• de Boelelaan 1108, O|2 building

    1081HZ Amsterdam

    Netherlands

  • de Boeleaan 1085, O|2 building, section Systems Bioinformatics, location code 2E51

    1081HV Amsterdam

    Netherlands

20052018
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Personal information

Prof Bas Teusink is head of the Systems Bioinformatics group, which he runs together with prof Frank Bruggeman. The  group currently has 3 staf members: dr Douwe Molenaar (microbiology, bioinformatics, data analysis), dr Rob van Spanning (microbiology, bioenergetics), and dr Brett Olivier (biochemist, scientific programmer, data manager of AIMMS). The lab contains a mix of disciplines, from theoretical to experimental, with state-of-the-art facilities for cell physiological work, from fermentation equipment to single-cell time-lapsed microscopy. These experimental activities are combined with modeling and theory, from the development of multivariate data analysis methods, to detailed kinetic models, to open-source software and standard developments for genome-scale metabolic models for dissemination to the scientific community, not in the least industrial partners. 

Prof Teusink’s main research interest is the design principles of biological networks. He studies how fundamental constraints and functional purposes of networks lead to the system specifications that determine the fittest designs. He combines excellence in such fundamental studies with industrially-oriented applied research, as is evident from the Midterm Carreer Award he received in 2014 from the Lactic Acid Bacteria Industrial Platform for excellent research with industrial relevance. 

He has been advisor for research programmes of DSM, Dupont USA and Braskem Brasil, as well as juror in several fundamental and applied funding schemes in the Netherlands, Germany and Denmark. He is part of the editorial boards of Molecular Biotechnology, BMC Systems Biology, BioEssays and Current Opinions in Systems Biology (a new journal launched in 2017).

He has coordinated both national (Kluyver Center for Genomics of Industrial Fermentations, Netherlands Consortium for System Biology) and international research programmes (Era-IB, SysMo-LAB). He has >100 publications, of which 3 patents.

Education/Academic qualification

PhD Systems Biology, PhD, University of Amsterdam

Keywords

  • Q Science (General)
  • systems biology
  • metabolism
  • modeling

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Bacteria Chemical Compounds
Metabolism Chemical Compounds
Lactic Acid Medicine & Life Sciences

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Research Output 2005 2018

An integrated model quantitatively describing metabolism, growth and cell cycle in budding yeast

Palumbo, P., Vanoni, M., Papa, F., Busti, S., Wortel, M., Teusink, B. & Alberghina, L., 2018, Artificial Life and Evolutionary Computation - 12th Italian Workshop, WIVACE 2017, Revised Selected Papers. Springer/Verlag, p. 165-180 16 p. (Communications in Computer and Information Science; vol. 830)

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

Integrated Model
Cell Cycle
Metabolism
Yeast
Cells

Constraint-based models of microbial physiology: Surprisingly versatile

Teusink, B., Planqué, B., Molenaar, D. & Bruggeman, F., 1 Jan 2018, 10th International Conference on Simulation and Modelling in the Food and Bio-Industry 2018, FOODSIM 2018. Eurosis, p. 5-10 6 p.

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

microbial physiology
Physiology
Fluxes
Microbiological Phenomena
Growth

Dynamic elementary mode modelling of non-steady state flux data

Folch-Fortuny, A., Teusink, B., Hoefsloot, H. C. J., Smilde, A. K. & Ferrer, A., 18 Jun 2018, In : BMC Systems Biology. 12, p. 1-15 15 p., 71

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolic Flux Analysis
Fluxes
Discriminant Analysis
Metabolic Networks and Pathways
Modeling

Further elucidation of galactose utilization in Lactococcus lactis MG1363

Solopova, A., Bachmann, H., Teusink, B., Kok, J. & Kuipers, O. P., 3 Aug 2018, In : Frontiers in Microbiology. 9, AUGUST, p. 1-9 9 p., 1803

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
Galactose
Lactose
Lactococcus
Membrane Transport Proteins

Low affinity uniporter carrier proteins can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M. J., De La Torre Cortés, P. & Teusink, B., 3 Apr 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 5576

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Facilitated Diffusion
Facilitative Glucose Transport Proteins
Glycolysis
Saccharomyces cerevisiae
Carrier Proteins

Prizes

VICI personal grant

B. Teusink (Recipient), 1 Jan 2015

Prize: Prize / AwardAcademic