Research Output 1988 2019

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2019

Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides

van der Heijden, G., van Schaik, T. B., Mouarrawis, V., de Wit, M. J. M., Velde, C. M. L. V., Ruijter, E. & Orru, R. V. A., 1 Jan 2019, In : European Journal of Organic Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

Cyanides
Amides
amides
Picolines
Piperidines

Enantioselective Bio-Hydrolysis of Geranyl-Derived rac-Epoxides: A Chemoenzymatic Route to trans-Furanoid Linalool Oxide

van Lint, M. J., Gümüs, A., Ruijter, E., Faber, K., Orru, R. V. A. & Hall, M., 1 Jan 2019, (Accepted/In press) In : Advanced Synthesis and Catalysis. 361, 4, p. 813-825

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Epoxide Hydrolases
Hydrolases
Enzymatic hydrolysis
Epoxy Compounds
Hydrolysis

Mild and Practical Indole C2 Allylation by Allylboration of in situ Generated 3-Chloroindolenines

Saya, J. M., van Wordragen, E. D. H., Orru, R. V. A. & Ruijter, E., 3 Jan 2019, In : European Journal of Organic Chemistry. p. 1-6 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Allylation
indoles
Indoles
products
Biological Products

Stereoselective Chemoenzymatic Cascade Synthesis of the bis-THF Core of Acetogenins

van Lint, M. J., Hall, M., Faber, K., van Spanning, R. J. M., Ruijter, E. & Orru, R. V. A., 7 Feb 2019, In : European Journal of Organic Chemistry. 2019, 5, p. 1092-1101 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Acetogenins
epoxy compounds
Epoxy Compounds
Biological Products
cascades
2018

Aging and sensitivity to illusory target motion with or without secondary tasks

De Dieuleveult, A. L., Brouwer, A. M., Siemonsma, P. C., Van Erp, J. B. F. & Brenner, E., 2018, In : Multisensory Research. 31, 3-4, p. 227-249 23 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Foams
Young Adult
Aging of materials
Feedback
Fingers

Angular scanning and variable wavelength surface plasmon resonance allowing free sensor surface selection for optimum material- and bio-sensing

Lakayan, D., Tuppurainen, J., Albers, M., van Lint, M. J., van Iperen, D. J., Weda, J. J. A., Kuncova-Kallio, J., Somsen, G. W. & Kool, J., 15 Apr 2018, In : Sensors and Actuators, B: Chemical. 259, 15 April, p. 972-979 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Surface plasmon resonance
surface plasmon resonance
Scanning
Wavelength
scanning

Chiral Control in Pentacoordinate Systems: The Case of Organosilicates

Van Der Boon, L. J. P., Van Gelderen, L., De Groot, T. R., Lutz, M., Slootweg, J. C., Ehlers, A. W. & Lammertsma, K., 15 Oct 2018, In : Inorganic Chemistry. 57, 20, p. 12697-12708 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Enantiomers
enantiomers
integrity
Ligands
Silicates

Coiled-Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection

Mueller, C. & Grossmann, T. N., 21 Dec 2018, In : Angewandte Chemie - International Edition. 57, 52, p. 17079-17083 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Peptides
Switches
Proteins
Epitopes
Protein folding

Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to β-Amino Alcohols

Saya, J. M., Berabez, R., Broersen, P., Schuringa, I., Kruithof, A., Orru, R. V. A. & Ruijter, E., 6 Jul 2018, In : Organic Letters. 20, 13, p. 3988-3991 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Imidoesters
Amino Alcohols
alcohols
acids
Acids

Identification of novel PANDAR protein interaction partners involved in splicing regulation

Pospiech, N., Cibis, H., Dietrich, L., Müller, F., Bange, T. & Hennig, S., 12 Feb 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 2798.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Antisense DNA
DNA Damage
RNA
Long Noncoding RNA
Proteins

Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation

Janssen, B., Vugts, D. J., Wilkinson, S. M., Ory, D., Chalon, S., Hoozemans, J. J. M., Schuit, R. C., Beaino, W., Kooijman, E. J. M., Van Den Hoek, J., Chishty, M., Doméné, A., Van Der Perren, A., Villa, A., Maggi, A., Molenaar, G. T., Funke, U., Shevchenko, R. V., Baekelandt, V., Bormans, G. & 3 othersLammertsma, A. A., Kassiou, M. & Windhorst, A. D., 1 Dec 2018, In : Scientific Reports. 8, 1, 6580.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Purinergic P2X7 Receptors
Positron-Emission Tomography
Brain
Autoradiography
Alzheimer Disease

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme

Pelay-Gimeno, M., Bange, T., Hennig, S. & Grossmann, T. N., 27 Aug 2018, In : Angewandte Chemie - International Edition. 57, 35, p. 11164-11170 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cyclization
Enzymes
Proteins
Denaturation
Labeling

Integrative Theory/Experiment-Driven Exploration of a Multicomponent Reaction towards Imidazoline-2-(thi)ones

Kruithof, A., Mulder, J. R., Ruiz, J. M., Janssen, E., Mooijman, M., Ruijter, E., Guerra, C. F., Bickelhaupt, F. M. & Orru, R. V. A., 10 Jan 2018, In : European Journal of Organic Chemistry. 2018, 1, p. 104-112 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cyanates
Aldehydes
Functional groups
Amines
Experiments

Iodospirocyclization of Tryptamine-Derived Isocyanides: Formal Total Synthesis of Aspidofractinine

Saya, J. M., Roose, T. R., Peek, J. J., Weijers, B., de Waal, T. J. S., Vande Velde, C. M. L., Orru, R. V. A. & Ruijter, E., 12 Nov 2018, In : Angewandte Chemie - International Edition. 57, 46, p. 15232-15236

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Imines
Cyanides
Iodides
aspidofractinine
tryptamine

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

Ortega Ugalde, S., de Koning, C. P., Wallraven, K., Bruyneel, B., Vermeulen, N. P. E., Grossmann, T. N., Bitter, W., Commandeur, J. N. M. & Vos, J. C., Nov 2018, In : Applied Microbiology and Biotechnology. 102, 21, p. 9231-9242 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Ferredoxins
Mycobacterium tuberculosis
Cytochrome P-450 Enzyme System
Oxidation-Reduction
Genome

Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade

Collet, J. W., Ackermans, K., Lambregts, J., Maes, B. U. W., Orru, R. V. A. & Ruijter, E., 19 Jan 2018, In : Journal of Organic Chemistry. 83, 2, p. 854-861 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cyclization
Cyanides
Chloroquine
Acids
4-aminoquinoline

Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction

Schmidtgall, B., Kuepper, A., Meng, M., Grossmann, T. N. & Ducho, C., 1 Feb 2018, In : Chemistry: A European Journal. 24, 7, p. 1544-1553 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Protein-RNA interactions: structural characteristics and hotspot amino acids

Krüger, D. M., Neubacher, S. & Grossmann, T. N., Nov 2018, In : RNA (New York, N.Y.). 24, 11, p. 1457-1465 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
RNA
Amino Acids
Proteins
Alanine
Computer Simulation

Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines

Rainoldi, G., Begnini, F., De Munnik, M., Lo Presti, L., Vande Velde, C. M. L., Orru, R., Lesma, G., Ruijter, E. & Silvani, A., 12 Feb 2018, In : ACS Combinatorial Science. 20, 2, p. 98-105 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Thiazolidines
Cyanides
Carboxylic Acids
X rays
Substrates

Stereoselective Synthesis of Fused Vinylcyclopropanes by Intramolecular Tsuji-Trost Cascade Cyclization

Braun, J., Ariëns, M. I., Matsuo, B. T., De Vries, S., Van Wordragen, E. D. H., Ellenbroek, B. D., Vande Velde, C. M. L., Orru, R. V. A. & Ruijter, E., 2 Nov 2018, In : Organic Letters. 20, 21, p. 6611-6615

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactams
Nucleophiles
Chirality
nucleophiles
Cyclization

Structural analysis of the interaction between the bacterial cell division proteins FTSQ and FTSB

Kureisaite-Ciziene, D., Varadajan, A., McLaughlin, S. H., Glas, M., Silva, A. M., Luirink, R., Mueller, C., Blaauwen, T. D., Grossmann, T. N., Luirink, J. & Löwe, J., 11 Sep 2018, In : mBio. 9, 5, p. 1-17 17 p., e01346-18.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cell Division
Proteins
Bacteria
Periplasm
Membrane Proteins

Synthesis of Secondary Amides from Thiocarbamates

Mampuys, P., Ruijter, E., Orru, R. V. A. & Maes, B. U. W., 20 Jul 2018, In : Organic Letters. 20, 14, p. 4235-4239 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Thiocarbamates
Amides
amides
disulfides
synthesis

Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage

Held, A., Glas, A., Dietrich, L., Bollmann, M., Brandstädter, K., Grossmann, T. N., Lohmann, C. H., Pap, T. & Bertrand, J., Jun 2018, In : Osteoarthritis and Cartilage. 26, 6, p. 818-823 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Toward Asymmetric Synthesis of Pentaorganosilicates

van der Boon, L. J. P., Fuku-en, S. I., Slootweg, J. C., Lammertsma, K. & Ehlers, A. W., Jun 2018, In : Topics in Catalysis. 61, 7-8, p. 674-684 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
phosphine
Cyclization
Ligands
Silicates
Rhodium
2017

A Direct Catalytic Synthesis of Sodium Diarylphosphinates and Their Corresponding Acids from Sodium Phosphinate

Botez, L., Slootweg, J. C. & Deelman, B-J., 2017, In : European Journal of Organic Chemistry. 2017, 3, p. 434-437

Research output: Contribution to JournalArticleAcademicpeer-review

Sodium
sodium
acids
Acids
synthesis

A Hybrid Solid-State NMR and Electron Microscopy Structure-Determination Protocol for Engineering Advanced para-Crystalline Optical Materials

Thomas, B., Rombouts, J., Oostergetel, G. T., Gupta, K. B. S. S., Buda, F., Lammertsma, K., Orru, R. & de Groot, H. J. M., 8 Mar 2017, In : Chemistry - A European Journal. 23, 14, p. 3280-3284 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Magic angle spinning
Optical materials
Naphthalene
Electron microscopy
Nuclear magnetic resonance spectroscopy

A quantitative analysis of light-driven charge transfer processes using voronoi partitioning of time dependent DFT-derived electron densities

Rombouts, J. A., Ehlers, A. W. & Lammertsma, K., 30 Jul 2017, In : Journal of Computational Chemistry. 38, 20, p. 1811-1818 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Charge Transfer
Voronoi
Quantitative Analysis
Discrete Fourier transforms
Carrier concentration

Biocatalytic access to nonracemic gamma-oxo esters via stereoselective reduction using ene-reductases

Turrini, N. G., Cioc, R. C., van der Niet, D. J. H., Ruijter, E., Orru, R. V. A., Hall, M. & Faber, K., 21 Jan 2017, In : Green Chemistry. 19, 2, p. 511-518

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Brønsted Acid Promoted Reduction of Tertiary Phosphine Oxides

Krachko, T., Lyaskovskyy, V., Lutz, M., Lammertsma, K. & Slootweg, J. C., 3 Aug 2017, In : Zeitschrift fur Anorganische und Allgemeine Chemie. 643, 14, p. 916-921 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

phosphine
Oxides
Phosphoric Acids
Phosphines
Acids

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

Dietrich, L., Rathmer, B., Ewan, K., Bange, T., Heinrichs, S., Dale, T. C., Schade, D. & Grossmann, T. N., 17 Aug 2017, In : Cell Chemical Biology. 24, p. 958–968

Research output: Contribution to JournalArticleAcademicpeer-review

Catenins
beta Catenin
Cell-Penetrating Peptides
Peptides
TCF Transcription Factors

Combining Isocyanides with Carbon Dioxide in Palladium-Catalyzed Heterocycle Synthesis: N3-Substituted Quinazoline-2,4(1H,3H)-diones via a Three-Component Reaction

Mampuys, P., Neumann, H., Sergeyev, S., Orru, R. V. A., Jiao, H., Spannenberg, A., Maes, B. U. W. & Beller, M., 4 Aug 2017, In : ACS Catalysis. 7, 8, p. 5549-5556 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Quinazolines
Palladium
Cyanides
Application programming interfaces (API)
Carbon Dioxide

Copper(I) catalyzed oxidative hydrolysis of Ugi 3-component and Ugi-azide reaction products towards 2 degrees alpha-ketoamides and alpha-ketotetrazoles

Collet, J. W., Foley, C., Shaw, A. Y., Orru, R. V. A., Ruijter, E. & Hulme, C., 7 Aug 2017, In : Organic and Biomolecular Chemistry. 15, 29, p. 6132-6135

Research output: Contribution to JournalArticleAcademicpeer-review

Determination of Controlled Self-Assembly of a Paracrystalline Material by Homology Modelling with Hybrid NMR and TEM

Thomas, B., Rombouts, J., Gupta, K. B. S. S., Orru, R. V. A., Lammertsma, K. & de Groot, H. J. M., 12 Jul 2017, In : Chemistry - A European Journal. 23, 39, p. 9346-9351 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Self assembly
Biomimetic materials
Nuclear magnetic resonance
Electric dipole moments
Transmission electron microscopy

Iminophosphanes: Synthesis, Rhodium Complexes, and Ruthenium(II)-Catalyzed Hydration of Nitriles

Rong, M. K., Van Duin, K., Van Dijk, T., De Pater, J. J. M., Deelman, B. J., Nieger, M., Ehlers, A. W., Slootweg, J. C. & Lammertsma, K., 13 Mar 2017, In : Organometallics. 36, 5, p. 1079-1090 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Nitriles
Rhodium
phosphine
Ruthenium
nitriles

Increased Conformational Flexibility of a Macrocycle–Receptor Complex Contributes to Reduced Dissociation Rates

Glas, A., Wamhoff, E. C., Krüger, D. M., Rademacher, C. & Grossmann, T. N., 16 Nov 2017, In : Chemistry - A European Journal. 23, 64, p. 16157-16161 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Peptides
Proteins
Conformations
Kinetics
Calorimetry

Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection

Krishna, B. A., Poole, E. L., Jackson, S. E., Smit, M. J., Wills, M. R. & Sinclair, J. H., 5 Dec 2017, In : mBio. 8, 6

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cytomegalovirus
Infection
Monocytes
Cytomegalovirus Infections
Viruses

Metalate-Mediated Functionalization of P4 by Trapping Anionic [Cp*Fe(CO)21-P4)] with Lewis Acids

Borger, J. E., Jongkind, M. K., Ehlers, A. W., Lutz, M., Slootweg, J. C. & Lammertsma, K., 1 Jun 2017, In : ChemistryOpen. 6, 3, p. 350-353 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lewis Acids
Carbon Monoxide
Transition metals
Anions
Phosphorus

Organocatalytic access to enantioenriched spirooxindole-based 4-methyleneazetidines

Rainoldi, G., Faltracco, M., Spatti, C., Silvani, A. & Lesma, G., 1 Nov 2017, In : Molecules. 22, 11, 2016.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Spiro Compounds
Cinchona
induction
Isatin
catalysts

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

White, M. D., Klecker, M., Hopkinson, R. J., Weits, D. A., Mueller, C., Naumann, C., O'Neill, R., Wickens, J., Yang, J., Brooks-Bartlett, J. C., Garman, E. F., Grossmann, T. N., Dissmeyer, N. & Flashman, E., 23 Mar 2017, In : Nature Communications. 8, p. 14690

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cysteine Dioxygenase
Sulfinic Acids
Dioxygenases
oxidase
cysteine

Probing Zeolite Crystal Architecture and Structural Imperfections using Differently Sized Fluorescent Organic Probe Molecules

Hendriks, F. C., Schmidt, J. E., Rombouts, J. A., Lammertsma, K., Bruijnincx, P. C. A. & Weckhuysen, B. M., 5 May 2017, In : Chemistry - A European Journal. 23, 26, p. 6305-6314 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Zeolites
Defects
Crystals
Molecules
Microporous materials

Selective [3+1] Fragmentations of P4by “P” Transfer from a Lewis Acid Stabilized [RP4]Butterfly Anion

Borger, J. E., Ehlers, A. W., Lutz, M., Slootweg, J. C. & Lammertsma, K., 2017, In : Angewandte Chemie - International Edition. 56, 1, p. 285-290 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Organophosphorus Compounds
Lewis Acids
Discrete Fourier transforms
Dimers
Phosphorus

Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3-Center-2-Component Reactions of Cyclic Ketoacids

Cioc, R. C., Estevez, V., van der Niet, D. J., Vande Velde, C. M. L., Turrini, N. G., Hall, M., Faber, K., Ruijter, E. & Orru, R. V. A., 3 Mar 2017, In : European Journal of Organic Chemistry. 9, p. 1262-1271

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Structure-Based Design of Non-Natural Macrocyclic Peptides that Inhibit Protein-Protein Interactions

Krüger, D. M., Glas, A., Bier, D., Pospiech, N., Wallraven, K., Dietrich, L., Ottmann, C., Koch, O., Hennig, S. & Grossmann, T. N., 13 Oct 2017, In : Journal of Medicinal Chemistry. 60, p. 8982-8988

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Peptides
Proteins
Digital Libraries
Amino Acids
Workflow

Thiazine-2-thiones as Masked 1-Azadienes in Cascade Dimerization Reactions

Kruithof, A., Velde, C. M. L. V., Ruijter, E. & Orru, R. V. A., Apr 2017, In : Molecules. 22, 4

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion

Wilmes, A., Rauch, C., Carta, G., Kern, G., Meier, F., Posch, W., Wilflingseder, D., Armstrong, L., Lako, M., Beilmann, M., Gstraunthaler, G. & Jennings, P., 1 Dec 2017, In : Toxicology in Vitro. 45, p. 445-454 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Induced Pluripotent Stem Cells
Acidification
Stem cells
Cell culture
Nutrients

Translocation of an Intracellular Protein via Peptide-Directed Ligation

Stiller, C., Krüger, D. M., Brauckhoff, N., Schmidt, M., Janning, P., Salamon, H. & Grossmann, T. N., 17 Feb 2017, In : Acs chemical biology. 12, 2, p. 504-509 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Protein Transport
Ligation
Ligands
Peptides
Labeling

Ugi Four-Center Three-Component Reaction as a Direct Approach to Racetams

Cioc, R. C., van Riempst, L. S., Schuckman, P., Ruijter, E. & Orru, R. V. A., Apr 2017, In : Synthesis. 49, 7, p. 1664-1674

Research output: Contribution to JournalArticleAcademicpeer-review

Ugi-Type Reactions of Spirocyclic Indolenines as a Platform for Compound Library Generation

Estevez, V., Kloeters, L., Kwietniewska, N., Vicente-Garcia, E., Ruijter, E. & Orru, R. V. A., Feb 2017, In : Synlett. 28, 3, p. 376-380

Research output: Contribution to JournalArticleAcademicpeer-review

Using a specific RNA-protein interaction to quench the fluorescent RNA Spinach

Roszyk, L., Kollenda, S. & Hennig, S., 15 Dec 2017, In : Acs chemical biology.

Research output: Contribution to JournalArticleAcademicpeer-review

Spinacia oleracea
RNA
Proteins
Energy Transfer
Energy transfer
2016

2-bromo-6-isocyanopyridine as a universal convertible isocyanide for multicomponent chemistry.

van der Heijden, G., Jong, J. A. W., Ruijter, E. & Orru, R. V. A., 2016, In : Organic Letters. 18, p. 984-987

Research output: Contribution to JournalArticleAcademicpeer-review