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2011

Remarkable metal-complexed phosphorus analogues of the cyclopropenylcarbene–cyclobutadiene rearrangement

Lyaskovskyy, V., Elders, N., Ehlers, A. W., Lutz, M., Slootweg, J. C. & Lammertsma, K., 2011, In : Journal of the American Chemical Society. 133, p. 9704-9707

Research output: Contribution to JournalArticleAcademicpeer-review

Phosphorus
Metals

Role of residue 87 in the activity and regioselectivity of clozapine metabolism by drug-metabolizing CYP102A1 M11H: application for structural characterization of clozapine GSH conjugates

Rea, V., Dragovic, S., Boerma, J. S., de Kanter, F. J. J., Vermeulen, N. P. E. & Commandeur, J. N. M., 2011, (Accepted/In press) In : Drug Metabolism and Disposition. p. 39(12): 2411-20. doi: 10.1124/dmd.111.041046.

Research output: Contribution to JournalArticleAcademicpeer-review

Clozapine
Pharmaceutical Preparations
Amino Acids
Glutathione Transferase
Drug-Related Side Effects and Adverse Reactions

Synthesis of 4-aminoquinazolines by palladium-catalyzed intramolecular imidoylation of N-(2-bromoaryl)amidines

van Baelen, G. A. K., Kuijer, S., Rycek, L., Sergeyev, S., Janssen, E., de Kanter, F. J. J., Maes, B. U. W., Ruijter, E. & Orru, R. V. A., 23 Dec 2011, In : Chemistry: A European Journal. 17, 52, p. 15039-15044 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Amidines
Palladium
Drug products
Ligands
Cyanides

Valence isomerization of cyclohepta-1,3,5-triene and its heteroelement analogues

Jansen, H., Slootweg, J. C. & Lammertsma, K., 2011, In : Beilstein Journal of Organic Chemistry. 7, p. 1713-1721

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Isomerization
Isomers
Carbon
bicyclo(4.1.0)hepta-2,4-diene
2010

Activity and Enantioselectivity of the Hydroxynitrile Lyase MeHNL in Dry Organic Solvents

Paravidino, M., Sorgedrager, M. J., Orru, R. V. A. & Hanefeld, U., 2010, In : Chemistry: A European Journal. 16, 25, p. 7596-7604 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
mandelonitrile lyase
Enantioselectivity
Organic solvents
Enzymes
Water

A facile route to ruthenium-carbene complexes and their application in furfural hydrogenation

Strassberger, Z., Mooijman, M., Ruijter, E., Alberts, A. H., de Graaff, C., Orru, R. V. A. & Rothenberg, G., 2010, In : Applied Organometallic Chemistry. 24, 2, p. 142-146 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Furaldehyde
Ruthenium
Hydrogenation
Ligands
2-Propanol

A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions

Znabet, A., Polak, M. M., Janssen, E., de Kanter, F. J. J., Turner, N. J., Orru, R. V. A. & Ruijter, E., 14 Nov 2010, In : Chemical Commununications. 46, 42, p. 7918-7920 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Stereoselectivity
Atoms
Economics
Pharmaceutical Preparations
telaprevir

An Enzymatic Toolbox for the Kinetic Resolution of 2-(Pyridin-x-yl)but-3-yn-2-ols and Tertiary Cyanohydrins

Nguyen, G., Kourist, R., Paravidino, M., Hummel, A., Rehdorf, J., Orru, R. V. A., Hanefeld, U. & Bornscheuer, T., 2010, In : European Journal of Organic Chemistry. 14, p. 2753-2758 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

enzymes
Kinetics
alcohols
Enantioselectivity
Alcohols

Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence

Znabet, A., Zonneveld, J., Janssen, E., De Kanter, F. J. J., Helliwell, M., Turner, N. J., Ruijter, E. & Orru, R. V. A., 7 Nov 2010, In : Chemical Commununications. 46, 41, p. 7706-7708 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Pyrrolidines
Polycyclic Compounds
Alkaloids
Cyclization
Biocatalysis

C≡C triple bond activation by heterocyclic aluminum phosphinides

Westenberg, H., Slootweg, J. C., Hepp, A., Koesters, J., Roters, S., Ehlers, A. W., Lammertsma, K. & Uhl, W., 2010, In : Organometallics. 29, 6, p. 1323-1330

Research output: Contribution to JournalArticleAcademicpeer-review

Phosphines
Aluminum
phosphines
Chemical activation
activation

Dithiocarbamates Induce Craniofacial Abnormalities and Downregulate sox9a during Zebrafish Development

van Boxtel, A. L., Pieterse, B., Cenijn, P., Kamstra, J. H., Brouwer, A. M., van Wieringen, W. N., de Boer, J. & Legler, J., 2010, In : Toxicological Sciences. 117, 1, p. 209-217

Research output: Contribution to JournalArticleAcademicpeer-review

Craniofacial Abnormalities
Zebrafish
Down-Regulation
Genes
Teratogenesis

Effects of Spatial Coherence on the Angular Distribution of Radiant Intensity Generated by Scattering on a Sphere

van Dijk, T., Fischer, D. G., Visser, T. D. & Wolf, E., 2010, In : Physical Review Letters. 104, 17, p. 173902

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
radiant flux density
angular distribution
scattering
elastic waves
colloids

Fast photo-processes in triazole-based push-pull systems.

Zoon, P. D., van Stokkum, I. H. M., Parent, M., Mongin, O., Blanchard-Desce, M. & Brouwer, A. M., 2010, In : Physical Chemistry Chemical Physics - PCCP. 12, p. 2706-2715

Research output: Contribution to JournalArticleAcademicpeer-review

Triazoles
Excited states
Derivatives
Electrons
Crystal symmetry

Finding Furfural Hydrogenation Catalysts via Predictive Modelling

Strassberger, Z., Mooijman, M., Ruijter, E., Alberts, A. H., Maldonado, A. G., Orru, R. V. A. & Rothenberg, G., 2010, In : Advanced Synthesis and Catalysis. 352, 13, p. 2201-2210 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Furaldehyde
Furfural
Ruthenium
Hydrogenation
Catalysts

Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions

Znabet, A., Ruijter, E., de Kanter, F. J. J., Köhler, V., Helliwell, M., Turner, N. J. & Orru, R. V. A., 2010, In : Angewandte Chemie International Edition in English. 49, 31, p. 5289-5292 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Monoamine Oxidase
Tides
Carboxylic acids
Drug products
Peptides

Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions

Rose, R., Erdmann, S., Bovens, S., Wolf, A., Rose, M., Hennig, S., Waldmann, H. & Ottmann, C., 1 Jun 2010, In : Angewandte Chemie International Edition in English. 49, 24, p. 4129-32 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Isocyanoacetate Derivatives: Synthesis, Reactivity, and Application

Gulevich, A. V., Zhdanko, A. G., Orru, R. V. A. & Nenajdenko, V. G., 2010, In : Chemical Reviews. 110, 9, p. 5235-5331

Research output: Contribution to JournalArticleAcademicpeer-review

Tubulin
Derivatives
Peptides
Sphingolipids
Molecules

Methyl Cation Affinities of Neutral and Anionic Maingroup-Element Hydrides: Trends Across the Periodic Table and Correlation with Proton Affinities

Mulder, R. J., Guerra, C. F. & Bickelhaupt, F. M., 22 Jul 2010, In : Journal of Physical Chemistry A. 114, 28, p. 7604-7608 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Nucleophilic phosphinidene complexes – access and applicability

Aktas, H., Slootweg, J. C. & Lammertsma, K., 2010, In : Angewandte Chemie International Edition in English. 49, p. 2102-2113

Research output: Contribution to JournalArticleAcademicpeer-review

P-C dichotomy: divergent iron(-I)-mediated alkyne and phosphaalkyne cycloligomerisations

Wolf, R., Ghavtadze, N., Weber, K., Schnockelborg, E. M., de Bruin, B., Ehlers, A. W. & Lammertsma, K., 2010, In : Dalton Transactions. 39, 6, p. 1453-1456

Research output: Contribution to JournalArticleAcademicpeer-review

Alkynes
Iron

Photohuperzine A-A new photoisomer of huperzine A: Structure elucidation, formation kinetics and activity assessment

de Azevedo Marques, L., Giera, M., de Kanter, F. J. J., Niessen, W. M. A., Lingeman, H. & Irth, H., 2010, In : Journal of Pharmaceutical and Biomedical Analysis. 52, 2, p. 190-194 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Photoisomerization
Kinetics
Pharmaceutical Preparations
photohuperzine A
huperzine A

Preparation, Characterization and Electronic Structure of Homoleptic Diphosphacyclobutadiene Complexes [M(η4-P2C2R2)2]x– (M = Fe, Co; x = 0, 1)

Wolf, R., Ehlers, A. W., Khusniyarov, M. M., Hartl, F., Bruin, B., Long, G. J., Grandjean, F., Schappacher, F. M., Pöttgen, R., Slootweg, J. C., Lutz, M., Spek, A. L. & Lammertsma, K., 2010, In : Chemistry: A European Journal. 16, p. 14322-14334

Research output: Contribution to JournalArticleAcademicpeer-review

Electronic structure
Ligands
K-18 conjugate
18-crown-6

Preparation of a Ligand-Stabilized [P4O4]2+ via Controlled Hydrolysis of a Janus-Head Type Diphosphorus Trication

Weigand, J. J., Feldmann, K. O., Echterhoff, A. K. C., Ehlers, A. W. & Lammertsma, K., 2010, In : Angewandte Chemie International Edition in English. 49, p. 6178-6181 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Phosphorus
Hydrolysis
Ligands

Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine

de Azevedo Marques, L., Kool, J., de Kanter, F. J. J., Lingeman, H., Niessen, W. M. A. & Irth, H., 2010, In : Journal of Pharmaceutical and Biomedical Analysis. 53, 3, p. 609-616 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Tacrine
Acetylcholinesterase
Bioactivity
Degradation
Liquid Chromatography

Reactive Intermediates: A Transient Electrophilic Phosphinidene Caught in the Act

Jansen, H., Samuels, M. C., Couzijn, E. P. A., Slootweg, J. C., Ehlers, A. W., Chen, P. & Lammertsma, K., 2010, In : Chemistry: A European Journal. 16, 5, p. 1454-1458 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Carbon Monoxide

Scope and limitations of an efficient four-component reaction for dihydropyridin-2-ones

Scheffelaar, R., Paravidino, M., Znabet, A., Schmitz, R. F., de Kanter, F. J. J., Lutz, M., Spek, A. L., Guerra, C. F., Bickelhaupt, F. M., Groen, M. B., Ruijter, E. & Orru, R. V. A., 2010, In : Journal of Organic Chemistry. p. 1723-1732 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Organophosphonates
Nitriles
Aldehydes
Esters
Acidity

Semi-rational design of beta-catenin targeting peptides for the inhibition of Wnt-dependent signaling

Grossmann, T. N., Yeh, J. T. -H. & Verdine, G. L., Nov 2010, In : European Journal of Cancer. Supplement. 8, 7, p. 31-31

Research output: Contribution to JournalArticleAcademic

Phosphoranes
Silicates
Graph theory
Coordination Complexes
Interchanges

Subcomponent Assembly and Transmetallation of Dinuclear Helicates

Dömer, J., Slootweg, J. C., Hupka, F., Lammertsma, K. & Hahn, F. E., 2010, In : Angewandte Chemie International Edition in English. 49, p. 6430-6433 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Synthesis, Structure and Reactivity of [N,N-Dimethyl-BABAR-Phos]OTf

Jansen, H., Läng, F. B., Slootweg, J. C., Ehlers, A. W., Lammertsma, K. & Grützmacher, H., 2010, In : Angewandte Chemie International Edition in English. 49, p. 5485-5488 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Synthesis of polycyclic alkaloid-type compounds by an N -acyliminium Pictet-Spengler/diels-alder sequence

Ruijter, E., Garcia-Hartjes, J., Hoffmann, F., Vanwandelen, L. T. M., Dekanter, F. J. J., Janssen, E. & Orru, R. V. A., Oct 2010, In : Synlett. 2010, 16, p. 2485-2489 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Alkaloids
Cycloaddition
Amines
Chlorides
Derivatives

The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARα-dependent mechanisms

Feige, J. N., Gerber, A., Casals-Casas, C., Yang, Q., Winkler, C., Bedu, E., Bueno, M., Gelman, L., Auwerx, J., Gonzalez, F. J. & Desvergne, B., 1 Feb 2010, In : Environmental Health Perspectives. 118, 2, p. 234-241 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Diethylhexyl Phthalate
Peroxisome Proliferator-Activated Receptors
Energy Metabolism
Liver
Plasticizers

Valence Isomerization of Phosphepines

Jansen, H., Slootweg, J. C., Ehlers, A. W. & Lammertsma, K., 2010, In : Organometallics. 29, p. 6653-6659

Research output: Contribution to JournalArticleAcademicpeer-review

Isomerization
isomerization
Metals
valence
Heating

YidC is in involved in the biogenesis of the secreted autotransporter Hemoglobin Protease

Jong, W. S. P., ten Hagen-Jongman ten, C. M., Ruijter, E., Orru, R. V. A., Genevaux, P. & Luirink, S., 2010, In : Journal of Biological Chemistry. 285, 51, p. 39682-39690 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Hemoglobins
Peptide Hydrolases
Membranes
Periplasm
Signal Recognition Particle
2009

2,2,6,6-Tetrakis(biphenyl-2-yl)-4,4,8,8-tetramethylcyclotetrasiloxane

Couzijn, E. P. A., Lutz, M., Spek, A. L. & Lammertsma, K., 2009, In : Acta Crystallographica Section E. Structure Reports. 65, p. O2182-O2183

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
diphenyl

A multicomponent reaction towards N-(cyanomethyl)amides

Elders, N., Ruijter, E., de Kanter, F. J. J., Janssen, E., Lutz, M., Spek, A. L. & Orru, R. V. A., 15 Jun 2009, In : Chemistry: A European Journal. 15, 25, p. 6096-6099 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Amides
Amines
Ketones
Aldehydes
Functional groups

A Novel Three-Component Reaction toward Dihydrooxazolopyridines

Scheffelaar, R., Paravidino, M., Muilwijk, D., Lutz, M., Spek, A. L., de Kanter, F. J. J., Orru, R. V. A. & Ruijter, E., 2009, In : Organic Letters. 11, 1, p. 125-128

Research output: Contribution to JournalArticleAcademicpeer-review

Aldehydes
Amines
aldehydes
amines
reactivity

A Phosphorus Analogue of Bis(eta(4)-cyclobutadiene)iron(0)

Wolf, R., Slootweg, J. C., Ehlers, A. W., Hartl, F., de Bruin, B., Lutz, M., Spek, A. L. & Lammertsma, K., 2009, In : Angewandte Chemie International Edition in English. 48, 17, p. 3104-3107

Research output: Contribution to JournalArticleAcademicpeer-review

Phosphorus
Iron
Electrons

Author Profile

Lammertsma, K., 2009, In : Angewandte Chemie International Edition in English. 48, p. 4670-4764 121 p.

Research output: Contribution to JournalArticleProfessional

Bisphosphine-functionalized cyclic decapeptides based on the natural product Gramicidin S: a potential scaffold for transition-metal coordination

Burck, S., van Assema, S. G. A., Lastdrager, B., Slootweg, J. C., Ehlers, A. W., Otero, J. M., Dacunha-Marinho, B., Llamas-Saiz, A. L., Overhand, M., van Raaij, M. J. & Lammertsma, K., 2009, In : Chemistry: A European Journal. 15, 33, p. 8134-45

Research output: Contribution to JournalArticleAcademicpeer-review

phosphine
Gramicidin
Biological Products
Scaffolds
Transition metals

Coherence singularities in the field generated by partially coherent sources

van Dijk, T., Schouten, H. & Visser, T. D., 2009, In : Physical Review A. 79, 3

Research output: Contribution to JournalArticleAcademicpeer-review

coherent sources
hyperbolas
ellipses
far fields
topology

Configurationally rigid pentaorganosilicates

Couzijn, E. P. A., van den Engel, D. W. F., Slootweg, J. C., de Kanter, F. J. J., Ehlers, A. W., Schakel, M. & Lammertsma, K., 2009, In : Journal of the American Chemical Society. 131, 10, p. 3741-51

Research output: Contribution to JournalArticleAcademicpeer-review

Ligands
Silicates
Interchanges
Anions
Carrier concentration

Coordination chemistry of the sulfur analog of tricatechol siderophores

Birkmann, B., Seidel, W. W., Pape, T., Ehlers, A. W., Lammertsma, K. & Hahn, F. E., 2009, In : Dalton Transactions. 36, p. 7350-2

Research output: Contribution to JournalArticleAcademicpeer-review

Siderophores
Benzene
Sulfur
Ligands
dithiol

Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists

Celanire, S., Wijtmans, M., Christophe, B., Collart, P., de Esch, I. J. P., Dassesse, D., Delaunoy, C., Denonne, F., Durieu, V., Gelens, E., Gillard, M., Lallemand, B., Lamberty, Y., Lebon, F., Nicolas, J. M., Quere, L., Snip, E., Vanbellinghen, A., Van Houtvin, N., Verbois, V. & 4 othersTimmerman, H., Talaga, P., Leurs, R. & Provins, L., 2009, In : ChemMedChem. 4, 7, p. 1063-8

Research output: Contribution to JournalArticleAcademicpeer-review

Evolution of singularities in a partially coherent vortex beam

van Dijk, T. & Visser, T. D., 2009, In : Journal of the Optical Society of America. A: Optics, image science, and vision.. 26, 4, p. 741-744

Research output: Contribution to JournalArticleAcademicpeer-review

Vortex flow
vortices
light modulators
far fields
Spatial light modulators

Familial juvenile hyperuricemic nephropathy: Report on a new mutation and a pregnancy

Lhotta, K., Gehringer, A., Jennings, P., Kronenberg, F., Brezinka, C., Andersone, I. & Strazdins, V., Jan 2009, In : Clinical Nephrology. 71, 1, p. 80-83 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Uromodulin
Pregnancy
Mutation
Gout
Uric Acid

High-Throughput Reaction Optimisation and Activity Screening of Ferrocene-Based Lewis Acid-Catalyst Complexes by Using Continuous-Flow Reaction Detection Mass Spectrometry

Martha, C. T., Heemskerk, A., Hoogendoorn, J. C., Elders, N., Niessen, W. M. A., Orru, R. V. A. & Irth, H., 2009, In : Chemistry: A European Journal. 15, 30, p. 7368-7375

Research output: Contribution to JournalArticleAcademicpeer-review

Lewis Acids
Mass spectrometry
Screening
Throughput
Catalysts

Iridium phosphinidene complexes: a comparison with iridium imido complexes in their reaction with isocyanides

Aktas, H., Mulder, J. M., de Kanter, F. J. J., Slootweg, J. C., Schakel, M., Ehlers, A. W., Lutz, M., Spek, A. L. & Lammertsma, K., 2009, In : Journal of the American Chemical Society. 131, 37, p. 13531-7

Research output: Contribution to JournalArticleAcademicpeer-review

Iridium
Cyanides
Cycloaddition
Electrons
Model structures

Metallosupramolecular complexes derived from bis(benzene-o-dithiol) ligands

Birkmann, B., Ehlers, A. W., Frohlich, R., Lammertsma, K. & Hahn, F. E., 2009, In : Chemistry: A European Journal. 15, 17, p. 4301-4311

Research output: Contribution to JournalArticleAcademicpeer-review

Benzene
Ligands
dithiol
catechol

Mononuclear Platinum(II) Complexes Incorporating kappa(2)-Carboxylate Ligands: Synthesis, Structure, and Reactivity

Moret, M. E., Keller, S. F., Slootweg, J. C. & Chen, P., 2009, In : Inorganic Chemistry. 48, 14, p. 6972-6978

Research output: Contribution to JournalArticleAcademicpeer-review

Platinum
Dimers
carboxylates
platinum
reactivity