Aurélien Zarca

M. Sc.

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Aurélien M. Zarca, from France, obtained his B. Sc. Degree in Biochemistry, and his M. Sc. Degree in Biotechnologies in 2013 at Université Joseph Fourier, Grenoble. After graduating, he worked for 18 months at Actelion Pharmaceuticals Ltd, Basel, in CNS Biology department, with focusing on signaling of class A GPCRs subfamily under the supervision of Dr. Xavier Leroy.


Since September 2015, he has been carrying out his Ph. D. under the supervision of Prof. Dr. Martine Smit, Prof. Dr. Rob Leurs and Dr. Henry Vischer at the Division of Medicinal Chemistry, Vrije Universiteit Amsterdam. His research is supported by a European Union's Horizon2020 MSCA Program in a Marie Curie ITN (ONCORNET). His research, entitled Differential phosphorylation of CXCR4 and CXCR7, focuses on developing assays to determine cell-type specific phosphorylation profiles and effector proteins, depending on different ligands, to unravel the mechanism of action of recycling/degradation, and working on signaling and screening of novel modulators of those receptors.

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Chemokine Receptors Medicine & Life Sciences
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CXCR4 Receptors Medicine & Life Sciences
Quantitative Structure-Activity Relationship Medicine & Life Sciences
Screening Chemical Compounds
HIV Medicine & Life Sciences
Pharmacology Medicine & Life Sciences
Ligands Medicine & Life Sciences

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Research Output 2018 2019

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists

Adlere, I., Sun, S., Zarca, A., Roumen, L., Gozelle, M., Viciano Perpiñá, C., Caspar, B., Arimont, M., Bebelman, J. P., Briddon, S. J., Hoffmann, C., Hill, S. J., Smit, M. J., Vischer, H. F., Wijtmans, M., de Graaf, C., de Esch, I. J. P. & Leurs, R., 15 Jan 2019, In : European Journal of Medicinal Chemistry. 162, p. 631-649 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

CXCR4 Receptors
Quantitative Structure-Activity Relationship
Chemokine Receptors

Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions

Bobkov, V., Zarca, A. M., Van Hout, A., Arimont, M., Doijen, J., Bialkowska, M., Toffoli, E., Klarenbeek, A., van der Woning, B., van der Vliet, H. J., Van Loy, T., de Haard, H., Schols, D., Heukers, R. & Smit, M. J., Dec 2018, In : Biochemical Pharmacology. 158, p. 413-424 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Single-Domain Antibodies
Chemokine Receptors