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Research Output 1985 2019

2019

A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

BIOS Consortium, 26 Sep 2019, In : European Journal of Human Genetics.

Research output: Contribution to JournalArticleAcademicpeer-review

RNA
Gene Expression
Genes
Genome-Wide Association Study
Cytokines

A Genetic Investigation of the Well-Being Spectrum

Baselmans, B. M. L., van de Weijer, M. P., Abdellaoui, A., Vink, J. M., Hottenga, J. J., Willemsen, G., Nivard, M. G., de Geus, E. J. C., Boomsma, D. I. & Bartels, M., 15 May 2019, In : Behavior Genetics. 49, 3, p. 286-297 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Phenotype
phenotype
Loneliness
Health
genetic correlation

Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium

Malanchini, M., Smith-Woolley, E., Ayorech, Z., Rimfeld, K., Krapohl, E., Vuoksimaa, E., Korhonen, T., Bartels, M., van Beijsterveldt, T. C. E. M., Rose, R. J., Lundström, S., Anckarsäter, H., Kaprio, J., Lichtenstein, P., Boomsma, D. I. & Plomin, R., Mar 2019, In : Psychological Medicine. 49, 4, p. 646-654 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Smoking
Aggression
Mothers
Pregnancy
Twin Studies

A linear mixed-model approach to study multivariate gene-environment interactions

't Hoen, P. A., van Meurs, J. B. J., Isaacs, A., Jansen, R., Franke, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Van Greevenbroek, M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, A., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D. & 30 othersVeldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Iterson, M., van Galen, M., Bot, J., van’t Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Zhernakova, D. V., Luijk, R., Jan Bonder, M., van Dijk, F., Arindrarto, W., Kielbasa, P. S. M., Swertz, M. A., van Zwet, E. W. & BIOS Consortium, Jan 2019, In : Nature Genetics. 51, 1, p. 180-186 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Gene-Environment Interaction
Linear Models
Genotype
Body Mass Index
Diet

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P. C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., Hwang, S. J. & 37 othersBressler, J., Gondalia, R., Salfati, E. L., Herder, C., Hidalgo, B. A., Tanaka, T., Moore, A. Z., Lemaitre, R. N., Jhun, M. A., Smith, J. A., Sotoodehnia, N., Bandinelli, S., Ferrucci, L., Arnett, D. K., Grallert, H., Assimes, T. L., Hou, L., Baccarelli, A., Whitsel, E. A., van Dijk, K. W., Amin, N., Uitterlinden, A. G., Sijbrands, E. J. G., Franco, O. H., Dehghan, A., Spector, T. D., Dupuis, J., Hivert, M. F., Rotter, J. I., Meigs, J. B., Pankow, J. S., van Meurs, J. B. J., Isaacs, A., Boomsma, D. I., Bell, J. T., Demirkan, A. & van Duijn, C. M., 13 Jun 2019, In : Nature Communications. 10, p. 1-11 11 p., 2581.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
homeostasis
insulin
methylation
Methylation
DNA Methylation
Open Access
Suicidal Ideation
Mental Disorders
Longitudinal Studies
Anxiety
Psychiatry

A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms

The EAGLE-ADHD Consortium, 18 Jan 2019, In : Behavior Genetics. p. 1-16 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Impulsive Behavior
Single Nucleotide Polymorphism
Meta-Analysis
signs and symptoms (animals and humans)
meta-analysis

A role for vitamin D and omega-3 fatty acids in major depression? An exploration using genomics

Milaneschi, Y., Peyrot, W. J., Nivard, M. G., Mbarek, H., Boomsma, D. I. & W J H Penninx, B., 5 Sep 2019, In : Translational Psychiatry. 9, 1, p. 219

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cholecalciferol
Major Depressive Disorder
Omega-3 Fatty Acids
Genomics
Depression

Association between rs1051730 and smoking during pregnancy in Dutch women

Mbarek, H., van Beijsterveldt, C. E. M., Hottenga, J. J., Dolan, C. V., Boomsma, D. I., Willemsen, G. & Vink, J. M., Jun 2019, In : Nicotine and Tobacco Research. 21, 6, p. 835-840 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Smoking
Pregnancy
Pregnant Women
Parturition
Smoking Cessation

Association of amyloid pathology with memory performance and cognitive complaints in cognitively normal older adults: a monozygotic twin study

Konijnenberg, E., den Braber, A., ten Kate, M., Tomassen, J., Mulder, S. D., Yaqub, M., Teunissen, C. E., Lammertsma, A. A., van Berckel, B. N. M., Scheltens, P., Boomsma, D. I. & Visser, P. J., May 2019, In : Neurobiology of Aging. 77, p. 58-65 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Twin Studies
Monozygotic Twins
Amyloid
Pathology
Cerebrospinal Fluid

Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition

Writing Committee for the ENIGMA-CNV Working Group , 30 Oct 2019, In : JAMA Psychiatry. p. 1-11 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cognition
Aptitude
Brain
Iceland
Parietal Lobe

Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Nivard, M. G., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. JC., W J H Penninx, B., Jansen, R. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jan 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Anisotropy
Genome
Radiation
Diffusion Tensor Imaging

Associations between Loneliness and Personality are Mostly Driven by a Genetic Association with Neuroticism

Abdellaoui, A., Chen, H-Y., Willemsen, G., Ehli, E. A., Davies, G. E., Verweij, K. J. H., Nivard, M. G., de Geus, E. J. C., Boomsma, D. I. & Cacioppo, J. T., Apr 2019, In : Journal of Personality. 87, 2, p. 386-397 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Loneliness
Personality
Monozygotic Twins
Neuroticism
Molecular Biology

Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years

Legdeur, N., Tijms, B. M., Konijnenberg, E., den Braber, A., Ten Kate, M., Sudre, C. H., Tomassen, J., Badissi, M., Yaqub, M., Barkhof, F., van Berckel, B. N., Boomsma, D. I., Scheltens, P., Holstege, H., Maier, A. B. & Visser, P. J., 14 Aug 2019, In : The journals of gerontology. Series A, Biological sciences and medical sciences.

Research output: Contribution to JournalArticleAcademicpeer-review

Pathology
Brain
Amyloid
Cognition
Physical Phenomena

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

23Andme Research Team & HUNT All-In Psychiatry, Feb 2019, In : Nature Genetics. 51, 2, p. 237-244 8 p.

Research output: Contribution to JournalLetterAcademicpeer-review

Tobacco Use
Alcohols
Tobacco Use Cessation
Genetic Association Studies
Synaptic Transmission

Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability (Nature Neuroscience, (2018), 21, 9, (1161-1170), 10.1038/s41593-018-0206-1)

The 23andMe Research Team, The Substance Use Disorders Working Group of the Psychiatric Genomics Consortium & International Cannabis Consortium, 1 Jul 2019, In : Nature Neuroscience. 22, 7, p. 1196 1 p.

Research output: Contribution to JournalComment / Letter to the editorAcademic

Open Access
File
Genetic Loci
Genome-Wide Association Study
Cannabis
Neurosciences
Psychiatry

Awareness and perceptions of clinical guidelines for the diagnostics and treatment of severe behavioural problems in children across Europe: A qualitative survey with academic experts

Gatej, A-R., Lamers, A., van Domburgh, L., Crone, M., Ogden, T., Rijo, D., Aronen, E., Barroso, R., Boomsma, D. I. & Vermeiren, R., Apr 2019, In : European Psychiatry. 57, p. 1-9 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Guidelines
Practice Guidelines
Therapeutics
Textbooks
Evidence-Based Practice

Biological insights into multiple birth: genetic findings from UK Biobank

Mbarek, H., van de Weijer, M. P., van der Zee, M. D., Ip, H. F., Beck, J. J., Abdellaoui, A., Ehli, E. A., Davies, G. E., Baselmans, B. M. L., Nivard, M. G., Bartels, M., de Geus, E. J. & Boomsma, D. I., Jun 2019, In : European Journal of Human Genetics. 27, 6, p. 970-979 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Multiple Birth Offspring
Fertility
Dizygotic Twins
Genome-Wide Association Study
Mothers

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Derks, E. M., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. J. C., W J H Penninx, B. & Sullivan, P., 11 Nov 2019, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Bipolar Disorder
Psychiatry
Schizophrenia
Depression
Major Depressive Disorder

Childhood individual differences: Risk and protective factors in twin and population cohorts

Veldkamp, S. A. M., 2019, 206 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M., Peyrot, W. J., Posthuma, D. & Willemsen, G., 5 Aug 2019, In : Biological Psychiatry. p. 1-12 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
HLA Antigens
Haplotypes
Alleles
Depression
Major Histocompatibility Complex

Cohabitation is associated with a greater resemblance in gut microbiota which can impact cardiometabolic and inflammatory risk

Finnicum, C. T., Beck, J. J., Dolan, C. V., Davis, C., Willemsen, G., Ehli, E. A., Boomsma, D. I., Davies, G. E. & de Geus, E. J. C., 22 Oct 2019, In : BMC Microbiology. 19, 1, p. 1-10 10 p., 230.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Spouses
Public Opinion
Microbiota
Gastrointestinal Microbiome
Open Access
Social Class
Netherlands
Individuality
Problem Behavior
United Kingdom

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Davies, G. E., Ehli, E. A., Fedko, I. O., Groen-Blokhuis, M. M., Hammerschlag, A. R., Hottenga, J. J., Hudziak, J., Ouwens, K. G. & ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Jan 2019, In : Nature Genetics. 51, 1, p. 63-75 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Genome
Genome-Wide Association Study
Meta-Analysis
Population

DNA Methylation Signatures of Breastfeeding in Buccal Cells Collected in Mid-Childhood

Odintsova, V. V., Hagenbeek, F. A., Suderman, M., Caramaschi, D., van Beijsterveldt, C. E. M., Kallsen, N. A., Ehli, E. A., Davies, G. E., Sukhikh, G. T., Fanos, V., Relton, C., Bartels, M., Boomsma, D. I. & van Dongen, J., 17 Nov 2019, In : Nutrients. 11, 11

Research output: Contribution to JournalArticleAcademicpeer-review

Cheek
breast feeding
DNA methylation
DNA Methylation
Breast Feeding

EEG-based age-prediction models as stable and heritable indicators of brain maturational level in children and adolescents

Vandenbosch, M. M. L. J. Z., Ent, D. V. ., Boomsma, D. I., Anokhin, A. P. & Smit, D. J. A., 15 Apr 2019, In : Human Brain Mapping. 40, 6, p. 1919-1926 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Electroencephalography
Brain
Puberty
Netherlands
Longitudinal Studies

Een tweelingstudie naar indicatoren van genetische en culturele transmissie

van der Laan, C. M., vande Weijer, S. G. A., Nivard, M. G. & Boomsma, D. I., Apr 2019, In : Tijdschrift voor Criminologie. 2019, 2, p. 148-164 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Eleven loci with new reproducible genetic associations with allergic disease risk

23Andme Research Team, Feb 2019, In : Journal of Allergy and Clinical Immunology. 143, 2, p. 691-699 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Genes
Interleukin-27
Seasonal Allergic Rhinitis
Eczema

Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults

van Dongen, J., Boomsma, D. I. & BIOS Consortium, 15 Oct 2019, In : Biological Psychiatry. 86, 8, p. 599-607 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Methylation
DNA Methylation
Netherlands
Meta-Analysis

Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci

Gupta, R., Van Dongen, J., Fu, Y., Abdellaoui, A., Tyndale, R. F., Velagapudi, V., Boomsma, D. I., Korhonen, T., Kaprio, J., Loukola, A. & Ollikainen, M., 5 Jan 2019, In : Clinical epigenetics. 11, 1, p. 1-13 13 p., 1.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cotinine
Nicotine
DNA Methylation
Smoking
Serum

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Jia, T., Chu, C., Liu, Y., van Dongen, J., Papastergios, E., Armstrong, N. J., Bastin, M. E., Carrillo-Roa, T., den Braber, A., Harris, M., Jansen, R., Liu, J., Luciano, M., Ori, A. P. S., Roiz Santiañez, R., Ruggeri, B., Sarkisyan, D., Shin, J., Sungeun, K., Tordesillas Gutiérrez, D. & 62 othersAmes, D., Artiges, E., Bakalkin, G., Banaschewski, T., Bokde, A. L. W., Brodaty, H., Bromberg, U., Brouwer, R., Büchel, C., Burke Quinlan, E., Cahn, W., de Zubicaray, G. I., Ehrlich, S., Ekström, T. J., Flor, H., Fröhner, J. H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Hoare, J., Ittermann, B., Jahanshad, N., Jiang, J., Kwok, J. B., Martin, N. G., Martinot, J-L., Mather, K. A., McMahon, K. L., McRae, A. F., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Sämann, P. G., Schofield, P. R., Smolka, M. N., Stein, D. J., Strike, L. T., Teeuw, J., Thalamuthu, A., Trollor, J., Walter, H., Wardlaw, J. M., Wen, W., Whelan, R., Apostolova, L. G., Binder, E. B., Boomsma, D. I., Calhoun, V., Crespo-Facorro, B., Deary, I. J., Hulshoff Pol, H., Ophoff, R. A., Pausova, Z., Sachdev, P. S., Saykin, A., Wright, M. J., Thompson, P. M., Schumann, G., van t Ent, D. & Desrivières, S., 6 Dec 2019, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

DNA Methylation
Epigenomics
Meta-Analysis
Nucleus Accumbens
Thalamus
Bullying
Crime Victims
aggression
gene
etiology

Genetic and environmental influences on functional connectivity within and between canonical cortical resting-state networks throughout adolescent development in boys and girls

Teeuw, J., Brouwer, R. M., Guimarães, J. P. O. F. T., Brandner, P., Koenis, M. M. G., Swagerman, S. C., Verwoert, M., Boomsma, D. I. & Hulshoff Pol, H. E., 15 Nov 2019, In : NeuroImage. 202, p. 1-16 16 p., 116073.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Adolescent Development
Twin Studies
Siblings
Head
Magnetic Resonance Imaging

Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., Smith, A. V., Bis, J. C., Jian, X., Luciano, M., Hofer, E., Teumer, A., van der Lee, S. J., Yang, J., Yanek, L. R., Lee, T. V. & 269 othersLi, S., Hu, Y., Koh, J. Y., Eicher, J. D., Desrivières, S., Arias-Vasquez, A., Chauhan, G., Athanasiu, L., Rentería, M. E., Kim, S., Hoehn, D., Armstrong, N. J., Chen, Q., Holmes, A. J., den Braber, A., Kloszewska, I., Andersson, M., Espeseth, T., Grimm, O., Abramovic, L., Alhusaini, S., Milaneschi, Y., Papmeyer, M., Axelsson, T., Ehrlich, S., Roiz-Santiañez, R., Kraemer, B., Håberg, A. K., Jones, H. J., Pike, G. B., Stein, D. J., Stevens, A., Bralten, J., Vernooij, M. W., Harris, T. B., Filippi, I., Witte, A. V., Guadalupe, T., Wittfeld, K., Mosley, T. H., Becker, J. T., Doan, N. T., Hagenaars, S. P., Saba, Y., Cuellar-Partida, G., Amin, N., Hilal, S., Nho, K., Mirza-Schreiber, N., Arfanakis, K., Becker, D. M., Ames, D., Goldman, A. L., Lee, P. H., Boomsma, D. I., Lovestone, S., Giddaluru, S., Le Hellard, S., Mattheisen, M., Bohlken, M. M., Kasperaviciute, D., Schmaal, L., Lawrie, S. M., Agartz, I., Walton, E., Tordesillas-Gutierrez, D., Davies, G. E., Shin, J., Ipser, J. C., Vinke, L. N., Hoogman, M., Jia, T., Burkhardt, R., Klein, M., Crivello, F., Janowitz, D., Carmichael, O., Haukvik, U. K., Aribisala, B. S., Schmidt, H., Strike, L. T., Cheng, C-Y., Risacher, S. L., Pütz, B., Fleischman, D. A., Assareh, A. A., Mattay, V. S., Buckner, R. L., Mecocci, P., Dale, A. M., Cichon, S., Boks, M. P., Matarin, M., Penninx, B. W. J. H., Calhoun, V. D., Chakravarty, M. M., Marquand, A. F., Macare, C., Kharabian Masouleh, S., Oosterlaan, J., Amouyel, P., Hegenscheid, K., Rotter, J. I., Schork, A. J., Liewald, D. C. M., de Zubicaray, G. I., Wong, T. Y., Shen, L., Sämann, P. G., Brodaty, H., Roffman, J. L., de Geus, E. J. C., Tsolaki, M., Erk, S., van Eijk, K. R., Cavalleri, G. L., van der Wee, N. J. A., McIntosh, A. M., Gollub, R. L., Bulayeva, K. B., Bernard, M., Richards, J. S., Himali, J. J., Loeffler, M., Rommelse, N., Hoffmann, W., Westlye, L. T., Valdés Hernández, M. C., Hansell, N. K., van Erp, T. G. M., Wolf, C., Kwok, J. B. J., Vellas, B., Heinz, A., Olde Loohuis, L. M., Delanty, N., Ho, B-C., Ching, C. R. K., Shumskaya, E., Singh, B., Hofman, A., van der Meer, D., Homuth, G., Psaty, B. M., Bastin, M. E., Montgomery, G. W., Foroud, T. M., Reppermund, S., Hottenga, J-J., Simmons, A., Meyer-Lindenberg, A., Cahn, W., Whelan, C. D., van Donkelaar, M. M. J., Yang, Q., Hosten, N., Green, R. C., Thalamuthu, A., Mohnke, S., Hulshoff Pol, H. E., Lin, H., Jack, C. R., Schofield, P. R., Mühleisen, T. W., Maillard, P., Potkin, S. G., Wen, W., Fletcher, E., Toga, A. W., Gruber, O., Huentelman, M., Davey Smith, G., Launer, L. J., Nyberg, L., Jönsson, E. G., Crespo-Facorro, B., Koen, N., Greve, D. N., Uitterlinden, A. G., Weinberger, D. R., Steen, V. M., Fedko, I. O., Groenewold, N. A., Niessen, W. J., Toro, R., Tzourio, C., Longstreth, W. T., Ikram, M. K., Smoller, J. W., van Tol, M-J., Sussmann, J. E., Paus, T., Lemaître, H., Schroeter, M. L., Mazoyer, B., Andreassen, O. A., Holsboer, F., Depondt, C., Veltman, D. J., Turner, J. A., Pausova, Z., Schumann, G., van Rooij, D., Djurovic, S., Deary, I. J., McMahon, K. L., Müller-Myhsok, B., Brouwer, R. M., Soininen, H., Pandolfo, M., Wassink, T. H., Cheung, J. W., Wolfers, T., Martinot, J-L., Zwiers, M. P., Nauck, M., Melle, I., Martin, N. G., Kanai, R., Westman, E., Kahn, R. S., Sisodiya, S. M., White, T., Saremi, A., van Bokhoven, H., Brunner, H. G., Völzke, H., Wright, M. J., van 't Ent, D., Nöthen, M. M., Ophoff, R. A., Buitelaar, J. K., Fernández, G., Sachdev, P. S., Rietschel, M., van Haren, N. E. M., Fisher, S. E., Beiser, A. S., Francks, C., Saykin, A. J., Mather, K. A., Romanczuk-Seiferth, N., Hartman, C. A., DeStefano, A. L., Heslenfeld, D. J., Weiner, M. W., Walter, H., Hoekstra, P. J., Nyquist, P. A., Franke, B., Bennett, D. A., Grabe, H. J., Johnson, A. D., Chen, C., van Duijn, C. M., Lopez, O. L., Fornage, M., Wardlaw, J. M., Schmidt, R., DeCarli, C., De Jager, P. L., Villringer, A., Debette, S., Gudnason, V., Medland, S. E., Shulman, J. M., Thompson, P. M., Seshadri, S. & Ikram, M. A., Nov 2019, In : Nature Genetics. 51, 11, p. 1624-1636 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Axonal Transport
Globus Pallidus
Caudate Nucleus
Genome-Wide Association Study
Putamen

Genetic Influences on the Development of Cerebral Cortical Thickness During Childhood and Adolescence in a Dutch Longitudinal Twin Sample: The Brainscale Study

Teeuw, J., Brouwer, R. M., Koenis, M. M. G., Swagerman, S. C., Boomsma, D. I. & Hulshoff Pol, H. E., Mar 2019, In : Cerebral Cortex. 29, 3, p. 978-993 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Psychiatry
Magnetic Resonance Imaging
Brain

Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease

Dennis, J., Sealock, J., Levinson, R. T., Farber-Eger, E., Franco, J., Fong, S., Straub, P., Hucks, D., Song, W-L., Linton, M. F., Fontanillas, P., Elson, S. L., Ruderfer, D., Abdellaoui, A., Sanchez-Roige, S., Palmer, A. A., Boomsma, D. I., Cox, N. J., Chen, G., Mosley, J. D. & 2 othersWells, Q. S. & Davis, L. K., 3 Dec 2019, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Loneliness
Major Depressive Disorder
Coronary Artery Disease
Atherosclerosis
Electronic Health Records

Genetic Similarity Assessment of Twin-Family Populations by Custom-Designed Genotyping Array

Beck, J. J., Hottenga, J. J., Mbarek, H., Finnicum, C. T., Ehli, E. A., Hur, Y-M., Martin, N. G., de Geus, E. J. C., Boomsma, D. I. & Davies, G. E., Aug 2019, In : Twin research and human genetics : the official journal of the International Society for Twin Studies. 22, 4, p. 210-219 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Population
Netherlands
Genome-Wide Association Study
Nigeria
Genotype

Genetic Vulnerability for Smoking and Cannabis Use: Associations With E-Cigarette and Water Pipe Use

International Cannabis Consortium, 21 May 2019, In : Nicotine and Tobacco Research. 21, 6, p. 723-730 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Marijuana Smoking
Smoking
Water
Cannabis
Phenotype

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Social Science Genetic Association Consortium, 23and Me Research Team, eQTLGen Consortium & International Cannabis Consortium, 1 Feb 2019, In : Nature Genetics. 51, 2, p. 245-257 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genetic Loci
Genome-Wide Association Study
Single Nucleotide Polymorphism
Computational Biology
Synaptic Transmission

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

van Setten, J., Verweij, N., Mbarek, H., Niemeijer, M. N., Trompet, S., Arking, D. E., Brody, J. A., Gandin, I., Grarup, N., Hall, L. M., Hemerich, D., Lyytikäinen, L. P., Mei, H., Müller-Nurasyid, M., Prins, B. P., Robino, A., Smith, A. V., Warren, H. R., Asselbergs, F. W., Boomsma, D. I. & 41 othersCaulfield, M. J., Eijgelsheim, M., Ford, I., Hansen, T., Harris, T. B., Heckbert, S. R., Hottenga, J. J., Iorio, A., Kors, J. A., Linneberg, A., MacFarlane, P. W., Meitinger, T., Nelson, C. P., Raitakari, O. T., Silva Aldana, C. T., Sinagra, G., Sinner, M., Soliman, E. Z., Stoll, M., Uitterlinden, A., van Duijn, C. M., Waldenberger, M., Alonso, A., Gasparini, P., Gudnason, V., Jamshidi, Y., Kääb, S., Kanters, J. K., Lehtimäki, T., Munroe, P. B., Peters, A., Samani, N. J., Sotoodehnia, N., Ulivi, S., Wilson, J. G., de Geus, E. J. C., Jukema, J. W., Stricker, B., van der Harst, P., de Bakker, P. I. W. & Isaacs, A., Jun 2019, In : European Journal of Human Genetics. 27, 6, p. 952-962 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Quantitative Trait Loci
Genome-Wide Association Study
Single Nucleotide Polymorphism
Meta-Analysis
Genome

Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

Forstner, A. J., Awasthi, S., Wolf, C., Maron, E., Erhardt, A., Czamara, D., Eriksson, E., Lavebratt, C., Allgulander, C., Friedrich, N., Becker, J., Hecker, J., Rambau, S., Conrad, R., Geiser, F., McMahon, F. J., Moebus, S., Hess, T., Buerfent, B. C., Hoffmann, P. & 55 othersHerms, S., Heilmann-Heimbach, S., Kockum, I., Olsson, T., Alfredsson, L., Weber, H., Alpers, G. W., Arolt, V., Fehm, L., Fydrich, T., Gerlach, A. L., Hamm, A., Kircher, T., Pané-Farré, C. A., Pauli, P., Rief, W., Ströhle, A., Plag, J., Lang, T., Wittchen, H-U., Mattheisen, M., Meier, S., Metspalu, A., Domschke, K., Reif, A., Hovatta, I., Lindefors, N., Andersson, E., Schalling, M., Mbarek, H., Milaneschi, Y., de Geus, E. J. C., Boomsma, D. I., Penninx, B. W. J. H., Thorgeirsson, T. E., Steinberg, S., Stefansson, K., Stefansson, H., Müller-Myhsok, B., Hansen, T. F., Børglum, A. D., Werge, T., Mortensen, P. B., Nordentoft, M., Hougaard, D. M., Hultman, C. M., Sullivan, P. F., Nöthen, M. M., Woldbye, D. P. D., Mors, O., Binder, E. B., Rück, C., Ripke, S., Deckert, J. & Schumacher, J., 11 Nov 2019, In : Molecular Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Panic Disorder
Depression
Single Nucleotide Polymorphism
Genome

Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts

Zhang, X., Abdellaoui, A., Rucker, J., de Jong, S., Potash, J. B., Weissman, M. M., Shi, J., Knowles, J. A., Pato, C., Pato, M., Sobell, J., Smit, J. H., Hottenga, J. J., de Geus, E. J. C., Lewis, C. M., Buttenschøn, H. N., Craddock, N., Jones, I., Jones, L., McGuffin, P. & 13 othersMors, O., Owen, M. J., Preisig, M., Rietschel, M., Rice, J. P., Rivera, M., Uher, R., Gejman, P. V., Sanders, A. R., Boomsma, D., Penninx, B. W. J. H., Breen, G. & Levinson, D. F., 15 Jun 2019, In : Biological Psychiatry. 85, 12, p. 1065-1073 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Genome
Intergenic DNA
Nucleic Acid Regulatory Sequences
Genome-Wide Association Study

Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes

Chen, J., Loukola, A., Gillespie, N. A., Peterson, R., Jia, P., Riley, B., Maes, H., Dick, D. M., Kendler, K. S., Damaj, M. I., Miles, M. F., Zhao, Z., Li, M. D., Vink, J. M., Minica, C. C., Willemsen, G., Boomsma, D. I., Qaiser, B., Madden, P. A. F., Korhonen, T. & 26 othersJousilahti, P., Hällfors, J., Gelernter, J., Kranzler, H. R., Sherva, R., Farrer, L., Maher, B., Vanyukov, M., Taylor, M., Ware, J. J., Munafò, M. R., Lutz, S. M., Hokanson, J. E., Gu, F., Landi, M. T., Caporaso, N. E., Hancock, D. B., Gaddis, N. C., Baker, T. B., Bierut, L. J., Johnson, E. O., Chenoweth, M., Lerman, C., Tyndale, R., Kaprio, J. & Chen, X., 11 Jul 2019, In : Nicotine and Tobacco Research.

Research output: Contribution to JournalArticleAcademicpeer-review

Tobacco Use Disorder
Meta-Analysis
Genome
Phenotype
Smoking

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

eQTLGen Consortium, 15 Jan 2019, In : eLife. 8, p. 1-40 40 p., e39856.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genomics
Genes
Furin
Transport Vesicles
Peer Review

Genomics of human aggression: current state of genome-wide studies and an automated systematic review tool

Odintsova, V. V., Roetman, P. J., Ip, H. F., Pool, R., Van der Laan, C. M., Tona, K. D., Vermeiren, R. R. J. M. & Boomsma, D. I., 1 Oct 2019, In : Psychiatric genetics. 29, 5, p. 170-190 21 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genomics
Aggression
Genome-Wide Association Study
Genome
Attention Deficit and Disruptive Behavior Disorders

Heritability of cortisol production and metabolism throughout adolescence: a twin study

van Keulen, B. J., Dolan, C. V., Andrew, R., Walker, B. R., Hulshoff Pol, H. E., Boomsma, D. I., Rotteveel, J. & Finken, M. J. J., 14 Oct 2019, In : The Journal of clinical endocrinology and metabolism.

Research output: Contribution to JournalArticleAcademicpeer-review

Twin Studies
Metabolism
Hydrocortisone
Individuality
Oxidoreductases

Homogenizing estimates of heritability among SOLAR-eclipse, OpenMX, APACE, and FPHI software packages in neuroimaging data

Kochunov, P., Patel, B., Ganjgahi, H., Donohue, B., Ryan, M., Hong, E. L., Chen, X., Adhikari, B., Jahanshad, N., Thompson, P. M., Van’t Ent, D., den Braber, A., de Geus, E. J. C., Brouwer, R. M., Boomsma, D. I., Hulshoff Pol, H. E., de Zubicaray, G. I., McMahon, K. L., Martin, N. G., Wright, M. J. & 1 othersNichols, T. E., Mar 2019, In : Frontiers in Neuroinformatics. 13, March, p. 1-11 11 p., 16.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Diffusion tensor imaging
Neuroimaging
Maximum likelihood estimation
Software packages
Software

Identification of common genetic risk variants for autism spectrum disorder

Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23Andme Research Team, Mar 2019, In : Nature Genetics. 51, 3, p. 431-444 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Phenotype
Sample Size
Meta-Analysis
Autism Spectrum Disorder

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 11 Jun 2019, In : Nature Communications. 10, p. 1-18 18 p., 2548.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
methylation
DNA Methylation
Fetal Blood
blood
Blood