Research Output 1985 2019

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Review article
2019

Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs

De Groof, T. W. M., Bobkov, V., Heukers, R. & Smit, M. J., 15 Mar 2019, In : Molecular and Cellular Endocrinology. 484, p. 15-24 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Single-Domain Antibodies
G-Protein-Coupled Receptors
Imaging techniques
Immunoglobulin Fragments
Antibodies

Nanobodies detecting and modulating GPCRs outside in and inside out

Heukers, R., De Groof, T. W. M. & Smit, M. J., 1 Apr 2019, In : Current Opinion in Cell Biology. 57, p. 115-122 8 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Single-Domain Antibodies
G-Protein-Coupled Receptors
Immunoglobulin Fragments
Physiological Phenomena
Drug Discovery
2018

Biogenesis and function of extracellular vesicles in cancer

Bebelman, M. P., Smit, M. J., Pegtel, D. M. & Baglio, S. R., Aug 2018, In : Pharmacology and Therapeutics. 188, p. 1-11 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Exosomes
Neoplasms
Biological Phenomena
Endosomes
Growth

Chemical Diversity in the G Protein-Coupled Receptor Superfamily

Vass, M., Kooistra, A. J., Yang, D., Stevens, R. C., Wang, M. W. & de Graaf, C., 1 May 2018, In : Trends in Pharmacological Sciences. 39, 5, p. 494-512 19 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

G-Protein-Coupled Receptors
Ligands
Cell signaling
Chemical compounds
Modulators

Diagnostic accuracy of diagnostic imaging for lumbar disc herniation in adults with low back pain or sciatica is unknown; a systematic review

Kim, J-H., van Rijn, R. M., van Tulder, M. W., Koes, B. W., de Boer, M. R., Ginai, A. Z., Ostelo, R. W. G. J., van der Windt, D. A. M. W. & Verhagen, A. P., 2018, In : Chiropractic and Manual Therapies. 26, p. 37

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Sciatica
Myelography
Diagnostic Imaging
Low Back Pain
Tomography
2017

Extending the Structural View of Class B GPCRs

de Graaf, C., Song, G., Cao, C., Zhao, Q., Wang, M. W., Wu, B. & Stevens, R. C., 1 Dec 2017, In : Trends in Biochemical Sciences. 42, 12, p. 946-960 15 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

G-Protein-Coupled Receptors
GTP-Binding Proteins
Secretin
Chemical activation
Modulation

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

Schuetz, D. A., de Witte, W. E. A., Wong, Y. C., Knasmueller, B., Richter, L., Kokh, D. B., Sadiq, S. K., Bosma, R., Nederpelt, I., Heitman, L. H., Segala, E., Amaral, M., Guo, D., Andres, D., Georgi, V., Stoddart, L. A., Hill, S., Cooke, R. M., de Graaf, C., Leurs, R. & 6 othersFrech, M., Wade, R. C., de Lange, E. C. M., IJzerman, A. P., Müller-Fahrnow, A. & Ecker, G. F., 1 Jun 2017, In : Drug Discovery Today. 22, 6, p. 896-911 16 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Drug Industry
Drug Discovery
Pharmaceutical Preparations
Decision Making
Industry

Structural Analysis of Chemokine Receptor-Ligand Interactions

Arimont, M., Sun, S-L., Leurs, R., Smit, M., De Esch, I. J. P. & de Graaf, C., 22 Jun 2017, In : Journal of Medicinal Chemistry. 60, 12, p. 4735-4779 45 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Chemokine Receptors
Ligands
Molecular Models
Structure-Activity Relationship
Site-Directed Mutagenesis

The clinical pharmacology of non-sedating antihistamines

Yanai, K., Yoshikawa, T., Yanai, A., Nakamura, T., Iida, T., Leurs, R. & Tashiro, M., 1 Oct 2017, In : Pharmacology and Therapeutics. 178, p. 148-156 9 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Clinical Pharmacology
Histamine Antagonists
Histamine H1 Antagonists
Histamine H1 Receptors
Hypnotics and Sedatives
2015

Generic GPCR residue numbers - Aligning topology maps while minding the gaps

Isberg, V., de Graaf, C., Bortolato, A., Cherezov, V., Katritch, V., Marshall, F. H., Mordalski, S., Pin, J. P., Stevens, R. C., Vriend, G. & Gloriam, D. E., 2015, In : Trends in Pharmacological Sciences. 36, 1, p. 22-31 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

G-Protein-Coupled Receptors
Topology
Constriction
Crystal structure
Databases

G Protein-Coupled Receptor Multimers: A Question Still Open Despite the Use of Novel Approaches

Vischer, H. F., Castro, M. & Pin, J. P., Sep 2015, In : Molecular Pharmacology. 88, 3, p. 561-71 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
G-Protein-Coupled Receptors
Fluorescence Microscopy

Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It

Hoffmann, R. C., Castro, M., Rinken, A., Leurs, R., Hill, S. J. & Vischer, H. F., Sep 2015, In : Molecular Pharmacology. 88, 3, p. 552-60 9 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

G-Protein-Coupled Receptors
Ligands
Pharmaceutical Preparations
Molecular Dynamics Simulation
Plasma Cells

Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors

de Munnik, S. M., Smit, M. J., Leurs, R. & Vischer, H. F., 2015, In : Frontiers in Pharmacology. 6, MAR, 40.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Herpesviridae
Viral Proteins
G-Protein-Coupled Receptors
Immune Evasion
Chemokine Receptors
2013

Targeting tumors with nanobodies for cancer imaging and therapy

Oliveira, S., Heukers, R., Sornkom, J., Kok, R. J. & van Bergen En Henegouwen, P. M. P., 28 Dec 2013, In : Journal of Controlled Release. 172, 3, p. 607-17 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Single-Domain Antibodies
Neoplasms
Molecular Imaging
Therapeutics
Monoclonal Antibodies
2011

Molecular determinants of selective agonist and antagonist binding to the histamine H₄ receptor

Istyastono, E. P., de Graaf, C., de Esch, I. J. P. & Leurs, R., 2011, In : Current Topics in Medicinal Chemistry. 11, 6, p. 661-79 19 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Histamine Receptors
Ligands
Structure-Activity Relationship
Computer Simulation
Histamine
2009

A new generation of anti-histamines: Histamine H4 receptor antagonists on their way to the clinic

Engelhardt, H., Smits, R. A., Leurs, R., Haaksma, E. & de Esch, I. J. P., Sep 2009, In : Current Opinion in Drug Discovery and Development. 12, 5, p. 628-643 16 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Histamine Receptors
Histamine
Ligands
Drug Industry
Human Genome
2006

The emerging role of the histamine H4 receptor in anti-inflammatory therapy

Lim, H. D., Smits, R. A., Leurs, R. & De Esch, I. J. P., 2006, In : Current Topics in Medicinal Chemistry. 6, 13, p. 1365-73 9 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Histamine Receptors
Histamine Antagonists
Histamine
Anti-Inflammatory Agents
Ligands
G-Protein-Coupled Receptors
Viruses
Pharmaceutical Preparations
Virus Receptors
Human Herpesvirus 8
2005

Fish FSH receptors bind LH: how to make the human FSH receptor to be more fishy?

Bogerd, J., Granneman, J. C. M., Schulz, R. W. & Vischer, H. F., 15 May 2005, In : General and Comparative Endocrinology. 142, 1-2, p. 34-43 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Human Follicle Stimulating Hormone
FSH Receptors
Catfishes
luteinizing hormone
Luteinizing Hormone
2004

Histamine H3 receptor agonists

De Esch, I. J. P. & Belzar, K. J., Nov 2004, In : Mini-Reviews in Medicinal Chemistry. 4, 9, p. 955-63 9 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Histamine Agonists
Protein Isoforms
Ligands
2001

Chemistry and biological activity of novel selenium-containing compounds

Commandeur, J. N., Rooseboom, M. & Vermeulen, N. P., 2001, In : Advances in Experimental Medicine and Biology. 500, p. 105-12 8 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Gonadotropins, their receptors, and the regulation of testicular functions in fish

Schulz, R. W., Vischer, H. F., Cavaco, J. E., Dos Santos Rocha, M. E., Tyler, R. C., Goos, H. J. & Bogerd, J., Jun 2001, In : Comparative biochemistry and physiology b-biochemistry & molecular biology. 129, 2-3, p. 407-17 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Gonadotropin Receptors
Luteinizing Hormone
Fish
Fishes
Follicle Stimulating Hormone
1998

Mammalian adenylyl cyclases

Smit, M. J. & Iyengar, R., 1998, In : Advances in second messenger and phosphoprotein research. 32, p. 1-21 21 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

1997

Modeling the active sites of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes

De Groot, M. J. & Vermeulen, N. P., Aug 1997, In : Drug Metabolism Reviews. 29, 3, p. 747-99 53 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

1995

Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway

Goeptar, A. R., Commandeur, J. N., van Ommen, B., van Bladeren, P. J. & Vermeulen, N. P., 1 Jan 1995, In : Chemical Research in Toxicology. 8, 1, p. 3-21 19 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

1993

Cytochromes P450: their active-site structure and mechanism of oxidation

Koymans, L., Donné-op den Kelder, G. M., te Koppele, J. M. & Vermeulen, N. P., 1993, In : Drug Metabolism Reviews. 25, 3, p. 325-87 63 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Cytochromes P450 and drug resistance

Doehmer, J., Goeptar, A. R. & Vermeulen, N. P., 1993, In : Cytotechnology. 12, 1-3, p. 357-66 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Drug Resistance
Cytochrome P-450 Enzyme System
Pharmaceutical Preparations
Nutrition
Drug interactions

Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents

Koymans, L., Donné-Op den Kelder, G. M., te Koppele, J. M. & Vermeulen, N. P., Jun 1993, In : Xenobiotica. 23, 6, p. 633-48 16 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Oxygenation
Phenacetin
Acetaminophen
Cytochrome P-450 Enzyme System
Acetanilides
1992

Monitoring of oxidative free radical damage in vivo: analytical aspects

Hageman, J. J., Bast, A. & Vermeulen, N. P. E., May 1992, In : Chemico-Biological Interactions. 82, 3, p. 243-293 51 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Free Radicals
Monitoring
Pathologic Processes
Toxicology
Fluids