D. Bald

dr.

1993 …2019
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Dr. Dirk Bald studied Chemistry and Biology at the University of Münster (Germany) and subsequently obtained his PhD in Biochemistry, working on membrane proteins involved in photosynthesis. From 1995 to 2001, Bald worked at the Tokyo Institute of Technology as post-doctoral researcher, studying biochemical and single molecule aspects of the motor protein ATP synthase, a pivotal component of energy metabolism in living cells.

In 2001, Bald started as assistant professor in the Department of Molecular Cell Biology at VU University Amsterdam. His research interests include both fundamental aspects of bacterial energy metabolism as well as discovery and characterization of novel antibiotics. His group has investigated the biochemistry and microbiology of energy metabolism in pathogenic bacteria and significantly contributed to the (surprising) view that this central pathway can be utilized as efficient target for new antibiotics, in particular against tuberculosis.

Dr. Bald collaborates with international research groups from both universities and pharmaceutical industry. From 2006 to 2009, Bald coordinated a EU-funded Marie Curie Research Training Network involving thirteen partners in eight European Countries.

Bald coordinates the course Protein Science, a portal course of the Master’s program Biomolecular Sciences and also the Minor program Biomolecular Science & Neuroscience, thereby integrating ongoing AIMMS research in the course subject matter.

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Research Output 1993 2019

Isoniazid bactericidal activity involves electron transport chain perturbation

Zeng, S., Soetaert, K., Ravon, F., Vandeput, M., Bald, D., Kauffmann, J. M., Mathys, V., Wattiez, R. & Fontaine, V., 1 Mar 2019, In : Antimicrobial Agents and Chemotherapy. e01841-18.

Research output: Contribution to JournalArticleAcademicpeer-review

Isoniazid
Electron Transport
Adenosine Triphosphate
Electron Transport Complex IV
NADH Dehydrogenase

Ionophoric effects of the antitubercular drug bedaquiline

Hards, K., McMillan, D. G. G., Schurig-Briccio, L. A., Gennis, R. B., Lill, H., Bald, D. & Cook, G. M., 10 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. 7326-7331 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

File
bedaquiline
Antitubercular Agents
Adenosine Triphosphate
Escherichia coli
Proton-Motive Force

The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.

Lu, P., Asseri, A. H. O., Kremer, M., Maaskant, J., Ummels, R., Lill, H. & Bald, D., 8 Feb 2018, In : Scientific Reports. 8

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cytochromes
Electron Transport
Mycobacterium tuberculosis
Energy Metabolism
Mycobacterium smegmatis

A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection.

Boot, M., JIm, K. K., Liu, T., Commandeur, S., Lu, P., Verboom, T., Lill, H., Bitter, W. & Bald, D., 2017, In : Scientific Reports. 7, 10665.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cytochromes
Fluorescence
Mycobacterium marinum
Infection
Oxidative Phosphorylation

Targeting energy metabolism in Mycobacterium tuberculosis – a new paradigm in anti-mycobacterial drug discovery.

Bald, D., Villellas, C., Lu, P. & Koul, A., 2017, In : mBio. 8, 2, p. 1-11 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Oxidative Phosphorylation
Drug Discovery
Mycobacterium tuberculosis
Energy Metabolism
Drug Delivery Systems