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Dr. Edith Houben graduated in Biology at the Vrije Universiteit Amsterdam in 1999, with a specialization in Molecular and Cellular Biology. She subsequently performed her PhD research on membrane protein biogenesis in the model organism Escherichia coli at Molecular Microbiology at the Vrije Universiteit Amsterdam. After her PhD project, she worked for one year as a postdoctoral research fellow in the same group on signal sequence mediated protein secretion in Bacillus subtilis.
In 2004, Edith Houben moved to Switzerland to enter the tuberculosis research field as a postdoctoral fellow in the group of prof. Jean Pieters, Biozentrum, University of Basel. This work was funded by a long-term Febs fellowship.
In 2007, she obtained a Veni-grant from NWO-ALW and moved to the VU University medical center in Amsterdam to start her study on the inner workings of type VII secretion systems in pathogenic mycobacteria.
In 2013, Edith Houben subsequently obtained a VIDI-grant from NWO-ALW on the molecular and biochemical analysis of mycobacterial transport systems and was appointed Assistant Professor at Molecular Microbiology at the Vrije Universiteit Amsterdam.
As awardee of an ASPASIA grant from NWO she has been promoted to Associate Professor in 2018.
Keywords
- Q Science
- protein secretion
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 14 Life Below Water
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Collaborations and top research areas from the last five years
Research output
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Reconstitution of a minimal ESX-5 type VII secretion system suggests a role for PPE proteins in the outer membrane transport of proteins
Bunduc, C. M., Ding, Y., Kuijl, C., Marlovits, T. C., Bitter, W. & Houben, E. N. G., 24 Oct 2023, In: mSphere. 8, 5, p. 1-16 16 p., e0040223.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinum
Damen, M. P. M., Meijers, A. S., Keizer, E. M., Piersma, S. R., Jiménez, C. R., Kuijl, C. P., Bitter, W. & Houben, E. N. G., Dec 2022, In: mBio. 13, 6, p. 1-18 18 p., e02819-22.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Structure and dynamics of a mycobacterial type VII secretion system
Bunduc, C. M., Fahrenkamp, D., Wald, J., Ummels, R., Bitter, W., Houben, E. N. G. & Marlovits, T. C., 20 May 2021, In: Nature. 593, 7859, p. 445-448 4 p.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Structure and Function of the Mycobacterial Type VII Secretion Systems
Bunduc, C. M., Bitter, W. & Houben, E. N. G., Sept 2020, In: Annual Review of Microbiology. 74, p. 315-335 21 p.Research output: Contribution to Journal › Review article › Academic › peer-review
Open AccessFile1170 Downloads (Pure) -
Species-specific secretion of ESX-5 type VII substrates is determined by the linker 2 of EccC5
Bunduc, C. M., Ummels, R., Bitter, W. & Houben, E. N. G., Jul 2020, In: Molecular Microbiology. 114, 1, p. 66-76 11 p.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access