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D.J. Scholten

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20082015
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Research Output 2008 2015

  • 15 Article
  • 1 PhD Thesis - Research VU, graduation VU
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Article
2015
Chemokine Receptors
Metabolites
Mass spectrometry
Mass Spectrometry
Ligands

Exploring the cxcr3 chemokine receptor with small-molecule antagonists and agonists

Wijtmans, M., Scholten, D., Mooij, W., Smit, M. J., De Esch, I. J. P., de Graaf, C. & Leurs, R., 2015, In : Topics in Medicinal Chemistry. 14, p. 119-185 68 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Chemokine Receptors
Ligands
Chemokines
Mutagenesis
CXCR Receptors

Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment

Mladic, M., Scholten, D. J., Wijtmans, M., Falck, D., Leurs, R., Niessen, W. M. A., Smit, M. J. & Kool, J., Sep 2015, In : Analytical and Bioanalytical Chemistry. 407, 23, p. 7067-81 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chemokine Receptors
Liquid chromatography
Liquid Chromatography
Mass spectrometry
Mass Spectrometry

Pharmacological characterization of [3H]VUF11211, a novel radiolabeled small-molecule inverse agonist for the chemokine receptor CXCR3

Scholten, D. J., Wijtmans, M., van Senten, J. R., Custers, H., Stunnenberg, A., de Esch, I. J. P., Smit, M. J. & Leurs, R., Apr 2015, In : Molecular Pharmacology. 87, 4, p. 639-48 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Chemokine Receptors
Pharmacology
Ligands
CXC Chemokines
5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpiperazin-1-yl)-N-ethylnicotinamide
2014

Identification of Overlapping, but Differential Binding Sites for the High-affinity CXCR3 antagonists NBI-74330 and VUF11211

Scholten, D. J., Roumen, L., Wijtmans, M., Verkade-Vreeker, M. C., Custers, H., Lai, M., de Hooge, D., Canals, M., de Esch, I. J. P., Smit, M. J., de Graaf, C. & Leurs, R., 2014, In : Molecular Pharmacology. 85, 1, p. 116-126

Research output: Contribution to JournalArticleAcademicpeer-review

Binding Sites
Computer Simulation
CXCR Receptors
CXCR3 Receptors
Ligands
2012

C(X)CR in silico: Computer-aided prediction of chemokine receptor-ligand interactions

Roumen, L., Scholten, D. J., de Kruijf, P., de Esch, I. J. P., Leurs, R. & de Graaf, C., 2012, In : Drug Discovery Today. 9, p. e281-e291

Research output: Contribution to JournalArticleAcademicpeer-review

Chemokine Receptors
Computer Simulation
Ligands
Structural Models
Crowns

Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 bisaryl-type ligands

Wijtmans, M., Scholten, D. J., Roumen, L., Canals, M., Custers, H., Glas, M., Vreeker, M., de Graaf, C., Smit, M. J., de Esch, I. J. P. & Leurs, R., 2012, In : Journal of Medicinal Chemistry. 55, p. 10572-10583

Research output: Contribution to JournalArticleAcademicpeer-review

Peptide Receptors
Chemokine Receptors
Ligands
Halogens
Structure-Activity Relationship
Artificial Receptors
Chemokine Receptors
G-Protein-Coupled Receptors
Electric Impedance
Labels

Pharmacological Modulation of Chemokine Receptor Function

Scholten, D. J., Canals, M., Maussang Detaille, D. A. B., Roumen, L., Smit, M. J., Wijtmans, M., de Graaf, C., Vischer, H. F. & Leurs, R., Mar 2012, In : British Journal of Pharmacology. 165, 6, p. 1617-1643 27 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Chemokine Receptors
Pharmacology
Ligands
HIV Infections
HIV-1

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists

Wijtmans, M., Maussang, D., Sirci, F., Scholten, D. J., Canals, M., Mujić-Delić, A., Chong, M., Chatalic, K. L. S., Custers, H., Janssen, E., de Graaf, C., Smit, M. J., de Esch, I. J. P. & Leurs, R., May 2012, In : European Journal of Medicinal Chemistry. 51, p. 184-192 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Styrene
Amides
Ligands
Molecules
Arrestin

The application of unnatural amino acids to chemokine receptor research

Siderius, M. H., van der Wal, M., Scholten, D. J., Smit, M. J., Sakmar, T. P., Leurs, R. & de Graaf, C., 2012, In : Drug Discovery Today. 9, p. e301-e313

Research output: Contribution to JournalArticleAcademicpeer-review

Chemokine Receptors
G-Protein-Coupled Receptors
Amino Acids
Research
CXCR4 Receptors

Therapeutic targeting of chemokine receptors by small molecules

Wijtmans, M., Scholten, D. J., de Esch, I. J. P., Smit, M. J. & Leurs, R., 2012, In : Drug Discovery Today. 9, p. e229-e236

Research output: Contribution to JournalArticleAcademicpeer-review

Chemokine Receptors
Disclosure
CCR1 Receptors
Therapeutics
Ligands

Ubiquitination of CXCR7 controls receptor trafficking

Canals, M., Scholten, D. J., de Munnik, S. M., Han, M. K. L., Smit, M. J. & Leurs, R., 2012, In : PLoS ONE. 7, p. e34192

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Chemokine Receptors
Ubiquitination
receptors
chemokines
G-Protein-Coupled Receptors
2011

Pharmacological Characterisation of a Small-Molecule Agonist for the Chemokine Receptor CXCR3

Scholten, D. J., Canals, M., Wijtmans, M., de Munnik, S. M., Nguyen, D., Verzijl, D., de Esch, I. J. P., Vischer, H. F., Smit, M. J. & Leurs, R., 2011, In : British Journal of Pharmacology. 166, 3, p. 898-911

Research output: Contribution to JournalArticleAcademicpeer-review

Chemokine Receptors
Pharmacology
CXCR3 Receptors
Chemotaxis
Complementary DNA
2008

Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors

Verzijl, D., Storelli, S., Scholten, D. J., Bosch, L., Reinhart, T. A., Streblow, D. N., Tensen, C. P., Fitzsimons, C. P., Zaman, G. J., Pease, J. E., de Esch, I. J. P., Smit, M. J. & Leurs, R., 2008, In : The Journal of Pharmacology and Experimental Therapeutics. 325, 2, p. 544-55

Research output: Contribution to JournalArticleAcademicpeer-review

CXCR3 Receptors
Chemokine Receptors
Primates
Rodentia
Anilides