B. Teusink

prof. dr.

  • de Boelelaan 1108, O|2 building

    1081HZ Amsterdam

    Netherlands

  • de Boeleaan 1085, O|2 building, section Systems Bioinformatics, location code 2E51

    1081HV Amsterdam

    Netherlands

20052019
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Research Output 2005 2019

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Article
2019

Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength

Price, C. E., Branco Dos Santos, F., Hesseling, A., Uusitalo, J. J., Bachmann, H., Benavente, V., Goel, A., Berkhout, J., Bruggeman, F. J., Marrink, S. J., Montalban-Lopez, M., De Jong, A., Kok, J., Molenaar, D., Poolman, B., Teusink, B. & Kuipers, O. P., 10 Jan 2019, In : BMC Evolutionary Biology. 19, 1, p. 1-15 15 p., 15.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
strength (mechanics)
glucose
mutation
chemostat
fitness

A genome-scale metabolic network of the aroma bacterium Leuconostoc mesenteroides subsp. cremoris

Özcan, E., Selvi, S. S., Nikerel, E., Teusink, B., Toksoy Öner, E. & Çakır, T., 1 Jan 2019, In : Applied Microbiology and Biotechnology.

Research output: Contribution to JournalArticleAcademicpeer-review

Metabolic Networks and Pathways
Citric Acid
Genome
Bacteria
phosphoketolase

A systematic assessment of current genome-scale metabolic reconstruction tools

Mendoza, S. N., Olivier, B. G., Molenaar, D. & Teusink, B., 7 Aug 2019, In : Genome Biology. 20, 1, 158.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Software
genome
Genome
software
Benchmarking

Finding functional differences between species in a microbial community: Case studies in wine fermentation and Kefir culture

Melkonian, C., Gottstein, W., Blasche, S., Kim, Y., Abel-Kistrup, M., Swiegers, H., Saerens, S., Edwards, N., Patil, K. R., Teusink, B. & Molenaar, D., 25 Jun 2019, In : Frontiers in Microbiology. 10, JUNE, p. 1-14 14 p., 01347.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Wine
Fermentation
Metagenomics
Gluconobacter
Pantoea

In vivo characterisation of fluorescent proteins in budding yeast

Botman, D., de Groot, D. H., Schmidt, P., Goedhart, J. & Teusink, B., 19 Feb 2019, In : Scientific Reports. 9, p. 1-14 14 p., 2234.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Saccharomycetales
Proteins
Codon
Yeasts
Saccharomyces cerevisiae

The number of active metabolic pathways is bounded by the number of cellular constraints at maximal metabolic rates

de Groot, D. H., van Boxtel, C., Planque, R., Bruggeman, F. J. & Teusink, B., 11 Mar 2019, In : PLoS Computational Biology. 15, 3, p. 1-24 24 p., e1006858.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolic Networks and Pathways
biochemical pathways
Pathway
enzyme
Fluxes
2018

Dynamic elementary mode modelling of non-steady state flux data

Folch-Fortuny, A., Teusink, B., Hoefsloot, H. C. J., Smilde, A. K. & Ferrer, A., 18 Jun 2018, In : BMC Systems Biology. 12, p. 1-15 15 p., 71.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolic Flux Analysis
Fluxes
Discriminant Analysis
Metabolic Networks and Pathways
Modeling

Further elucidation of galactose utilization in Lactococcus lactis MG1363

Solopova, A., Bachmann, H., Teusink, B., Kok, J. & Kuipers, O. P., 3 Aug 2018, In : Frontiers in Microbiology. 9, AUGUST, p. 1-9 9 p., 1803.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
Galactose
Lactose
Lactococcus
Membrane Transport Proteins

Low affinity uniporter carrier proteins can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M. J., De La Torre Cortés, P. & Teusink, B., 3 Apr 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 5576.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Facilitated Diffusion
Facilitative Glucose Transport Proteins
Glycolysis
Saccharomyces cerevisiae
Carrier Proteins

Maintaining maximal metabolic flux by gene expression control

Planqué, R., Hulshof, J., Teusink, B., Hendriks, J. C. & Bruggeman, F. J., 20 Sep 2018, In : PLoS Computational Biology. 14, 9, p. 1-20 20 p., e1006412.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolites
Metabolic Networks and Pathways
Gene expression
Gene Expression
gene expression

Training for translation between disciplines: A philosophy for life and data sciences curricula

Anton Feenstra, K., Abeln, S., Westerhuis, J. A., Brancos Dos Santos, F., Molenaar, D., Teusink, B., Hoefsloot, H. C. J. & Heringa, J., 1 Jul 2018, In : Bioinformatics. 34, 13, p. i4-i12 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Understanding start-up problems in yeast glycolysis

Overal, G. B., Teusink, B., Bruggeman, F. J., Hulshof, J. & Planqué, R., May 2018, In : Mathematical Biosciences. 299, May, p. 117-126 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Glycolysis
Start-up
glycolysis
Yeast
Yeasts
2017

Low affinity membrane transporters can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M., de la Torre Cortés, P. & Teusink, B., 2 Nov 2017, In : bioRxiv.

Research output: Contribution to JournalArticleAcademic

Maintaining maximal metabolic rates by gene expression control

Planque, R., Hulshof, J., Teusink, B., Hendriks, J. C. & Bruggeman, F. J., 9 Mar 2017, In : bioRxiv.

Research output: Contribution to JournalArticleAcademicpeer-review

Model-based quantification of metabolic interactions from dynamic microbial-community data

Hanemaaijer, M., Olivier, B. G., Röling, W. F. M., Bruggeman, F. J. & Teusink, B., 1 Mar 2017, In : PLoS ONE. 12, 3, e0173183.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Microbial Interactions
Coculture Techniques
microbial communities
Hydrogen
Wolinella

Probing the genome-scale metabolic landscape of Bordetella pertussis, the causative agent of whooping cough

dos Santos, F. B., Olivier, B. G., Boele, J., Krumpochova, P., Klau, G. W., Giera, M. & Teusink, B., 1 Nov 2017, In : Applied and Environmental Microbiology. 83, 21

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Bordetella pertussis
whooping cough
Whooping Cough
thiosulfate
physiology

Systems biology of lactic acid bacteria: For food and thought

Teusink, B. & Molenaar, D., 1 Dec 2017, In : Current Opinion in Systems Biology. 6, p. 7-13 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Systems Biology
Lactic acid
Bacteria
Lactic Acid
Food
2016

Constraint-based stochiometric modelling from single organisms to microbial communities.

Gottstein, W. G., Olivier, B. G., Bruggeman, F. J. & Teusink, B., 2016, In : Journal of the Royal Society Interface. 13, 124, 20160627.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Evolutionary pressures on microbial metabolic strategies in the chemostat.

Wortel, M. T., Bosdriesz, E., Teusink, B. & Bruggeman, F. J., 2016, In : Scientific Reports. 6, 29503.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-scale reconstruction of the Streptococcus pyogenes M49 metabolic network reveals growth requirements and indicates potential drug targets.

Levering, J., Fiedler, T., Sieg, A., van Grinsven, K. W., Hering, S., Veith, N., Olivier, B. G., Klett, L., Hugenholtz, J., Teusink, B., Kreikemeyer, B. & Kummer, U., 2016, In : Journal of Biotechnology. 232, p. 25-37

Research output: Contribution to JournalArticleAcademicpeer-review

Modelling? Using standards can help you.

Olivier, B. G. & Teusink, B., 2016, In : ERCIM NEWS. 104, p. 34-38

Research output: Contribution to JournalArticleProfessional

Public goods and metabolic strategies

Bachmann, H., Bruggeman, F. J., Molenaar, D., Santos, F. & Teusink, B., Jun 2016, In : Current Opinion in Microbiology. 31, p. 109-115

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Strategies for structuring interdisciplinary education in Systems Biology: an European perspective.

Cvijovic, M., Hofer, T., Acimovic, J., Alberghina, L., Almaas, E., Besozzi, D., Blomberg, A., Bretschneider, T., Cascante, M., Collin, O., de Atauri, P., Depner, C., Dickinson, R., Dobrzynski, M., Fleck, C., Garcia-Ojalvo, J., Gonze, D., Hahn, J., Hess, H. M., Hollmann, S. & 13 othersKrantz, M., Kummer, U., Lundh, T., Martial, G., Martins dos Santos, V., Mauer-Oberthur, A., Regierer, B., Skene, B., Stalidzans, E., Stelling, J., Teusink, B., Workman, C. T. & Hohmann, S., 2016, In : NPJ systems biology and applications. 2, 16011.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2015

A novel consortium of Lactobacillus rhamnosus and Streptococcus thermophilus for increased access to functional fermented foods

Kort, R., Westerik, N., Mariela Serrano, L., Douillard, F. P., Gottstein, W. G., Mukisa, I. M., Tuijn, C. J., Basten, L., Hafkamp, B., Meijer, W. C., Teusink, B., de Vos, W. M., Reid, G. & Sybesma, W., 2015, In : Microbial Cell Factories. 14, 195

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactobacillus rhamnosus
Streptococcus thermophilus
Functional Food
Bacteria
Starters

Binding proteins enhance specific uptake rate by increasing the substrate-transporter encounter rate.

Bosdriesz, E., Magnúsdóttir, S., Bruggeman, F. J., Teusink, B. & Molenaar, D., 2015, In : The FEBS Journal. 282, p. 2394-2407 12.

Research output: Contribution to JournalArticleAcademicpeer-review

Carrier Proteins
Substrates
Nutrients
Food
Active Biological Transport

Evolutionary engineering to enhance starter culture performance in food fermentations.

Bachmann, H., Pronk, J. T., Kleerebezem, M. & Teusink, B., 2015, In : Current Opinion in Biotechnology. p. 1-7 32.

Research output: Contribution to JournalArticleAcademicpeer-review

Starters
Fermentation
Phenotype
Food
Flavors

How fast-growing bacteria robustly tune their ribosome concentration to approximate growth-rate maximization.

Bosdriesz, E., Molenaar, D., Teusink, B. & Bruggeman, F. J., 2015, In : The FEBS Journal. 282, p. 2029-2044 10.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Ribosomes
Bacteria
Escherichia coli
Growth
Ribosomal Proteins

Interplay between constraints, objectives, and optimality for genome-scale stoichiometric models.

Maarleveld, T. R., Wortel, M. T., Olivier, B. G., Teusink, B. & Bruggeman, F. J., 2015, In : PLoS Computational Biology. 7, 11, 4.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolic Networks and Pathways
Optimality
Genome
genome
Genes

Metabolism at Evolutionary Optimal States.

Rabbers, I., van Heerden, J. H., Nordholt, N., Bachmann, H., Teusink, B. & Bruggeman, F. J., 2015, In : Metabolites. 5, 2, p. 311-343

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

MetDFBA: incorporating time-resolved metabolomics measurements into dynamic flux balance analysis.

Willemsen, A. M., Hedrickx, D. M., Hoefsloot, H. C., Hendriks, M. M. W. B., Wahl, S. A., Teusink, B., Smilde, A. K. & van Kampen, A. H. C., 2015, In : Molecular BioSystems. 11, 11, p. 137-145 1.

Research output: Contribution to JournalArticleAcademicpeer-review

Metabolomics
Systems Biology

Multi-tasking of biosynthetic and energetic functions of glycolysis explained by supply and demand logic.

van Heerden, J. H., Bruggeman, F. J. & Teusink, B., 2015, In : BioEssays. 37, p. 34-45 1.

Research output: Contribution to JournalArticleAcademicpeer-review

Multitasking
Glycolysis
Metabolic Networks and Pathways
Biosynthesis
Free energy

Protein costs do not explain evolution of metabolic strategies and regulation of ribosomal content: does protein investment explain an anaerobic bacterial Crabtree effect?

Goel, A., Eckhardt, T. H., Puri, P., de Jong, A., Santos, F., Giera, M. A., Fusetti, F., Vos, W. M., Kok, J., Poolman, B., Molenaar, D., Kuipers, O. P. & Teusink, B., 2015, In : Molecular Microbiology. 97, p. 77-92 1.

Research output: Contribution to JournalArticleAcademicpeer-review

Fermentation
Costs and Cost Analysis
Glucose
Growth
Proteins

Systems modeling approaches for microbial community studies: from metagenomics to inference of the community structure

Hanemaaijer, M. J., Roling, W. F. M., Olivier, B. G., Khandelwal, R. A., Teusink, B. & Bruggeman, F. J., 2015, In : Frontiers in Microbiology. 6, 213.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metagenomics
Genome
Ecosystem
Theoretical Models
Occupational Health

Using a genome-scale metabolic model of Enterococcus faecalis V583 to assess amino acid uptake and its impact on central metabolism

Veith, N., Solheim, M., van Grinsven, K. W. A., Olivier, B. G., Levering, J., Grosseholz, R., Hugenholtz, J., Holo, H., Nes, I., Teusink, B. & Kummer, U., Mar 2015, In : Applied and Environmental Microbiology. 81, 5, p. 1622-1633 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Enterococcus faecalis
Metabolic Networks and Pathways
Metabolome
genome
amino acid
2014

A data integration and visualization resource for the metabolic network of synechocystis sp. PCC6803.

Maarleveld, T. R., Boele, J., Bruggeman, F. J. & Teusink, B., 2014, In : Plant Physiology. 164, p. 1111-1121

Research output: Contribution to JournalArticleAcademicpeer-review

Synechocystis sp. PCC 6803
Synechocystis
Metabolic Networks and Pathways
Systems Biology
Boidae

Bethedging during bacterial diauxic shift.

Solopova, A., van Gestel, J., Weissing, F. J., Bachmann, H., Teusink, B., Kok, J. & Kuipers, O. P., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. p. 7427-7432

Research output: Contribution to JournalArticleAcademicpeer-review

sugars
phenotype
Lactococcus lactis
bacteria
microbiology

Fatal attraction in glycolysis: how Saccharomyces cerevisiae manages sudden transitions to high glucose.

van Heerden, J. H., Wortel, M. T., Bruggeman, F. J., Heijnen, J. J., Bollen, Y. J. M., Planque, R., Hulshof, J., O'Toole, T. G., Wahl, A. & Teusink, B., 2014, In : Microbial Cell. 1, 3, p. 103-106

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Lactic Acid Bacteria: embarking on 30 more years of research.

Kok, J., Johansen, E., Kleerebezem, M. & Teusink, B., 2014, In : Microbial Cell Factories. 13, Suppl 1: I1

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Lost in transition: start-up of glycolysis yields subpopulations of nongrowing cells.

van Heerden, J. H., Wortel, M. T., Bruggeman, F. J., Heijnen, J. J., Bollen, Y. J. M., Planque, R., Hulshof, J., O'Toole, T. G., Wahl, S. A. & Teusink, B., 2014, In : Science. 343, 6174, 1245114.

Research output: Contribution to JournalArticleAcademicpeer-review

Glycolysis
Substrate Cycling
Energy Metabolism
Hydrolysis
Adenosine Triphosphate

Metabolic states with maximal specific rate carry flux through an elementary flux mode.

Wortel, M. T., Peters, H., Hulshof, J., Teusink, B. & Bruggeman, F. J., 2014, In : The FEBS Journal. 28, p. 1547-1555

Research output: Contribution to JournalArticleAcademicpeer-review

Genes
Metabolic Networks and Pathways
Fluxes
Genome
Enzyme kinetics

Monte-Carlo modeling of the central carbon metabolism of Lactococcus lactis: Insigths into metabolic regulation.

Murabito, E., Verma, M., Bekker, M., Bellomo, D., Westerhoff, H. V., Teusink, B. & Steuer, R., 2014, In : PLoS ONE. 9, 9, e106453.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
Metabolic Networks and Pathways
Metabolism
Carbon
Starvation

PAPD5-mediated 3'adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease.

Boele, J., Persson, H., Shin, J. W., Ishizu, Y., Newie, I. S., Sokilde, R., Hawkins, S. M., Coarfa, C., Ikeda, K., Takayama, K-I., Hori-Inoue, K., Ando, Y., Maxwell Burroughs, A., Sasaki, C., Suzuki, C., Sakai, M., Aoki, S., Ogawa, A., Hasegawa, A., Lizio, M. & 9 othersKaida, K., Teusink, B., Caminic, P., Suzuki, H., Inoue, S., Gunaratne, P. H., Rovira, C., Hayashizaki, Y. & de Hoon, M. J. L., 2014, (Accepted/In press) In : Proceedings of the National Academy of Sciences of the United States of America. 111, 31, p. 11467-11472

Research output: Contribution to JournalArticleAcademicpeer-review

MicroRNAs
Exoribonucleases
Polynucleotide Adenylyltransferase
RNA Sequence Analysis
Neoplasms

Understanding bistability in yeast glycolysis using general properties of metabolic pathways.

Planque, R., Bruggeman, F. J., Teusink, B. & Hulshof, J., 2014, In : Mathematical Biosciences. 7492, p. 33-42

Research output: Contribution to JournalArticleAcademicpeer-review

Glycolysis
Bistability
glycolysis
Metabolic Networks and Pathways
Yeast
2013

Availability of public goods shapes the evolution of competing metabolic strategies.

Bachmann, H., Fischlechner, M., Rabbers, I., Barfa, N., Branco dos Santos, F., Molenaar, D. & Teusink, B., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, p. 14302-14307

Research output: Contribution to JournalArticleAcademicpeer-review

biomass
emulsions
organisms
privatization
Lactococcus lactis

Basic concepts and principles of stoichiometric modeling of metabolic networks.

Maarleveld, T. R., Khandelwal, R. A., Olivier, B. G., Teusink, B. & Bruggeman, F. J., 2013, In : Biotechnology Journal. 8, 9, p. 997-1008

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolic Networks and Pathways
Maintenance
Growth

Bioinformatics and systems biology: bridging the gap between heterogeneous student backgrounds

Abeln, S., Molenaar, D., Feenstra, K. A., Hoefsloot, H. C., Teusink, B. & Heringa, J., Sep 2013, In : Briefings in bioinformatics. 14, 5, p. 589-98 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Systems Biology
Bioinformatics
Computational Biology
Students
Teaching

Community flux balance analysis for microbial consortia at balanced growth

Khandelwal, R. A., Olivier, B. G., Roling, W. F. M., Teusink, B. & Bruggeman, F. J., 2013, In : PLoS ONE. 8, 5

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Microbial Consortia
microbial communities
Fluxes
microorganisms
Growth

Gene network requirements for regulation of metabolic gene expression to a desired state

Berkhout, J., Teusink, B. & Bruggeman, F. J., 2013, In : Scientific Reports. 3, p. 1417

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Gene Regulatory Networks
Gene Expression Regulation
Galactose
Metabolic Networks and Pathways
Noise

How biochemical constraints of cellular growth shape evolutionary adaptations in metabolism

Berkhout, J., Bosdriesz, E., Nikerel, E., Molenaar, D., de Ridder, D., Teusink, B. & Bruggeman, F. J., 2013, In : Genetics. 194, 2, p. 505-512

Research output: Contribution to JournalArticleAcademicpeer-review

Towards metagenome-scale models for industrial applications - the case of Lactic Acid Bacteria

Teusink, B., Branco dos Santos, F. & de Vos, W. M., 2013, In : Current Opinion in Biotechnology. 24, 2, p. 200-206

Research output: Contribution to JournalArticleAcademicpeer-review

Metagenome
Lactic acid
Industrial applications
Lactic Acid
Bacteria