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Research Output 2003 2020

2020

Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers

Egger, R., Narayanan, R. T., Guest, J. M., Bast, A., Udvary, D., Messore, L. F., Das, S., de Kock, C. P. J. & Oberlaender, M., 8 Jan 2020, In : Neuron. 105, 1, p. 122-137.e8 24 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neurons
Axons
Pyramidal Tracts
Pyramidal Cells
Neocortex
2019

Cholinergic modulation of microcircuits in the cortex

Obermayer, J. M. G., 2019, 135 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Functional Architecture and Encoding of Tactile Sensorimotor Behavior in Rat Posterior Parietal Cortex

Mohan, H., de Haan, R., Broersen, R., Pieneman, A. W., Helmchen, F., Staiger, J. F., Mansvelder, H. D. & de Kock, C. P. J., 11 Sep 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 37, p. 7332-7343 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Parietal Lobe
Touch
Vibrissae
Population
Brain-Computer Interfaces

Millivolts to movement: Electrophysiological studies on cortical coding and behavior

de Haan, R., 2019, 231 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

Obermayer, J., Luchicchi, A., Heistek, T. S., de Kloet, S. F., Terra, H., Bruinsma, B., Mnie-Filali, O., Kortleven, C., Galakhova, A. A., Khalil, A. J., Kroon, T., Jonker, A. J., de Haan, R., van den Berg, W. D. J., Goriounova, N. A., de Kock, C. P. J., Pattij, T. & Mansvelder, H. D., 1 Dec 2019, In : Nature Communications. 10, 1, 5280.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
cholinergics
choline
Choline O-Acetyltransferase
Interneurons
neurons
2018

Barrel Cortex Function Special Issue Editorial

de Kock, C. P. J., Luhmann, H. J. & Maravall, M., 1 Jan 2018, In : Neuroscience. 368, p. 1-2 2 p.

Research output: Contribution to JournalEditorialAcademicpeer-review

Human cortical pyramidal neurons: From spines to spikes via models

Eyal, G., Verhoog, M. B., Testa-Silva, G., Deitcher, Y., Piccione, R. B., DeFelipe, J., de Kock, C. P. J., Mansvelder, H. D. & Segev, I., 29 Jun 2018, In : Frontiers in Cellular Neuroscience. 12, June, p. 1-24 24 p., 181.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Pyramidal Cells
Spine
N-Methylaspartate
Synapses
Dendritic Spines

Large and fast human pyramidal neurons associate with intelligence

Goriounova, N. A., Heyer, D. B., Wilbers, R., Verhoog, M. B., Giugliano, M., Verbist, C., Obermayer, J., Kerkhofs, A., Smeding, H., Verberne, M., Idema, S., Baayen, J. C., Pieneman, A. W., de Kock, C. P. J., Klein, M. & Mansvelder, H. D., 18 Dec 2018, In : eLife. 7, p. 1-21 21 p., e41714.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Pyramidal Cells
Intelligence
Neurons
Action Potentials
Kinetics

Neural Representation of Motor Output, Context and Behavioral Adaptation in Rat Medial Prefrontal Cortex During Learned Behavior

de Haan, R., Lim, J., van der Burg, S. A., Pieneman, A. W., Nigade, V., Mansvelder, H. D. & de Kock, C. P. J., 1 Oct 2018, In : Frontiers in Neural Circuits. 12, p. 1-17 17 p., 75.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Prefrontal Cortex
Population
Neurons
Vibrissae
Task Performance and Analysis

Sensory representation of an auditory cued tactile stimulus in the posterior parietal cortex of the mouse

Mohan, H., Gallero-Salas, Y., Carta, S., Sacramento, J., Laurenczy, B., Sumanovski, L. T., De Kock, C. P. J., Helmchen, F. & Sachidhanandam, S., 17 May 2018, In : Scientific Reports. 8, 1, 7739.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Parietal Lobe
Touch
Neurons
Photons
Cues

The posterior parietal cortex as integrative hub for whisker sensorimotor information

Mohan, H., de Haan, R., Mansvelder, H. D. & de Kock, C. P. J., 1 Jan 2018, In : Neuroscience. 368, 1 January, p. 240-245 6 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Vibrissae
Parietal Lobe
Touch
Brain-Computer Interfaces
Locomotion
2017
Open Access
Pyramidal Cells
Dendrites
Action Potentials
Calcium
Vibrissae

Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex

Deitcher, Y., Eyal, G., Kanari, L., Verhoog, M. B., Atenekeng Kahou, G. A., Mansvelder, H. D., de Kock, C. P. J. & Segev, I., 1 Nov 2017, In : Cerebral Cortex. 27, 11, p. 5398-5414 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Pyramidal Cells
Temporal Lobe
Neurons
Neocortex
Carisoprodol

Organizational principles of human and rodent association cortex

Mohan, H., 2017, 109 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
2015

Beyond Columnar Organization: Cell Type- and Target Layer-Specific Principles of Horizontal Axon Projection Patterns in Rat Vibrissal Cortex.

Narayanan, R. T., Egger, R., Johnson, A. S., Mansvelder, H. D., Sakmann, B., de Kock, C. P. J. & Oberlaender, M., 2015, In : Cerebral Cortex. 25, 11, p. 4450-4468

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Axons
Communication
Vibrissae
Somatosensory Cortex
Cellular Structures

Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex.

Mohan, H., Verhoog, M. B., Doreswamy, K. K., Eyal, G., Aardse, R., Lodder, B. N., Goriounova, N. A., Asamoah, B., Brakspear, A. B., Groot, C., van der Sluis, S., Testa-Silva, G., Obermayer, J. M. G., Boudewijns, Z. S. R. M., Narayanan, R. T., Baayen, J. C., Segev, I., Mansvelder, H. D. & de Kock, C. P. J., 2015, In : Cerebral Cortex. 25, 12, p. 4839-4853

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Pyramidal Cells
Neocortex
Neurons
Macaca
Dendrites

Integrative Properties of Cortical Pyramidal Neurons: linking structure to function

Boudewijns, Z. S. R. M., 2015, 160 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Mice with megalencephalic leukoencephalopathy with cysts: a developmental angle

Dubey, M., Bugiani, M., Ridder, M. C., Postma, N. L., Brouwers, E., Polder, E., Jacobs, J. G., Baaijen, J. C., Klooster, J., Kamermans, M., Aardse, R., de Kock, C. P. J., Dekker, M. P., van Weering, J. R. T., Heine, V. M., Abbink, T. E. M., Scheper, G. C., Boor, P. K. I., Lodder, J. C., Mansvelder, H. D. & 1 othersKnaap, M., 2015, In : Annals of Neurology. 77, 11, p. 114-131

Research output: Contribution to JournalArticleAcademicpeer-review

Leukoencephalopathies
Cysts
Astrocytes
Edema
Brain
2014

Dendrites impact the encoding capabilities of the axon.

Eyal, G., Mansvelder, H. D., de Kock, C. P. J. & Segev, I., 2014, In : Journal of Neuroscience. 34, 24, p. 8063-8071

Research output: Contribution to JournalArticleAcademicpeer-review

Dendrites
Axons
Neurons
Pyramidal Cells
Action Potentials

High bandwidth synaptic communication and frequency tracking in human neocortex.

Testa-Silva, G., Verhoog, M. B., Linaro, D., de Kock, C. P. J., Baayen, J. C., Meredith, R. M., Zeeuw, C. I., Giugliano, M. & Mansvelder, H. D., 2014, In : PloS Biology. 12, 11, p. e1002007 e1002007.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
neocortex
Neocortex
animal communication
Neurons
Communication

Juxtasomal biocytin labeling to study the structure-function relationship of individual cortical neurons.

Narayanan, R. T., Mohan, H., Broersen, R., de Haan, R., Pieneman, A. W. & de Kock, C. P. J., 2014, In : Journal of Visualized Experiments. 84, p. e51359 e51359.

Research output: Contribution to JournalArticleAcademicpeer-review

Labeling
Neurons
Animals
Action Potentials
Animal Behavior
2013

Layer-specific high-frequency action potential spiking in the prefrontal cortex of awake rats

Boudewijns, Z. S. R. M., Groen, M. R., Lodder, B. N., McMaster, M. T., Kaleogrades, L., de Haan, R., Narayanan, R. T., Meredith, R. M., Mansvelder, H. D. & de Kock, C. P. J., 2013, In : Frontiers in Cellular Neuroscience. 7, p. 1-10 10 p., 99.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Prefrontal Cortex
Action Potentials
Pyramidal Cells
Calcium
Calcium Signaling

Layer-specific modulation of the prefrontal cortex by nicotinic acetylcholine receptors

Poorthuis, R. B., Bloem, B., Schak, B., Wester, J., de Kock, C. P. J. & Mansvelder, H. D., 2013, In : Cerebral Cortex. 23, 1, p. 148-161 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Pyramidal Cells
Nicotinic Receptors
Prefrontal Cortex
Interneurons
Neurons

Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses

Verhoog, M. B., Goriounova, N. A., Obermayer, J., Stroeder, J., Hjorth, J. J. J., Testa-Silva, G., Baaijen, J. C., de Kock, C. P. J., Meredith, R. M. & Mansvelder, H. D., 2013, In : Journal of Neuroscience. 33, 43, p. 17197-17208 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Synapses
Neocortex
Neuronal Plasticity
Brain
Long-Term Memory
2012

Cell type-specific three-dimensional structure of thalamocortical circuits in a column of rat vibrissal cortex

Oberlaender, M., de Kock, C. P. J., Bruno, R. M., Ramirez, A., Meyer, H. S., Dercksen, V. J., Helmstaedter, M. & Sakmann, B., 2012, In : Cerebral Cortex. 22, 10, p. 2375-2391 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Carisoprodol
Dendrites
Neurons
Afferent Pathways
Vibrissae

Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism

Testa-Silva, G., Loebel, A., Giugliano, M., de Kock, C. P. J., Mansvelder, H. D. & Meredith, R. M., 2012, In : Cerebral Cortex. 22, 6, p. 1333-1342 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Pyramidal Cells
Autistic Disorder
Prefrontal Cortex
Intellectual Disability
Synapses

State and location dependence of action potential metabolic cost in cortical pyramidal neurons

Hallermann, S., de Kock, C. P. J., Stuart, G. J. & Kole, M. H., 2012, In : Nature Neuroscience. 15, 7, p. 1007-1014 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Pyramidal Cells
Action Potentials
Costs and Cost Analysis
Axons
Dendrites

Third-Harmonic Generation Microscopy For Label-Free Brain Imaging

Witte, S., Kuzmin, N. V., Negrean, A., Lodder, J. C., Testa-Silva, G., de Kock, C. P. J., Mansvelder, H. D. & Groot, M. L., 2012, Biomedical Optics, OSA Technical Digest. Optical Society of America, p. BSu4B.4

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

2011

Label-free live brain imaging and targeted patching with third-harmonic generation microscopy

Witte, S., Negrean, A., Lodder, J. C., de Kock, C. P. J., Testa-Silva, G., Mansvelder, H. D. & Groot, M. L., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 15, p. 5970-5975

Research output: Contribution to JournalArticleAcademicpeer-review

Neuroimaging
Microscopy
Brain
Fluorescent Dyes
Neurons

Label-free live brain imaging with third-harmonic generation microscopy

Witte, S., Negrean, A., Lodder, J. C., de Kock, C. P. J., Testa-Silva, G., Mansvelder, H. D. & Groot, M. L., 2011, CLEO/Europe and EQEC 2011 Conference Digest. Optical Society of America

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademic

Semi-automated three-dimensional reconstructions of individual neurons reveal cell type-specific circuits in cortex

Boudewijns, Z. S. R. M., Kleele, T., Mansvelder, H. D., Sakmann, B., de Kock, C. P. J. & Oberlaender, M., 2011, In : Communicative & Integrative Biology. 4, 4, p. 486-488 2 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Three-dimensional axon morphologies of individual layer 5 neurons indicate cell type-specific intracortical pathways for whisker motion and touch

Oberlaender, M., Boudewijns, Z. S. R. M., Kleele, T., Mansvelder, H. D., Sakmann, B. & de Kock, C. P. J., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 10, p. 4188-4193 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Vibrissae
Touch
Axons
Neurons
Dendrites
2010

Cell-type specific thalamic innervation in a column of rat vibrissal cortex

Meyer, H. S., Wimmer, V. C., Hemberger, M., Bruno, R. M., de Kock, C. P. J., Frick, A., Sakmann, B. & Helmstaedter, M., 2010, In : Cerebral Cortex. 20, 10, p. 2287-2303 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Pyramidal Cells
Neurons
Ventral Thalamic Nuclei
Somatosensory Cortex
Synaptophysin

Dimensions of a projection column and architecture of VPM- and POm-axons in rat vibrissal cortex

Wimmer, V. C., Bruno, R. M., de Kock, C. P. J., Kuner, T. & Sakmann, B., 2010, In : Cerebral Cortex. 20, 10, p. 2265-2276 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Ventral Thalamic Nuclei
Axons
Parvovirus
Somatosensory Cortex
Neurons

Human synapses show a wide temporal window for spike-timing-dependent plasticity

Testa-Silva, G., Verhoog, M. B., Goriounova, N. A., Loebel, A., Hjorth, J., Baayen, J. C., de Kock, C. P. J. & Mansvelder, H. D., 2010, In : Frontiers in Synaptic Neuroscience. 2, p. 12 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Synapses
Rodentia
Synaptic Potentials
Action Potentials
Hippocampus

Label-Free Live Brain Imaging with Ultrafast Nonlinear Microscopy

Witte, S. M., Negrean, A., Lodder, J. C., Testa-Silva, G., de Kock, C. P. J., Mansvelder, H. D. & Groot, M. L., 2010, Ultrafast Phenomena XVII: Proceedings of the 17th International Conference. Chergui, M. (ed.). New York: Oxford University press, p. 871-873 952 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex

Meyer, H. S., Wimmer, V. C., Oberlaender, M., de Kock, C. P. J., Sakmann, B. & Helmstaedter, M., 2010, In : Cerebral Cortex. 20, 10, p. 2277-2286 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Somatosensory Cortex
Neurons
Carisoprodol
2009

Sensory experience alters specific branches of individual corticocortical axons during development

Bruno, A. C., Hahn, T. T., Wallace, D. J., de Kock, C. P. J. & Sakmann, B., 2009, In : Journal of Neuroscience. 29, 10, p. 3172-3181 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Axons
Vibrissae
Dendritic Spines
Pyramidal Cells
Carisoprodol
Vibrissae
Somatosensory Cortex
Head
Neurons
Action Potentials

The multifaceted physiology of action potentials in neocortical pyramidal neurons

Schiller, J., Korngreen, A., Polsky, A. & de Kock, C. P. J., 2009, In : Cellscience Reviews. 6, 2, p. 6-18 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2006

NMDA receptors trigger neurosecretion of 5-HT within dorsal raphé nucleus of the rat in the absence of action potential firing

de Kock, C. P. J., Cornelisse, L. N., Burnashev, N., Lodder, J. C., Timmerman, A. J., Couey, J. J., Mansvelder, H. D. & Brussaard, A. B., 2006, In : Journal of Physiology - London. 577, 3, p. 891-905 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Neurosecretion
N-Methyl-D-Aspartate Receptors
Action Potentials
Serotonin
Calcium
2004

NMDA receptors induce somatodendritic secretion in hypothalamic neurones of lactating female rats

de Kock, C. P. J., Burnashev, N., Lodder, J. C., Mansvelder, H. D. & Brussaard, A. B., 2004, In : Journal of Physiology - London. 561, p. 53-64 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Oxytocin
N-Methyl-D-Aspartate Receptors
Neurons
Synapses
gamma-Aminobutyric Acid

On the somatodendritic secretion of neurotransmitters in the brain

de Kock, C. P. J., 2004, 178 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

2003

Somatodendritic secretion in oxytocin neurons is upregulated during the female reproductive cycle

de Kock, C. P. J., Wierda, K. D. B., Bosman, L. W. J., Min, R., Koksma, J. J., Mansvelder, H. D., Verhage, M. & Brussaard, A. B., 2003, In : Journal of Neuroscience. 23, 7, p. 2726-2734 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File