Research output per year
Research output per year
Personal profile
Research
I have a fascination for the basic principles of life, using methods from systems biology and biophysics. I mostly focus on unraveling basic mechanisms of microbial growth and regulation of metabolism and protein expression, using experimental, computational and theoretical methods. Our lab has expertise on experimental microbial physiology, genome-scale stoichiometric modelling, stochastic theory, differential equation and stochastic dynamic models, fluorescence microscopy of microbial growth and reporter protein expression and software development.
Teaching
Classes on experimental and theoretical systems biology and biophysics methods focussing on microorganisms and biochemical reaction networks.
Prizes and Awards
University Research Chair 2014-2019
NWO VIDI 2012 - 2017
Ancillary activities
No ancillary activities
Ancillary activities are updated daily
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
User created Keywords
- Systems Biology
- Biophysics
- Computational Biology
- Fluorescence Microscopy
- Microbial Physiology
- Microbiology
Fingerprint
Dive into the research topics where FJ Bruggeman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Effective bet-hedging through growth rate dependent stability
de Groot, D. H., Tjalma, A. J., Bruggeman, F. J. & van Nimwegen, E., 21 Feb 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 8, p. 1-10 10 p., e2211091120.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Is distance from equilibrium a good indicator for a reaction's flux control?
van Niekerk, D. D., Rust, E., Bruggeman, F., Westerhoff, H. V. & Snoep, J. L., Oct 2023, In: BioSystems. 232, p. 1-8 8 p., 104988.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Trade-offs between the instantaneous growth rate and long-term fitness: Consequences for microbial physiology and predictive computational models
Bruggeman, F. J., Teusink, B. & Steuer, R., Oct 2023, In: BioEssays. 45, 10, p. 1-20 20 p., 2300015.Research output: Contribution to Journal › Review article › Academic › peer-review
Open Access -
Understanding spatiotemporal coupling of gene expression using single molecule RNA imaging technologies
Gerber, A., van Otterdijk, S., Bruggeman, F. J. & Tutucci, E., 12 Apr 2023, (E-pub ahead of print) In: Transcription. 22 p.Research output: Contribution to Journal › Review article › Academic › peer-review
Open Access -
Whole-cell metabolic control analysis
Bruggeman, F. J., Remeijer, M., Droste, M., Salinas, L., Wortel, M., Planqué, R., Sauro, H. M., Teusink, B. & Westerhoff, H. V., Dec 2023, In: BioSystems. 234, p. 1-20 20 p., 105067.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access
Courses
Datasets
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Additional file 1: of Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength
Price, C. (Contributor), Santos, F. B. D. (Contributor), Hesseling, A. (Contributor), Uusitalo, J. (Contributor), Bachmann, H. (Contributor), Benavente, V. (Contributor), Goel, A. (Contributor), Berkhout, J. (Contributor), Bruggeman, F. (Contributor), Marrink, S. (Contributor), Montalban-Lopez, M. (Contributor), Jong, A. (Contributor), Kok, J. (Contributor), Molenaar, D. (Contributor), Poolman, B. (Contributor), Teusink, B. (Contributor) & Kuipers, O. (Contributor), Unknown Publisher, 1 Oct 2019
DOI: 10.6084/m9.figshare.7576595.v1, https://springernature.figshare.com/articles/Additional_file_1_of_Adaption_to_glucose_limitation_is_modulated_by_the_pleotropic_regulator_CcpA_independent_of_selection_pressure_strength/7576595/1
Dataset
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Additional file 1: of Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength
Price, C. E. (Creator), Branco Dos Santos, F. (Contributor), Hesseling, A. (Creator), Uusitalo, J. J. (Creator), Bachmann, H. (Creator), Benavente, V. (Creator), Goel, A. (Contributor), Berkhout, J. (Creator), Bruggeman, F. (Creator), Marrink, S. (Contributor), Montalban-Lopez, M. (Creator), De Jong, A. (Contributor), Kok, J. (Creator), Molenaar, D. (Creator), Poolman, B. (Creator), Teusink, B. (Creator) & Kuipers, O. P. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.7576595, https://springernature.figshare.com/articles/Additional_file_1_of_Adaption_to_glucose_limitation_is_modulated_by_the_pleotropic_regulator_CcpA_independent_of_selection_pressure_strength/7576595
Dataset
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Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies
Elsemman, I. E. (Creator), Rodriguez Prado, A. (Creator), Grigaitis, P. (Creator), Garcia Albornoz, M. (Creator), Harman, V. (Creator), Holman, S. W. (Creator), van Heerden, J. H. (Creator), Bruggeman, F. (Creator), Bisschops, M. M. M. (Creator), Sonnenschein, N. (Creator), Hubbard, S. (Creator), Beynon, R. (Creator), Daran-Lapujade, P. (Creator), Nielsen, J. (Creator) & Teusink, B. (Creator), Zenodo, 2021
DOI: 10.5281/zenodo.5732995, https://zenodo.org/record/5732995
Dataset