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Research Output 2005 2019

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Article
2019

Compound Identification Using Liquid Chromatography and High-Resolution Noncontact Fraction Collection with a Solenoid Valve

Jonker, W., de Vries, K., Althuisius, N., van Iperen, D., Janssen, E., ten Broek, R., Houtman, C., Zwart, N., Hamers, T., Lamoree, M. H., Ooms, B., Hidding, J., Somsen, G. W. & Kool, J., 1 Dec 2019, In : SLAS Technology. 24, 6, p. 543-555 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Solenoid valves
Liquid chromatography
Liquid Chromatography
Bioactivity
Flow rate

Method development for effect-directed analysis of endocrine disrupting compounds in human amniotic fluid

Dusza, H., Janssen, E., Kanda, R. & Legler, J., 17 Dec 2019, In : Environmental Science and Technology. 53, 24, p. 14649-14659 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Bioassay
bioassay
Fluids
fluid
Fractionation
2018

Integrative Theory/Experiment-Driven Exploration of a Multicomponent Reaction towards Imidazoline-2-(thi)ones

Kruithof, A., Mulder, J. R., Ruiz, J. M., Janssen, E., Mooijman, M., Ruijter, E., Guerra, C. F., Bickelhaupt, F. M. & Orru, R. V. A., 10 Jan 2018, In : European Journal of Organic Chemistry. 2018, 1, p. 104-112 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cyanates
Aldehydes
Functional groups
Amines
Experiments
2015

Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction

de Graaff, C., Bensch, L., Boersma, S. J., Cioc, R. C., van Lint, M. J., Janssen, E., Turner, N. J., Orru, R. V. A. & Ruijter, E., 16 Nov 2015, In : Angewandte Chemie - International Edition. 54, 47, p. 14133-14136 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

One-Pot Synthesis of N-Substituted β-Amino Alcohols from Aldehydes and Isocyanides

Cioc, R. C., van der Niet, D. J. H., Janssen, E., Ruijter, E. & Orru, R. V. A., 18 May 2015, In : Chemistry: A European Journal. 21, 21, p. 7808-7813 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2014

Chemoselective addition of isocyanides to N-tert-butanesulfinimines

Janssen, G. V., Janssen, E., Vande Velde, C. M. L., Ehlers, A. W., Slootweg, J. C., Ruijter, E., Lammertsma, K. & Orru, R. V. A., 3 Oct 2014, In : Organic Letters. 16, 19, p. 5116-5119 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cyanides
Acetamides
selectivity
Derivatives
sulfinimine

Synthesis of Pyridopyrimidines by Palladium-Catalyzed Isocyanide Insertion

Estévez, V., Van Baelen, G., Lentferink, B. H., Vlaar, T., Janssen, E., Maes, B. U. W., Orru, R. V. A. & Ruijter, E., 3 Jan 2014, In : ACS Catalysis. 2014, 4, p. 40-43 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Pyrimidines
Palladium
Cyanides
Chemical activation
Amidines
2012

Concise synthesis of highly substituted benzo[a]quinolizines by a multicomponent reaction/allylation/heck reaction sequence

Den Heeten, R., Van Der Boon, L. J. P., Broere, D. L. J., Janssen, E., De Kanter, F. J. J., Ruijter, E. & Orru, R. V. A., Jan 2012, In : European Journal of Organic Chemistry. 2012, 2, p. 275-280 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Quinolizines
Allylation
Polycyclic Compounds
Cyclization
synthesis

Multicomponent synthesis of 3,6-dihydro-2H-1,3-thiazine-2-thiones

Kruithof, A., Ploeger, M. L., Janssen, E., Helliwell, M., de Kanter, F. J. J., Ruijter, E. & Orru, R. V. A., 8 Feb 2012, In : Molecules. 17, 2, p. 1675-1685 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Thiazines
thiazine (trademark)
Thiones
synthesis
Amidines

Stereoselective synthesis of N-aryl proline amides by biotransformation-Ugi-Smiles sequence

Znabet, A., Blanken, S., Janssen, E., de Kanter, F. J. J., Helliwell, M., Turner, N. J., Ruijter, E. & Orru, R. V. A., 7 Feb 2012, In : Organic and Biomolecular Chemistry. 10, 5, p. 941-944 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Monoamine Oxidase
Biotransformation
Proline
Amides
amides

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists

Wijtmans, M., Maussang, D., Sirci, F., Scholten, D. J., Canals, M., Mujić-Delić, A., Chong, M., Chatalic, K. L. S., Custers, H., Janssen, E., de Graaf, C., Smit, M. J., de Esch, I. J. P. & Leurs, R., May 2012, In : European Journal of Medicinal Chemistry. 51, p. 184-192 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Styrene
Amides
Ligands
Molecules
Arrestin
2011

Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis

Edink, E. S., Rucktooa, P., Retra, K., Akdemir, A., Nahar, T. T., Zuiderveld, O. P., van Elk, R., Janssen, E., van Nierop, P., van Muijlwijk-Koezen, J. E., Smit, A. B., Sixma, T. K., Leurs, R. & de Esch, I. J. P., 15 Feb 2011, In : Journal of the American Chemical Society. 133, 14, p. 5363-5371 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Thermodynamics
Acetylcholine
Carrier Proteins
Ligands
Cysteine Loop Ligand-Gated Ion Channel Receptors

Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion

Vlaar, T., Ruijter, E., Znabett, A., Janssen, E., de Kanter, F. J. J., Maes, B. U. W. & Orru, R. V. A., 15 Nov 2011, In : Organic Letters. 13, 24, p. 6496-6499 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Hydrazines
cross coupling
Palladium
Cyanides
hydrazines

Synthesis of 4-aminoquinazolines by palladium-catalyzed intramolecular imidoylation of N-(2-bromoaryl)amidines

van Baelen, G. A. K., Kuijer, S., Rycek, L., Sergeyev, S., Janssen, E., de Kanter, F. J. J., Maes, B. U. W., Ruijter, E. & Orru, R. V. A., 23 Dec 2011, In : Chemistry: A European Journal. 17, 52, p. 15039-15044 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Amidines
Palladium
Drug products
Ligands
Cyanides
2010

A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions

Znabet, A., Polak, M. M., Janssen, E., de Kanter, F. J. J., Turner, N. J., Orru, R. V. A. & Ruijter, E., 14 Nov 2010, In : Chemical Commununications. 46, 42, p. 7918-7920 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Stereoselectivity
Atoms
Economics
Pharmaceutical Preparations
telaprevir

Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence

Znabet, A., Zonneveld, J., Janssen, E., De Kanter, F. J. J., Helliwell, M., Turner, N. J., Ruijter, E. & Orru, R. V. A., 7 Nov 2010, In : Chemical Commununications. 46, 41, p. 7706-7708 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Pyrrolidines
Polycyclic Compounds
Alkaloids
Cyclization
Biocatalysis

Inhibition of brain [(3)H]cimetidine binding by improgan-like antinociceptive drugs

Stadel, R., Carpenter, A. B., Nalwalk, J. W., de Esch, I. J. P., Janssen, E. & Hough, L. B., 25 Apr 2010, In : European Journal of Pharmacology. 632, 1-3, p. 33-38 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cimetidine
Brain
Pharmaceutical Preparations
Histamine
Binding Sites

Synthesis of polycyclic alkaloid-type compounds by an N -acyliminium Pictet-Spengler/diels-alder sequence

Ruijter, E., Garcia-Hartjes, J., Hoffmann, F., Vanwandelen, L. T. M., Dekanter, F. J. J., Janssen, E. & Orru, R. V. A., Oct 2010, In : Synlett. 2010, 16, p. 2485-2489 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Alkaloids
Cycloaddition
Amines
Chlorides
Derivatives
2009

A multicomponent reaction towards N-(cyanomethyl)amides

Elders, N., Ruijter, E., de Kanter, F. J. J., Janssen, E., Lutz, M., Spek, A. L. & Orru, R. V. A., 15 Jun 2009, In : Chemistry: A European Journal. 15, 25, p. 6096-6099 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Amides
Amines
Ketones
Aldehydes
Functional groups

The efficient one-pot reaction of up to eight components by the union of multicomponent reactions

Elders, N., van der Born, D., Hendrickx, L. J. D., Timmer, B. J. J., Krause, A., Janssen, E., de Kanter, F. J. J., Ruijter, E. & Orru, R. V. A., 27 Jul 2009, In : Angewandte Chemie - International Edition. 48, 32, p. 5856-5859 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2007

CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist

Hough, L. B., Nalwalk, J. W., Phillips, J. G., Kern, B., Shan, Z., Wentland, M. P., de Esch, I. J. P., Janssen, E., Barr, T. & Stadel, R., Apr 2007, In : Neuropharmacology. 52, 5, p. 1244-55 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cimetidine
Ligands
Analgesia
Analgesics
Pharmacology
2006

Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic

Hough, L. H., de Esch, I. J. P., Janssen, E., Phillips, J. R., Svokos, K., Kern, B., Trachler, J., Abood, M. E., Leurs, R. & Nalwalk, J. B., Sep 2006, In : Neuropharmacology. 51, 3, p. 447-456 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Analgesics
Cannabinoids
Cannabinoid Receptor CB1
rimonabant
SKF 92374