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Personal information

Camelia Minica is a postdoctoral researcher at the Department of Biological Psychology and the Netherlands Twin Register. She specialized in Psychological Research Methods (major) and Brain and Cognition (minor) at the University of Amsterdam (Research Master Psychology). For the PhD degree (earned at the Vrije Universiteit Amsterdam) she worked on refining methods for efficient analysis of clustered/family data in genome-wide association studies, with applications to addiction phenotypes. Currently, her research focuses on developing new methods for testing causal hypotheses using genetic instruments in epidemiological studies.

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Research

Focus on testing causal hypotheses using genetic variants

I am interested in the state of the art methods for testing causality using genetic instruments, with an emphasis on developing means for testing their assumptions. Specifically, my research focuses on integrating Mendelian Randomization with the classical twin design to develop new methods for testing causal hypotheses in observational studies. The approach I am developing is primarily tailored to the wealth of phenotypic and biological data collected at the Twin and Family Registries. These genetically informative samples can be exploited to test causal hypotheses even in the presence of pleiotropic instruments. I am also working on extending this approach to distantly related individuals. These methods will allow us to translate the remarkable GWAS findings into prevention strategies and may suggest rational treatment.

Below are some links to my recent work on Mendelian Randomization:

  • Abstract of the talk Mendelian Randomization meets the Classical Twin Design presented within the 'Causation' symposium at the Behavior Genetics Association annual meeting in Brisbane, Australia (22 June 2016)
  • Brief report on the discussion From association to causation I have moderated during the Amsterdam Public Health kick-off meeting (25 November 2016)
  • Mendelian Randomization quiz accompanying the practicum I co-taught with Dave Evans during the 2017 International Workshop on Statistical Genetic Methods for Human Complex Traits, Boulder, Colorado (10 March 2017)

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2012 2018

  • 18 Article
  • 2 Poster
  • 1 PhD Thesis - Research VU, graduation VU
Open Access
pleiotropy
Random Allocation
Causality
observational studies
childhood

Fetal Origins of Mental Disorders? An Answer Based on Mendelian Randomization

Arafat, S. & Minică, C. C., Dec 2018, In : Twin research and human genetics : the official journal of the International Society for Twin Studies. 21, 6, p. 485-494 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Random Allocation
Birth Weight
Mental Disorders
Major Depressive Disorder
Attention Deficit Disorder with Hyperactivity

Genome-wide association meta-analysis of age at first cannabis use

Minică, C. C., Verweij, K. J. H., van der Most, P. J., Mbarek, H., Bernard, M., van Eijk, K. R., Lind, P. A., Liu, M. Z., Maciejewski, D. F., Palviainen, T., Sánchez-Mora, C., Sherva, R., Taylor, M., Walters, R. K., Abdellaoui, A., Bigdeli, T. B., Branje, S. J. T., Brown, S. A., Casas, M., Corley, R. P. & 50 othersDavey-Smith, G., Davies, G. E., Ehli, E. A., Farrer, L., Fedko, I. O., Garcia-Martínez, I., Gordon, S. D., Hartman, C. A., Heath, A. C., Hickie, I. B., Hickman, M., Hopfer, C. J., Hottenga, J. J., Kahn, R. S., Kaprio, J., Korhonen, T., Kranzler, H. R., Krauter, K., van Lier, P. A. C., Madden, P. A. F., Medland, S. E., Neale, M. C., Meeus, W. H. J., Montgomery, G. W., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Wall, T. L., Ware, J. J., Wright, M. J., Zhao, H., Koot, H. M., Paus, T., Hewitt, J. K., Ribasés, M., Loukola, A., Boks, M. P., Snieder, H., Munafò, M. R., Gelernter, J., Boomsma, D. I., Martin, N. G., Gillespie, N. A., Vink, J. M. & Derks, E. M., Nov 2018, In : Addiction. 113, 11, p. 2073-2086 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Cannabis
Meta-Analysis
Single Nucleotide Polymorphism
Calcium Signaling

Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence

Hancock, D. B., Guo, Y., Reginsson, G. W., Gaddis, N. C., Lutz, S. M., Sherva, R., Loukola, A., Minica, C. C., Markunas, C. A., Han, Y., Young, K. A., Gudbjartsson, D. F., Gu, F., McNeil, D. W., Qaiser, B., Glasheen, C., Olson, S., Landi, M. T., Madden, P. A. F., Farrer, L. A. & 18 othersVink, J., Saccone, N. L., Neale, M. C., Kranzler, H. R., McKay, J., Hung, R. J., Amos, C. I., Marazita, M. L., Boomsma, D. I., Baker, T. B., Gelernter, J., Kaprio, J., Caporaso, N. E., Thorgeirsson, T. E., Hokanson, J. E., Bierut, L. J., Stefansson, K. & Johnson, E. O., 3 Oct 2018, In : Molecular Psychiatry. 23, 9, p. 1-9 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Tobacco Use Disorder
Genome-Wide Association Study
African Americans
Single Nucleotide Polymorphism
Smoking

Pathways to smoking behaviours: biological insights from the Tobacco and Genetics Consortium meta-analysis

Minicã, C. C., Mbarek, H., Pool, R., Dolan, C. V., Boomsma, D. I. & Vink, J. M., Jan 2017, In : Molecular Psychiatry. 22, 1, p. 82-88 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Tobacco
Meta-Analysis
Smoking
Genes
Untranslated RNA

Activities 2016 2016

  • 2 Lecture / Presentation
  • 1 Conference

Connecting the dots: ADHD and Addiction

C.C. Minica (Speaker)
19 Feb 2016

Activity: Lecture / PresentationAcademic

Mendelian Randomization in the Classical Twin Design

C.C. Minica (Speaker)
20 Jun 2016

Activity: Lecture / PresentationAcademic

Moderator discussion on “From association to causation” - Amsterdam Public Health Kick-off meeting

C.C. Minica (Organiser)
25 Nov 2016

Activity: Participating in or organising an eventConferenceAcademic