Research Output 1988 2019

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2017

Ugi Four-Center Three-Component Reaction as a Direct Approach to Racetams

Cioc, R. C., van Riempst, L. S., Schuckman, P., Ruijter, E. & Orru, R. V. A., Apr 2017, In : Synthesis. 49, 7, p. 1664-1674

Research output: Contribution to JournalArticleAcademicpeer-review

Ugi-Type Reactions of Spirocyclic Indolenines as a Platform for Compound Library Generation

Estevez, V., Kloeters, L., Kwietniewska, N., Vicente-Garcia, E., Ruijter, E. & Orru, R. V. A., Feb 2017, In : Synlett. 28, 3, p. 376-380

Research output: Contribution to JournalArticleAcademicpeer-review

Using a specific RNA-protein interaction to quench the fluorescent RNA Spinach

Roszyk, L., Kollenda, S. & Hennig, S., 15 Dec 2017, In : Acs chemical biology.

Research output: Contribution to JournalArticleAcademicpeer-review

Spinacia oleracea
RNA
Proteins
Energy Transfer
Energy transfer
2016

2-bromo-6-isocyanopyridine as a universal convertible isocyanide for multicomponent chemistry.

van der Heijden, G., Jong, J. A. W., Ruijter, E. & Orru, R. V. A., 2016, In : Organic Letters. 18, p. 984-987

Research output: Contribution to JournalArticleAcademicpeer-review

Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

Zhu, Y. P., Sergeyev, S., Franck, P., Orru, R. V. A. & Maes, B. U. W., 16 Sep 2016, In : Organic Letters. 18, 18, p. 4602-4605 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Carboxylic Acids
carboxylic acids
Amines
amines
Chemical activation

A Significant but Constrained Geometry Pt→Al Interaction: Fixation of CO2 and CS2, Activation of H2 and PhCONH2

Devillard, M., Declercq, R., Nicolas, E. C., Ehlers, A. W., Backs, J., Merceron-Saffon, N., Bouhadir, G., Slootweg, J. C., Uhl, W. & Bourissou, D., 2016, In : Journal of the American Chemical Society. 138, p. 4917-4926

Research output: Contribution to JournalArticleAcademicpeer-review

Bis(imino)phosphanes – synthesis and coordination chemistry

van Dijk, T., Rong, M. K., Borger, J. E., Nieger, M., Slootweg, J. C. & Lammertsma, K., 2016, In : Organometallics. 35, p. 827-835

Research output: Contribution to JournalArticleAcademicpeer-review

Bronsted acid-catalyzed cyanotritylaton of aldehydes by trityl isocyanide.

Cioc, R. C., Schuckman, P., Preschel, H. D., Vlaar, T., Ruijter, E. & Orru, R. V. A., 2016, In : Organic Letters. 18, p. 3562-3565

Research output: Contribution to JournalArticleAcademicpeer-review

Constraining an irregular peptide secondary structure through ring-closing alkyne metathesis

Cromm, P. M., Wallraven, K., Glas, A., Bier, D., Furstner, A., Ottmann, C. & Grossmann, T. N., 2016, In : ChemBioChem. 17, p. 1915-1919

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Functionalization of P4 in the coordination sphere of coinage metal cations

Borger, J. E., Bakker, M., Ehlers, A. W., Lutz, M., Slootweg, J. C. & Lammertsma, K., 2016, In : Chemical Commununications. 52, p. 3284-3287

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Iodide-catalyzed synthesis of secondary thiocarbamates from isocyanides and thiosulfonates.

Mampuys, P., Zhu, Y., Sergeyev, S., Ruijter, E. & Orru, R. V. A., 2016, In : Organic Letters. 18, p. 2808-2811

Research output: Contribution to JournalArticleAcademicpeer-review

iPr2N–P=Fe(CO)4 in olefinic solvents: a reservoir of a transient phosphinidene complex capable of substrate hopping

Wit, J. B. M., de Jong, G. B., Schakel, M., Lutz, M., Ehlers, A. W., Slootweg, J. C. & Lammertsma, K., 2016, In : Organometallics. 35, p. 1170-1176

Research output: Contribution to JournalArticleAcademicpeer-review

Metal-free one-pot alpha-carboxylation of primary alcohols.

van der Heijden, G., Kraakman, J., Biemolt, J., Ruijter, E. & Orru, R. V. A., 2016, In : Organic and Biomolecular Chemistry. 14, p. 9716-9719

Research output: Contribution to JournalArticleAcademicpeer-review

Metal-Free Reduction of Phosphine Oxides Using Polymethylhydrosiloxane

Nicolas, E. C., Guerriero, A., Lyaskovskyy, V., Peruzzini, M., Lammertsma, K., Gonsalvi, L. & Slootweg, J. C., 2016, In : Inorganics. 4, 34.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Nickel-based dye-sensitized photocathode towards proton reduction using a molecular nickel catalyst and an organic dye.

van den Bosch, B., Rombouts, J. A., Orru, R. V. A., Reek, J. N. H. & Detz, R. J., 2016, In : ChemCatChem. 8, p. 1392-1398

Research output: Contribution to JournalArticleAcademicpeer-review

Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides.

Cromm, P. M., Schaubach, S., Spiegel, J., Furstner, A., Grossmann, T. N. & Waldmann, H., 2016, In : Nature Communications. 7, p. 11300

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Palladium-Catalyzed Construction of Amidines from Arylboronic Acids under Oxidative Conditions

Zhu, F., Li, Y., Wang, Z., Orru, R. V. A., Maes, B. U. W. & Wu, X. F., 1 Jan 2016, In : Chemistry - A European Journal. 22, 23, p. 7743-7746 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Amidines
Palladium
Aniline
Functional groups
Aniline Compounds

Protease-resistant and cell-permeable double-stapled peptides targeting the Rab8a GTPase.

Cromm, P. M., Spiegel, J., Kuchler, P., Dietrich, L., Kriegesmann, J., Wendt, M., Goody, R. S., Waldmann, H. & Grossmann, T. N., 2016, In : Acs chemical biology. 11, p. 2375-2382

Research output: Contribution to JournalArticleAcademicpeer-review

Selective Protein hyperpolarization in cell lysates using targeted dynamic nuclear polarization.

Viennet, T., Viegas, A., Kuepper, A., Arens, S., Gelev, V., Petrov, O., Grossmann, T. N., Heise, H. & Etzkorn, M., 2016, In : Angewandte Chemie International Edition in English. 55, p. 10746-10750

Research output: Contribution to JournalArticleAcademicpeer-review

Stabilization and transfer of the transient [Mes*P4]‒ butterfly anion using BPh3

Borger, J. E., Ehlers, A. W., Lutz, M., Slootweg, J. C. & Lammertsma, K., 2016, In : Angewandte Chemie International Edition in English. 55, p. 613-617

Research output: Contribution to JournalArticleAcademicpeer-review

Stereoselective monoamine oxidase-catalyzed oxidative Aza-Friedel-Crafts reactions of mesopyrrolidines in aqueous buffer.

de Graaff, C., Oppelaar, B., Peruch, O., Vandervelde, M. L., Bechi, B., Turner, N. J., Ruijter, E. & Orru, R. V. A., 2016, In : Advanced Synthesis and Catalysis. 358, p. 1555-1560

Research output: Contribution to JournalArticleAcademicpeer-review

Synthesis, characterization and biological acitvity of fluorescently labeled bedaquiline analogues.

Rombouts, J. A., Veenboer, R. M. P., Villellas, C., Lu, P., Ehlers, A. W., Andries, K., Koul, A., Lill, H., Ruijter, E., Orru, R. V. A., Lammertsma, K., Bald, D. & Slootweg, J. C., 2016, In : RSC Advances. 6, p. 108708-108716

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Synthesis of polycyclic spiroindolines by highly diastereoselective interrupted Ugi cascade reactions of 3-(2-isocyanoethyl)indoles.

Saya, J. M., Oppelaar, B., Cioc, R. C., van der Heijden, G., Vandevelde, C. M. L., Orru, R. V. A. & Ruijter, E., 2016, In : Chemical Commununications. 52, p. 12482-12485

Research output: Contribution to JournalArticleAcademicpeer-review

Tris(pyrazolyl)phosphines with copper(I): from monomers to polymers,

Tazelaar, C. G. J., Nicolas, E. C., van Dijk, T., Broere, D. L. J., Cardol, M., Lutz, M., Gudat, D., Slootweg, J. C. & Lammertsma, K., 2016, In : Dalton Transactions. 45, p. 2237-2249

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Trityl isocyanide as a mechanistic probe in multicomponent chemistry: Walking the line between Ugi- and Strecker-type reactions.

Cioc, R. C., Preschel, H. D., van der Heijden, G., Ruijter, E. & Orru, R. V. A., 2016, In : Chemistry: A European Journal. 22, p. 7837-7842

Research output: Contribution to JournalArticleAcademicpeer-review

“A new synthetic route to the electron-deficient ligand tris(3,4,5-tribromopyrazol-1-yl)phosphine oxide”

Nicolas, E. C., Cheisson, T., de Jong, G. B., Tazelaar, C. G. J. & Slootweg, J. C., 2016, In : Acta Crystallographica Section C. Crystal Structure Communications. C72, p. 846-849

Research output: Contribution to JournalArticleAcademicpeer-review

2015

Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction

de Graaff, C., Bensch, L., Boersma, S. J., Cioc, R. C., van Lint, M. J., Janssen, E., Turner, N. J., Orru, R. V. A. & Ruijter, E., 16 Nov 2015, In : Angewandte Chemie - International Edition. 54, 47, p. 14133-14136 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

IBX-mediated oxidation of unactivated cyclic amines: application in highly diastereoselective oxidative Ugi-type and aza-Friedel-Crafts reactions

de Graaff, C., Bensch, L., van Lint, M. J., Ruijter, E. & Orru, R. V. A., 2015, In : Organic and Biomolecular Chemistry. 13, 40, p. 10108-10112

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

One-Pot Synthesis of N-Substituted β-Amino Alcohols from Aldehydes and Isocyanides

Cioc, R. C., van der Niet, D. J. H., Janssen, E., Ruijter, E. & Orru, R. V. A., 18 May 2015, In : Chemistry: A European Journal. 21, 21, p. 7808-7813 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes

Lee, C-U., Hahne, G., Hanske, J., Bange, T., Bier, D., Rademacher, C., Hennig, S. & Grossmann, T. N., 9 Nov 2015, In : Angewandte Chemie International Edition in English. 54, 46, p. 13796-13800 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Stereoselective synthesis of fluorinated aminoglycosyl phosphonates

Bouwman, S., Orru, R. V. A. & Ruijter, E., 2015, In : Organic and Biomolecular Chemistry. 13, 5, p. 1317-1321

Research output: Contribution to JournalArticleAcademicpeer-review

Synthesis of Heterocycles by Formal Cycloadditions of Isocyanides

Kruithof, A., Ruijter, E. & Orru, R. V. A., Mar 2015, In : Chemistry - An Asian Journal. 10, 3, p. 508-520

Research output: Contribution to JournalArticleAcademicpeer-review

2014

A Universal Procedure for the [F-18]Trifluoromethylation of Aryl Iodides and Aryl Boronic Acids with Highly Improved Specific Activity

van der Born, D., Sewing, C., Herscheid, J. D. M., Windhorst, A. D., Orru, R. V. A. & Vugts, D. J., 2014, In : Angewandte Chemie International Edition in English. 53, 41, p. 11046-11050

Research output: Contribution to JournalArticleAcademicpeer-review

Boronic Acids
Iodides
Acids

Chemoselective addition of isocyanides to N-tert-butanesulfinimines

Janssen, G. V., Janssen, E., Vande Velde, C. M. L., Ehlers, A. W., Slootweg, J. C., Ruijter, E., Lammertsma, K. & Orru, R. V. A., 3 Oct 2014, In : Organic Letters. 16, 19, p. 5116-5119 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cyanides
Acetamides
selectivity
Derivatives
sulfinimine

Crystal structure of tert-butyl-N-phenyl-carbonitrilium tetrachloroaluminate

van Dijk, T., Zant, D. W., Wolf, R., Lammertsma, K. & Slootweg, J. C., 2014, In : Acta Crystallographica Section E. Structure Reports. E70, p. 331-333

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Crystal structure
crystal structure

Diastereoselective One-pot Synthesis of Tetra-Functionalized 2-Imidazolines

Janssen, G. V., Slobbe, P., Mooijman, M., Kruithof, A., Ehlers, A. W., Fonseca Guerra, C., Bickelhaupt, F. M., Slootweg, J. C., Ruijter, E., Lammertsma, K. & Orru, R. V. A., 2014, In : Journal of Organic Chemistry. 79, 11, p. 5219-5226

Research output: Contribution to JournalArticleAcademicpeer-review

Nitriles
Imines
Cycloaddition
Scaffolds
2-imidazoline

Facile Synthesis of Phospha-amidines and Phospha-amidinates using Nitrilium Ions as Imine Synthon

van Dijk, T., Burck, S., Rong, M. K., Rosenthal, A. J., Nieger, M., Slootweg, J. C. & Lammertsma, K., 2014, In : Angewandte Chemie International Edition in English. 53, p. 9068-9071

Research output: Contribution to JournalArticleAcademicpeer-review

phosphine
Amidines
Imines
Lithium
Gold

Functionalization of P4 by means of a Lewis acid stabilized bicyclo[1.1.0]tetraphosphabutane anion

Borger, J. E., Ehlers, A. W., Lutz, M., Slootweg, J. C. & Lammertsma, K., 2014, In : Angewandte Chemie International Edition in English. 53, p. 12836-12839

Research output: Contribution to JournalArticleAcademicpeer-review

Lewis Acids
Phosphorus
Anions
Negative ions
Acids

Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics

Koopmanschap, G., Ruijter, E. & Orru, R. V. A., 4 Mar 2014, In : Beilstein Journal of Organic Chemistry. 10, p. 544-598

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Main group and transition metal-mediated phosphaalkyne oligomerizations

Chirila, A., Wolf, R., Slootweg, J. C. & Lammertsma, K., 2014, In : Coordination Chemistry Reviews. 270-271, p. 57-74

Research output: Contribution to JournalArticleAcademicpeer-review

Oligomerization
Transition metals
transition metals
metal compounds
trimers

Miniaturized bioactivity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail

Heus, F. A. H., Otvos, R. A., Aspers, R. L. E. G., van Elk, R., Halff, J. I., Ehlers, A. W., Duterte, S., Lewis, R. J., Wijmenga, S., Smit, A. B., Niessen, W. M. A. & Kool, J., 2014, In : Biology. 3, p. 139-156

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Snails
toads
Bioactivity
Anura
Purification

Multicomponent reactions: advanced tools for sustainable organic synthesis

Cioc, R. C., Ruijter, E. & Orru, R. V. A., 2014, In : Green Chemistry. 16, 6, p. 2958-2975

Research output: Contribution to JournalArticleAcademicpeer-review

Platinacycloalkane complexes containing [P,N] bidentate ligands: synthesis and decomposition studies

Mahamo, T., Moss, J. R., Mapolie, S. F., Smith, G. S., Slootweg, J. C. & Lammertsma, K., 2014, In : Dalton Transactions. 43, p. 5546-5557

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Ligands
Decomposition

Stereoselective synthesis of β-sulfinylamino isocyanides and 2-imidazolines

Janssen, G. V., Vincente-Garcia, E., Vogels, W., Slootweg, J. C., Ruijter, E., Lammertsma, K. & Orru, R. V. A., 2014, In : European Journal of Organic Chemistry. 2014, 18, p. 3762-3766

Research output: Contribution to JournalArticleAcademicpeer-review

Cyanides
synthesis
peptides
chemistry
preparation

Sustainable Three-Component Synthesis of Isothioureas from Isocyanides, Thiosulfonates, and Amines

Mampuys, P., Zhu, Y., Vlaar, T., Ruijter, E., Orru, R. V. A. & Maes, B. U. W., 17 Nov 2014, In : Angewandte Chemie International Edition in English. 53, 47, p. 12849-12854

Research output: Contribution to JournalArticleAcademicpeer-review

Synthesis and photophysics of a red light absorbing supramolecular antenna system having stable photophysical properties upon binding of pyridines

Rombouts, J. A., Ravensbergen, J., Frese, R. N., Kennis, J. T. M., Ehlers, A. W., Slootweg, J. C., Ruijter, E., Lammertsma, K. & Orru, R. V. A., 2014, In : Chemistry: A European Journal. 20, p. 10285-10291

Research output: Contribution to JournalArticleAcademicpeer-review

Pyridines
Pyridine
Chromophores
Antennas
Excited states

Synthesis and Photophysics of a Red-Light Absorbing Supramolecular Chromophore System

Rombouts, J. A., Ravensbergen, J., Frese, R. N., Kennis, J. T. M., Ehlers, A. W., Slootweg, J. C., Ruijter, E., Lammertsma, K. & Orru, R. V. A., 11 Aug 2014, In : Chemistry: A European Journal. 20, 33, p. 10185-10185

Research output: Contribution to JournalArticleAcademicpeer-review

Synthesis of Diverse Azolo[c]quinazolines by Palladium(II)-Catalyzed Aerobic Oxidative Insertion of Isocyanides

Vlaar, T., Bensch, L., Kraakman, J., Vande Velde, C. M. L., Maes, B. U. W., Orru, R. V. A. & Ruijter, E., 14 Apr 2014, In : Advanced Synthesis and Catalysis. 356, 6, p. 1205-1209

Research output: Contribution to JournalArticleAcademicpeer-review

Synthesis of Pyridopyrimidines by Palladium-Catalyzed Isocyanide Insertion

Estévez, V., Van Baelen, G., Lentferink, B. H., Vlaar, T., Janssen, E., Maes, B. U. W., Orru, R. V. A. & Ruijter, E., 3 Jan 2014, In : ACS Catalysis. 2014, 4, p. 40-43 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Pyrimidines
Palladium
Cyanides
Chemical activation
Amidines