Research Output 1988 2019

2019

Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides

van der Heijden, G., van Schaik, T. B., Mouarrawis, V., de Wit, M. J. M., Velde, C. M. L. V., Ruijter, E. & Orru, R. V. A., 1 Jan 2019, In : European Journal of Organic Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

Cyanides
Amides
amides
Picolines
Piperidines

Enantioselective Bio-Hydrolysis of Geranyl-Derived rac-Epoxides: A Chemoenzymatic Route to trans-Furanoid Linalool Oxide

van Lint, M. J., Gümüs, A., Ruijter, E., Faber, K., Orru, R. V. A. & Hall, M., 1 Jan 2019, (Accepted/In press) In : Advanced Synthesis and Catalysis. 361, 4, p. 813-825

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Epoxide Hydrolases
Hydrolases
Enzymatic hydrolysis
Epoxy Compounds
Hydrolysis

Enlightening developments in 1,3-P,N-ligand-stabilized multinuclear complexes: A shift from catalysis to photoluminescence

Rong, M. K., Holtrop, F., Slootweg, J. C. & Lammertsma, K., 1 Mar 2019, In : Coordination Chemistry Reviews. 382, p. 57-68 12 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Catalysis
catalysis
Photoluminescence
Coinage
Metals

Mild and Practical Indole C2 Allylation by Allylboration of in situ Generated 3-Chloroindolenines

Saya, J. M., van Wordragen, E. D. H., Orru, R. V. A. & Ruijter, E., 3 Jan 2019, In : European Journal of Organic Chemistry. p. 1-6 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Allylation
indoles
Indoles
products
Biological Products

Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft

Neubacher, S., Hennig, S. & Grossmann, T. N., 1 May 2019, In : BioSpektrum. 25, 3, p. 338-339 2 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

RNA Structure and Cellular Applications of Fluorescent Light-Up Aptamers

Neubacher, S. & Hennig, S., 28 Jan 2019, In : Angewandte Chemie - International Edition. 58, 5, p. 1266-1279 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

RNA
Nucleotide Aptamers
Proteins
Long Noncoding RNA
Blueprints

Stereoselective Chemoenzymatic Cascade Synthesis of the bis-THF Core of Acetogenins

van Lint, M. J., Hall, M., Faber, K., van Spanning, R. J. M., Ruijter, E. & Orru, R. V. A., 7 Feb 2019, In : European Journal of Organic Chemistry. 2019, 5, p. 1092-1101 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Acetogenins
epoxy compounds
Epoxy Compounds
Biological Products
cascades

Total Synthesis of Aspidosperma and Strychnos Alkaloids through Indole Dearomatization

Saya, J. M., Ruijter, E. & Orru, R. V. A., 1 Jan 2019, In : Chemistry - A European Journal.

Research output: Contribution to JournalReview articleAcademicpeer-review

Alkaloids
Secologanin Tryptamine Alkaloids
Indoles
indole
tryptamine

Tryptamine-Derived Isocyanides I Have Known and Loved: From Multicomponent Reactions to Natural Product Synthesis

Saya, J. M., 2019, 184 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
2018

Advances in Palladium-Catalyzed Cascade Cyclizations

Biemolt, J. & Ruijter, E., 18 Oct 2018, In : Advanced Synthesis and Catalysis. 360, 20, p. 3821-3871 51 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
File
Cyclization
Palladium
Functional groups
Molecules

Aging and sensitivity to illusory target motion with or without secondary tasks

De Dieuleveult, A. L., Brouwer, A. M., Siemonsma, P. C., Van Erp, J. B. F. & Brenner, E., 2018, In : Multisensory Research. 31, 3-4, p. 227-249 23 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Foams
Young Adult
Aging of materials
Feedback
Fingers

Angular scanning and variable wavelength surface plasmon resonance allowing free sensor surface selection for optimum material- and bio-sensing

Lakayan, D., Tuppurainen, J., Albers, M., van Lint, M. J., van Iperen, D. J., Weda, J. J. A., Kuncova-Kallio, J., Somsen, G. W. & Kool, J., 15 Apr 2018, In : Sensors and Actuators, B: Chemical. 259, 15 April, p. 972-979 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Surface plasmon resonance
surface plasmon resonance
Scanning
Wavelength
scanning

Chiral Control in Pentacoordinate Systems: The Case of Organosilicates

Van Der Boon, L. J. P., Van Gelderen, L., De Groot, T. R., Lutz, M., Slootweg, J. C., Ehlers, A. W. & Lammertsma, K., 15 Oct 2018, In : Inorganic Chemistry. 57, 20, p. 12697-12708 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Enantiomers
enantiomers
integrity
Ligands
Silicates

Coiled-Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection

Mueller, C. & Grossmann, T. N., 21 Dec 2018, In : Angewandte Chemie - International Edition. 57, 52, p. 17079-17083 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Peptides
Switches
Proteins
Epitopes
Protein folding

Coordination chemistry of tris(azolyl)phosphines

Tazelaar, C. G. J., Slootweg, J. C. & Lammertsma, K., 1 Feb 2018, In : Coordination Chemistry Reviews. 356, p. 115-126 12 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
phosphine
Phosphines
phosphines
chemistry
Methane

Design and Synthesis of Photoactive Molecules

Rombouts, J. A., 2018, 172 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Fluorine-18 Labelled Building Blocks for PET Tracer Synthesis: Overview and Recent Advances in 18F-Trifluoromethylation

van der Born, D., 2018, 248 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to β-Amino Alcohols

Saya, J. M., Berabez, R., Broersen, P., Schuringa, I., Kruithof, A., Orru, R. V. A. & Ruijter, E., 6 Jul 2018, In : Organic Letters. 20, 13, p. 3988-3991 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Imidoesters
Amino Alcohols
alcohols
acids
Acids

Identification of novel PANDAR protein interaction partners involved in splicing regulation

Pospiech, N., Cibis, H., Dietrich, L., Müller, F., Bange, T. & Hennig, S., 12 Feb 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 2798.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Antisense DNA
DNA Damage
RNA
Long Noncoding RNA
Proteins

Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation

Janssen, B., Vugts, D. J., Wilkinson, S. M., Ory, D., Chalon, S., Hoozemans, J. J. M., Schuit, R. C., Beaino, W., Kooijman, E. J. M., Van Den Hoek, J., Chishty, M., Doméné, A., Van Der Perren, A., Villa, A., Maggi, A., Molenaar, G. T., Funke, U., Shevchenko, R. V., Baekelandt, V., Bormans, G. & 3 othersLammertsma, A. A., Kassiou, M. & Windhorst, A. D., 1 Dec 2018, In : Scientific Reports. 8, 1, 6580.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Purinergic P2X7 Receptors
Positron-Emission Tomography
Brain
Autoradiography
Alzheimer Disease

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme

Pelay-Gimeno, M., Bange, T., Hennig, S. & Grossmann, T. N., 27 Aug 2018, In : Angewandte Chemie - International Edition. 57, 35, p. 11164-11170 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cyclization
Enzymes
Proteins
Denaturation
Labeling

Integrative Theory/Experiment-Driven Exploration of a Multicomponent Reaction towards Imidazoline-2-(thi)ones

Kruithof, A., Mulder, J. R., Ruiz, J. M., Janssen, E., Mooijman, M., Ruijter, E., Guerra, C. F., Bickelhaupt, F. M. & Orru, R. V. A., 10 Jan 2018, In : European Journal of Organic Chemistry. 2018, 1, p. 104-112 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cyanates
Aldehydes
Functional groups
Amines
Experiments

Iodospirocyclization of Tryptamine-Derived Isocyanides: Formal Total Synthesis of Aspidofractinine

Saya, J. M., Roose, T. R., Peek, J. J., Weijers, B., de Waal, T. J. S., Vande Velde, C. M. L., Orru, R. V. A. & Ruijter, E., 12 Nov 2018, In : Angewandte Chemie - International Edition. 57, 46, p. 15232-15236

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Imines
Cyanides
Iodides
aspidofractinine
tryptamine

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

Ortega Ugalde, S., de Koning, C. P., Wallraven, K., Bruyneel, B., Vermeulen, N. P. E., Grossmann, T. N., Bitter, W., Commandeur, J. N. M. & Vos, J. C., Nov 2018, In : Applied Microbiology and Biotechnology. 102, 21, p. 9231-9242 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Ferredoxins
Mycobacterium tuberculosis
Cytochrome P-450 Enzyme System
Oxidation-Reduction
Genome

MCRs to APIs: Tailoring Multicomponent Reactions for the Production of Pharmaceuticals

van der Heijden, G., 2018, 188 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade

Collet, J. W., Ackermans, K., Lambregts, J., Maes, B. U. W., Orru, R. V. A. & Ruijter, E., 19 Jan 2018, In : Journal of Organic Chemistry. 83, 2, p. 854-861 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cyclization
Cyanides
Chloroquine
Acids
4-aminoquinoline

Multicomponent reactions in drug discovery and medicinal chemistry

Synthetic and BioOrganic Chemistry Group, Ruijter, E. & Orru, R., Nov 2018, In : Drug Discovery Today: Technologies. 29, p. 1-2 2 p.

Research output: Contribution to JournalEditorialAcademicpeer-review

Open Access
File

Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction

Schmidtgall, B., Kuepper, A., Meng, M., Grossmann, T. N. & Ducho, C., 1 Feb 2018, In : Chemistry: A European Journal. 24, 7, p. 1544-1553 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Protein-RNA interactions: structural characteristics and hotspot amino acids

Krüger, D. M., Neubacher, S. & Grossmann, T. N., Nov 2018, In : RNA (New York, N.Y.). 24, 11, p. 1457-1465 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
RNA
Amino Acids
Proteins
Alanine
Computer Simulation

Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines

Rainoldi, G., Begnini, F., De Munnik, M., Lo Presti, L., Vande Velde, C. M. L., Orru, R., Lesma, G., Ruijter, E. & Silvani, A., 12 Feb 2018, In : ACS Combinatorial Science. 20, 2, p. 98-105 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Thiazolidines
Cyanides
Carboxylic Acids
X rays
Substrates

Stereoselective Synthesis of Fused Vinylcyclopropanes by Intramolecular Tsuji-Trost Cascade Cyclization

Braun, J., Ariëns, M. I., Matsuo, B. T., De Vries, S., Van Wordragen, E. D. H., Ellenbroek, B. D., Vande Velde, C. M. L., Orru, R. V. A. & Ruijter, E., 2 Nov 2018, In : Organic Letters. 20, 21, p. 6611-6615

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactams
Nucleophiles
Chirality
nucleophiles
Cyclization

Structural analysis of the interaction between the bacterial cell division proteins FTSQ and FTSB

Kureisaite-Ciziene, D., Varadajan, A., McLaughlin, S. H., Glas, M., Silva, A. M., Luirink, R., Mueller, C., Blaauwen, T. D., Grossmann, T. N., Luirink, J. & Löwe, J., 11 Sep 2018, In : mBio. 9, 5, p. 1-17 17 p., e01346-18.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cell Division
Proteins
Bacteria
Periplasm
Membrane Proteins

Synthesis of Secondary Amides from Thiocarbamates

Mampuys, P., Ruijter, E., Orru, R. V. A. & Maes, B. U. W., 20 Jul 2018, In : Organic Letters. 20, 14, p. 4235-4239 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Thiocarbamates
Amides
amides
disulfides
synthesis

Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage

Held, A., Glas, A., Dietrich, L., Bollmann, M., Brandstädter, K., Grossmann, T. N., Lohmann, C. H., Pap, T. & Bertrand, J., Jun 2018, In : Osteoarthritis and Cartilage. 26, 6, p. 818-823 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

The Therapeutic Potential of PTEN Modulation: Targeting Strategies from Gene to Protein

McLoughlin, N. M., Mueller, C. & Grossmann, T. N., 18 Jan 2018, In : Cell Chemical Biology. 25, 1, p. 19-29

Research output: Contribution to JournalReview articleAcademicpeer-review

Tumors
Genes
Modulation
MicroRNAs
Phosphoric Monoester Hydrolases

Toward Asymmetric Synthesis of Pentaorganosilicates

van der Boon, L. J. P., Fuku-en, S. I., Slootweg, J. C., Lammertsma, K. & Ehlers, A. W., Jun 2018, In : Topics in Catalysis. 61, 7-8, p. 674-684 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
phosphine
Cyclization
Ligands
Silicates
Rhodium

Tris(pyrazolyl)phosphines and their Copper(I) Complexes

Tazelaar, C. G. J., 2018, 130 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
2017

A Direct Catalytic Synthesis of Sodium Diarylphosphinates and Their Corresponding Acids from Sodium Phosphinate

Botez, L., Slootweg, J. C. & Deelman, B-J., 2017, In : European Journal of Organic Chemistry. 2017, 3, p. 434-437

Research output: Contribution to JournalArticleAcademicpeer-review

Sodium
sodium
acids
Acids
synthesis

A Hybrid Solid-State NMR and Electron Microscopy Structure-Determination Protocol for Engineering Advanced para-Crystalline Optical Materials

Thomas, B., Rombouts, J., Oostergetel, G. T., Gupta, K. B. S. S., Buda, F., Lammertsma, K., Orru, R. & de Groot, H. J. M., 8 Mar 2017, In : Chemistry - A European Journal. 23, 14, p. 3280-3284 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Magic angle spinning
Optical materials
Naphthalene
Electron microscopy
Nuclear magnetic resonance spectroscopy

A New Strategy for the Functionalization of White Phosphorus

Borger, J. E., 2017, 168 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

A quantitative analysis of light-driven charge transfer processes using voronoi partitioning of time dependent DFT-derived electron densities

Rombouts, J. A., Ehlers, A. W. & Lammertsma, K., 30 Jul 2017, In : Journal of Computational Chemistry. 38, 20, p. 1811-1818 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Charge Transfer
Voronoi
Quantitative Analysis
Discrete Fourier transforms
Carrier concentration

Biocatalytic access to nonracemic gamma-oxo esters via stereoselective reduction using ene-reductases

Turrini, N. G., Cioc, R. C., van der Niet, D. J. H., Ruijter, E., Orru, R. V. A., Hall, M. & Faber, K., 21 Jan 2017, In : Green Chemistry. 19, 2, p. 511-518

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Brønsted Acid Promoted Reduction of Tertiary Phosphine Oxides

Krachko, T., Lyaskovskyy, V., Lutz, M., Lammertsma, K. & Slootweg, J. C., 3 Aug 2017, In : Zeitschrift fur Anorganische und Allgemeine Chemie. 643, 14, p. 916-921 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

phosphine
Oxides
Phosphoric Acids
Phosphines
Acids

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

Dietrich, L., Rathmer, B., Ewan, K., Bange, T., Heinrichs, S., Dale, T. C., Schade, D. & Grossmann, T. N., 17 Aug 2017, In : Cell Chemical Biology. 24, p. 958–968

Research output: Contribution to JournalArticleAcademicpeer-review

Catenins
beta Catenin
Cell-Penetrating Peptides
Peptides
TCF Transcription Factors

Combining Isocyanides with Carbon Dioxide in Palladium-Catalyzed Heterocycle Synthesis: N3-Substituted Quinazoline-2,4(1H,3H)-diones via a Three-Component Reaction

Mampuys, P., Neumann, H., Sergeyev, S., Orru, R. V. A., Jiao, H., Spannenberg, A., Maes, B. U. W. & Beller, M., 4 Aug 2017, In : ACS Catalysis. 7, 8, p. 5549-5556 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Quinazolines
Palladium
Cyanides
Application programming interfaces (API)
Carbon Dioxide

Copper(I) catalyzed oxidative hydrolysis of Ugi 3-component and Ugi-azide reaction products towards 2 degrees alpha-ketoamides and alpha-ketotetrazoles

Collet, J. W., Foley, C., Shaw, A. Y., Orru, R. V. A., Ruijter, E. & Hulme, C., 7 Aug 2017, In : Organic and Biomolecular Chemistry. 15, 29, p. 6132-6135

Research output: Contribution to JournalArticleAcademicpeer-review

Determination of Controlled Self-Assembly of a Paracrystalline Material by Homology Modelling with Hybrid NMR and TEM

Thomas, B., Rombouts, J., Gupta, K. B. S. S., Orru, R. V. A., Lammertsma, K. & de Groot, H. J. M., 12 Jul 2017, In : Chemistry - A European Journal. 23, 39, p. 9346-9351 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Self assembly
Biomimetic materials
Nuclear magnetic resonance
Electric dipole moments
Transmission electron microscopy

Fluorine-18 labelled building blocks for PET tracer synthesis

Van Der Born, D., Pees, A., Poot, A. J., Orru, R. V. A., Windhorst, A. D. & Vugts, D. J., 7 Aug 2017, In : Chemical Society Reviews. 46, 15, p. 4709-4773 65 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Positron emission tomography
Fluorine
Radioisotopes
Imaging techniques

Functionalization of P4 through Direct P−C Bond Formation

Borger, J. E., Ehlers, A. W., Slootweg, J. C. & Lammertsma, K., 4 Sep 2017, In : Chemistry - A European Journal. 23, 49, p. 11738-11746 9 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Organophosphorus Compounds
Chlorine
Metals
carbene

Iminophosphanes: Synthesis, Rhodium Complexes, and Ruthenium(II)-Catalyzed Hydration of Nitriles

Rong, M. K., Van Duin, K., Van Dijk, T., De Pater, J. J. M., Deelman, B. J., Nieger, M., Ehlers, A. W., Slootweg, J. C. & Lammertsma, K., 13 Mar 2017, In : Organometallics. 36, 5, p. 1079-1090 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Nitriles
Rhodium
phosphine
Ruthenium
nitriles