Research Output 1988 2019

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2014

Synthesis of Pyridopyrimidines by Palladium-Catalyzed Isocyanide Insertion

Estévez, V., Van Baelen, G., Lentferink, B. H., Vlaar, T., Janssen, E., Maes, B. U. W., Orru, R. V. A. & Ruijter, E., 3 Jan 2014, In : ACS Catalysis. 2014, 4, p. 40-43 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Pyrimidines
Palladium
Cyanides
Chemical activation
Amidines

Tris(pyrazolyl)phosphine Oxide and Tris(triazolyl)phosphine Oxide Scorpion Ligands

Tazelaar, C. G. J., Lyaskovskyy, V., van Doorn, I. M., Schaapkens, X., Lutz, M., Ehlers, A. W., Lammertsma, K. & Slootweg, J. C., 2014, In : European Journal of Inorganic Chemistry. 10, p. 1836-1842

Research output: Contribution to JournalArticleAcademicpeer-review

phosphine
Methane
Discrete Fourier transforms
Oxides
Copper
2013

Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity

Gerber, A., Esnault, C., Aubert, G., Treisman, R., Pralong, F. & Schibler, U., 31 Jan 2013, In : Cell. 152, 3, p. 492-503 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Serum Response Factor
Actins
Blood
Transcription Factors
Tandem Repeat Sequences
p38 Mitogen-Activated Protein Kinases
Biotransformation
Screening
Phosphotransferases
Small Molecule Libraries

Dibenzo[b,f]phosphepines – Novel phosphane-olefin ligands for transition metals

Lyaskovskyy, V., Moes, R. J. A., Burck, S., Dzik, W. I., Lutz, M., Ehlers, A. W., de Bruin, B. & Lammertsma, K., 2013, In : Organometallics. 32, p. 363-373

Research output: Contribution to JournalArticleAcademicpeer-review

phosphine
Rhodium
Alkenes
rhodium
Discrete Fourier transforms

Efficiency Efficiency, Diversity, and Complexity with Multicomponent Reactions Efficiency Efficiency, Diversity, and Complexity with Multicomponent Reactions

van der Heijden, G., Ruijter, E. & Orru, R. V. A., 2013, In : Synlett. 2013, p. 666-68

Research output: Contribution to JournalArticleAcademicpeer-review

Scaffolds
Palladium
Cyanides
Biocatalysis

Efficient synthesis of [F-18] trifluoromethane and its application in the synthesis of PET tracers

van der Born, D., Herscheid, J. D. M., Orru, R. V. A. & Vugts, D. J., 2013, In : Chemical Commununications. 49, 38, p. 4018-4020

Research output: Contribution to JournalArticleAcademicpeer-review

Ketones
Aldehydes
Methanol
fluoroform

Multicomponent reactions - opportunities for the pharmaceutical industry

Ruijter, E. & Orru, R. V. A., 2013, In : Drug Discovery Today: Technologies. 10, 1, p. e15-e20

Research output: Contribution to JournalArticleAcademic

Pharmaceutical Chemistry
Drug Industry
Drug Discovery
Pharmaceutical Preparations
Lead

Multicomponent Synthesis of 4-Aminophthalazin-1(2H)-ones by Palladium-Catalyzed Isocyanide Insertion

Vlaar, T., Mampuys, P., Helliwell, M., Maes, B. U. W., Orru, R. V. A. & Ruijter, E., 2013, In : Journal of Organic Chemistry. 2013, 78, p. 6735-674

Research output: Contribution to JournalArticleAcademicpeer-review

Palladium
Cyanides
Scaffolds
Hydrazines
Heterocyclic Compounds

Oxaphospholes and bis-phospholes from phosphino-phosphonates and α,β-unsaturated ketones

Arkhypchuk, A. I., Mihali, V. A., Orthaber, A., Ehlers, A. W., Lammertsma, K. & Ott, S., 2013, In : Chemistry: A European Journal. 19, p. 13692-13704

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Organophosphonates
Carbon Monoxide
Ketones

Palladium-Catalyzed Migratory Insertion of Isocyanides: An Emerging Platform in Cross-Coupling Chemistry

Vlaar, T., Ruijter, E., Maes, B. U. W. & Orru, R. V. A., 2013, In : Angewandte Chemie International Edition in English. 2013, 52, p. 7084-7097

Research output: Contribution to JournalArticleAcademicpeer-review

Palladium
Cyanides

Palladium-Catalyzed Synthesis of 2-Aminobenzoxazinones by Aerobic Oxidative Coupling of Anthranilic Acids and Isocyanides

Vlaar, T., Orru, R. V. A., Maes, B. U. W. & Ruijter, E., 2013, In : Journal of Organic Chemistry. 2013, 78, p. 10469

Research output: Contribution to JournalArticleAcademicpeer-review

ortho-Aminobenzoates
Palladium
Cyanides

Palladiumkatalysierte migratorische Insertion von Isocyaniden: eine neue Methode für die Kreuzkupplungschemie

Vlaar, T., Ruijter, E., Maes, B. U. W. & Orru, R. V. A., 2013, In : Angewandte Chemie. 125, 28, p. 7222-7236 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cyanides
Boranes
Dehydrogenation
Amines

Reactivity of dimeric P/Al-based Lewis pairs toward carbon dioxide and tert-butyl isocyanate

Bertini, F., Hoffmann, F., Appelt, C., Uhl, W., Ehlers, A. W., Slootweg, J. C. & Lammertsma, K., 2013, In : Organometallics. 32, p. 6764-6769

Research output: Contribution to JournalArticleAcademicpeer-review

isocyanates
methylene
Carbon Dioxide
carbon dioxide
reactivity

Scarcity of rare earth elements

de Boer, M. A. & Lammertsma, K., 2013, In : ChemSusChem. 6, p. 2045-2055

Research output: Contribution to JournalArticleAcademicpeer-review

Rare earth elements
rare earth element
Recycling
Praseodymium
Dysprosium

Synthesis of 4-aminoquinolines by aerobic oxidative palladium-catalyzed double C-H activation and isocyanide insertion

Vlaar, T., Maes, B. U. W., Ruijter, E. & Orru, R. V. A., 2013, In : Chemistry of Heterocyclic Compounds. 2013, 49, p. 902-908

Research output: Contribution to JournalArticleAcademicpeer-review

Palladium
Cyanides
Chemical activation
Industry
4-aminoquinoline

Tris(pyrazolyl)phosphine oxides. Synthesis and coordination chemistry with copper(I)

Tazelaar, C. G. J., Lyaskovskyy, V., van Dijk, T., Broere, D. L. J., Kolfschoten, L. A., Khiar, R. O. H. & Lutz, M., 2013, In : Organometallics. 31, p. 3308-3315

Research output: Contribution to JournalArticleAcademicpeer-review

phosphine
synthesis (chemistry)
phosphines
Oxides
Copper
2012

Alkynide and acetonitrile Activation by strained AlPC2 heterocycles

Roters, S., Hepp, A., Slootweg, J. C., Lammertsma, K. & Uhl, W., 2012, In : Chemical Commununications. 48, p. 9616-9618

Research output: Contribution to JournalArticleAcademicpeer-review

Acetonitrile
Chemical activation
acetonitrile
Alkali Metals
Alkali metals
Aluminum
Hydrides
Phosphorus

Concise synthesis of highly substituted benzo[a]quinolizines by a multicomponent reaction/allylation/heck reaction sequence

Den Heeten, R., Van Der Boon, L. J. P., Broere, D. L. J., Janssen, E., De Kanter, F. J. J., Ruijter, E. & Orru, R. V. A., Jan 2012, In : European Journal of Organic Chemistry. 2012, 2, p. 275-280 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Quinolizines
Allylation
Polycyclic Compounds
Cyclization
synthesis

Detection of genotoxic and non-genotoxic renal carcinogens in vitro in NRK-52E cells using a transcriptomics approach

Bloch, K. M., Yaqoob, N., Evans, A., Radford, R., Jennings, P., Boei, J. J. W. A., McMorrow, T., Slattery, C., Ryan, M. P., Gmuender, H., Van Delft, J. H. M. & Lock, E. A., 2012, In : Toxicology Research. 1, 3, p. 211-219 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Carcinogens
Kidney
In Vitro Techniques
Genes
Rats

Dimeric aluminum-phosphorus compounds as masked frustrated Lewis pairs for small molecule activation

Roters, S., Appelt, C., Westenberg, H., Hepp, A., Slootweg, J. C., Lammertsma, K. & Uhl, W., 2012, In : Dalton Transactions. 41, p. 9033-9045

Research output: Contribution to JournalArticleAcademicpeer-review

Phosphorus Compounds
Aluminum
Hydrides
Dimers
Chemical activation

Multicomponent synthesis of 3,6-dihydro-2H-1,3-thiazine-2-thiones

Kruithof, A., Ploeger, M. L., Janssen, E., Helliwell, M., de Kanter, F. J. J., Ruijter, E. & Orru, R. V. A., 8 Feb 2012, In : Molecules. 17, 2, p. 1675-1685 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Thiazines
thiazine (trademark)
Thiones
synthesis
Amidines

Neutral Palladium(II) Complexes with P,N Schiff-base Ligands: Synthesis, Characterization and Application as Suzuki-Miyaura Coupling Catalysts

Mahamo, T., Mogorosi, M. M., Moss, J. R., Mapolie, S. F., Smith, G. S., Slootweg, J. C. & Lammertsma, K., 2012, In : Journal of Organometallic Chemistry. 703, p. 34-42

Research output: Contribution to JournalArticleAcademicpeer-review

Schiff Bases
Palladium
imines
palladium
Ligands

Novel Bis(azido)phosphole building block for extended π-conjugated systems

Weymiens, W., Hartl, F., Lutz, M., Slootweg, J. C., Ehlers, A. W. & Lammertsma, K., 2012, In : European Journal of Organic Chemistry. 34, p. 6711-6721

Research output: Contribution to JournalArticleAcademicpeer-review

Sulfides
sulfides
Electrochemical properties
rings

Pre-organized frustrated Lewis pairs

Bertini, F., Lyaskovskyy, V., Timmer, B. J. J., de Kanter, F. J. J., Lutz, M., Ehlers, A. W., Slootweg, J. C. & Lammertsma, K., 2012, In : Journal of the American Chemical Society. 134, p. 201-204

Research output: Contribution to JournalArticleAcademicpeer-review

Recent Advances in Transition-Metal-Catalyzed [2+2+2]Cyclo(co)trimerization Reactions

Broere, D. L. J. & Ruijter, E., Sep 2012, In : Synthesis. 44, 17, p. 2639-2672 33 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Recent applications of multicomponent reactions in medicinal chemistry

Slobbe, P., Ruijter, E. & Orru, R. V. A., 2012, In : MedChemComm. 3, 10, p. 1189-1218

Research output: Contribution to JournalArticleAcademicpeer-review

Pharmaceutical Chemistry
Scaffolds
Molecules

Recent developments in asymmetric multicomponent reactions

de Graaff, C., Ruijter, E. & Orru, R. V. A., 2012, In : Chemical Society Reviews. 41, 10, p. 3969-4009

Research output: Contribution to JournalArticleAcademicpeer-review

Pharmaceutical Preparations
Biological Products
Agriculture
Catalysis
Transition metals

Semi-Crystalline Polyesters Based on a Novel Renewable Building Block

Wu, J., Eduard, P., Thiyagarajan, S., Jasinska-Walc, L., Rozanski, A., Fonseca Guerra, C., Noordover, B. A. J., van Haveren, J., van Es, D. S. & Koning, C. E., 2012, In : Macromolecules. 45, p. 5069-5080

Research output: Contribution to JournalArticleAcademicpeer-review

Polyesters
Dicarboxylic Acids
Crystalline materials
Polymers
Acids

Stereoselective synthesis of N-aryl proline amides by biotransformation-Ugi-Smiles sequence

Znabet, A., Blanken, S., Janssen, E., de Kanter, F. J. J., Helliwell, M., Turner, N. J., Ruijter, E. & Orru, R. V. A., 7 Feb 2012, In : Organic and Biomolecular Chemistry. 10, 5, p. 941-944 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Monoamine Oxidase
Biotransformation
Proline
Amides
amides

Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein

Edink, E. S., Akdemir, A., Jansen, C. J. W., van Elk, R., Zuiderveld, O. P., de Kanter, F. J. J., van Muijlwijk- Koezen, J. E., Smit, A. B., Leurs, R. & de Esch, I. J. P., 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 3, p. 1448-1454 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Benzoates
Nicotinic Receptors
Structure-Activity Relationship
Acetylcholine
Carrier Proteins

Sustainable Synthesis of Diverse Privileged Heterocycles by Palladium-Catalyzed Aerobic Oxidative Isocyanide Insertion

Vlaar, T., Cioc, R. C., Mampuys, P., Maes, B. U. W., Orru, R. V. A. & Ruijter, E., 2012, In : Angewandte Chemie International Edition in English. p. 13058-13061

Research output: Contribution to JournalArticleAcademicpeer-review

Diamines
Palladium
Cyanides
Scaffolds
Toxicity

Synthesis of Imidazolidine-2-(thi)ones via C2-Selective Oxidation and Thionation of 2-Imidazolinium Halides

Mooijman, M., Bon, R. S., Sprenkels, N. E., Oosterhout, H. N., de Kanter, F. J. J., Groen, M. B., Ruijter, E. & Orru, R. V. A., 2012, In : Synlett. 2012, 1, p. 80-84

Research output: Contribution to JournalArticleAcademicpeer-review

Imidazolidines
Alkylation
Oxidation
2-imidazoline

Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function

Kucera, N., Schmalen, I., Hennig, S., Öllinger, R., Strauss, H. M., Grudziecki, A., Wieczorek, C., Kramer, A. & Wolf, E., 28 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3311-6 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cellular Structures
Tryptophan
Fluorescence Recovery After Photobleaching
Circadian Clocks
Ultracentrifugation
2011

A Microwave-Assisted Diastereoselective Multicomponent Reaction To Access Dibenzo[c,e]azepinones: Synthesis and Biological Evaluation

Mehta, V. P., Modha, S. G., Ruijter, E., van Hecke, K., van Meervelt, L., Pannecouque, C., Balzarini, J., Orru, R. V. A. & van der Eycken, E., 2011, In : Journal of Organic Chemistry. 76, 8, p. 2828-2839

Research output: Contribution to JournalArticleAcademicpeer-review

Bioactivity
Scaffolds
Microwaves

A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines

Coffinier, D., El Kaim, L., Grimaud, L., Ruijter, E. & Orru, R. V. A., 2011, In : Tetrahedron Letters. 52, 23, p. 3023-3025

Research output: Contribution to JournalArticleAcademicpeer-review

Pyridines
Cycloaddition
Cycloaddition Reaction
Pyrimidines
Cyanides

Construct optimization for studying protein complexes: obtaining diffraction-quality crystals of the pseudosymmetric PSPC1-NONO heterodimer

Lee, M., Passon, D. M., Hennig, S., Fox, A. H. & Bond, C. S., Nov 2011, In : Acta Crystallographica Section D. Biological Crystallography. 67, Pt 11, p. 981-7 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Crystallography
Crystallization
Computational Biology
Solubility
Carrier Proteins

Corrigendum: Recent Advances in Palladium-Catalyzed Cascade Cyclizations

Vlaar, T., Ruijter, E. & Orru, R. V. A., Jun 2011, In : Advanced Synthesis and Catalysis. 353, 9, p. 1405-1405 1 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis

Edink, E. S., Rucktooa, P., Retra, K., Akdemir, A., Nahar, T. T., Zuiderveld, O. P., van Elk, R., Janssen, E., van Nierop, P., van Muijlwijk-Koezen, J. E., Smit, A. B., Sixma, T. K., Leurs, R. & de Esch, I. J. P., 15 Feb 2011, In : Journal of the American Chemical Society. 133, 14, p. 5363-5371 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Thermodynamics
Acetylcholine
Carrier Proteins
Ligands
Cysteine Loop Ligand-Gated Ion Channel Receptors

Geminal phosphorus/aluminum-based frustrated Lewis pairs: C-H versus C≡C activation and CO2 fixation

Appelt, C., Westenberg, H., Bertini, F., Ehlers, A. W., Slootweg, J. C., Lammertsma, K. & Uhl, W., 2011, In : Angewandte Chemie International Edition in English. 50, p. 3925-3928

Research output: Contribution to JournalArticleAcademicpeer-review

Boranes
Lewis Acids
Alkynes
Acetylene
Aluminum

Hydroxynitrile Lyase from Arabidopsis thaliana: Identification of Reaction Parameters for Enantiopure Cyanohydrin Synthesis by Pure and Immobilized Catalyst

Okrob, D., Paravidino, M., Orru, R. V. A., Wiechert, W., Hanefeld, U. & Pohl, M., 2011, In : Advanced Synthesis and Catalysis. 353, 13, p. 2399-2408

Research output: Contribution to JournalArticleAcademicpeer-review

mandelonitrile lyase
Diatomaceous Earth
Lipases
Enzymes
Lipase

Ladder-type P,S-bridged trans-stilbenes

Weymiens, W., Zaal, M., Slootweg, J. C., Ehlers, A. W. & Lammertsma, K., 2011, In : Inorganic Chemistry. 50, p. 8516-8523

Research output: Contribution to JournalArticleAcademicpeer-review

Stilbenes
stilbene
Ladders
ladders
Phosphorus

Mehrkomponentenreaktionen als Weg zu molekularer Komplexität und Diversität

Ruijter, E., Scheffelaar, R. & Orru, R. V. A., 4 Jul 2011, In : Angewandte Chemie. 123, 28, p. 6358-6371 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Microbial-catalysed resolution of sterically demanding cyanohydrins

Paravidino, M., Holt, J., Romano, D., Singh, N., Arends, I. W. C. E., Minnaard, A. J., Orru, R. V. A., Molinari, F. & Hanefeld, U., 2011, In : Journal of Molecular Catalysis B. Enzymatic. 63, 1-2, p. 87-92 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Alcohols
Enzymes
Enzyme kinetics
Mycelium
Esterases

Microwave-Assisted Multicomponent Synthesis of Heterocycles

Kruithof, A., Ruijter, E. & Orru, R. V. A., 2011, In : Current Organic Chemistry. 15, 2, p. 204-236

Research output: Contribution to JournalArticleAcademicpeer-review

Microwaves
Heating
Stereoselectivity
Regioselectivity
Microwave irradiation

Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity

Ruijter, E., Scheffelaar, R. & Orru, R. V. A., 2011, In : Angewandte Chemie International Edition in English. 50, 28, p. 6234-6246

Research output: Contribution to JournalArticleAcademicpeer-review

Molecules
Drug Discovery

Neutral palladium(II) complexes with P,N Schiff-base ligands: synthesis, characterisation and catalytic oligomerisation of ethylene

Mogorosi, M. M., Maimela, C., Mahamo, T., Moss, J. R., Mapolie, S. F., Slootweg, J. C., Ehlers, A. W., Lammertsma, K. & Smith, G. S., 2011, In : Journal of Organometallic Chemistry. 696, p. 3585-3592

Research output: Contribution to JournalArticleAcademicpeer-review

Thiophenes
Oligomerization
Schiff Bases
Palladium
Thiophene

Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion

Vlaar, T., Ruijter, E., Znabett, A., Janssen, E., de Kanter, F. J. J., Maes, B. U. W. & Orru, R. V. A., 15 Nov 2011, In : Organic Letters. 13, 24, p. 6496-6499 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Hydrazines
cross coupling
Palladium
Cyanides
hydrazines