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Research Description
We combine optical imaging with computational techniques. While some optical imaging techniques are only possible by using appropriate algorithms, others benefit from them by improving resolution, image quality, or cost-effectiveness. We develop these methods and apply them in biomedicine. For example, we research computational methods for optical coherence tomography (OCT) and their applications. Using a dedicated full-field Fourier-domain OCT system, we achieve record-breaking acquisition rates of up to 100 million depth scans (A-scans) per second, reducing motion artifacts and allowing us to use the phase of the light for image reconstruction and for additional contrast. This capability also permits label-free observation of microscopic structural and functional changes in retinal cells, such as photoreceptors and neurons, following light stimulation.
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Academic qualification
PhD, Holoscopy, Luebeck University
Award Date: 18 Jun 2013
Keywords
- QC Physics
- Biophotonics
- Biomedical Imaging
- Optical Coherence Tomography (OCT)
- Computational Optical Imaging
- Microscopy
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Collaborations and top research areas from the last five years
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Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer
Pfäffle, C., Spahr, H., Gercke, K., Burhan, S., Melenberg, D., Miura, Y., Hüttmann, G. & Hillmann, D., 2021, Ophthalmic Technologies XXXI. Hammer, D. X., Joos, K. M. & Palanker, D. V. (eds.). SPIE, 1162313. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11623).Research output: Chapter in Book / Report / Conference proceeding › Conference contribution › Academic › peer-review
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Retinal blood flow imaging with combined full-field swept-source optical coherence tomography and laser Doppler holography
Puyo, L., Spahr, H., Pfäffle, C., Hüttmann, G. & Hillmann, D., 1 Mar 2022, In: Optics Letters. 47, 5, p. 1198-1201 4 p.Research output: Contribution to Journal › Article › Academic › peer-review
Open AccessFile201 Downloads (Pure) -
Phase-sensitive interferometry of decorrelated speckle patterns
Spahr, H., Pfäffle, C., Burhan, S., Kutzner, L., Hilge, F., Hüttmann, G. & Hillmann, D., 1 Dec 2019, In: Scientific Reports. 9, 1, 11748.Research output: Contribution to Journal › Article › Academic › peer-review
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Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina
Pfäffle, C., Spahr, H., Kutzner, L., Burhan, S., Hilge, F., Miura, Y., Hüttmann, G. & Hillmann, D., 1 Dec 2019, In: Optics Letters. 44, 23, p. 5671-5674Research output: Contribution to Journal › Article › Academic › peer-review
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In vivo optical imaging of physiological responses to photostimulation in human photoreceptors
Hillmann, D., Spahr, H., Pfäffle, C., Sudkamp, H., Franke, G. & Hüttmann, G., 15 Nov 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 46, p. 13138-13143Research output: Contribution to Journal › Article › Academic › peer-review
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Projects
- 1 Active
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Imaging of individual cells and their function in the living human retina
Hillmann, D. (Project Researcher)
1/06/24 → 31/05/28
Project: Research