E.N.G. Houben

dr.

  • De Boelelaan 1108, O2 building

    1081 HZ Amsterdam

    Netherlands

19992019
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Personal profile

Ancillary activities

  • VUMC | Amsterdam | Onderzoeker | 2013-01-01 - present

Ancillary activities are updated daily

Personal information

Dr. Edith Houben graduated in Biology at the Vrije Universiteit Amsterdam in 1999, with a specialization in Molecular and Cellular Biology. She subsequently performed her PhD research on membrane protein biogenesis in the model organism Escherichia coli at Molecular Microbiology at the Vrije Universiteit Amsterdam. After her PhD project, she worked for one year as a postdoctoral research fellow in the same group on signal sequence mediated protein secretion in Bacillus subtilis.

In 2004, Edith Houben moved to Switzerland to enter the tuberculosis research field as a postdoctoral fellow in the group of prof. Jean Pieters, Biozentrum, University of Basel. This work was funded by a long-term Febs fellowship.

In 2007, she obtained a Veni-grant from NWO-ALW and moved to the VU University medical center in Amsterdam to start her study on the inner workings of type VII secretion systems in pathogenic mycobacteria.

In 2013, Edith Houben subsequently obtained a VIDI-grant from NWO-ALW on the molecular and biochemical analysis of mycobacterial transport systems and was appointed Assistant Professor at Molecular Microbiology at the Vrije Universiteit Amsterdam.

As awardee of an ASPASIA grant from NWO she has been promoted to Associate Professor in 2018.

Keywords

  • Q Science
  • protein secretion

Fingerprint Dive into the research topics where E.N.G. Houben is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 13 Similar Profiles
Membrane Proteins Medicine & Life Sciences
Mycobacterium Medicine & Life Sciences
Mycobacterium marinum Medicine & Life Sciences
Membranes Medicine & Life Sciences
Escherichia coli Medicine & Life Sciences
Proteins Medicine & Life Sciences
Signal Recognition Particle Medicine & Life Sciences
Mycobacterium tuberculosis Medicine & Life Sciences

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Research Output 1999 2019

  • 37 Article
  • 4 PhD Thesis - Research VU, graduation VU
  • 1 Chapter
  • 1 Review article

Chaperones and substrate specificity, type VII secretion systems reconnected

Phan, T. H., 2019, 194 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Protease and transmembrane domain of the type VII secretion mycosin protease determine system-specific functioning in mycobacteria

van Winden, V. J. C., Damen, M. P. M., Ummels, R., Bitter, W. & Houben, E. N. G., 29 Mar 2019, In : Journal of Biological Chemistry. 294, 13, p. 4806-4814 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Mycobacterium
Peptide Hydrolases
Mycobacterium marinum
Membranes
Stabilization

Bacterial secretion chaperones: The mycobacterial type VII case

Phan, T. H. & Houben, E. N. G., 1 Sep 2018, In : FEMS Microbiology Letters. 365, 18, p. 1-8 8 p., fny197.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Secretory Pathway
Protein Folding
Protein Transport
Mycobacterium
Cytosol

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF

Phan, T. H., van Leeuwen, L. M., Kuijl, C., Ummels, R., van Stempvoort, G., Rubio-Canalejas, A., Piersma, S. R., Jiménez, C. R., van der Sar, A. M., Houben, E. N. G. & Bitter, W., 13 Aug 2018, In : Plos Pathogens. 14, 8, p. 1-26 26 p., e1007247.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mycobacterium marinum
Virulence
Zebrafish
Phagocytes
Infection

Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis

Ates, L. S., Dippenaar, A., Ummels, R., Piersma, S. R., van der Woude, A. D., van der Kuij, K., Le Chevalier, F., Mata-Espinosa, D., Barrios-Payán, J., Marquina-Castillo, B., Guapillo, C., Jiménez, C. R., Pain, A., Houben, E. N. G., Warren, R. M., Brosch, R., Hernández-Pando, R. & Bitter, W., Feb 2018, In : NATURE MICROBIOLOGY. 3, 2, p. 181-188 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Mycobacterium tuberculosis
Virulence
Mutation
Tuberculosis
Proteins