-Diphenyl-1,4-pentadiene-3-ones and cyclic analogues as antioidative agents.

Sardjiman, S. S., Samhoedi, M., Hakim, L., van der Goot, H. & Timmerman, H., 1997, Recent developments in curcumin pharmacochemistry.. Pramono, S., Jenie, U. A., Sudibyo, R. & Gunawan, D. (eds.). Yogyakarta, Indonesia: Aditya Media, p. 175-186

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

An overview of lipoate chemistry.

Biewenga, G. P., Haenen, G. R. M. M. & Bast, A., 1997, Lipoic acid in health and disease.. Fuchs, J., Packer, L. & Zimmer, G. (eds.). New York: Marcel Dekker, Inc., p. 1-32

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Cytotoxicity and cytoprotective activity of curcumin.

Commandeur, J. N. M. & Vermeulen, N. P. E., 1997, Recent developments in curcumin pharmacochemistry.. Pramono, S., Jenie, U. A., Sudibyo, R. & Gunawan, D. (eds.). Yogyakarta, Indonesie: Aditya Media, p. 66-83

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Effect of curcumin and its derivatives on glutathione S-transferase activity in liver cytosolic of betanaphthoflavone-treated rats.

Sudibyo, M., Hakim, L., Samhoedi, M., Commandeur, J. N. M. & Vermeulen, N. P. E., 1997, Recent development in curcumin pharmacochemistry.. Pramono, S., Jenie, U. A., Sudibyo, R. & Gunawan, D. (eds.). Yogyakarta, Indonesia: Aditya Media, p. 126-135

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Histamine H1-receptor antagonists.

Zhang, M. Q., Leurs, R. & Timmerman, H., 1997, Burger's Medicinal Chemistry an Drug Discovery, fifth edition, volume 5: Therapeutic Agents.. Wolff, M. E. (ed.). p. 495-559 (5; no. 5).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Interactions between curcumin and curcumin analogues and cytochrome P-450: Inhibition of rat hepatic microsomal ethoxyresorufin O-dealkylase and their structure-activity relationships.

Oetari, S., Commandeur, J. N. M., Suwaldi, M., Sugiyanto, D., Bijlo, G., Samhoedi, M. & Vermeulen, N. P. E., 1997, Recent developments in curcumin pharmacochemistry.. Pramono, S., Jenie, U. A., Sudibyo, R. & Gunawan, D. (eds.). Yogyakarta, Indonesia: Aditya Media, p. 136-151

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

New perspectives for anti-inflammatory drugs.

Timmerman, H., 1997, Recent developments in curcumin pharmacochemistry.. Pramono, S., Jenie, U. A., Sudibyo, R. & Gunawan, D. (eds.). Yogyakarta Indonesia: Aditya Media, p. 1-12

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Signal transduction via protein-coupled receptors: Ternary complexes as secondary proton pumps and GTP synthases.

Nederkoorn, P. H. J. & Timmerman, H., 1997, Computer-assisted lead finding and optimization. Current tools for medicinal chemistry.. van der Waterbeemd, H., Testa, B. & Folkers, G. (eds.). Basel, Weinheim/New York: Verlag Helvetica Chimia Acta, Basel and Wiley-VCH, Weinheim, p. 511-526

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Structural aspects of antioxidant activity of flavonoids

van Acker, S. A. B. E., Bast, A. & van der Vijgh, W. J. F., 1997, Flavonoids in health and disease. Rice-Evans, C. A. & Pecker, L. (eds.). New York USA: Marcel Dekker Inc, p. 221-251

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Structural aspects of antioxidant activity of flavonoids.

van Acker, S. A. B. E., Bast, A. & van der Vijgh, W. J. F., 1997, Flavonoids in health and disease.. Rice-Evans, C. A. & Packer, L. (eds.). New York: Marcel Dekker Inc., p. 221-251

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Synthesis and hydroxyl scavenging activity of some 4-alkylcurcumin derivatives.

Supardjan, A. M., Jenie, U. A., Samhoedi, M., Timmerman, H. & van der Goot, H., 1997, Recent developments in curcumin pharmacochemistry.. Pramono, S., Jenie, U. A., Sudibyo, R. & Gunawan, D. (eds.). Yogyakarta, Indonesia: Aditya Media, p. 164-174

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

The antioxidant-prooxidant balance in neurodegeneration and neuroprotection.

Bast, A. & Bär, P. R., 1997, Neuroprotection in CNS diseases.. Bär, P. R. & Flint Beal, M. (eds.). New York: Marcel Dekker, Inc., p. 147-159

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

The chemistry and qualitative structure-activity relationships of curcumin.

van der Goot, H., 1997, Recent developments in curcumin pharmacochemistry.. Pramono, S., Jenie, U. A., Sudibyo, R. & Gunawan, D. (eds.). Yogyakarta, Indonesie: Aditya Media, p. 13-26

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

The relationship between structure and inhibition of lipoxygenase activity of curcumin derivatives.

Nurfina, A. N., Samhoedi, M., Timmerman, H., Jenie, U. A., Sugiyanto, D. & van der Goot, H., 1997, Recent developments in curcumin pharmacochemistry.. Pramono, S., Jenie, U. A., Sudibyo, R. & Gunawan, D. (eds.). Yogyakarta Indonesia: Aditya Media, p. 152-163

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic