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Research Output 1985 2019

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2019

A linear mixed-model approach to study multivariate gene-environment interactions

BIOS Consortium, 't Hoen, P. A. , van Meurs, J. B. J. , Isaacs, A. , Jansen, R. , Franke, L. , Boomsma, D. I. , Pool, R. , van Dongen, J. , Hottenga, J. J. , Van Greevenbroek, M. J. , Stehouwer, C. D. A. , van der Kallen, C. J. H. , Schalkwijk, C. G. , Wijmenga, C. , Zhernakova, A. , Tigchelaar, E. F. , Slagboom, P. E. , Beekman, M. , Deelen, J. & 30 others van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Iterson, M., van Galen, M., Bot, J., van’t Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Zhernakova, D. V., Luijk, R., Jan Bonder, M., van Dijk, F., Arindrarto, W., Kielbasa, P. S. M., Swertz, M. A. & van Zwet, E. W., Jan 2019, In : Nature Genetics. 51, 1, p. 180-186 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Gene-Environment Interaction
Linear Models
Body Mass Index
Genotype
Diet

A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms

EAGLE-ADHD Consortium, 18 Jan 2019, In : Behavior Genetics.

Research output: Contribution to JournalArticleAcademicpeer-review

Impulsive Behavior
Single Nucleotide Polymorphism
Meta-Analysis
signs and symptoms (animals and humans)
meta-analysis

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

23Andme Research Team, 14 Jan 2019, In : Nature Genetics.

Research output: Contribution to JournalArticleAcademicpeer-review

Tobacco Use
Alcohols
Tobacco Use Cessation
Genetic Association Studies
Synaptic Transmission

Awareness and perceptions of clinical guidelines for the diagnostics and treatment of severe behavioural problems in children across Europe: A qualitative survey with academic experts

Gatej, A-R., Lamers, A., van Domburgh, L., Crone, M., Ogden, T., Rijo, D., Aronen, E., Barroso, R., Boomsma, D. I. & Vermeiren, R., 15 Jan 2019, In : European Psychiatry. 57, p. 1-9 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Guidelines
Practice Guidelines
Therapeutics
Textbooks
Evidence-Based Practice

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Davies, G. E., Ehli, E. A., Fedko, I. O., Groen-Blokhuis, M. M., Hammerschlag, A. R., Hottenga, J. J., Hudziak, J. & Ouwens, K. G., Jan 2019, In : Nature Genetics. 51, 1, p. 63-75 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Genome
Genome-Wide Association Study
Meta-Analysis
Population

EEG-based age-prediction models as stable and heritable indicators of brain maturational level in children and adolescents

Vandenbosch, M. M. L. J. Z., Ent, D. V. ., Boomsma, D. I., Anokhin, A. P. & Smit, D. J. A., 4 Jan 2019, In : Human Brain Mapping.

Research output: Contribution to JournalArticleAcademicpeer-review

Electroencephalography
Brain
Puberty
Netherlands
Longitudinal Studies

Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci

Gupta, R., van Dongen, J., Fu, Y., Abdellaoui, A., Tyndale, R. F., Velagapudi, V., Boomsma, D. I., Korhonen, T., Kaprio, J., Loukola, A. & Ollikainen, M., 5 Jan 2019, In : Clinical epigenetics. 11, 1, p. 1

Research output: Contribution to JournalArticleAcademicpeer-review

Cotinine
Nicotine
DNA Methylation
Smoking
Serum

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

23and Me Research Team, Benjamin, D. J., Koellinger, P. D., van Dongen, J., Willemsen, G., Dolan, C. V. & Beauchamp, J. P., 14 Jan 2019, In : Nature Genetics.

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic Loci
Genome-Wide Association Study
Single Nucleotide Polymorphism
Computational Biology
Synaptic Transmission

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

eQTLGen Consortium, 15 Jan 2019, In : eLife. 8

Research output: Contribution to JournalArticleAcademicpeer-review

Genomics
Genes
Furin
Transport Vesicles
Peer Review

Multivariate genome-wide analyses of the well-being spectrum

BIOS Consortium, 14 Jan 2019, In : Nature Genetics.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Genome
Meta-Analysis
Interneurons
Computational Biology
2018

A characterization of post-zygotic mutations identified in monozygotic twins

Ouwens, K. G., Jansen, R., Tolhuis, B., Slagboom, P. E., Penninx, B. W. J. H. & Boomsma, D. I., Oct 2018, In : Human Mutation. 39, 10, p. 1393-1401 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Mutation
Mosaicism
Genome
Recombinant DNA

Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium

Malanchini, M., Smith-Woolley, E., Ayorech, Z., Rimfeld, K., Krapohl, E., Vuoksimaa, E., Korhonen, T., Bartels, M., van Beijsterveldt, T. C. E. M., Rose, R. J., Lundström, S., Anckarsäter, H., Kaprio, J., Lichtenstein, P., Boomsma, D. I. & Plomin, R., 11 Jun 2018, In : Psychological Medicine. p. 1-9 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Smoking
Aggression
Mothers
Pregnancy
Twin Studies

Analysis of shared heritability in common disorders of the brain

The Brainstorm Consortium, 22 Jun 2018, In : Science. 360, 6395, p. 1-15 15 p., 8757

Research output: Contribution to JournalArticleAcademicpeer-review

Brain Diseases
Psychiatry
Phenotype
Genetic Heterogeneity
Genome-Wide Association Study

An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register

Boomsma, D. I., Helmer, Q., Nieuwboer, H. A., Hottenga, J. J., de Moor, M. H., van den Berg, S. M., Davies, G. E., Vink, J. M., Schouten, M. J., Dolan, C. V., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Ligthart, L. & de Geus, E. J., 1 Jan 2018, In : Behavior Genetics. 48, 1, p. 1-11

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Twin Studies
Pedigree
pedigree
Netherlands
households

Are Migraine and Tension-Type Headache Genetically Related? An Investigation of Twin Family Data

Ligthart, L., Huijgen, A., Willemsen, G., De Geus, E. J. C. & Boomsma, D. I., Apr 2018, In : Twin Research and Human Genetics. 21, 2, p. 112-118 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Tension-Type Headache
Migraine Disorders
Comorbidity
Dizygotic Twins
Monozygotic Twins

A SNP panel for identification of DNA and RNA specimens

Yousefi, S., Abbassi-Daloii, T., Kraaijenbrink, T., Vermaat, M., Mei, H., van 't Hof, P., van Iterson, M., Zhernakova, D. V., Claringbould, A., Franke, L., 't Hart, L. M., Slieker, R. C., van der Heijden, A., de Knijff, P., 't Hoen, P. A. C., BIOS consortium, Boomsma, D. I., van Dongen, J., Hottenga, J. J. & Pool, R., 25 Jan 2018, In : BMC Genomics. 19, 1, p. 90

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Single Nucleotide Polymorphism
RNA
DNA
Genotype
RNA Sequence Analysis

Association Between Population Density and Genetic Risk for Schizophrenia

Colodro-Conde, L. , Couvy-Duchesne, B. , Whitfield, J. B. , Streit, F. , Gordon, S. , Kemper, K. E. , Yengo, L. , Zheng, Z. , Trzaskowski, M. , De Zeeuw, E. L. , Nivard, M. G. , Das, M. , Neale, R. E. , MacGregor, S. , Olsen, C. M. , Whiteman, D. C. , Boomsma, D. I. , Yang, J. , Rietschel, M. , McGrath, J. J. & 2 others Medland, S. E. & Martin, N. G., Sep 2018, In : JAMA Psychiatry. 75, 9, p. 901-910 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Population Genetics
Population Density
Schizophrenia
Netherlands
Social Class

Association between structural brain network efficiency and intelligence increases during adolescence

Koenis, M. M. G., Brouwer, R. M., Swagerman, S. C., van Soelen, I. L. C., Boomsma, D. I. & Hulshoff Pol, H. E., 1 Feb 2018, In : Human Brain Mapping. 39, 2, p. 822-836

Research output: Contribution to JournalArticleAcademicpeer-review

Intelligence
Brain
Genes
Longitudinal Studies
Siblings

Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts

Piirtola, M. , Jelenkovic, A. , Latvala, A. , Sund, R. , Honda, C. , Inui, F. , Watanabe, M. , Tomizawa, R. , Iwatani, Y. , Ordoñana, J. R. , Sánchez-Romera, J. F. , Colodro-Conde, L. , Tarnoki, A. D. , Tarnoki, D. L. , Martin, N. G. , Montgomery, G. W. , Medland, S. E. , Rasmussen, F. , Tynelius, P. , Tan, Q. & 38 others Zhang, D., Pang, Z., Rebato, E., Stazi, M. A., Fagnani, C., Brescianini, S., Busjahn, A., Harris, J. R., Brandt, I., Nilsen, T. S., Cutler, T. L., Hopper, J. L., Corley, R. P., Huibregtse, B. M., Sung, J., Kim, J., Lee, J., Lee, S., Gatz, M., Butler, D. A., Franz, C. E., Kremen, W. S., Lyons, M. J., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Öncel, S. Y., Aliev, F., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Silberg, J. L., Maes, H. H., Boomsma, D. I., Sørensen, T. I. A., Korhonen, T., Kaprio, J. & Silventoinen, K., 12 Jul 2018, In : PLoS ONE. 13, 7, p. 1-17 17 p., e0200140

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
body mass index
Body Mass Index
Smoking
confidence interval
Confidence Intervals

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

for the BIOS Consortium & for the GLOBAL Meth QTL Consortium, Dec 2018, In : Ebiomedicine. 38, p. 206-216 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

DNA Methylation
Smoking
Mothers
Phenotype
Waist Circumference

Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Nivard, M. G., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. JC., W J H Penninx, B. & Jansen, R., 31 Jul 2018, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Anisotropy
Genome
Beta Particles
Diffusion Tensor Imaging

Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project

Jelenkovic, A. , Yokoyama, Y. , Sund, R. , Hur, Y. M. , Harris, J. R. , Brandt, I. , Nilsen, T. S. , Ooki, S. , Ullemar, V. , Almqvist, C. , Magnusson, P. K. E. , Saudino, K. J. , Stazi, M. A. , Fagnani, C. , Brescianini, S. , Nelson, T. L. , Whitfield, K. E. , Knafo-Noam, A. , Mankuta, D. , Abramson, L. & 30 others Cutler, T. L., Hopper, J. L., Llewellyn, C. H., Fisher, A., Corley, R. P., Huibregtse, B. M., Derom, C. A., Vlietinck, R. F., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Krueger, R. F., McGue, M., Pahlen, S., Alexandra Burt, S., Klump, K. L., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Willemsen, G., Bartels, M., van Beijsterveld, C. E. M., Craig, J. M., Saffery, R., Rasmussen, F., Tynelius, P., Heikkilä, K. & Boomsma, D. I., May 2018, In : Early Human Development. 120, p. 53-60 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Parturition
Birth Weight
Monozygotic Twins
Dizygotic Twins
Linear Models

Associations between Loneliness and Personality are Mostly Driven by a Genetic Association with Neuroticism

Abdellaoui, A., Chen, H-Y., Willemsen, G., Ehli, E. A., Davies, G. E., Verweij, K. J. H., Nivard, M. G., de Geus, E. J. C., Boomsma, D. I. & Cacioppo, J. T., 12 May 2018, In : Journal of Personality.

Research output: Contribution to JournalArticleAcademicpeer-review

Loneliness
Personality
Monozygotic Twins
Neuroticism
Molecular Biology

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

BIOS Consortium, Luijk, R. , Wu, H. , Ward-Caviness, C. K. , Hannon, E. , Carnero-Montoro, E. , Min, J. L. , Mandaviya, P. , Müller-Nurasyid, M. , Mei, H. , van der Maarel, S. M. , Beekman, M. , der Breggen, R. V. , Deelen, J. , Lakenberg, N. , Moed, M. , Suchiman, H. E. D. , Arindrarto, W. , van’t Hof, P. , Jan Bonder, M. & 32 others Deelen, P., Tigchelaar, E. F., Zhernakova, A., Zhernakova, D. V., van Dongen, J., Hottenga, J. J., Pool, R., Isaacs, A., Hofman, B. A., Jhamai, M., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., van den Berg, L. H., van Galen, M., Vermaat, M., van Rooij, J., Uitterlinden, A. G., Verbiest, M., Verkerk, M., Kielbasa, P. S. M., Bot, J., Nooren, I., van Dijk, F., Swertz, M. A., van Heemst, D., Relton, C., Mill, J., Waldenberger, M., Bell, J. T., Jansen, R. & Boomsma, D. I., 14 Sep 2018, In : Nature Communications. 9, 1, p. 1-9 9 p., 3738

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
X Chromosome Inactivation
methylation
chromosomes
DNA Methylation
Chromosomes

Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts

Jelenkovic, A. , Sund, R. , Yokoyama, Y. , Hur, Y. M. , Ullemar, V. , Almqvist, C. , Magnusson, P. K. , Willemsen, G. , Bartels, M. , Beijsterveldt, C. E. V. , Bogl, L. H. , Pietiläinen, K. H. , Vuoksimaa, E. , Ji, F. , Ning, F. , Pang, Z. , Nelson, T. L. , Whitfield, K. E. , Rebato, E. , Llewellyn, C. H. & 30 others Fisher, A., Bayasgalan, G., Narandalai, D., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Tarnoki, A. D., Tarnoki, D. L., Ooki, S., Stazi, M. A., Fagnani, C., Brescianini, S., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Cutler, T. L., Hopper, J. L., Krueger, R. F., McGue, M., Pahlen, S., Craig, J. M., Saffery, R., Haworth, C. M., Plomin, R., Knafo-Noam, A., Mankuta, D., Abramson, L. & Boomsma, D. I., 19 Apr 2018, In : Scientific Reports. 8, 1, 6300

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Gestational Age
Cohort Studies
Parturition
Siblings
Birth Weight

Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes

't Hart, L. M. , Vogelzangs, N. , Mook-Kanamori, D. O. , Brahimaj, A. , Nano, J. , van der Heijden, A. A. W. A. , Willems van Dijk, K. , Slieker, R. C. , Steyerberg, E. W. , Ikram, M. A. , Beekman, M. , Boomsma, D. I. , van Duijn, C. M. , Slagboom, P. E. , Stehouwer, C. D. A. , Schalkwijk, C. G. , Arts, I. C. W. , Dekker, J. M. , Dehghan, A. , Muka, T. & 3 others van der Kallen, C. J. H., Nijpels, G. & van Greevenbroek, M. M. J., 1 Dec 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 12, p. 4569-4579 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Metabolomics
Medical problems
Type 2 Diabetes Mellitus
Blood
Pharmaceutical Preparations

Brain reward responses to food stimuli among female monozygotic twins discordant for BMI

Doornweerd, S., De Geus, E. J., Barkhof, F., van Bloemendaal, L., Boomsma, D. I., van Dongen, J., Drent, M. L., Willemsen, G., Veltman, D. J. & IJzerman, R. G., 8 Jun 2018, In : Brain Imaging and Behavior. 12, 3, p. 718-727

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Reward
Food
Brain
Obesity

Characterizing the Relation Between Expression QTLs and Complex Traits: Exploring the Role of Tissue Specificity

UK Brain Expression Consortium, Sep 2018, In : Behavior Genetics. 48, 5, p. 374-385 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Organ Specificity
Quantitative Trait Loci
quantitative trait loci
Genome-Wide Association Study
rheumatoid arthritis

Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3–16 years from multiple raters in six cohorts in the EU-ACTION project

Bartels, M. , Hendriks, A. , Mauri, M. , Krapohl, E. , Whipp, A. , Bolhuis, K. , Conde, L. C. , Luningham, J. , Fung Ip, H. , Hagenbeek, F. , Roetman, P. , Gatej, R. , Lamers, A. , Nivard, M. , van Dongen, J. , Lu, Y. , Middeldorp, C. , van Beijsterveldt, T. , Vermeiren, R. , Hankemeijer, T. & 16 others Kluft, C., Medland, S., Lundström, S., Rose, R., Pulkkinen, L., Vuoksimaa, E., Korhonen, T., Martin, N. G., Lubke, G., Finkenauer, C., Fanos, V., Tiemeier, H., Lichtenstein, P., Plomin, R., Kaprio, J. & Boomsma, D. I., Sep 2018, In : European Child and Adolescent Psychiatry. 27, 9, p. 1105-1121 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Aggression
Psychopathology
Anxiety
Problem Behavior
Depression

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

van der Lee, S. J. , Teunissen, C. E. , Pool, R. , Shipley, M. J. , Teumer, A. , Chouraki, V. , Melo van Lent, D. , Tynkkynen, J. , Fischer, K. , Hernesniemi, J. , Haller, T. , Singh-Manoux, A. , Verhoeven, A. , Willemsen, G. , de Leeuw, F. A. , Wagner, H. , van Dongen, J. , Hertel, J. , Budde, K. , Willems van Dijk, K. & 28 others Weinhold, L., Ikram, M. A., Pietzner, M., Perola, M., Wagner, M., Friedrich, N., Slagboom, P. E., Scheltens, P., Yang, Q., Gertzen, R. E., Egert, S., Li, S., Hankemeier, T., van Beijsterveldt, C. E. M., Vasan, R. S., Maier, W., Peeters, C. F. W., Jörgen Grabe, H., Ramirez, A., Seshadri, S., Metspalu, A., Kivimäki, M., Salomaa, V., Demirkan, A., Boomsma, D. I., van der Flier, W. M., Amin, N. & van Duijn, C. M., Jun 2018, In : Alzheimers & Dementia. 14, 6, p. 707-722 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Aptitude
Cognition
Dementia
Cohort Studies
Life Style

Cohort profile: the Geoscience and Health Cohort Consortium (GECCO) in the Netherlands

Timmermans, E. J., Lakerveld, J., Beulens, J. W. J., Boomsma, D. I., Kramer, S. E., Oosterman, M., Willemsen, G., Stam, M., Nijpels, G., Schuengel, C., Smit, J. H., Brunekreef, B., Dekkers, J. E. C., Deeg, D. J. H., Penninx, B. W. J. H. & Huisman, M., 9 Jun 2018, In : BMJ Open. 8, 6, p. 1-14 14 p., e021597

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Earth Sciences
Netherlands
Cohort Studies
Health
Information Storage and Retrieval

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

Culverhouse, R. C. , Saccone, N. L. , Horton, A. C. , Ma, Y. , Anstey, K. J. , Banaschewski, T. , Burmeister, M. , Cohen-Woods, S. , Etain, B. , Fisher, H. L. , Goldman, N. , Guillaume, S. , Horwood, J. , Juhasz, G. , Lester, K. J. , Mandelli, L. , Middeldorp, C. M. , Olié, E. , Villafuerte, S. , Air, T. M. & 73 others Araya, R., Bowes, L., Burns, M. R., Byrne, E. M., Coffey, J. C., Coventry, W. L., Gawronski, K. A. B., Glei, D., Hatzimanolis, A., Hottenga, J-J., Jaussent, I., Jawahar, C., Jennen-Steinmetz, C., Kramer, J. R., Lajnef, M., Little, K., Meyer zu Schwabedissen, H., Nauck, M., Nederhof, E., Petschner, P., Peyrot, W. J., Schwahn, C., Sinnamon, G., Stacey, D., Tian, Y., Toben, C., Van der Auwera, S., Wainwright, N. W., Wang, J-C., Willemsen, G., Anderson, I. M., Arolt, V., Åslund, C., Bagdy, G., Baune, B. T., Bellivier, F., Boomsma, D. I., Courtet, P., Dannlowski, U., de Geus, E. J. C., Deakin, J. F. W., Easteal, S., Eley, T. C., Fergusson, D. M., Goate, A. M., Gonda, X., Grabe, H. J., Holzman, C., Johnson, E. O., Kennedy, D. M., Laucht, M., Martin, N. G., Munafò, M. R., Nilsson, K. W., Oldehinkel, A. J., Olsson, C. A., Ormel, J., Otte, C., Patton, G. C., Penninx, B. W. J. H., Ritchie, K., Sarchiapone, M., Scheid, J. M., Serretti, A., Smit, J. H., Stefanis, N. C., Surtees, P. G., Völzke, H., Weinstein, M., Whooley, M. A., Nurnberger, J. I., Breslau, N. & Bierut, L. J., 2 Jan 2018, In : Molecular Psychiatry. 23, 1, p. 133-142

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Meta-Analysis
Genotype
Depression
Alleles
Serotonin Plasma Membrane Transport Proteins

Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families

23Andme Research Team, Boomsma, D. I., Ligthart, R. S. L. & Posthuma, D., 16 May 2018, In : Neuron. 98, 4, p. 743-753

Research output: Contribution to JournalArticleAcademicpeer-review

Migraine Disorders
Migraine without Aura
Migraine with Aura
Population

DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis

Ward-Caviness, C. K. , Huffman, J. E. , Everett, K. , Germain, M. , Van Dongen, J. , Hill, W. D. , Jhun, M. A. , Brody, J. A. , Ghanbari, M. , Du, L. , Roetker, N. S. , De Vries, P. S. , Waldenberger, M. , Gieger, C. , Wolf, P. , Prokisch, H. , Koenig, W. , O’Donnell, C. J. , Levy, D. , Liu, C. & 34 others Truong, V., Wells, P. S., Trégouët, D. A., Tang, W., Morrison, A. C., Boerwinkle, E., Wiggins, K. L., McKnight, B., Guo, X., Psaty, B. M., Sotoodenia, N., Boomsma, D. I., Willemsen, G., Ligthart, L., Deary, I. J., Zhao, W., Ware, E. B., Kardia, S. L. R., Van Meurs, J. B. J., Uitterlinden, A. G., Franco, O. H., Eriksson, P., Franco-Cereceda, A., Pankow, J. S., Johnson, A. D., Gagnon, F., Morange, P. E., De Geus, E. J. C., Starr, J. M., Smith, J. A., Dehghan, A., Björck, H. M., Smith, N. L. & Peters, A., 25 Oct 2018, In : Blood. 132, 17, p. 1842-1850 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Hemostatics
DNA Methylation
Epigenomics
Meta-Analysis
Aging of materials

DNA methylation and associated gene expression in blood prior to lung cancer diagnosis in the Norwegian Women and Cancer cohort

Sandanger, T. M., Nøst, T. H., Guida, F., Rylander, C., Campanella, G., Muller, D. C., van Dongen, J., Boomsma, D. I., Johansson, M., Vineis, P., Vermeulen, R., Lund, E. & Chadeau-Hyam, M., 13 Nov 2018, In : Scientific Reports. 8, p. 1-10 10 p., 16714

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
DNA Methylation
Lung Neoplasms
Smoking
Gene Expression
Neoplasms

DNA methylation signatures of educational attainment

Dongen, J. V., Bonder, M. J., Dekkers, K. F., Nivard, M. G., Iterson, M. V., Willemsen, G., Beekman, M., Spek, A. V. D., Meurs, J. B. J. V., Franke, L., Heijmans, B. T., Duijn, C. M. V., Slagboom, P. E. & Boomsma, D. I., 23 Mar 2018, In : npj Science of Learning 2018 3:1. 3, p. 1-14 14 p., 7

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
DNA Methylation
Smoking
Methylation
Air Pollution
Brain

Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

Peyrot, W. J. , Van der Auwera, S. , Milaneschi, Y. , Dolan, C. V. , Madden, P. A. F. , Sullivan, P. F. , Strohmaier, J. , Ripke, S. , Rietschel, M. , Nivard, M. G. , Mullins, N. , Montgomery, G. W. , Henders, A. K. , Heat, A. C. , Fisher, H. L. , Dunn, E. C. , Byrne, E. M. , Air, T. A. , Baune, B. T. , Breen, G. & 10 others Levinson, D. F., Lewis, C. M., Martin, N. G., Nelson, E. N., Boomsma, D. I., Grabe, H. J., Wray, N. R., Penninx, B. W. J. H., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Hottenga, J. J., 1 Jul 2018, In : Biological Psychiatry. 84, 2, p. 138-147

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Genomics
Psychiatry
Meta-Analysis
Depression

Eleven loci with new reproducible genetic associations with allergic disease risk

23Andme Research Team, 18 Apr 2018, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Genes
Interleukin-27
Seasonal Allergic Rhinitis
Eczema

Establishing a Twin Register: An Invaluable Resource for (Behavior) Genetic, Epidemiological, Biomarker, and 'Omics' Studies

Odintsova, V. V., Willemsen, G., Dolan, C. V., Hottenga, J. J., Martin, N. G., Slagboom, P. E., Ordoñana, J. R. & Boomsma, D. I., Jun 2018, In : Twin Research and Human Genetics. 21, 3, p. 239-252 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Biomarkers
Research
Behavioral Genetics
Molecular Epidemiology
Medical Genetics
Open Access
pleiotropy
Random Allocation
Causality
observational studies
childhood

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

23Andme Research Team, Abdellaoui, A., Peyrot, W. J., Hottenga, J. J., Vinkhuyzen, A. A. E., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Penninx, B., Posthuma, D. & Uitterlinden, A. G., Aug 2018, In : Nature Genetics. 50, 8, p. 1112-1121 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Genetic Association Studies
Single Nucleotide Polymorphism
Genome
Phenotype

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

the Million Veteran Program, Oct 2018, In : Nature Genetics. 50, 10, p. 1412-1431 20 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Blood Pressure
Cardiovascular Diseases
Genetic Association Studies
Life Style
Hypertension

Genetic and Environmental Contributions to the Development of Childhood Aggression

Lubke, G. H., McArtor, D. B., Boomsma, D. I. & Bartels, M., 1 Jan 2018, In : Developmental Psychology. 54, 1, p. 39-50

Research output: Contribution to JournalArticleAcademicpeer-review

Aggression
aggression
childhood
Checklist
Netherlands

Genetic and environmental factors affecting birth size variation: A pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts

Yokoyama, Y. , Jelenkovic, A. , Hur, Y. M. , Sund, R. , Fagnani, C. , Stazi, M. A. , Brescianini, S. , Ji, F. , Ning, F. , Pang, Z. , Knafo-Noam, A. , Mankuta, D. , Abramson, L. , Rebato, E. , Hopper, J. L. , Cutler, T. L. , Saudino, K. J. , Nelson, T. L. , Whitfield, K. E. , Corley, R. P. & 40 others Huibregtse, B. M., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Llewellyn, C. H., Fisher, A., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Krueger, R. F., McGue, M., Pahlen, S., Bartels, M., Van Beijsterveldt, C. E. M., Willemsen, G., Harris, J. R., Brandt, I., Nilsen, T. S., Craig, J. M., Saffery, R., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Haworth, C. M. A., Plomin, R., Bayasgalan, G., Narandalai, D., Rasmussen, F., Tynelius, P., Tarnoki, A. D., Tarnoki, D. L., Ooki, S., Rose, R. J., Pietiläinen, K. H., Sørensen, T. I. A., Boomsma, D. I., Kaprio, J. & Silventoinen, K., 1 Aug 2018, In : International Journal of Epidemiology. 47, 4, p. 1195-1206 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Parturition
Gestational Age
Weights and Measures
Far East
North America
Open Access
Antisocial Personality Disorder
Crime
Sex Characteristics
Netherlands
Open Access
teachers
academic achievement
Netherlands
Self Report
Educational Status

Genetic Influences on the Development of Cerebral Cortical Thickness During Childhood and Adolescence in a Dutch Longitudinal Twin Sample: The Brainscale Study

Teeuw, J., Brouwer, R. M., Koenis, M. M. G., Swagerman, S. C., Boomsma, D. I. & Hulshoff Pol, H. E., 25 Jan 2018, In : Cerebral Cortex.

Research output: Contribution to JournalArticleAcademicpeer-review

Psychiatry
Magnetic Resonance Imaging
Brain

Genetic vulnerability for smoking and cannabis use: associations with e-cigarette and water pipe use

International Cannabis Consortium, 19 Jul 2018, In : Nicotine and Tobacco Research.

Research output: Contribution to JournalArticleAcademicpeer-review

Marijuana Smoking
Tobacco Products
Water
Smoking
Cannabis

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

LifeLines Cohort Study & CHARGE Inflammation Working Group, 1 Nov 2018, In : American Journal of Human Genetics. 103, 5, p. 691-706 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

C-Reactive Protein
Genome
Inflammation
Mendelian Randomization Analysis
Genome-Wide Association Study

Genome-wide analysis of DNA methylation in buccal cells: A study of monozygotic twins and mQTLs

Van Dongen, J., Ehli, E. A., Jansen, R., Van Beijsterveldt, C. E. M., Willemsen, G., Hottenga, J. J., Kallsen, N. A., Peyton, S. A., Breeze, C. E., Kluft, C., Heijmans, B. T., Bartels, M., Davies, G. E. & Boomsma, D. I., 25 Sep 2018, In : Epigenetics and Chromatin. 11, p. 1-14 14 p., 54

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Cheek
DNA Methylation
Methylation
Quantitative Trait Loci