A. Brouwer

prof. dr.

1987 …2019
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Research Output 1987 2019

2019

Antimicrobial activity and carbohydrate metabolism in the bacterial metagenome of the soil-living invertebrate Folsomia candida

Agamennone, V., Le, N. G., van Straalen, N. M., Brouwer, A. & Roelofs, D., 13 May 2019, In : Scientific Reports. 9, p. 1-13 13 p., 7308.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metagenome
Microbiota
Carbohydrate Metabolism
Invertebrates
Candida

Genome annotation and antimicrobial properties of Bacillus toyonensis VU-DES13, isolated from the Folsomia candida gut

Agamennone, V., van Straalen, J., Brouwer, A., de Boer, T. E., Hensbergen, P. J., Zaagman, N., Braster, M., van Straalen, N. M., Roelofs, D. & Janssens, T. K. S., Mar 2019, In : Entomologia experimentalis et applicata. 167, 3, p. 269-285 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Folsomia candida
anti-infective properties
antibiotic resistance
genome
digestive system

Identification of PPAR-activating compounds in herbal and edible plants and fungi from Vietnam

Pham Ngoc, L., Man, H. Y., Besselink, H., Dang Thi Cam, H., Brouwer, A. & van der Burg, B., Mar 2019, In : Industrial Crops and Products. 129, p. 195-200 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Vietnam
fungi
metabolic syndrome
obesity
peroxisome proliferator-activated receptors

Impact of Nitrogen Fertilizer on the Mycorrhizal Inoculating Potential and Fungal Community Structure in Rhizosphere of Medicinal Plant Curcuma longa L.

Hoang, C. K., Pham, N. H., Le, C. H., Tran, H. T. N., Dang, H. T. C., Chu, H. H., Brouwer, B. & Le, H. M., 2019, In : Geomicrobiology Journal. 36, 5, p. 385-395 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Fungal Structures
Nitrogen fertilizers
Curcuma
Rhizosphere
medicinal plant

Screening white-rot fungi for bioremediation potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin

Dao, A. T. N., Vonck, J., Janssens, T. K. S., Dang, H. T. C., Brouwer, A. & de Boer, T. E., Feb 2019, In : Industrial Crops and Products. 128, p. 153-161 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

tetrachlorodibenzo-p-dioxin
white-rot fungi
bioremediation
laccase
dioxins
2018

Diversity and functions of bacteria associated with springtails

Agamennone, V., 2018, 160 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive

Escher, B. I., Aїt-Aїssa, S., Behnisch, P. A., Brack, W., Brion, F., Brouwer, A., Buchinger, S., Crawford, S. E., Du Pasquier, D., Hamers, T., Hettwer, K., Hilscherová, K., Hollert, H., Kase, R., Kienle, C., Tindall, A. J., Tuerk, J., van der Oost, R., Vermeirssen, E. & Neale, P. A., Jul 2018, In : Science of the Total Environment. 628-629, July, p. 748-765 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bioassay
Surface waters
bioassay
surface water
Water

Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity

van Vugt-Lussenburg, B. M. A., van der Lee, R. B., Man, H. Y., Middelhof, I., Brouwer, A., Besselink, H. & van der Burg, B., Jan 2018, In : Reproductive Toxicology. 75, p. 40-48 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bioassay
Reporter Genes
Biological Assay
Assays
Genes

Steroid hormonal bioactivities, culprit natural and synthetic hormones and other emerging contaminants in waste water measured using bioassays and UPLC-tQ-MS

Houtman, C. J., ten Broek, R. & Brouwer, A., 15 Jul 2018, In : Science of the Total Environment. 630, p. 1492-1501 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

bioactivity
Bioassay
Hormones
steroid
Bioactivity
2017

Development and validation of an on-linewater toxicity sensor with immobilized luminescent bacteria for on-line surface water monitoring

Woutersen, M., Van Der Gaag, B., Boakye, A. A., Mink, J., Marks, R. S., Wagenvoort, A. J., Ketelaars, H. A. M., Brouwer, B. & Heringa, M. B., 22 Nov 2017, In : Sensors (Switzerland). 17, 11, 2682.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
surface water
Surface waters
toxicity
bacteria
Toxicity

SIMONI (smart integrated monitoring) as a novel bioanalytical strategy for water quality assessment: Part i–model design and effect-based trigger values

van der Oost, R., Sileno, G., Suárez-Muñoz, M., Nguyen, M. T., Besselink, H. & Brouwer, A., 1 Sep 2017, In : Environmental Toxicology and Chemistry. 36, 9, p. 2385-2399 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Water Quality
Water quality
Hazards
hazard
water quality

SIMONI (Smart Integrated Monitoring) as a novel bioanalytical strategy for water quality assessment: Part II–field feasibility survey

van der Oost, R., Sileno, G., Janse, T., Nguyen, M. T., Besselink, H. & Brouwer, A., 1 Sep 2017, In : Environmental Toxicology and Chemistry. 36, 9, p. 2400-2416 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bioassay
Water Quality
Biological Assay
Water quality
bioassay
2013

Applicability of functional genomics tools for water quality assessment

van der Linden, S. C., 2013, 128 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Development and validation of an on-line water toxicity sensor based on genetically modified, luminescent bacteria

Woutersen, M., 2013, Bilthoven: GVO drukkers & vormgevers. 143 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
2012
Sewage lagoons
Iron ores
Retinoids
coastal lagoon
iron ore

Influence of prenatal organohalogen levels on infant male sexual development: sex hormone levels, testes volume and penile length

Meijer, L., Martijn, A., Melessen, J., Brouwer, A., Weiss, J. M., de Jong, F. H. & Sauer, P. J. J., 2012, In : Human Reproduction. 27, 3, p. 867-872 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Sexual Development
Gonadal Steroid Hormones
Testis
Pentachlorophenol
Testosterone

Toxicological risks to humans of toxaphene residues in fish

Leonards, P. E. G., Besselink, H. T., Klungsøyr, J., McHugh, B., Nixon, E., Rimkus, G. G., Brouwer, A. & de Boer, J., 2012, In : Integrated Environmental Assessment and Management. 8, 3, p. 523-529

Research output: Contribution to JournalArticleAcademicpeer-review

fishery
fish
tumor
Norway
Ireland
Open Access
File
2011

Identification of major dioxin-like compounds and androgen receptor antagonist in acid-treated tissue extracts of high trophic-level animals

Suzuki, G., Tue, N. M., van der Linden, S. C., Brouwer, A., van der Burg, B., van Velzen, M. J. M., Lamoree, M. H., Someya, M., Takahashi, S., Isobe, T., Tajima, S., Yamada, T. K., Takigami, H. & Tanabe, S., 2011, In : Environmental Science and Technology. 45, p. 10203-10211 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Androgen Receptor Antagonists
Dioxins
Tissue Extracts
Luciferases
Gene Expression
2010

Evaluation of potential bioaccumulative compounds exerting endocrine-disrupting activities in wild animals using vitro bioassays and chemical fractionation

Suzuki, G., Tue, N. M., ven der Linden, S., Someya, M., Takahashi, S., Brouwer, A., van der Burg, B., Lamoree, M. H., van Velzen, M., Isobe, T., Tajima, Y., Yamada, T. & Tanabe, S., 2010.

Research output: Contribution to ConferencePosterOther research output

Lysyl Oxidases in Zebrafish Craniofacial Development and Teratogenesis

van Boxtel, A. L., 2010, Amsterdam: Vrije Universiteit. 144 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
2009

Reduced egg laying caused by a male accessory gland product opens the possibility for sexual conflict in a simultaneous hermaphrodite.

Koene, J. M., Brouwer, A. & Hoffer, J. N. A., 2009, In : Animal Biology. 59, p. 435-448

Research output: Contribution to JournalArticleAcademicpeer-review

sexual conflict
hermaphrodite
fertilization (reproduction)
oviposition
spermatozoa
2008

A genomics approach to identifying mechanisms of developmental toxicity in zebrafish

van Boxtel, A. L., Brouwer, A., van der Burg, B., Bergman, A. & Legler, J., 2008.

Research output: Contribution to ConferencePosterOther research output

Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2',4,4'-brominated diphenyl ether (BDE-47)

Hamers, T., Kamstra, J. H., Sonneveld, E., Murk, A. J., Visser, T. J., van Velzen, M. J. M., Brouwer, A. & Bergman, A., 2008, In : Molecular Nutrition and Food Research. 52, 2, p. 284-298 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Flame Retardants
flame retardants
Biotransformation
biotransformation
Prealbumin

Detection of multiple hormonal activities in wastewater effluents and surface water, using a panel of steroid receptor CALUX bioassays

van der Linden, S. C., Heringa, M. B., Man, H. Y., Sonneveld, E., Puijker, L. M., Brouwer, A. & van der Burg, B., 2008, In : Environmental Science and Technology. 42, 15, p. 5814-5820 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

steroid
hormone
androgen
bioassay
effluent

Effects of iron-ore mining and processing on metal bioavailability in a tropical coastal lagoon

Pereira, A. A., van Hattum, A. G. M., Brouwer, A., van Bodegom, P. M., Rezende, C. E. & Salomons, W., 2008, In : Journal of Soils and Sediments. 8, 4, p. 239-252

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
coastal lagoon
iron ore
bioavailability
metal
lagoon

Evaluation of tumour promoting potency of fish borne toxaphene residues as compared to technical toxaphene and uv-irradiated toxaphene

Besselink, H. T., Nixon, E., McHugh, B., Rimkus, G., Klungsoyr, J., Leonards, P. E. G., de Boer, J. & Brouwer, A., 2008, In : Food and Chemical Toxicology. 46, 8, p. 2629-2638 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Toxaphene
toxaphene
Fish
Tumors
Fishes

Microarray analysis reveals a mechanism of phenolic polybrominated diphenylether toxicity in zebrafish

van Boxtel, A. L., Kamstra, J. H., Cenijn, P. H., Pieterse, B., Wagner, M. J., Antink, M., Krab, K., van der Burg, B., Marsh, G., Brouwer, A. & Legler, J., 2008, In : Environmental Science and Technology. 42, 5, p. 1773-1779 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Zebrafish
Microarray Analysis
Oxidative Phosphorylation
Electron Transport Complex II
Aquatic Organisms

Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in the Netherlands

Meijer, L., Weiss, J. M., van Velzen, M. J. M., Brouwer, A., Bergman, A. & Sauer, P. J. J., 2008, In : Environmental Science and Technology. 42, p. 3428-3433

Research output: Contribution to JournalArticleAcademicpeer-review

Netherlands
Pregnant Women
Serum
2,4,5,2',4',5'-hexachlorobiphenyl
Mothers

Statistical analysis of geochemical processes, speciation and bioavailability of trace metals in a tropical coastal lagoon

Alves Pereira Wilken, A., van Hattum, A. G. M., Brouwer, A., van Bodegom, P. M., Rezende, C. E. & Salomons, W., 2008, In : Journal of Soils and Sediments. 8, p. 239-252

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
coastal lagoon
bioavailability
trace metal
statistical analysis
metal
2007

Biomonitoring of estrogenic exposure and identification of responsible compounds in bream from Dutch surface waters.

Houtman, C. J., Booij, P., van der Valk, K. M., van Bodegom, P. M., van den Ende, F., Gerritsen, A. A. M., Lamoree, M. H., Legler, J. & Brouwer, A., 2007, In : Environmental Toxicology and Chemistry. 26, 5, p. 898-907

Research output: Contribution to JournalArticleAcademicpeer-review

Environmental Monitoring
biomonitoring
Gastrointestinal Contents
estrogenic compound
Surface waters

Glucocorticoid-enhanced expression of dioxin target genes through regulation of the rat aryl hydrocarbon receptor

Sonneveld, E., Jonas, A. J. G., Meijer, O. C., Brouwer, A. & van der Burg, B., 2007, In : Toxicological Sciences. 99, 2, p. 455-469 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

Post-mortem stability of blubber DLCs, PCB and tDDT in by-caught harbour porpoises (Phocoena phocoena)

Borrell, A., Aquilar, A., Zeljkovic, S., Brouwer, A., Besselink, H. T., Koopman, H., Read, A. & Reijnders, P. J., 2007, In : Marine Pollution Bulletin. 54, 10, p. 1663-1666 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Sample preparation method for the ER-CALUX bioassay screening of (xeno-)estrogenic activity in sediment extracts

Houtman, C. J., Leonards, P. E. G., Kapiteijn, W., Bakker, J. F., Brouwer, A., Lamoree, M. H., Legler, J. & Klamer, H. J. C., 2007, In : Science of the Total Environment. 386, p. 134-144 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bioassay
sample preparation
Luciferases
Gene expression
Estrogen Receptors

Tracing endocrine disruptors: Identification and effects of endocrine disrupting compounds in the aquatic environment

Houtman, C. J., 2007, 144 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
2006

Applications of in vitro screening tools to support risk assessment of brominated flame retardants

Hamers, T. H. M., Kamstra, J. H., Sonneveld, E., Brouwer, A., Murk, A. J., Andersson, P. L., Boon, J. P., van der Ven, L. T. M., Hopman-Ubbels, G. H. J., Swart, C. P., Leonards, P. E. G. & Legler, J., 2006, In : Organohalogen Compounds. 68, p. 976-979 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Biological validation of a sample preparation method for ER-CALUX bioanalysis of estrogenic activity in sediments using mixtures of xeno-estrogens

Houtman, C. J., Houten, Y. K., Leonards, P. E. G., Brouwer, A., Lamoree, M. H. & Legler, J., 2006, In : Environmental Science and Technology. 40, 7, p. 2455-2461 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Estrogens
Sediments
Trichloroethanes
Recovery
Dichloroethylenes

Blue-green catastrophe: remote sensing of mass viral lysis of cyanobacteria

Simis, S. G. H., 2006, Amsterdam: Instituut voor Milieuvraagstukken. 144 p.

Research output: PhD ThesisPhD Thesis - Research external, graduation VUAcademic

Open Access
File

Comparison of in vitro and in vivo screening models for androgenic and estrogenic activities

Sonneveld, E., Jansen, H. J., Man, S., Jonas, A. J. G., Brouwer, A. & van der Burg, B., 2006, In : Toxicological Sciences. 89, p. 173-187 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Luciferases
Assays
Screening
Reporter Genes
Gene expression

Development of Calux bioassay-based systems as instruments to detect hormones and contaminants

Brouwer, A., Sonneveld, E., Sterk, S., Stephany, R. & van der Burg, B., 2006, In : Journal of Veterinary Pharmacology and Therapeutics. 29, 51, p. 55-56 2 p.

Research output: Contribution to JournalArticleAcademic

adrenergic receptors
Vascular Smooth Muscle
blood vessels
Biological Assay
smooth muscle

Development of CALUX bioassay-based systems as instruments to detect hormones and contaminants

Brouwer, A., Sonneveld, E., Sterk, S., Stephany, R. & van der Burg, B., 2006, In : Journal of Veterinary Pharmacology and Therapeutics. 29, 51, p. 35-35 1 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File

Expression profiling of zebrafish embryonic fibroblast cells exposed to 6-OH-BDE 47

van Boxtel, A. L., Cenijn, P. H., Kamstra, J. H., Hamers, T. H. M., Bergman, Å., Pieterse, B., Brouwer, A. & Legler, J., 2006.

Research output: Contribution to ConferencePosterOther research output

Glucocorticoid mediated expression of dioxin target genes in rat H4IIe cells but not in human HepG2 and T47D cells

Sonneveld, E., Jansen, H. J., Man, S., Jonas, A. J. G., Brouwer, A. & van der Burg, B., 2006, In : Organohalogen Compounds. V, p. 1-4 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Glucocorticoid mediated expression of dioxin target genes in rat H4IIe cells but not in human HepG2 and T47D cells

Sonneveld, E., Jansen, H. J., Man, S., Jonas, A. J. G., Brouwer, A. & van der Burg, B., 2006, In : Organohalogen Compounds. 68, p. 564-567 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

In vitro profiling of the endocrine-disrupting potency of brominated flame retardants

Hamers, T. H. M., Kamstra, J. H., Sonneveld, E., Murk, A. J., Kester, M. H. A., Andersson, P. L., Legler, J. & Brouwer, A., 2006, In : Toxicological Sciences. 92, 1, p. 157-173 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Flame Retardants
Androgen Receptors
Halogenated Diphenyl Ethers
Prealbumin
Progesterone Receptors

Prenatal exposure of rats to hydroxylated PCBs and some brominated flame retardants

Buitenhuis, C. J. K., Cenijn, P. H., van Velzen, M. J. M., Lilienthal, H., Malmberg, T., Bergman, Å., Gutleb, A. C., Legler, J. & Brouwer, A., 2006, Amsterdam: Instituut voor Milieuvraagstukken. 7 p. (IVM Report; no. I-06/01)

Research output: Book / ReportReportAcademic

Toxicological risks to humans of toxaphene residues in fish.

Leonards, P. E. G., Besseling, H., Brouwer, A., McHigh, B., Nixon, E., Rimkus, G. G. & de Boer, J., 2006.

Research output: Contribution to ConferencePosterOther research output

2005

Bio/chemical analysis of dioxin-like compounds in sediment samples from Osaka Bay, Japan

Takigami, H., Sakai, S. & Brouwer, A., 2005, In : Environmental Technology. 26, 4, p. 459-469 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

Development of androgen-and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays

Sonneveld, E., Jansen, H. J., Riteco, J. A. C. & Brouwer, A., 2005, In : Toxicological Sciences. 83, 1, p. 136-148 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Bioassay
Androgen Receptors
Luciferases
Biological Assay
Androgens

Estrogenic mixture effects in the ER-CALUX® assay used for the biological validation of an extraction and clean up method for sediments

Houtman, C. J., Houten, Y. K., Kapiteijn, W., Leonards, P. E. G., Lamoree, M. H., Legler, J. & Brouwer, A., 2005.

Research output: Contribution to ConferencePosterOther research output