Research output per year
Research output per year
Personal profile
Research
I have a fascination for the basic principles of life, using methods from systems biology and biophysics. I mostly focus on unraveling basic mechanisms of microbial growth and regulation of metabolism and protein expression, using experimental, computational and theoretical methods. Our lab has expertise on experimental microbial physiology, genome-scale stoichiometric modelling, stochastic theory, differential equation and stochastic dynamic models, fluorescence microscopy of microbial growth and reporter protein expression and software development.
Teaching
Classes on experimental and theoretical systems biology and biophysics methods focussing on microorganisms and biochemical reaction networks.
Prizes and Awards
University Research Chair 2014-2019
NWO VIDI 2012 - 2017
Ancillary activities
No ancillary activities
Ancillary activities are updated daily
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
User created Keywords
- Systems Biology
- Biophysics
- Computational Biology
- Fluorescence Microscopy
- Microbial Physiology
- Microbiology
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Harnessing noncanonical redox cofactors to advance synthetic assimilation of one-carbon feedstocks
Orsi, E., Hernández-Sancho, J. M., Remeijer, M. S., Kruis, A. J., Volke, D. C., Claassens, N. J., Paul, C. E., Bruggeman, F. J., Weusthuis, R. A. & Nikel, P. I., Dec 2024, In: Current Opinion in Biotechnology. 90, p. 1-13 13 p., 103195.Research output: Contribution to Journal › Review article › Academic › peer-review
Open Access -
Understanding and computational design of genetic circuits of metabolic networks
Berkvens, A., Salinas, L., Remeijer, M., Planqué, R., Teusink, B. & Bruggeman, F. J., Apr 2024, In: Essays in Biochemistry. 68, 1, p. 41-51 11 p.Research output: Contribution to Journal › Review article › Academic › peer-review
Open Access -
A temperature-sensitive metabolic valve and a transcriptional feedback loop drive rapid homeoviscous adaptation in Escherichia coli
Hoogerland, L., van den Berg, S. P. H., Suo, Y., Moriuchi, Y. W., Zoumaro-Djayoon, A., Geurken, E., Yang, F., Bruggeman, F., Burkart, M. D. & Bokinsky, G., 2024, In: Nature Communications. 15, p. 1-13 13 p., 9386.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Whole-cell metabolic control analysis
Bruggeman, F. J., Remeijer, M., Droste, M., Salinas, L., Wortel, M., Planqué, R., Sauro, H. M., Teusink, B. & Westerhoff, H. V., Dec 2023, In: BioSystems. 234, p. 1-20 20 p., 105067.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Understanding spatiotemporal coupling of gene expression using single molecule RNA imaging technologies
Gerber, A., van Otterdijk, S., Bruggeman, F. J. & Tutucci, E., 20 Oct 2023, In: Transcription. 14, 3-5, p. 105-126 22 p.Research output: Contribution to Journal › Review article › Academic › peer-review
Open Access
Courses
Datasets
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Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies
Elsemman, I. E. (Creator), Rodriguez Prado, A. (Creator), Grigaitis, P. (Creator), Garcia Albornoz, M. (Creator), Harman, V. (Creator), Holman, S. W. (Creator), van Heerden, J. H. (Creator), Bruggeman, F. (Creator), Bisschops, M. M. M. (Creator), Sonnenschein, N. (Creator), Hubbard, S. (Creator), Beynon, R. (Creator), Daran-Lapujade, P. (Creator), Nielsen, J. (Creator) & Teusink, B. (Creator), Zenodo, 2021
DOI: 10.5281/zenodo.5732995, https://zenodo.org/record/5732995
Dataset / Software: Dataset
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Additional file 1: of Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength
Price, C. E. (Creator), Branco Dos Santos, F. (Contributor), Hesseling, A. (Creator), Uusitalo, J. J. (Creator), Bachmann, H. (Creator), Benavente, V. (Creator), Goel, A. (Contributor), Berkhout, J. (Creator), Bruggeman, F. (Creator), Marrink, S. (Contributor), Montalban-Lopez, M. (Creator), De Jong, A. (Contributor), Kok, J. (Creator), Molenaar, D. (Creator), Poolman, B. (Creator), Teusink, B. (Creator) & Kuipers, O. P. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.7576595, https://springernature.figshare.com/articles/Additional_file_1_of_Adaption_to_glucose_limitation_is_modulated_by_the_pleotropic_regulator_CcpA_independent_of_selection_pressure_strength/7576595
Dataset / Software: Dataset
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Additional file 1: of Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength
Price, C. (Contributor), Santos, F. B. D. (Contributor), Hesseling, A. (Contributor), Uusitalo, J. (Contributor), Bachmann, H. (Contributor), Benavente, V. (Contributor), Goel, A. (Contributor), Berkhout, J. (Contributor), Bruggeman, F. (Contributor), Marrink, S. (Contributor), Montalban-Lopez, M. (Contributor), Jong, A. (Contributor), Kok, J. (Contributor), Molenaar, D. (Contributor), Poolman, B. (Contributor), Teusink, B. (Contributor) & Kuipers, O. (Contributor), Unknown Publisher, 1 Oct 2019
DOI: 10.6084/m9.figshare.7576595.v1, https://springernature.figshare.com/articles/Additional_file_1_of_Adaption_to_glucose_limitation_is_modulated_by_the_pleotropic_regulator_CcpA_independent_of_selection_pressure_strength/7576595/1
Dataset / Software: Dataset