B. Teusink

prof. dr.

  • de Boelelaan 1108, O|2 building

    1081HZ Amsterdam

    Netherlands

  • de Boeleaan 1085, O|2 building, section Systems Bioinformatics, location code 2E51

    1081HV Amsterdam

    Netherlands

20052019
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Prof Bas Teusink is head of the Systems Bioinformatics group, which he runs together with prof Frank Bruggeman. The  group further consists of dr Douwe Molenaar (microbiology, bioinformatics, data analysis), dr Rob van Spanning (microbiology, bioenergetics), dr Johan van Heerden (single-cell physiology, microbiologist) and dr Herwig Bachmann (0.35 fte, microbiologist affiliated also to NIZO food research), supported by dr Jurgen Haanstra (managing director AIMMS, teaching coordinator) and dr Brett Olivier (biochemist, scientific programmer, data manager of AIMMS).

The lab contains a mix of disciplines, from theoretical to experimental, with state-of-the-art facilities for cell physiological work, from fermentation equipment to single-cell time-lapsed microscopy. These experimental activities are combined with modeling and theory, from the development of multivariate data analysis methods, to detailed kinetic models, to open-source software and standard developments for genome-scale metabolic models for dissemination to the scientific community, not in the least industrial partners. 

Prof Teusink’s main research interest is the design principles of biological networks. He studies how fundamental constraints and functional purposes of networks lead to the system specifications that determine the fittest designs. He combines excellence in such fundamental studies with industrially-oriented applied research, as is evident from the Midterm Carreer Award he received in 2014 from the Lactic Acid Bacteria Industrial Platform for excellent research with industrial relevance. 

He has been advisor for research programmes of DSM, Dupont USA and Braskem Brasil, as well as juror in several fundamental and applied funding schemes in the Netherlands, Germany and Denmark. He is part of the editorial boards of Molecular Biotechnology, BMC Systems Biology, BioEssays, Current Opinions in Systems Biology and Cell Systems.

He has coordinated both national (Kluyver Center for Genomics of Industrial Fermentations, Netherlands Consortium for System Biology) and international research programmes (Era-IB, SysMo-LAB). He has >100 publications, of which 3 patents.

Education/Academic qualification

PhD Systems Biology, PhD, University of Amsterdam

Keywords

  • Q Science (General)
  • systems biology
  • metabolism
  • modeling

Fingerprint Dive into the research topics where B. Teusink is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Metabolic Networks and Pathways Medicine & Life Sciences
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Metabolism Chemical Compounds

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Research Output 2005 2019

Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength

Price, C. E., Branco Dos Santos, F., Hesseling, A., Uusitalo, J. J., Bachmann, H., Benavente, V., Goel, A., Berkhout, J., Bruggeman, F. J., Marrink, S. J., Montalban-Lopez, M., De Jong, A., Kok, J., Molenaar, D., Poolman, B., Teusink, B. & Kuipers, O. P., 10 Jan 2019, In : BMC Evolutionary Biology. 19, 1, p. 1-15 15 p., 15.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
strength (mechanics)
glucose
mutation
chemostat
fitness

A genome-scale metabolic network of the aroma bacterium Leuconostoc mesenteroides subsp. cremoris

Özcan, E., Selvi, S. S., Nikerel, E., Teusink, B., Toksoy Öner, E. & Çakır, T., 1 Jan 2019, In : Applied Microbiology and Biotechnology.

Research output: Contribution to JournalArticleAcademicpeer-review

Metabolic Networks and Pathways
Citric Acid
Genome
Bacteria
phosphoketolase

A systematic assessment of current genome-scale metabolic reconstruction tools

Mendoza, S. N., Olivier, B. G., Molenaar, D. & Teusink, B., 7 Aug 2019, In : Genome Biology. 20, 1, 158.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Software
genome
Genome
software
Benchmarking

Finding functional differences between species in a microbial community: Case studies in wine fermentation and Kefir culture

Melkonian, C., Gottstein, W., Blasche, S., Kim, Y., Abel-Kistrup, M., Swiegers, H., Saerens, S., Edwards, N., Patil, K. R., Teusink, B. & Molenaar, D., 25 Jun 2019, In : Frontiers in Microbiology. 10, JUNE, p. 1-14 14 p., 01347.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Wine
Fermentation
Metagenomics
Gluconobacter
Pantoea

In vivo characterisation of fluorescent proteins in budding yeast

Botman, D., de Groot, D. H., Schmidt, P., Goedhart, J. & Teusink, B., 19 Feb 2019, In : Scientific Reports. 9, p. 1-14 14 p., 2234.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Saccharomycetales
Proteins
Codon
Yeasts
Saccharomyces cerevisiae