If you made any changes in Pure these will be visible here soon.

Personal profile

Ancillary activities

  • Boehringer Ingelheim RCV GmbH | Wenen, Oostenrijk | Bestuurder | 2013-10-21
  • Boehringer Ingelheim RCV GmbH | Wenen, Oostenrijk | Bestuurder | 2013-10-21

Ancillary activities are updated daily

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Ligands Medicine & Life Sciences
Matched-Pair Analysis Medicine & Life Sciences
Histamine Receptors Medicine & Life Sciences
Pharmaceutical Chemistry Medicine & Life Sciences
Transition Temperature Medicine & Life Sciences
Structure-Activity Relationship Medicine & Life Sciences
Histamine Medicine & Life Sciences
Freezing Medicine & Life Sciences

Research Output 2003 2013

  • 5 Article
  • 2 PhD Thesis - Research VU, graduation VU

Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode

Engelhardt, H., Schultes, S., de Graaf, C., Nijmeijer, S., Vischer, H. F., Zuiderveld, O. B., Dobler, J., Stachurski, K., Mayer, M., Arnhof, H., Scharn, D., Haaksma, E. J. J., de Esch, I. J. P. & Leurs, R., 2013, In : Journal of Medicinal Chemistry. 2013, 56, p. 4264-4276

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Structure-Activity Relationship
Histamine
Ligands

Combining quantum mechanical ligand conformation analys is and protein modeling to elucidate GPCR–ligand binding modes

Schultes, S., Engelhardt, H., Roumen, L., Zuiderveld, O. P., Haaksma, E. J. J., de Esch, I. J. P., Leurs, R. & de Graaf, C., 2013, In : ChemMedChem. 8, 1, p. 49-53

Research output: Contribution to JournalArticleAcademicpeer-review

Computational Medicinal Chemistry in Drug Discovery

Schultes, S., 2013

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Design and Preparation of New Ligands Interacting with the Histamine H4 Receptor

Engelhardt, H., 2013

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

A medicinal chemistry perspective on melting point: matched molecular pair analysis of the effects of simple descriptors on the melting point of drug-like compounds

Schultes, S., de Graaf, C., Berger, H., Mayer, M., Steffen, A., Haaksma, E. J. J., de Esch, I. J. P., Leurs, R. & Krämer, O., 2012, In : MedChemComm. 3, p. 584-591

Research output: Contribution to JournalArticleAcademicpeer-review

Matched-Pair Analysis
Pharmaceutical Chemistry
Transition Temperature
Freezing
Melting point