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Giada Carta achieved a Bachelor degree in Cellular and Molecular Biology at the University of Rome "Tor Vergata" (Italy), she moved then to Innsbruck (Austria) where she graduated with a Master in Molecular Cell-Biology at the "Leopold-Franzes-Universität". Her Master thesis was based on pure molecular biology for the identification of releasing related candidate genes in the flatworm Microstumum Lignano adhesive system, for the production of biological glues. 

After her Master, she moved to the field of in-vitro toxicology, by joining the group of Dr. Paul Jennings at the department of Physiology and Medical Physics of the Innsbruck Medical University with a doctoral program. 

Since 2017, she has moved to Vrije Universiteit Amsterdam, to continue her doctoral degree under the supervision of Prof. Dr. Paul Jennings at the department of Molecular and Computational Toxicology.

Research

Giada´s study, is part of the EU-ToxRisk project and focuses on the prediction and modelling of chemical induced mitochondrial toxicity utilizing state-of-the-art in vitro models. More in detail, her work aims to establish a fit-for-purpose integrated testing strategies for the in vitro assessment of mitochondrial toxicity to predict human in vivo adverse outcomes by identifying: cell models suitable to report mitochondrial impairment, assays that reflect mitochondrial involvement in tissue's toxicity and specific compounds for repeated dose testing with mitochondrial and cell specific endpoints.

Primary models for the aforementioned work are cultured human renal proximal tubule epithelial cells iPSCs derived, the non-cancerous proximal tubule cell line (RPTEC/TERT1), the human hepatocellular carcinoma cell line (HepG2) and the immortalized hepatic cell line (HepaRG). To be extended to various iPSCs derived tissues for systemic studies.

Academic qualification

Molecular Cell- and Developmental Biology, Master, Leopold-Franzens-Universität Innsbruck

Award Date: 1 Nov 2015

Cellular and Molecular Biology, Bachelor, University of Rome Tor Vergata

Award Date: 1 Jun 2012

Keywords

  • Q Science
  • Mitochondria
  • Toxicology
  • in-vitro

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