20152018
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Ancillary activities

  • Aeolus Investments N.V. | Wormerveer | Directeur/eigenaar | 2018-07-01

Ancillary activities are updated daily

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 2 Similar Profiles
Phosphoric Diester Hydrolases Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
Trypanosoma brucei brucei Medicine & Life Sciences
Antiparasitic Agents Medicine & Life Sciences
Phosphodiesterase Inhibitors Medicine & Life Sciences
Surface Plasmon Resonance Medicine & Life Sciences
Surface plasmon resonance Chemical Compounds
Biosensing Techniques Medicine & Life Sciences

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Research Output 2015 2018

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Blaazer, A. R. , Singh, A. K. , De Heuvel, E. , Edink, E. , Orrling, K. M. , Veerman, J. J. N. , Van Den Bergh, T. , Jansen, C. , Balasubramaniam, E. , Mooij, W. J. , Custers, H. , Sijm, M. , Tagoe, D. N. A. , Kalejaiye, T. D. , Munday, J. C. , Tenor, H. , Matheeussen, A. , Wijtmans, M. , Siderius, M. , De Graaf, C. & 7 others Maes, L., De Koning, H. P., Bailey, D. S., Sterk, G. J., De Esch, I. J. P., Brown, D. G. & Leurs, R., 10 May 2018, In : Journal of Medicinal Chemistry. 61, 9, p. 3870-3888 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Phosphodiesterase Inhibitors
Phosphoric Diester Hydrolases
Parasites
African Trypanosomiasis
Trypanosoma brucei brucei

Surface plasmon resonance biosensor assay for the analysis of small-molecule inhibitor binding to human and parasitic phosphodiesterases.

Siderius, M. H., Shanmugham, A., England, P., van der Meer, T. K., Bebelman, J. P., Blaazer, A. R., de Esch, I. J. P. & Leurs, R., 2016, In : Analytical Biochemistry. 503, p. 41-49

Research output: Contribution to JournalArticleAcademicpeer-review

Surface Plasmon Resonance
Phosphoric Diester Hydrolases
Surface plasmon resonance
Biosensing Techniques
Biosensors

Exploration of the Molecular Architecture of the Orthosteric Binding Site in the 42 Nicotinic Acetylcholine Receptor with Analogs of 3-(Dimethylamino)butyl Dimethylcarbamate (DMABC) and 1-(Pyridin-3-yl)-1,4-diazepane

Bach, T. T., Jensen, A. A., Petersen, J. G., Sørensen, T. E., Della Volpe, S., Liu, J., Blaazer, A. R., van Muijlwijk-Koezen, J. E., Balle, T. & Frølund, B., 2015, In : European Journal of Medicinal Chemistry. 102, p. 425-444

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits

Blaazer, A. R., Orrling, K. M., Shanmugham, A., Jansen, C., Maes, L., Edink, E., Sterk, G. J., Siderius, M., England, P., Bailey, D., de Esch, I. J. P. & Leurs, R., Jan 2015, In : Journal of Biomolecular Screening. 20, 1, p. 131-140 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Antiparasitic Agents
African Trypanosomiasis
Screening
Trypanosoma brucei brucei
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