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Anja Wilmes graduated with a Diplom in “Biology” from the University of Heidelberg, Germany in 2004. She then completed her PhD thesis in “Cell and Molecular Biology” in 2008 at Victoria University of Wellington, New Zealand under the supervision of Prof. John Miller. Her PhD thesis was entitled “Differences in Mode of Action between Peloruside A and Paclitaxel, two Microtubule Stabilizing Agents”. She joined Pauls Jenning’s group at the Medical University of Innsbruck, Austria as a PostDoc in 2009 where she habilitated in “Physiology” with the thesis "Molecular investigations of chemical stress induction in the renal proximal tubule” in 2016. In 2017, she won the Otto-Kraupp prize for her habilitation. Her work focuses on the development of human renal cell culture models for toxicity screening with a major focus on iPS cell differentiation into proximal tubular cells and glomerulus cells. She is currently involved in the StemBANCC and the in3 project. Her works also focusses on studying functional roles of claudin expression and water transport in renal proximal tubular epithelial cells. 

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Toxicity Chemical Compounds
Kidney Medicine & Life Sciences
Metabolomics Medicine & Life Sciences
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Cell culture Chemical Compounds
Proximal Kidney Tubule Medicine & Life Sciences
Oxidative stress Chemical Compounds
Cell Culture Techniques Medicine & Life Sciences

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Research Output 2004 2018

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

Limonciel, A., Ates, G., Carta, G., Wilmes, A., Watzele, M., Shepard, P. J., VanSteenhouse, H. C., Seligmann, B., Yeakley, J. M., van de Water, B., Vinken, M. & Jennings, P., Aug 2018, In : Archives of Toxicology. 92, 8, p. 2517-2531 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Workflow
Toxic Actions
Costs and Cost Analysis
Glycolysis
Computational Biology

Differentiation of human iPSCs into functional podocytes

Rauch, C., Feifel, E., Kern, G., Murphy, C., Meier, F., Parson, W., Beilmann, M., Jennings, P., Gstraunthaler, G. & Wilmes, A., Sep 2018, In : PLoS ONE. e0203869

Research output: Contribution to JournalArticleAcademicpeer-review

Investigation of Nrf2, AhR and ATF4 activation in toxicogenomic databases

Zgheib, E., Limonciel, A., Jiang, X., Wilmes, A., Wink, S., Van De Water, B., Kopp-Schneider, A., Bois, F. Y. & Jennings, P., 2 Oct 2018, In : Frontiers in Genetics. 9, October, p. 1-17 17 p., 429

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Toxicogenetics
Chemical Safety
Databases
Computational Biology
Toxicology

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

Limonciel, A., van Breda, S. G., Jiang, X., Tredwell, G. D., Wilmes, A., Aschauer, L., Siskos, A. P., Sachinidis, A., Keun, H. C., Kopp-Schneider, A., de Kok, T. M., Kleinjans, J. C. S. & Jennings, P., 2018, In : Frontiers in Genetics. 9, p. 558

Research output: Contribution to JournalArticleAcademicpeer-review

Epigenomics
Histones
Acetylation
Gene Expression
DNA Methylation

Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion

Wilmes, A., Rauch, C., Carta, G., Kern, G., Meier, F., Posch, W., Wilflingseder, D., Armstrong, L., Lako, M., Beilmann, M., Gstraunthaler, G. & Jennings, P., 1 Dec 2017, In : Toxicology in Vitro. 45, p. 445-454 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Induced Pluripotent Stem Cells
Acidification
Stem cells
Cell culture
Nutrients

Prizes

Otto Kraupp Preis

A. Wilmes (Recipient), 6 Jun 2017

Prize: Prize / AwardAcademic