D. Bald

dr.

1993 …2019
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Research Output 1993 2019

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Article
2019

Isoniazid bactericidal activity involves electron transport chain perturbation

Zeng, S., Soetaert, K., Ravon, F., Vandeput, M., Bald, D., Kauffmann, J. M., Mathys, V., Wattiez, R. & Fontaine, V., 1 Mar 2019, In : Antimicrobial Agents and Chemotherapy. e01841-18.

Research output: Contribution to JournalArticleAcademicpeer-review

Isoniazid
Electron Transport
Adenosine Triphosphate
Electron Transport Complex IV
NADH Dehydrogenase
2018

Ionophoric effects of the antitubercular drug bedaquiline

Hards, K., McMillan, D. G. G., Schurig-Briccio, L. A., Gennis, R. B., Lill, H., Bald, D. & Cook, G. M., 10 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. 7326-7331 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

File
bedaquiline
Antitubercular Agents
Adenosine Triphosphate
Escherichia coli
Proton-Motive Force

The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.

Lu, P., Asseri, A. H. O., Kremer, M., Maaskant, J., Ummels, R., Lill, H. & Bald, D., 8 Feb 2018, In : Scientific Reports. 8

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cytochromes
Electron Transport
Mycobacterium tuberculosis
Energy Metabolism
Mycobacterium smegmatis
2017

A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection.

Boot, M., JIm, K. K., Liu, T., Commandeur, S., Lu, P., Verboom, T., Lill, H., Bitter, W. & Bald, D., 2017, In : Scientific Reports. 7, 10665.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cytochromes
Fluorescence
Mycobacterium marinum
Infection
Oxidative Phosphorylation

Targeting energy metabolism in Mycobacterium tuberculosis – a new paradigm in anti-mycobacterial drug discovery.

Bald, D., Villellas, C., Lu, P. & Koul, A., 2017, In : mBio. 8, 2, p. 1-11 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Oxidative Phosphorylation
Drug Discovery
Mycobacterium tuberculosis
Energy Metabolism
Drug Delivery Systems
2016

Cytochrome bd as survival factor in mycobacteria

Lu, P., Heineke, M., Koul, A., Andries, K., Cook, G. M., Lill, H., van Spanning, R. & Bald, D., Aug 2016, In : Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1857, p. e120

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cytochromes
Mycobacterium
Mycobacterium smegmatis
Electron Transport Complex III
bedaquiline

Cytochrome bd displays significant quinol peroxidase activity

Al-Attar, S., Yu, Y., Pinske, M., Hoeser, J., Friedrich, T., Bald, D. & de Vries, S., 2016, In : Scientific Reports. 6, 27631

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Hydroquinones
Cytochromes
Heme
Peroxidase
Oxidoreductases

Synthesis, characterization and biological acitvity of fluorescently labeled bedaquiline analogues.

Rombouts, J. A., Veenboer, R. M. P., Villellas, C., Lu, P., Ehlers, A. W., Andries, K., Koul, A., Lill, H., Ruijter, E., Orru, R. V. A., Lammertsma, K., Bald, D. & Slootweg, J. C., 2016, In : RSC Advances. 6, p. 108708-108716

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2015

A review on emerging diagnostic assay for viral detection: the case of avian influenza virus.

Roodbar Shojaei, T., Tabatabaei, M., Shawky, S., Salleh, M. A. M. & Bald, D., 2015, In : Molecular Biology Reports. 42, 1, p. 187-199

Research output: Contribution to JournalArticleAcademicpeer-review

Influenza in Birds
Orthomyxoviridae
Viruses
Biotechnology

Bactericidal mode of action of bedaquiline.

Hards, K., Robson, J. R., Berney, M., Shaw, L., Bald, D., Koul, A., Andries, K. & Cook, G. M., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 7, p. 2028-2037

Research output: Contribution to JournalArticleAcademicpeer-review

bedaquiline
Adenosine Triphosphate
Proton-Motive Force
Mycobacterium
Oxygen Consumption

Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes

Brouwer, I., Giniatullina, A., Laurens, N., van Weering, J. R. T., Bald, D., Wuite, G. J. L. & Groffen, A. J. A., 2015, In : Nature Communications. 6, p. 8387 8387.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
membranes
Membranes
SNARE Proteins
secretions
Phosphatidylserines

The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress.

Lu, P., Heineke, M. H., Koul, A., Andries, K., Cook, G. M., Lill, H., van Spanning, R. J. M. & Bald, D., 2015, In : Scientific Reports. 5, 10333.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mycobacterium smegmatis
Peroxides
Cytochromes
Anti-Bacterial Agents
bedaquiline
2014

ATP synthase in mycobacteria: special features and implications for a function as drug target.

Lu, P., Lill, H. & Bald, D., 2014, In : Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1837, p. 1208-1218

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mycobacterium
Adenosine Triphosphate
Pharmaceutical Preparations
Energy Metabolism
Macrophages

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

Koul, A., Vranckx, L., Dhar, N., Göhlmann, H., Özdemir, E., Neefs, J-M., Schulz, M., Lu, P., Mortz, E., McKinney, J. D., Andries, K. & Bald, D., 2014, In : Nature Communications. 5, 3369.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
bedaquiline
tuberculosis
adenosine triphosphate
metabolism
Mycobacterium tuberculosis

The ATPsynthase inhibitor bedaquiline interferes with small-molecule efflux in Mycobacterium smegmatis.

Lu, P., Villelas, C., Koul, A., Andries, K., Lill, H. & Bald, D., 2014, In : The Journal of Antibiotics.

Research output: Contribution to JournalArticleAcademicpeer-review

2013

Advances and strategies in discovery of new antibacterials for combating metabolically resting bacteria

Bald, D. & Koul, A., 2013, In : Drug Discovery Today. 18, p. 250-255

Research output: Contribution to JournalArticleAcademicpeer-review

Anti-Bacterial Agents
Bacteria
Bacterial Infections
Pharmaceutical Preparations

Novel antibiotics targeting respiratory ATP in Gram-positive pathogenic bacteria

Balemans, W., Vranckx, L., Lounis, N., Pop, O., Guillemont, J., Vergauwen, K., Mol, S., Gilissen, R., Motte, M., Lanois, D., de Bolle, M., Bonroy, K., Lill, H., Andries, K., Bald, D. & Koul, A., 2013, In : Antimicrobial Agents and Chemotherapy. 56, p. 4131-4139

Research output: Contribution to JournalArticleAcademicpeer-review

Diarylquinolines
Gram-Positive Bacteria
bedaquiline
Adenosine Triphosphate
Anti-Bacterial Agents
2011

Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase.

Haagsma, A. C., Podasca, I., Koul, A., Andries, K., Guillemont, J., Lill, H. & Bald, D., 2011, In : PLoS ONE. 6, p. e23575

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
bedaquiline
Diarylquinolines
H-transporting ATP synthase
Adenosine Triphosphate
drugs

Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity and cellular ATP levels.

Lu, P., Haagsma, A. C., Pham, H., Maaskant, J. J., Mol, S., Lill, H. & Bald, D., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 11, p. 5354-5357

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Proton-Motive Force
Adenosine Triphosphate
Mycobacterium bovis
Pyrazinamide
Microbiology
2010

ATP synthase from slow and fast growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction.

Haagsma, A. C., Driessen, N. N., Hahn, M. M., Lill, H. & Bald, D., 2010, In : FEMS Microbiology Letters. 313, p. 68-74

Research output: Contribution to JournalArticleAcademicpeer-review

Mycobacterium
Hydrolysis
Adenosine Triphosphate
Proton-Motive Force
Mycobacterium bovis

Direct detection of unamplified hepatitis C virus RNA using unmodified gold nanoparticles

Shawky, S. M., Bald, D. & Azzazy, H. M., 2010, In : Clinical Biochemistry. 43, p. 1163-1168

Research output: Contribution to JournalArticleAcademicpeer-review

Viruses
Gold
Hepacivirus
Nanoparticles
Assays

Respiratory ATP synthesis: the new generation of mycobacterial drug targets?

Bald, D. & Koul, A., 2010, In : FEMS Microbiology Letters. 308, p. 1-7

Research output: Contribution to JournalArticleAcademicpeer-review

Adenosine Triphosphate
Tuberculosis
Pharmaceutical Preparations
NADH Dehydrogenase
Mycobacterium tuberculosis
2009

Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue

Haagsma, A. C., Ibrahim, R. A., Wagner, M. J., Krab, K., Vergauwen, K., Guillemont, J., Andries, K., Lill, H., Koul, A. & Bald, D., Mar 2009, In : Antimicrobial Agents and Chemotherapy. 53, 3, p. 1290-1292 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
bedaquiline
Adenosine Triphosphate
Inhibitory Concentration 50
Diarylquinolines
Mitochondrial Proton-Translocating ATPases

Two-stimuli manipulation of a biological motor

Ristic, Z., Vitali, M., Duci, A., Goetze, C., Kemnitz, K., Zuschratter, W., Lill, H. & Bald, D., 2009, In : Journal of Nanobiotechnology. 7, p. 3-3

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Enzymes
Proton-Translocating ATPases
Catalysis
Logic gates
Molecules
2008

Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis.

Koul, A., Vranckx, L., Dendouga, N., Balemans, W., van den Wyngaert, I., Vergauwen, K., Goehlmann, H. W. H., Willebrords, R., Poncelet, A., Guillemont, J., Bald, D. & Andries, K., 2008, In : Journal of Biological Chemistry. 283, p. 25273-25280

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Diarylquinolines
bedaquiline
Mycobacterium
Homeostasis
Adenosine Triphosphate
2007

Diarylquinolines target subunit c of mycobacterial ATP synthase.

Koul, A., Dendouga, N., Molenberghs, B., Vranckx, L., Willebrords, R., Ristic, Z., Lill, H., Dorange, I., Guillemont, J., Bald, D. & Andries, K., 2007, In : Nature Chemical Biology. 3, p. 323-324

Research output: Contribution to JournalArticleAcademicpeer-review

bedaquiline
Diarylquinolines
Adenosine Triphosphate
Drug Discovery
Mycobacterium
2004

A thermostable enzyme as an experimental platform to study properties of less stable homologues.

Lill, H., Hisabori, T., Groth, G. & Bald, D., 2004, In : Protein Engineering Design and Selection. 17, p. 553-555 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Enzymes
Proteins

Complete inhibition and partial re-activation of single F1-ATPase molecules by tentoxin: new properties of the re-activated enzyme.

Pavlova, P., Shimabukuro, K., Hisabori, T., Groth, G., Lill, H. & Bald, D., 2004, In : Journal of Biological Chemistry. 279, p. 9685-9688 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Proton-Translocating ATPases
Hydrolysis
Adenosine Triphosphate
Chemical activation
Molecules

Inverse regulation of rotation of F1-ATPase by the mutation at the regulatory region on the gamma subunit of chloroplast ATP synthase.

Ueoka-Nakanishi, H., Nakanishi, Y., Konno, H., Motohashi, K., Bald, D. & Hisabori, T., 2004, In : Journal of Biological Chemistry. 279, p. 16272-16277 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Chloroplast Proton-Translocating ATPases
Proton-Translocating ATPases
Nucleic Acid Regulatory Sequences
Mutation

Significance of the E subunit in the thiol modulation of chloroplast ATP synthase.

Konno, H., Suzuki, T., Bald, D., Yoshida, M. & Hisabori, T., 2004, In : Biochemical and Biophysical Research Communications. 318, p. 17-24 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Chloroplast Proton-Translocating ATPases
Sulfhydryl Compounds
Modulation
Membranes
2002

Molecular devices for the regulation of chloroplast ATP synthase

Hisabori, T., Konno, H., Ichimura, H., Strotmann, H. & Bald, D., 2002, In : Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1555, p. 140-146

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chloroplast Proton-Translocating ATPases
Protons
Adenosine Triphosphate
Equipment and Supplies
Chloroplasts

Substitution of a single amino acid switches the tentoxin resistant thermophilic F1-ATPase into a tentoxin sensitive enzyme.

Groth, G., Hisabori, T., Lill, H. & Bald, D., 2002, In : Journal of Biological Chemistry. 277, p. 20117-20119

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Proton-Translocating ATPases
Chloroplasts
Substitution reactions
Switches
Amino Acids
2001

Investigation of Fe(III) binding to thermophilic Bacillus PS3 F1-ATPase with respect to isolated alpha and beta subunits, alpha3 beta3 hexamer and apha1 beta1 heterodimer.

Contessi, S., Bald, D., Baeuerlein, E., Mavelli, I., Dabbeni-Sala, F. & Lippe, G., 2001, In : Biochemical and Biophysical Research Communications. 281, p. 1266-1270

Research output: Contribution to JournalArticleAcademicpeer-review

Proton-Translocating ATPases
Bacilli
Bacillus

Purine, but not pyrimidine, nucleotides support rotation of F1-ATPase.

Noji, H., Bald, D., Yasuda, R., Yoshida, M. & Kinosita Jr, K., 2001, In : Journal of Biological Chemistry. 276, p. 25480-25486

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Pyrimidine Nucleotides
Proton-Translocating ATPases
purine

Redox regulation of the Rotation of F0F1-ATP synthase.

Bald, D., Noji, H., Yoshida, M., Hirono-Hara, Y. & Hisabori, T., 2001, In : Journal of Biological Chemistry. 276, p. 39505-39507

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Oxidation-Reduction
Adenosine Triphosphate

The Role of the DELSEED Motif of the b Subunit in Rotation of F1-ATPase

Bald, D., 2000, In : Journal of Biological Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

Towards Structural Determination of the Water-splitting Enzyme

Bald, D., 2000, In : Journal of Biological Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

1999

e Subunit, an Endogenous Inhibitor of Bacterial F1-ATPase, Also Inhibits F0F1-ATPase

Bald, D., 1999, In : Journal of Biological Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

Two-Dimensional Crystallization on Lipid Layer: A Successful Approach for Membrane Proteins

Bald, D., 1999, In : Journal of Structural Biology.

Research output: Contribution to JournalArticleAcademicpeer-review

1994

Steady-state polarized light spectroscopy of isolated Photosystem I complexes

Bald, D., 1993, In : Photosynthesis Research.

Research output: Contribution to JournalArticleAcademicpeer-review