Photo of H. Lill
  • De Boelelaan 1108, AIMMS/MCB-Section of Structural Biology, O|2 building (room 1E - 05)

    1081 HZ Amsterdam

    Netherlands

1986 …2018
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Personal information

Holger Lill (Diploma in Biology 1984, Dr. rer.nat. in Biophysics 1987, Habilitation in Biochemistry 1995, all at University of Osnabrück, Germany), appointed Professor of Structural Biology at VU Amsterdam in 2000.

Employment

1988-1990 PostDoc at Roche Institute of Molecular Biology, Nutley, New Jersey, USA

1990-1995 Assistant Professor University of Osnabrück

1995-2000 Associate Professor University of Osnabrück

2000-        Professor VU Amsterdam

2008-        Dept. Head Molecular Cell Biology

 

General research interests: functional dynamics of proteins, i.e. how structural changes and intra- or intermolecular interactions lead to function. Methods used are ranging from Molecular Biology (cloning and mutagenesis) to Biochemistry (protein expression, purification and modification) and Biophysics (fluorescence spectroscopy and fluorescence microscopy, surface plasmon resonance spectroscopy etc.).

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Research Output 1986 2018

  • 51 Article
  • 10 PhD Thesis - Research VU, graduation VU
  • 2 Review article
  • 1 PhD Thesis - Research external, graduation VU

Ionophoric effects of the antitubercular drug bedaquiline

Hards, K., McMillan, D. G. G., Schurig-Briccio, L. A., Gennis, R. B., Lill, H., Bald, D. & Cook, G. M., 10 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. 7326-7331 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

File
bedaquiline
Antitubercular Agents
Adenosine Triphosphate
Escherichia coli
Proton-Motive Force

The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.

Lu, P., Asseri, A. H. O., Kremer, M., Maaskant, J., Ummels, R., Lill, H. & Bald, D., 8 Feb 2018, In : Scientific Reports. 8

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cytochromes
Electron Transport
Mycobacterium tuberculosis
Energy Metabolism
Mycobacterium smegmatis

A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection.

Boot, M., JIm, K. K., Liu, T., Commandeur, S., Lu, P., Verboom, T., Lill, H., Bitter, W. & Bald, D., 2017, In : Scientific Reports. 7, 10665

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cytochromes
Fluorescence
Mycobacterium marinum
Infection
Oxidative Phosphorylation

Intracellular transport studied with dynamic single-molecule super-resolution microscopy

Oswald, F., 2017, 173 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Arabidopsis 14-3-3 Proteins Control Sucrose Metabolism and Ion Homeostasis

Gao, J., 2016

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
homeostasis
Arabidopsis
sucrose
ions
metabolism