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Research Output 2013 2019

  • 19 Article
  • 1 Erratum
  • 1 PhD Thesis - Research VU, graduation VU
2019

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Davies, G. E., Ehli, E. A., Fedko, I. O., Groen-Blokhuis, M. M., Hammerschlag, A. R., Hottenga, J. J., Hudziak, J., Ouwens, K. G. & ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Jan 2019, In : Nature Genetics. 51, 1, p. 63-75 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Genome
Genome-Wide Association Study
Meta-Analysis
Population

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

The 23andMe Research Team, Mar 2019, In : Nature Genetics. 51, 3, p. 394-403 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Sleep Initiation and Maintenance Disorders
Genome
Sleep
Genes
Neurons

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Social Science Genetic Association Consortium, 23and Me Research Team, eQTLGen Consortium & International Cannabis Consortium, 1 Feb 2019, In : Nature Genetics. 51, 2, p. 245-257 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic Loci
Genome-Wide Association Study
Single Nucleotide Polymorphism
Computational Biology
Synaptic Transmission

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium, 7 Jan 2019, In : Molecular Psychiatry. p. 1-18 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic Loci
Meta-Analysis
Smoking
Nucleotides
Exome
2018

Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

CHD Exome+ Consortium & Consortium for Genetics of Smoking Behaviour, 6 Dec 2018, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Exome
Meta-Analysis
Smoking
Alcohols
Phenotype

Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use

Marees, A. T., Hammerschlag, A. R., Bastarache, L., de Kluiver, H., Vorspan, F., van den Brink, W., Smit, D. J., Denys, D., Gamazon, E. R., Li-Gao, R., Breetvelt, E. J., de Groot, M. C. H., Galesloot, T. E., Vermeulen, S. H., Poppelaars, J. L., Souverein, P. C., Keeman, R., de Mutsert, R., Noordam, R., Rosendaal, F. R. & 13 othersStringa, N., Mook-Kanamori, D. O., Vaartjes, I., Kiemeney, L. A., den Heijer, M., van Schoor, N. M., Klungel, O. H., Maitland-Van der Zee, A. H., Schmidt, M. K., Polderman, T. J. C., van der Leij, A. R., Posthuma, D. & Derks, E. M., 1 Jul 2018, In : Drug and Alcohol Dependence. 188, p. 94-101 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Tobacco
Tobacco Use
Alcohols
Alcohol Drinking
Exome

From genetic variants to biological pathways in neuropsychiatric traits

Hammerschlag, A. R., 2018, 191 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Savage, J. E., Jansen, P. R., Stringer, S., Watanabe, K., Bryois, J., de Leeuw, C. A., Nagel, M., Awasthi, S., Barr, P. B., Coleman, J. R. I., Grasby, K. L., Hammerschlag, A. R., Kaminski, J. A., Karlsson, R., Krapohl, E., Lam, M., Nygaard, M., Reynolds, C. A., Trampush, J. W., Young, H. & 97 othersZabaneh, D., Hägg, S., Hansell, N. K., Karlsson, I. K., Linnarsson, S., Montgomery, G. W., Muñoz-Manchado, A. B., Quinlan, E. B., Schumann, G., Skene, N. G., Webb, B. T., White, T., Arking, D. E., Avramopoulos, D., Bilder, R. M., Bitsios, P., Burdick, K. E., Cannon, T. D., Chiba-Falek, O., Christoforou, A., Cirulli, E. T., Congdon, E., Corvin, A., Davies, G., Deary, I. J., DeRosse, P., Dickinson, D., Djurovic, S., Donohoe, G., Conley, E. D., Eriksson, J. G., Espeseth, T., Freimer, N. A., Giakoumaki, S., Giegling, I., Gill, M., Glahn, D. C., Hariri, A. R., Hatzimanolis, A., Keller, M. C., Knowles, E., Koltai, D., Konte, B., Lahti, J., Le Hellard, S., Lencz, T., Liewald, D. C., London, E., Lundervold, A. J., Malhotra, A. K., Melle, I., Morris, D., Need, A. C., Ollier, W., Palotie, A., Payton, A., Pendleton, N., Poldrack, R. A., Räikkönen, K., Reinvang, I., Roussos, P., Rujescu, D., Sabb, F. W., Scult, M. A., Smeland, O. B., Smyrnis, N., Starr, J. M., Steen, V. M., Stefanis, N. C., Straub, R. E., Sundet, K., Tiemeier, H., Voineskos, A. N., Weinberger, D. R., Widen, E., Yu, J., Abecasis, G., Andreassen, O. A., Breen, G., Christiansen, L., Debrabant, B., Dick, D. M., Heinz, A., Hjerling-Leffler, J., Ikram, M. A., Kendler, K. S., Martin, N. G., Medland, S. E., Pedersen, N. L., Plomin, R., Polderman, T. J. C., Ripke, S., van der Sluis, S., Sullivan, P. F., Vrieze, S. I., Wright, M. J. & Posthuma, D., Jul 2018, In : Nature Genetics. 50, 7, p. 912-919 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Intelligence
Meta-Analysis
Mendelian Randomization Analysis
Genes

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

23Andme Research Team, Jul 2018, In : Nature Genetics. 50, 7, p. 920-927 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic Loci
Genome-Wide Association Study
Meta-Analysis
Mendelian Randomization Analysis
Psychiatry

MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission

He, E., Lozano, M. A. G., Stringer, S., Watanabe, K., Sakamoto, K., Oudsten, F. D., Koopmans, F., Giamberardino, S. N., Hammerschlag, A., Niels Cornelisse, L., Li, K. W., van Weering, J., Posthuma, D., Smit, A. B., Sullivan, P. F. & Verhage, M., 1 Jun 2018, In : Human Molecular Genetics. 27, 11, p. 1879-1891 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Internal-External Control
Synaptic Transmission
Synapses
Schizophrenia
Proteomics

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 30 othersFeitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Hammerschlag, A. R. & Polderman, T. J., Jan 2018, In : Nature Genetics. 50, 1, p. 26-41 22 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Energy Intake
Energy Metabolism
Body Mass Index
Obesity
Genes

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC-InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators & Understanding Society Scientific Group, 16 Mar 2018, In : Nature Genetics. 50, p. 1-2 2 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Energy Intake
Energy Metabolism
Names
Body Mass Index
Obesity
2017

Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Sniekers, S., Stringer, S., Watanabe, K., Jansen, P. R., Coleman, J. R. I., Krapohl, E., Taskesen, E., Hammerschlag, A. R., Okbay, A., Zabaneh, D., Amin, N., Breen, G., Cesarini, D., Chabris, C. F., Iacono, W. G., Ikram, M. A., Johannesson, M., Koellinger, P., Lee, J. J., Magnusson, P. K. E. & 10 othersMcGue, M., Miller, M. B., Ollier, W. E. R., Payton, A., Pendleton, N., Plomin, R., Rietveld, C. A., Tiemeier, H., van Duijn, C. M. & Posthuma, D., 27 Sep 2017, In : Nature Genetics. 49, 10, p. 1558

Research output: Contribution to JournalErratumAcademic

Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits

Hammerschlag, A. R., Stringer, S., de Leeuw, C. A., Sniekers, S., Taskesen, E., Watanabe, K., Blanken, T. F., Dekker, K., Te Lindert, B. H. W., Wassing, R., Jonsdottir, I., Thorleifsson, G., Stefansson, H., Gislason, T., Berger, K., Schormair, B., Wellmann, J., Winkelmann, J., Stefansson, K., Oexle, K. & 2 othersVan Someren, E. J. W. & Posthuma, D., Nov 2017, In : Nature Genetics. 49, 11, p. 1584-1592 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Sleep Initiation and Maintenance Disorders
Psychiatry
Restless Legs Syndrome
Genes

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Sniekers, S., Stringer, S., Watanabe, K., Jansen, P. R., Coleman, J. R. I., Krapohl, E., Taskesen, E., Hammerschlag, A. R., Okbay, A., Zabaneh, D., Amin, N., Breen, G., Cesarini, D., Chabris, C. F., Iacono, W. G., Ikram, M. A., Johannesson, M., Koellinger, P., Lee, J. J., Magnusson, P. K. E. & 10 othersMcGue, M., Miller, M. B., Ollier, W. E. R., Payton, A., Pendleton, N., Plomin, R., Rietveld, C. A., Tiemeier, H., van Duijn, C. M. & Posthuma, D., Jul 2017, In : Nature Genetics. 49, 7, p. 1107-1112 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Intelligence
Meta-Analysis
Genes
Single Nucleotide Polymorphism

Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior

Tielbeek, J. J., Johansson, A., Polderman, T. J. C., Rautiainen, M-R., Jansen, P., Taylor, M., Tong, X., Lu, Q., Burt, A. S., Tiemeier, H., Viding, E., Plomin, R., Martin, N. G., Heath, A. C., Madden, P. A. F., Montgomery, G., Beaver, K. M., Waldman, I., Gelernter, J., Kranzler, H. R. & 20 othersFarrer, L. A., Perry, J. R. B., Munafò, M., LoParo, D., Paunio, T., Tiihonen, J., Mous, S. E., Pappa, I., de Leeuw, C., Watanabe, K., Hammerschlag, A. R., Salvatore, J. E., Aliev, F., Bigdeli, T. B., Dick, D., Faraone, S. V., Popma, A., Medland, S. E., Posthuma, D. & Broad Antisocial Behavior Consortium collaborators, 1 Dec 2017, In : JAMA Psychiatry. 74, 12, p. 1242-1250 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Crime
Genome
Phenotype
Conduct Disorder
2016

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

Middeldorp, C. M., Hammerschlag, A. R., Ouwens, K. G., Blokhuis, M. M., St. Pourcain, B., Greven, C. U., Pappa, I., Tiesler, C. M. T., Ang, W., Nolte, I. M., Vilor-Tejedor, N., Bacelis, J., Ebejer, J. L., Zhao, H., Davies, G. E., Ehli, E. A., Evans, D. M., Fedko, I. O., Guxens, M., Hottenga, J. J. & 31 othersHudziak, J. J., Jugessur, A., Kemp, J. P., Krapohl, E., Martin, N. G., Murcia, M., Myhre, R., Ormel, J., Ring, S. M., Standl, M., Stergiakouli, E., Stoltenberg, C., Thiering, E., Timpson, N. J., Trzaskowski, M., van der Most, P. J., Wang, C., Nyholt, DR., Medland, S. E., Neale, B. M., Jacobsson, B., Sunyer, J., Hartman, C. A., Whitehouse, A. J. O., Pennell, C. E., Heinrich, J., Plomin, R., Davey Smith, G., Tiemeier, H., Posthuma, D. & Boomsma, D. I., 2016, In : Journal of the American Academy of Child and Adolescent Psychiatry. 55, 10, p. 896-905 10.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Attention Deficit Disorder with Hyperactivity
Single Nucleotide Polymorphism
Meta-Analysis
Pediatrics

Gene expression in major depressive disorder.

Jansen, R., Penninx, B. W. J. H., Madar, V., Xia, K., Milaneschi, Y., Hottenga, J. J., Hammerschlag, A. R., Beekman, A. T. F., van der Wee, N., Smit, J. H., Brooks, A. I., Tischfield, J., Posthuma, D., Schoevers, R., Grootheest, G., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Wright, F. A., Zou, F. & 2 othersSun, W. & Sullivan, P. F., 2016, In : Molecular Psychiatry. 21, p. 339 347 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Gene Expression
Multigene Family
Natural Killer Cells
Interleukin-6
2015

A Population-Based Imaging Genetics Study of Inattention/Hyperactivity: Basal Ganglia and Genetic Pathways.

Mous, S. E., Hammerschlag, A. R., Polderman, T. J., Verhulst, F. C., Tiemeier, H., van der Lugt, A., Jaddoe, V. W., Hofman, A., White, T. & Posthuma, D., 2015, In : Journal of the American Academy of Child and Adolescent Psychiatry. 2015, 54, p. 745-752 9.

Research output: Contribution to JournalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Basal Ganglia
Population
Putamen
Dopamine
2014
Open Access
Attention Deficit Disorder with Hyperactivity
Genes
Genome-Wide Association Study
Multifactorial Inheritance
Genomics
2013

Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia

Dopper, E. G. P., Rombouts, S. A. R. B., Jiskoot, L. C., den Heijer, T., de Graaf, J. R. A., de Koning, I., Hammerschlag, A. R., Seelaar, H., Seeley, W. W., Veer, I. M., van Buchem, M. A., Rizzu, P. & van Swieten, J. C., 2013, In : Neurology. 80, 9, p. 814-823

Research output: Contribution to JournalArticleAcademicpeer-review

Frontotemporal Dementia
Dementia
Diffusion Tensor Imaging
Gyrus Cinguli
Magnetic Resonance Imaging