Research Output 1988 2019

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2009

N-Heterocyclic Carbene Functionalized Group 7-9 Transition Metal Phosphinidene Complexes

Aktas, H., Slootweg, J. C., Ehlers, A. W., Lutz, M., Spek, A. L. & Lammertsma, K., 2009, In : Organometallics. 28, 17, p. 5166-5172

Research output: Contribution to JournalArticleAcademicpeer-review

Coordination Complexes
carbenes
Transition metals
transition metals
carbene

N-heterocyclic carbene-functionalized ruthenium phosphinidenes: what a difference a twist makes

Aktas, H., Slootweg, J. C., Schakel, M., Ehlers, A. W., Lutz, M., Spek, A. L. & Lammertsma, K., 2009, In : Journal of the American Chemical Society. 131, 19, p. 6666-7

Research output: Contribution to JournalArticleAcademicpeer-review

Ruthenium
Ligands
Transition metals
Phosphines
Coordination Complexes

On the electronic impact of abnormal C4-bonding in N-heterocyclic carbene complexes

Heckenroth, M., Neels, A., Garnier, M. G., Aebi, P., Ehlers, A. W. & Albrecht, M., 2009, In : Chemistry: A European Journal. 15, 37, p. 9375-86

Research output: Contribution to JournalArticleAcademicpeer-review

Metals
Carrier concentration
Ligands
Lewis Acids
Palladium

Pentaorganosilicates

Couzijn, E. P. A., Slootweg, J. C., Ehlers, A. W. & Lammertsma, K., 2009, In : Zeitschrift für Anorganische und Allgemeine Chemie. 635, 9-10, p. 1273-1278

Research output: Contribution to JournalArticleAcademicpeer-review

Ionic Liquids

Phosphinidene Addition to Conjugated Allenes

Bertini, F., Wit, J. B. M., Unal, M., de Kanter, F. J. J., Schakel, M., Slootweg, J. C., Ehlers, A. W., Nijbacker, T., Komen, C. M. D., Lutz, M., Spek, A. L. & Lammertsma, K., 2009, In : Advanced Synthesis and Catalysis. 351, 7-8, p. 1132-1138

Research output: Contribution to JournalArticleAcademicpeer-review

Tungsten
Carbon Monoxide
propadiene

Photocrosslinking and click chemistry enable the specific detection of proteins interacting with phospholipids at the membrane interface

Gubbens, J., Ruijter, E., de Fays, L. E., Damen, J., de Kruijff, B., Slijper, M., Rijkers, D. T., Liskamp, R. M. & Kroon, A., 2009, In : Chemistry and Biology. 16, 1, p. 3-14

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Silicon(IV)-chelates of an ONN’)-tridentate pyrrole-2-carbaldimine ligand: syntheses, structures and UV/Vis properties

Gerlach, D., Ehlers, A. W., Lammertsma, K. & Wagler, J., 2009, In : Zeitschrift für Naturforschung. Section B: A Journal of Chemical Sciences. 64B, 11/12, p. 1571

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2

Hennig, S., Strauss, H. M., Vanselow, K., Yildiz, O., Schulze, S., Arens, J., Kramer, A. & Wolf, E., 28 Apr 2009, In : PloS Biology. 7, 4, p. e94

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Drosophila
Crystal structure
mice
Mutagenesis
proteins

Synthesis of Conformationally Constrained Peptidomimetics using Multicomponent Reactions

Scheffelaar, R., Nijenhuis, R. A. K., Paravidino, M., Lutz, M., Spek, A. L., Ehlers, A. W., de Kanter, F. J. J., Groen, M. B., Orru, R. V. A. & Ruijter, E., 2009, In : Journal of Organic Chemistry. 74, 2, p. 660-668

Research output: Contribution to JournalArticleAcademicpeer-review

Peptidomimetics
Scaffolds
Nuclear magnetic resonance
Molecular modeling
X ray crystallography

The efficient one-pot reaction of up to eight components by the union of multicomponent reactions

Elders, N., van der Born, D., Hendrickx, L. J. D., Timmer, B. J. J., Krause, A., Janssen, E., de Kanter, F. J. J., Ruijter, E. & Orru, R. V. A., 27 Jul 2009, In : Angewandte Chemie - International Edition. 48, 32, p. 5856-5859 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

η3-Diphosphenylcarbene: a P2-analogue of the Dötz intermediate

Aktas, H., Slootweg, J. C., Ehlers, A. W., Lutz, M., Spek, A. L. & Lammertsma, K., 2009, In : Angewandte Chemie International Edition in English. 48, p. 3108-3111

Research output: Contribution to JournalArticleAcademicpeer-review

Metals
2008

1-Azadienes in cycloaddition and multicomponent reactions towards N-heterocycles

Groenendaal, B., Ruijter, E. & Orru, R. V. A., 2008, In : Chemical Commununications. 43, p. 5474-89

Research output: Contribution to JournalArticleAcademicpeer-review

Cycloaddition
Scaffolds
Substitution reactions

4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists

Wijtmans, M., Celanire, S., Snip, E., Gillard, M. R., Gelens, E., Collart, P. P., Venhuis, B. J., Christophe, B., Hulscher, ST., van der Goot, H., Lebon, F., Timmerman, H., Bakker, R. A., Leurs, R., Lallemand, B. I., Talaga, P. & de Esch, I. J. P., 2008, In : Journal of Medicinal Chemistry. 51, 10, p. 2944-53

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Agonists
Imidazoles
Therapeutic Human Experimentation
Histamine

Alkane Hydroxylation by Peroxy Acids: A Comparison with the Cytochrome P450 Hydroxylation

Groenhof, A. R., Ehlers, A. W. & Lammertsma, K., 2008, In : Journal of Physical Chemistry A.

Research output: Contribution to JournalArticleAcademicpeer-review

Hydroxylation
Alkanes
cytochromes
Cytochrome P-450 Enzyme System
alkanes

A multicomponent synthesis of triazinane diones

Groenendaal, B., Vugts, D. J., Schmitz, R. F., de Kanter, F. J. J., Ruijter, E., Groen, M. B. & Orru, R. V. A., 2008, In : Journal of Organic Chemistry. 73, 2, p. 719-22

Research output: Contribution to JournalArticleAcademicpeer-review

Scaffolds
Isocyanates
Organophosphonates
Nitriles
Aldehydes

A New Route of Synthesis of Estetrol

Warmerdam, E. G. J. C., de Visser, M., Coelingh Bennink, H. J. T. & Groen, M. B., 2008, In : Climacteric. 11, p. 59

Research output: Contribution to JournalArticleAcademicpeer-review

A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-Difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline

Pedram, B., van Oeveren, A., Mais, D. E., Marschke, K. B., Verbost, P. M., Groen, M. B. & Zhi, L., 2008, In : Journal of Medicinal Chemistry. 51, p. 3696-3699

Research output: Contribution to JournalArticleAcademicpeer-review

Bis(acetato-kappa O)[N,N,N ',N '-tetramethyl-ethane-1,2-diamine-kappa N-2,N ']copper(II)

Slootweg, J. C. & Chen, P., 2008, In : Acta Crystallographica Section E. Structure Reports. 64, p. M430-U1417

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
ethylenediamine
diamines
Ethane
ethane
Copper

Development of an automated on-line pepsin digestion-liquid chromatography-tandem mass spectrometry configuration for the rapid analysis of protein adducts of chemical warfare agents

Carol-Visser, J., van der Schans, M., Fidder, A., Huist, A. G., van Baar, B. L. M., Irth, H. & Noort, D., 2008, In : Journal of Chromatography B. 870, 1, p. 91-97

Research output: Contribution to JournalArticleAcademicpeer-review

Chemical Warfare Agents
Pepsin A
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography

Diastereoselective formation of complexed methylenediphosphiranes

Jansen, H., Rosenthal, A. J., Slootweg, J. C., Ehlers, A. W., Lutz, M., Spek, A. L. & Lammertsma, K., 2008, In : Organometallics. 27, 12, p. 2868-2872

Research output: Contribution to JournalArticleAcademicpeer-review

Carbon Monoxide

Efficient C2 functionalisation of 2H-2-imidazolines

Bon, R. S., Sprenkels, N. E., Koningstein, M. M., Schmitz, R. F., de Kanter, F. J. J., Domling, A., Groen, M. B. & Orru, R. V. A., 2008, In : Organic and Biomolecular Chemistry. 6, 1, p. 130-7

Research output: Contribution to JournalArticleAcademicpeer-review

alkylation
inhibitors
chemistry
analogs
microwaves

Fused tricyclic phosphiranes--analysis of phosphorus chemical shieldings

Couzijn, E. P. A., Ehlers, A. W., Slootweg, J. C., Schakel, M., Krill, S., Lutz, M., Spek, A. L. & Lammertsma, K., 2008, In : Chemistry: A European Journal. 14, 5, p. 1499-507

Research output: Contribution to JournalArticleAcademicpeer-review

Carbon Monoxide
Shielding
Phosphorus

Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones

Groenendaal, B., Ruijter, E., de Kanter, F. J. J., Lutz, M., Spek, A. L. & Orru, R. V. A., 2008, In : Organic and Biomolecular Chemistry. 6, 17, p. 3158-65

Research output: Contribution to JournalArticleAcademicpeer-review

Dione
platforms
halides
chemistry
products

Multicomponent Reactions as Useful Platforms to Explore the Chemical Space

Orru, R. V. A., 2008, In : Drugs of the Future. 33, p. 52

Research output: Contribution to JournalArticleAcademicpeer-review

Online screening of homogeneous catalyst performance using reaction detection mass spectrometry

Martha, C. T., Elders, N., Krabbe, J. G., Kool, J., Niessen, W. M. A., Orru, R. V. A. & Irth, H., 2008, In : Analytical Chemistry. 80, 18, p. 7121-7

Research output: Contribution to JournalArticleAcademicpeer-review

Mass spectrometry
Screening
Catalysts
Mass spectrometers
Substrates

Phospha-scorpionate complexes by click chemistry using phenyl azide and ethynylphosphine oxides

van Assema, S. G. A., Tazelaar, C. G. J., de Jong, G. T., van Maarseveen, J. H., Schakel, M., Lutz, M., Spek, A. L., Slootweg, J. C. & Lammertsma, K., 2008, In : Organometallics. 27, 13, p. 3210-3215

Research output: Contribution to JournalArticleAcademicpeer-review

phosphine
Azides
Oxides
chemistry
Triazoles

Selective formation of 2-imidazolines and 2-substituted oxazoles by using a three-component reaction

Elders, N., Ruijter, E., de Kanter, F. J. J., Groen, M. B. & Orru, R. V. A., 2008, In : Chemistry: A European Journal. 14, 16, p. 4961-73

Research output: Contribution to JournalArticleAcademicpeer-review

Oxazoles
Ketones
Aldehydes
Amides
Amines

Shaping the focal intensity distribution using spatial coherence

van Dijk, T., Gbur, G. J. & Visser, T. D., 2008, In : Journal of the Optical Society of America. A: Optics, image science, and vision.. 25, 3, p. 575-581

Research output: Contribution to JournalArticleAcademicpeer-review

Spatial distribution
spatial distribution
trapping

Synthesis of 3'-deoxyribolactones using a hydrolysis-induced lactonization cascade reaction of epoxy cyanohydrins

Vugts, D. J., Aktas, H., Al-Mafraji, K., de Kanter, F. J. J., Ruijter, E., Groen, M. B. & Orru, R. V. A., 2008, In : European Journal of Organic Chemistry. 8, p. 1336-1339

Research output: Contribution to JournalArticleAcademicpeer-review

hydrolysis
Hydrolysis
cascades
synthesis
cyanohydrin

Synthesis of 5,10-seco analogs of testosterone

Khripach, V. A., Zhabinskii, V. N., Kuchto, A. I., Zhiburtovich, Y. Y., Khripach, N. B., Lyakhov, A. S., Groen, M. B., Louw, J. P. E. & Groot, A. M. E., 2008, In : Steroids. 73, p. 1424

Research output: Contribution to JournalArticleAcademicpeer-review

The Grignard Reagent Formation Reaction of 2-Chloro-1,1,1-triphenylethane Revisited

Bickelhaupt, F., Newcomb, M., DeZutter, C. B. & den Boer, H., 2008, In : European Journal of Organic Chemistry. p. 6225-6231

Research output: Contribution to JournalArticleAcademicpeer-review

The homoleptic sandwich anion [Co(P2C2tBu2)2]-: a versatile building block for phosphaorganometallic chemistry

Wolf, R., Ehlers, A. W., Slootweg, J. C., Lutz, M., Gudat, D., Hunger, M., Spek, A. L. & Lammertsma, K., 2008, In : Angewandte Chemie International Edition in English. 47, 24, p. 4584-7

Research output: Contribution to JournalArticleAcademicpeer-review

Anthracene
Anions
Negative ions
anthracene

Tricarbonylchromium complexes of [5]- and [6]metacyclophane: an experimental and theoretical study

van Eis, M. J., Bickelhaupt, F. M., van Loon, S., Lutz, M., Spek, A. L., de Wolf, W. H. & van Zeist, W. J., 2008, In : Tetrahedron Symposia-in-Print. 64, 51, p. 11641-11646

Research output: Contribution to JournalArticleAcademicpeer-review

Carbon Monoxide
Theoretical Models
2007

Acetylene-substituted phosphane oxides: Building blocks for macrocycles

van Assema, S. G. A., de Jong, G. T., Ehlers, A. W., de Kanter, F. J. J., Schakel, M., Spek, A. L., Lutz, M. & Lammertsma, K., 2007, In : European Journal of Organic Chemistry. 15, p. 2405-2412

Research output: Contribution to JournalArticleAcademicpeer-review

phosphine
dibromides
Acetylene
Scaffolds
acetylene

A flexible six-component reaction to access constrained depsipeptides based on a dihydropyridinone core

Paravidino, M., Scheffelaar, R., Schmitz, R. F., de Kanter, F. J. J., Groen, M. B., Ruijter, E. & Orru, R. V. A., 2007, In : Journal of Organic Chemistry. 72, 26, p. 10239-42

Research output: Contribution to JournalArticleAcademicpeer-review

Depsipeptides

Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study.

Bonifacio, A., Groenhof, A. R., Keizers, P. H. J., de Graaf, C., Commandeur, J. N. M., Vermeulen, N. P. E., Ehlers, A. W., Lammertsma, K., Gooijer, C. & van der Zwan, G., 2007, In : Journal of Biological Inorganic Chemistry - JBIC. 12, 5, p. 645-654

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cytochrome P-450 CYP2D6
Catalytic Domain
Threonine
Heme
Cytochrome P-450 Enzyme System

A novel photoreaction mechanism for the circadian blue light photoreceptor Drosophila cryptochrome

Berndt, A., Kottke, T., Breitkreuz, H., Dvorsky, R., Hennig, S., Alexander, M. & Wolf, E., 27 Apr 2007, In : Journal of Biological Chemistry. 282, 17, p. 13011-21 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cryptochromes
Flavin-Adenine Dinucleotide
Drosophila
Light
Circadian Clocks

A resource-efficient and highly flexible procedure for a three-component synthesis of 2-imidazolines

Elders, N., Schmitz, R. F., de Kanter, F. J. J., Ruijter, E., Groen, M. B. & Orru, R. V. A., 2007, In : Journal of Organic Chemistry. 72, 16, p. 6135-42

Research output: Contribution to JournalArticleAcademicpeer-review

Cyanides
Carbonyl compounds
Column chromatography
Imines
Amines

Auto-regulation of the circadian slave oscillator component AtGRP7 and regulation of its targets is impaired by a single RNA recognition motif point mutation

Schöning, J. C., Streitner, C., Page, D. R., Hennig, S., Uchida, K., Wolf, E., Furuya, M. & Staiger, D., Dec 2007, In : Plant Journal. 52, 6, p. 1119-30 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

autoregulation
RNA-Binding Proteins
alternative splicing
point mutation
Point Mutation

Building blocks for phospha[n]pericyclynes

van Assema, S. G. A., Kraikivskii, P. B., Zelinskii, S. N., Saraev, V. V., de Jong, G. T., de Kanter, F. J. J., Schakel, M., Slootweg, J. C. & Lammertsma, K., 2007, In : Journal of Organometallic Chemistry. 692, 11, p. 2314-2323

Research output: Contribution to JournalArticleAcademicpeer-review

Mechanisms of cyaphide (C[triple bond]P(-)) formation

Ehlers, A. W., Cordaro, J. G., Stein, D. J. & Grutzmacher, H., 2007, In : Angewandte Chemie International Edition in English. 46, 41, p. 7878-81

Research output: Contribution to JournalArticleAcademicpeer-review

Cyanides
Silicon
Discrete Fourier transforms
Phosphorus
Ligands

Multicomponent Synthesis of N-Heterocyclic Carbene Complexes

Bon, R. S., de Kanter, F. J. J., Lutz, M., Spek, A. L., Jahnke, M. C., Hahn, F. E., Groen, M. B. & Orru, R. V. A., 2007, In : Organometallics. 26, p. 3639-3650

Research output: Contribution to JournalArticleAcademicpeer-review

carbenes
synthesis
Deprotonation
Cyanides
aldehydes

Near-infrared dyes and fluorophores based on diketopyrrolopyrroles

Fischer, G., Ehlers, A. W., Zumbusch, A. & Daltrozzo, E., 2007, In : Angewandte Chemie International Edition in English. 46, 20, p. 3750-3

Research output: Contribution to JournalArticleAcademicpeer-review

Proton assisted oxygen-oxygen bond splitting in cytochrome p450

Groenhof, A. R., Ehlers, A. W. & Lammertsma, K., 2007, In : Journal of the American Chemical Society. 129, 19, p. 6204-9

Research output: Contribution to JournalArticleAcademicpeer-review

Cytochrome P-450 Enzyme System
Protons
Iron
Oxygen
Protonation

Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption

Alders, D., Cornelussen, R. N., Prinzen, F. W., Specht, P. A. C., Noble, M. J., Drake-Holland, A. J., de Kanter, F. J. J. & van der Beek, J. P., 2007, In : Experimental Physiology. 92, p. 541-548

Research output: Contribution to JournalArticleAcademicpeer-review

Sympathectomy
Oxygen Consumption
Canidae
Perfusion
Chloralose

Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists

Storelli, S., Verzijl, D., Al-Badie, J., Elders, N., Bosch, L., Timmerman, H., Smit, M. J., De Esch, I. J. & Leurs, R., 2007, In : Archiv der Pharmazie. 340, 6, p. 281-91

Research output: Contribution to JournalArticleAcademicpeer-review

CXCR3 Receptors
Structure-Activity Relationship
Ligands
G-Protein-Coupled Receptors
4-hydroxyquinazoline

The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion

Pellissier, F., Gerber, A., Bauer, C., Ballivet, M. & Ossipow, V., 29 Oct 2007, In : BMC Neuroscience. 8, 90.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Oligodendroglia
Cell Adhesion
Axons
Nervous System
Blood Proteins

Trapping of the highly strained [5](2,4)quinolinophane system

van Eis, M. J., Lutz, M., Spek, A. L., de Wolf, W. H. & Bickelhaupt, F., 2007, In : Tetrahedron Symposia-in-Print. 63, p. 1689-1694

Research output: Contribution to JournalArticleAcademicpeer-review

Alkenes
Carbon
Water
carbene
2006

[η2-8-(tert-Butylimino)-1-naphthyl]bis­(η5-cyclopentadienyl)titanium(IV)

Kooijman, H., van Leijen, M., Akkerman, O. S., Bickelhaupt, F. M. & Spek, A. L., 2006, In : Acta Crystallographica Section E. Structure Reports. 62, p. 1545

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Titanium
titanium

A Mild Chemo-Enzymatic Oxidation-Hydrocyanation Cascade

Vugts, D. J., Veum, L., Al-Mafraji, K., Lemmens, R. H., Schmitz, R. F., de Kanter, F. J. J., Groen, M. B., Hanefeld, U. & R.V.A., O., 2006, In : European Journal of Organic Chemistry. p. 1672

Research output: Contribution to JournalArticleAcademicpeer-review

cascades
Oxidation
oxidation
Isomerization
aldehydes