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Research Output 2007 2019

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2019

Association between rs1051730 and smoking during pregnancy in Dutch women

Mbarek, H., van Beijsterveldt, C. E. M., Hottenga, J. J., Dolan, C. V., Boomsma, D. I., Willemsen, G. & Vink, J. M., Jun 2019, In : Nicotine and Tobacco Research. 21, 6, p. 835-840 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Smoking
Pregnancy
Pregnant Women
Parturition
Smoking Cessation

Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A., Dolan, C. V., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Nivard, M. G., Posthuma, D., Willemsen, G., Boomsma, D. I., de Geus, E. JC., W J H Penninx, B. & Jansen, R., Jan 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Anisotropy
Genome
Beta Particles
Diffusion Tensor Imaging

Biological insights into multiple birth: genetic findings from UK Biobank

Mbarek, H., van de Weijer, M. P., van der Zee, M. D., Ip, H. F., Beck, J. J., Abdellaoui, A., Ehli, E. A., Davies, G. E., Baselmans, B. M. L., Nivard, M. G., Bartels, M., de Geus, E. J. & Boomsma, D. I., Jun 2019, In : European Journal of Human Genetics. 27, 6, p. 970-979 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Multiple Birth Offspring
Fertility
Dizygotic Twins
Genome-Wide Association Study
Mothers

Evidence of causal effect of major depression on alcohol dependence: Findings from the psychiatric genomics consortium

Polimanti, R., Peterson, R. E., Ong, J. S., MacGregor, S., Edwards, A. C., Clarke, T. K., Frank, J., Gerring, Z., Gillespie, N. A., Lind, P. A., Maes, H. H., Martin, N. G., Mbarek, H., Medland, S. E., Streit, F., Agrawal, A., Edenberg, H. J., Kendler, K. S., Lewis, C. M., Sullivan, P. F. & 3 othersWray, N. R., Gelernter, J. & Derks, E. M., May 2019, In : Psychological Medicine. 49, 7, p. 1218-1226 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genomics
Alcoholism
Psychiatry
Alcohol Drinking
Depression

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

van Setten, J., Verweij, N., Mbarek, H., Niemeijer, M. N., Trompet, S., Arking, D. E., Brody, J. A., Gandin, I., Grarup, N., Hall, L. M., Hemerich, D., Lyytikäinen, L. P., Mei, H., Müller-Nurasyid, M., Prins, B. P., Robino, A., Smith, A. V., Warren, H. R., Asselbergs, F. W., Boomsma, D. I. & 41 othersCaulfield, M. J., Eijgelsheim, M., Ford, I., Hansen, T., Harris, T. B., Heckbert, S. R., Hottenga, J. J., Iorio, A., Kors, J. A., Linneberg, A., MacFarlane, P. W., Meitinger, T., Nelson, C. P., Raitakari, O. T., Silva Aldana, C. T., Sinagra, G., Sinner, M., Soliman, E. Z., Stoll, M., Uitterlinden, A., van Duijn, C. M., Waldenberger, M., Alonso, A., Gasparini, P., Gudnason, V., Jamshidi, Y., Kääb, S., Kanters, J. K., Lehtimäki, T., Munroe, P. B., Peters, A., Samani, N. J., Sotoodehnia, N., Ulivi, S., Wilson, J. G., de Geus, E. J. C., Jukema, J. W., Stricker, B., van der Harst, P., de Bakker, P. I. W. & Isaacs, A., Jun 2019, In : European Journal of Human Genetics. 27, 6, p. 952-962 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Quantitative Trait Loci
Genome-Wide Association Study
Single Nucleotide Polymorphism
Meta-Analysis
Genome

Identification of common genetic risk variants for autism spectrum disorder

Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23Andme Research Team, Mar 2019, In : Nature Genetics. 51, 3, p. 431-444 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Phenotype
Sample Size
Meta-Analysis
Autism Spectrum Disorder

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

EGG Consortium, 1 May 2019, In : Nature Genetics. 51, 5, p. 804-814 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Birth Weight
Mothers
Blood Pressure
Alleles
Genome-Wide Association Study

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Küpers, L. K., Monnereau, C., Sharp, G. C., Yousefi, P., Salas, L. A., Ghantous, A., Page, C. M., Reese, S. E., Wilcox, A. J., Czamara, D., Starling, A. P., Novoloaca, A., Lent, S., Roy, R., Hoyo, C., Breton, C. V., Allard, C., Just, A. C., Bakulski, K. M., Holloway, J. W. & 107 othersEverson, T. M., Xu, C. J., Huang, R. C., van der Plaat, D. A., Wielscher, M., Merid, S. K., Ullemar, V., Rezwan, F. I., Lahti, J., van Dongen, J., Langie, S. A. S., Richardson, T. G., Magnus, M. C., Nohr, E. A., Xu, Z., Duijts, L., Zhao, S., Zhang, W., Plusquin, M., DeMeo, D. L., Solomon, O., Heimovaara, J. H., Jima, D. D., Gao, L., Bustamante, M., Perron, P., Wright, R. O., Hertz-Picciotto, I., Zhang, H., Karagas, M. R., Gehring, U., Marsit, C. J., Beilin, L. J., Vonk, J. M., Jarvelin, M. R., Bergström, A., Örtqvist, A. K., Ewart, S., Villa, P. M., Moore, S. E., Willemsen, G., Standaert, A. R. L., Håberg, S. E., Sørensen, T. I. A., Taylor, J. A., Räikkönen, K., Yang, I. V., Kechris, K., Nawrot, T. S., Silver, M. J., Gong, Y. Y., Richiardi, L., Kogevinas, M., Litonjua, A. A., Eskenazi, B., Huen, K., Mbarek, H., Maguire, R. L., Dwyer, T., Vrijheid, M., Bouchard, L., Baccarelli, A. A., Croen, L. A., Karmaus, W., Anderson, D., de Vries, M., Sebert, S., Kere, J., Karlsson, R., Arshad, S. H., Hämäläinen, E., Routledge, M. N., Boomsma, D. I., Feinberg, A. P., Newschaffer, C. J., Govarts, E., Moisse, M., Fallin, M. D., Melén, E., Prentice, A. M., Kajantie, E., Almqvist, C., Oken, E., Dabelea, D., Boezen, H. M., Melton, P. E., Wright, R. J., Koppelman, G. H., Trevisi, L., Hivert, M. F., Sunyer, J., Munthe-Kaas, M. C., Murphy, S. K., Corpeleijn, E., Wiemels, J., Holland, N., Herceg, Z., Binder, E. B., Davey Smith, G., Jaddoe, V. W. V., Lie, R. T., Nystad, W., London, S. J., Lawlor, D. A., Relton, C. L., Snieder, H. & Felix, J. F., 23 Apr 2019, In : Nature Communications. 10, p. 1-11 11 p., 1893.

Research output: Contribution to JournalArticleAcademicpeer-review

methylation
DNA Methylation
Meta-Analysis
Methylation
deoxyribonucleic acid

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

EArly Genetics Lifecourse Epidemiology (EAGLE) consortium & Early Growth Genetics (EGG) Consortium, Mar 2019, In : European Journal of Epidemiology. 34, 3, p. 279-300

Research output: Contribution to JournalArticleAcademicpeer-review

Molecular Epidemiology
Sample Size
Genetic Research
Low Birth Weight Infant
Atopic Dermatitis
2018

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Abdellaoui, A., Derks, E. M., Dolan, C. V., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Nivard, M. G., Peyrot, W. J., Posthuma, D., Uitterlinden, A. G., Van der Auwera, S., Visscher, P. M., Willemsen, G., Boomsma, D. I., de Geus, E. JC., Martin, N. G., W J H Penninx, B. & Tiemeier, H., 2018, In : Communications biology. 1, p. 163

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Bipolar Disorder
Psychiatry
Pedigree
Inborn Genetic Diseases

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. M. F., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. F. T., Bigdeli, T. B., Binder, E. B., Blackwood, D. R. H., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N. & 30 othersCastelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. I. R., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Crowley, C. A., Dashti, H. S., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., DIrek, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Eriksson, N., Hottenga, J. J., Jansen, R., Mbarek, H., Middeldorp, C. M., Milaneschi, Y., Nivard, M. G., Posthuma, D., Smit, J. H., Willemsen, G., Boomsma, D. I. & Penninx, B. W. J. H., May 2018, In : Nature Genetics. 50, 5, p. 668-681 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Depression
Schizophrenia
Major Depressive Disorder
Suicide

Genome-wide association meta-analysis of age at first cannabis use

Minică, C. C., Verweij, K. J. H., van der Most, P. J., Mbarek, H., Bernard, M., van Eijk, K. R., Lind, P. A., Liu, M. Z., Maciejewski, D. F., Palviainen, T., Sánchez-Mora, C., Sherva, R., Taylor, M., Walters, R. K., Abdellaoui, A., Bigdeli, T. B., Branje, S. J. T., Brown, S. A., Casas, M., Corley, R. P. & 50 othersDavey-Smith, G., Davies, G. E., Ehli, E. A., Farrer, L., Fedko, I. O., Garcia-Martínez, I., Gordon, S. D., Hartman, C. A., Heath, A. C., Hickie, I. B., Hickman, M., Hopfer, C. J., Hottenga, J. J., Kahn, R. S., Kaprio, J., Korhonen, T., Kranzler, H. R., Krauter, K., van Lier, P. A. C., Madden, P. A. F., Medland, S. E., Neale, M. C., Meeus, W. H. J., Montgomery, G. W., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Wall, T. L., Ware, J. J., Wright, M. J., Zhao, H., Koot, H. M., Paus, T., Hewitt, J. K., Ribasés, M., Loukola, A., Boks, M. P., Snieder, H., Munafò, M. R., Gelernter, J., Boomsma, D. I., Martin, N. G., Gillespie, N. A., Vink, J. M. & Derks, E. M., Nov 2018, In : Addiction. 113, 11, p. 2073-2086 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Cannabis
Meta-Analysis
Single Nucleotide Polymorphism
Calcium Signaling

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

Generation Scotland & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 20 Dec 2018, In : PLoS ONE. 13, 12, p. 1-29 29 p., e0209160.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Proxy
Genes
Genome
genome

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative

MiBioGen Consortium Initiative, Boomsma, D. I., Davies, G. E., de Geus, E., Ehli, E. A., Finnicum, C. T. F., Mbarek, H. & Willemsen, G., 8 Jun 2018, In : Microbiome. 6, 1, p. 101

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Microbiota
Human Genome
Meta-Analysis
Genome-Wide Association Study
Genome

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Demenais, F., Margaritte-Jeannin, P., Barnes, K. C., Cookson, W. O. C., Altmüller, J., Ang, W., Barr, R. G., Beaty, T. H., Becker, A. B., Beilby, J., Bisgaard, H., Bjornsdottir, U. S., Bleecker, E., Bønnelykke, K., Boomsma, D. I., Bouzigon, E., Brightling, C. E., Brossard, M., Brusselle, G. G., Burchard, E. & 31 othersBurkart, K. M., Bush, A., Chan-Yeung, M., Chung, K. F., Couto Alves, A., Curtin, J. A., Custovic, A., Daley, D., de Jongste, J. C., Del-Rio-Navarro, B. E., Donohue, K. M., Duijts, L., Eng, C., Eriksson, J. G., Farrall, M., Fedorova, Y., Feenstra, B., Ferreira, M. A., Freidin, M. B., Gajdos, Z., Gauderman, J., Gehring, U., Geller, F., Genuneit, J., Gharib, S. A., Gilliland, F., Heckbert, S. R., Hottenga, J., Mbarek, H., Willemsen, G. & Australian Asthma Genetics Consortium (AAGC) collaborators, Jan 2018, In : Nature Genetics. 50, 1, p. 42-53 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Asthma
Seasonal Allergic Rhinitis
Genome-Wide Association Study
Autoimmune Diseases
Meta-Analysis

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

23Andme Research Team, 26 Nov 2018, In : Nature Neuroscience. 21, 12, p. 1656-1669 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Alcoholism
Psychiatry
Genome
Drinking Behavior
2017

Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder

Zeng, Y., Navarro, P., Shirali, M., Howard, D. M., Adams, M. J., Hall, L. S., Clarke, T-K., Thomson, P. A., Smith, B. H., Murray, A., Padmanabhan, S., Hayward, C., Boutin, T., MacIntyre, D. J., Lewis, C. M., Wray, N. R., Mehta, D., Penninx, B. W. J. H., Milaneschi, Y., Baune, B. T. & 20 othersAir, T., Hottenga, J-J., Mbarek, H., Castelao, E., Pistis, G., Schulze, T. G., Streit, F., Forstner, A. J., Byrne, E. M., Martin, N. G., Breen, G., Müller-Myhsok, B., Lucae, S., Kloiber, S., Domenici, E., Deary, I. J., Porteous, D. J., Haley, C. S., McIntosh, A. M. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Sep 2017, In : Biological Psychiatry. 82, 5, p. 312-321 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Haplotypes
Genome
Single Nucleotide Polymorphism
Genes

Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder

Mbarek, H., Milaneschi, Y., Hottenga, J-J., Ligthart, L., de Geus, E. J. C., Ehli, E. A., Willemsen, G., Davies, G. E., Smit, J. H., Boomsma, D. I. & Penninx, B. W. J. H., 1 Aug 2017, In : Twin Research and Human Genetics. 20, 4, p. 267-270 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Genome
Genome-Wide Association Study
Genes
Single Nucleotide Polymorphism

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Day, F. R., Thompson, D. J., Helgason, H., Chasman, D. I., Finucane, H., Sulem, P., Ruth, K. S., Whalen, S., Sarkar, A. K., Albrecht, E., Altmaier, E., Amini, M., Barbieri, C. M., Boutin, T., Campbell, A., Demerath, E., Giri, A., He, C., Hottenga, J. J., Karlsson, R. & 31 othersKolcic, I., Loh, P-R., Lunetta, K. L., Mangino, M., Marco, B., McMahon, G., Medland, S. E., Nolte, I. M., Noordam, R., Nutile, T., Paternoster, L., Perjakova, N., Porcu, E., Rose, L. M., Schraut, K. E., Segrè, A. V., Smith, A. V., Stolk, L., Teumer, A., Andrulis, I. L., Bandinelli, S., Beckmann, M. W., Benitez, J., Bergmann, S., Bochud, M., de Geus, E. J. C. N., Mbarek, H., Willemsen, G., Boomsma, D. I., Visser, J. A. & LifeLines Cohort Study, 1 Jun 2017, In : Nature Genetics. 49, 6, p. 834-841

Research output: Contribution to JournalArticleAcademicpeer-review

Menarche
Puberty
Mendelian Randomization Analysis
Multifactorial Inheritance
Neoplasms

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Rietschel, L., Streit, F., Zhu, G., McAloney, K., Frank, J., Couvy-Duchesne, B., Witt, S. H., Binz, T. M., McGrath, J., Hickie, I. B., Hansell, N. K., Wright, M. J., Gillespie, N. A., Forstner, A. J., Schulze, T. G., Wüst, S., Nöthen, M. M., Baumgartner, M. R., Walker, B. R., Crawford, A. A. & 12 othersColodro-Conde, L., Medland, S. E., Martin, N. G., Rietschel, M., CORtisolNETwork (CORNET) Consortium, Abdellaoui, A., de Geus, E., Hottenga, J. J., Mbarek, H., Middeldorp, C. M., Willemsen, G. & Boomsma, D. I., 10 Nov 2017, In : Scientific Reports. 7, 1, p. 15351

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Psychological Stress
Hair
Hydrocortisone
Genes
Psychology

Pathways to smoking behaviours: biological insights from the Tobacco and Genetics Consortium meta-analysis

Minicã, C. C., Mbarek, H., Pool, R., Dolan, C. V., Boomsma, D. I. & Vink, J. M., Jan 2017, In : Molecular Psychiatry. 22, 1, p. 82-88 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Tobacco
Meta-Analysis
Smoking
Genes
Untranslated RNA

The International Cannabis Consortium: What Did We Learn About The Genetics Of Cannabis Use

Verweij, K., Minica, C., Stringer, S., van der Most, P., Mbarek, H., Nivard, M., Abdellaoui, A., Hottenga, J-J., Martin, N., Boomsma, D., Gillespie, N., Derks, E. & Vink, J., 15 Aug 2017, In : European Neuropsychopharmacology. 27, p. S494-S495

Research output: Contribution to JournalArticleAcademicpeer-review

2016

Connecting the dots, genome-wide association studies in substance use

International Cannabis Consortium, 2016, In : Molecular Psychiatry. 21, 6, p. 733-735

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic variants in RBFOX3 are associated with sleep latency

Amin, N., Allebrandt, K. V., Spek, A., Müller-Myhsok, B., Hek, K., Teder-Laving, M., Hayward, C., Esko, T., van Mill, J. G., Mbarek, H., Watson, N. F., Melville, S. A., Del Greco, M. F., Byrne, E. M., Oole, E., Kolcic, I., Chen, T., Evans, D. S., Coresh, J., Vogelzangs, N. & 55 othersKarjalainen, J., Willemsen, G., Gharib, S. A., Zgaga, L., Mihailov, E., Stone, K. L., Campbell, H., Brouwer, R. W. W., Demirkan, A., Isaacs, A., Dogas, Z., Marciante, K., Campbell, S., Borovecki, F., Luik, A. I., Li, M., Hottenga, J. J., Huffman, J. E., van den Hout, M. C. G. N., Cummings, S. R., Aulchenko, Y. S., Gehrman, P. R., Uitterlinden, A. G., Wichmann, H. E., Müller-Nurasyid, M., Fehrmann, R. S. N., Montgomery, G. W., Hofman, A., Hong, W., Kao, L., Oostra, B. A., Wright, A. F., Vink, J. M., Wilson, J. F., Pramstaller, P. P., Hicks, A. A., Polasek, O., Punjabi, N. M., Redline, S., Psaty, B. M., Heath, A. C., Merrow, M., Tranah, G. J., Gottlieb, D. J., Boomsma, D. I., Martin, N. G., Rudan, I., Tiemeier, H., van Ijcken, W. F. J., Penninx, B. W. J. H., Metspalu, A., Meitinger, T., Franke, L., Roenneberg, T. & van Duijn, C. M., 2016, In : European Journal of Human Genetics. 24, 10, p. 1488-1495

Research output: Contribution to JournalArticleAcademicpeer-review

Sleep
Genes
Genome-Wide Association Study
Single Nucleotide Polymorphism
Meta-Analysis

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Barban, N., Jansen, R., de Vlaming, R., Vaez, A., Mandemakers, J. J., Tropf, F. C., Shen, X., Wilson, J. F., Chasman, D. I., Nolte, I. M., Mbarek, H., Boomsma, D. I., de Geus, E. J. C., Penninx, B. W. J. H., Willemsen, G., Zondervan, K. T., Stefansson, K., Krueger, R. F., Lee, J. J., Benjamin, D. J. & 5 othersCesarini, D., Koellinger, P. D., den Hoed, M. A. H., Snieder, H. & Mills, M. C., 2016, In : Nature Genetics. 48, 12, p. 1462-1472

Research output: Contribution to JournalArticleAcademicpeer-review

Reproductive Behavior
Birth Order
Genome
Genome-Wide Association Study
Infertility

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Stringer, S., Minică, C. C., Verweij, K. J. H., Mbarek, H., Bernard, M., Derringer, J., van Eijk, K. R., Isen, J. D., Loukola, A., Maciejewski, D. F., Mihailov, E., van der Most, P. J., Sánchez-Mora, C., Roos, L., Sherva, R., Walters, R., Ware, J. J., Abdellaoui, A., Bigdeli, T. B., Branje, S. J. T. & 60 othersBrown, S. A., Bruinenberg, M., Casas, M., Esko, T., Garcia-Martinez, I., Gordon, S. D. S., Harris, J. M., Hartman, C. A., Henders, A. K., Heath, A. C., Hickie, I. B., Hickman, M., Hopfer, C. J., Hottenga, J. J., Huizink, A. C., Irons, D. E., Kahn, R. S., Korhonen, T., Kranzler, H. R., Krauter, K., van Lier, P. A. C., Lubke, G. H., Madden, P. A. F., Mägi, R., McGue, M. K., Medland, S. E., Meeus, W. H. J., Miller, M. B., Montgomery, G. W., Nivard, M. G., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Qaiser, B., Quaye, L., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, M. J., Koot, H. M., Paus, T., Hewitt, J. K., Ribasés, M., Kaprio, J., Boks, M. P. M., Snieder, H., Spector, T., Munafò, M. R., Metspalu, A., Gelernter, J., Boomsma, D. I., Iacono, W. G., Martin, N. G., Gillespie, N. A., Derks, E. M. & Vink, J. M., 29 Mar 2016, In : Translational Psychiatry. 6, p. e769

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Cannabis
Single Nucleotide Polymorphism
Genome
Genes

Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility

Mbarek, H., Steinberg, S., Nyholt, DR., Gordon, S. D., Miller, M. B., McRae, A. F., Hottenga, J. J., Day, F. R., Willemsen, G., de Geus, E. J. C., Davies, G. E., Martin, H. C., Penninx, B. W. J. H., Jansen, R., McAloney, K., Vink, J. M., Kaprio, J., Plomin, R., Spector, T. D., Magnusson, P. K. & 17 othersReversade, B., Harris, R. A., Aagaard, K., Kristjansson, R. P., Olafsson, I., Eyjolfsson, G. I., Sigurdardottir, O., Iacono, W. G., Lambalk, C. B., Montgomery, G. W., McGue, M., Ong, K. K., Perry, J. R. B., Martin, N. G., Stefansson, H., Stefansson, K. & Boomsma, D. I., 2016, In : American Journal of Human Genetics. 98, 5, p. 898-908

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Fertility
Mothers
Dizygotic Twins
Genome-Wide Association Study
Single Nucleotide Polymorphism

KLB is associated with alcohol drinking, and its gene product B-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann, G., Liu, C., O'Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S. R., Hottenga, J. J., Mbarek, H., Boomsma, D. I., de Geus, E. J. C., Penninx, B. W. J. H., Bakalkin, G., Evangelou, E., Liu, Y., Rice, K. M., Desrivieres, S. & 5 othersKliewer, S. A., Mangelsdorf, D. J., Müller, C. P., Levy, D. & Elliott, P., 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14372-14377

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

van Leeuwen, E. M., Sabo, A., Bis, J. C., Huffman, J. E., Manichaikul, A., Smith, A. V., Feitosa, M. F., Demissie, S., Joshi, P. K., Duan, Q., Marten, J., van Klinken, J. B., Surakka, I., Nolte, I. M., Zhang, W., Mbarek, H., Li-Gao, R., Trompet, S., Verweij, N., Evangelou, E. & 78 othersLyytikäinen, L. P., Tayo, B. O., Deelen, J., van der Most, P. J., van der Laan, S. W., Arking, D. E., Morrison, A., Dehghan, A., Franco, O. H., Hofman, A., Rivadeneira, F., Sijbrands, E. J., Uitterlinden, A. G., Mychaleckyi, J. C., Campbell, A., Hocking, L. J., Padmanabhan, S., Brody, J. A., Rice, K. M., White, C. C., Harris, T., Isaacs, A., Campbell, H., Lange, L. A., Rudan, I., Kolcic, I., Navarro, P., Zemunik, T., Salomaa, V., Kooner, A. S., Kooner, J. S., Lehne, B., Scott, W. R., Tan, S. T., de Geus, E. J. C., Milaneschi, Y., Penninx, B. W. J. H., Willemsen, G., de Mutsert, R., Ford, I., Gansevoort, R. T., Segura-Lepe, M. P., Raitakari, O. T., Viikari, J. S., Nikus, K., Forrester, T., McKenzie, C. A., de Craen, A. J., den Ruijter, H. M., Pasterkamp, G., Snieder, H., Oldehinkel, A. J., Slagboom, P. E., Cooper, R. S., Kähönen, M., Lehtimäki, T., Elliott, P., van der Harst, P., Jukema, J. W., Mook-Kanamori, D. O., Boomsma, D. I., Chambers, J. C., Swertz, M. A., Ripatti, S., Willems van Dijk, K., Vitart, V., Polasek, O., Hayward, C., Wilson, J. G., Wilson, J. F., Gudnason, V., Rich, S. S., Psaty, B. M., Borecki, I. B., Boerwinkle, E., Rotter, J. I., Cupples, L. A. & van Duijn, C. M., 2016, In : Journal of Medical Genetics. 53, 7, p. 441-449

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

van den Berg, S. M., de Moor, M. H. M., Verweij, C. J. H., Krueger, R. F., Luciano, M., Vasquez, A. A., Matteson, L. K., Derringer, J., Esko, T., Amin, N., Gordon, S. D., Hansell, N. K., Hart, A. B., Seppälä, I., Huffman, J. E., Konte, B., Lahti, J., Miller, M., Nutile, T., Tanaka, T. & 95 othersTeumer, A., Viktorin, A., Wedenoja, J., Abdellaoui, A., Abecasis, G. R., Adkins, D. E., Agrawal, A., Allik, J., Appel, K., Bigdeli, T. B., Busonero, F., Campbell, H., Costa, P. T., Davey Smith, G., Davies, G., de Wit, H., Ding, J., Engelhardt, B. E., Eriksson, J. G., Fedko, I. O., Ferrucci, L., Franke, B., Giegling, I., Grucza, R., Hartmann, A. M., Heath, A. C., Heinonen, K., Henders, A. K., Homuth, G., Hottenga, J. J., Iacono, W. G., Janzing, J., Jokela, M., Karlsson, R., Kemp, J. P., Kirkpatrick, M. G., Latvala, A., Lehtimäki, T., Liewald, D. C., Madden, P. A. F., Magri, C., Magnusson, P. K. E., Marten, J., Maschio, A., Mbarek, H., Medland, S. E., Mihailov, E., Milaneschi, Y., Montgomery, G. W., Nauck, M., Nivard, M. G., Ouwens, K. G., Palotie, A., Pettersson, E., Polasek, O., Qian, Y., Pulkki-Raback, L., Raitakari, O. T., Realo, A., Rose, R. J., Ruggiero, D., Schmidt, C. O., Slutske, W. S., Sorice, R., Starr, J. M., St Pourcain, B., Sutin, A. R., Timpson, N. J., Trochet, H., Zgaga, L., Porteous, D., Minelli, A., Palmer, A. A., Rujescu, D., Ciullo, M., Hayward, C., Rudan, I., Metspalu, A., Kaprio, J., Deary, I. J., Räikkönen, K., Wilson, J. F., Keltikangas-Järvinen, L., Bierut, L. J., Hettema, J. M., Grabe, H. J., Penninx, B. W. J. H., van Duijn, C. M., Evans, D. M., Schlessinger, D., Pedersen, N. L., Terracciano, A., McGue, M., Martin, N. G. & Boomsma, D. I., 2016, In : Behavior Genetics. 46, 2, p. 170-182

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
meta-analysis
Personality
Meta-Analysis
genome

Polygenic dissection of major depression clinical heterogeneity

Milaneschi, Y., Winkelman, F., Peyrot, W., Abdellaoui, A., Willemsen, G., Hottenga, J. J., Jansen, R., Mbarek, H., Dehghan, A., Lu, C., Boomsma, D. I. & Penninx, B. W. J. H., 2016, In : Molecular Psychiatry. 21, 4, p. 516-522

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Dissection
Depression
Psychiatry
Odds Ratio

Two SNPs Associated With Spontaneous Dizygotic Twinning: Effect Sizes and How We Communicate Them

Mbarek, H., Dolan, C. V. & Boomsma, D. I., 2016, In : Twin Research and Human Genetics. 19, 5, p. 418-421

Research output: Contribution to JournalArticleAcademicpeer-review

Probability Theory
Newspapers
Genome-Wide Association Study
Medical Genetics
Single Nucleotide Polymorphism
2015

CNV Concordance in 1,097 MZ Twin Pairs

Abdellaoui, A., Ehli, E. A., Hottenga, J. J., Weber, Z., Mbarek, H., Willemsen, G., van Beijsterveldt, C. E. M., Brooks, A., Hudziak, J. J., Sullivan, P. F., de Geus, E. J. C., Davies, G. E. & Boomsma, D. I., 2015, In : Twin Research and Human Genetics. 18, 1, p. 1-12 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Monozygotic Twins
Cheek
DNA
Epithelium
Overlapping Genes

Effect of Smoking on Blood Pressure and Resting Heart Rate - A Mendelian Randomization Meta-Analysis in the CARTA Consortium

Linneberg, A., Jacobsen, R. K., Skaaby, T., Taylor, A. E., Fluharty, M. E., Jeppesen, J., Bjorngaard, J. H., Asvold, B. O., Gabrielsen, M. E., Campbell, A., Marioni, R. E., Kumari, M., Marques-Vidal, P., Kaakinen, M., Cavadino, A., Postmus, I., Ahluwalia, T. S., Wannamethee, S. G., Lahti, J., Räikkönen, K. & 40 othersPalotie, A., Wong, A., Dalgard, C., Ford, I., Ben-Shlomo, Y., Christiansen, L., Kyvik, K. O., Kuh, D., Eriksson, J. G., Whincup, P. H., Mbarek, H., de Geus, E. J. C., Vink, J. M., Boomsma, D. I., Davey Smith, G., Lawlor, D. A., Kisialiou, A., McConnachie, A., Padmanabhan, S., Jukema, J. W., Power, C., Hyppönen, E., Preisig, M., Waeber, G., Vollenweider, P., Korhonen, T., Laatikainen, T., Salomaa, V., Kaprio, J., Kivimaki, M., Smith, B. H., Hayward, C., Sorensen, T. I. A., Thuesen, B. H., Sattar, N., Morris, R. W., Romundstad, P. R., Munafò, M., Jarvelin, M. R. & Husemoen, L. L. N., 2015, In : Circulation-cardiovascular genetics. 8, 6, p. 832-841 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mendelian Randomization Analysis
Meta-Analysis
Heart Rate
Smoking
Blood Pressure

Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

van Leeuwen, E. M., Karssen, L. C., Deelen, J., Isaacs, A., Medina-Gomez, C., Mbarek, H., Kanterakis, A., Trompet, S., Postmus, I., Verweij, N., van Enckevort, D., Huffman, J. E., White, C. C., Feitosa, M. F., Bartz, T. M., Manichaikul, A., Joshi, P. K., Peloso, G. M., Deelen, P., Dijk, F. & 52 othersWillemsen, G., de Geus, E. J. C., Milaneschi, Y., Penninx, B. W. J. H., Francioli, L. C., Menelaou, A., Pulit, S. L., Rivadeneira, F., Hofman, A., Oostra, B. A., Franco, O. H., Mateo Leach, I., Beekman, M., de Craen, A. J., Uh, H. W., Trochet, H., Hocking, L. J., Porteous, D. J., Sattar, N., Packard, C. J., Buckley, B. M., Brody, J. A., Bis, J. C., Rotter, J. I., Mychaleckyj, J. C., Campbell, H., Duan, Q., Lange, L. A., Wilson, J. F., Hayward, C., Polasek, O., Vitart, V., Rudan, I., Wright, A. F., Rich, S. S., Psaty, B. M., Borecki, I. B., Kearney, P. M., Stott, D. J., Cupples, L. A., Jukema, J. W., van der Harst, P., Sijbrands, E. J., Hottenga, J. J., Uitterlinden, A. G., Swertz, M. A., van Ommen, G. J. B., Bakker, P. I. W., Slagboom, P. E., Boomsma, D. I., Wijmenga, C. & van Duijn, C. M., 2015, In : Nature Communications. 6, p. 6065 6 p., 6065.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
genome
Netherlands
cholesterol
Blood
Genes

Heritability, SNP- and Gene-Based Analyses of Cannabis Use Initiation and Age at Onset

Minica, C. C., Dolan, C. V., Hottenga, J. J., Pool, R., Fedko, I. O., Mbarek, H., Huppertz, C., Bartels, M., Boomsma, D. I. & Vink, J. M., 2015, In : Behavior Genetics. 45, 5, p. 503-513 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cannabis
heritability
Age of Onset
single nucleotide polymorphism
Single Nucleotide Polymorphism

Heritability and Genome-Wide Association Studies for Hair Color in a Dutch Twin Family Based Sample

Lin, B., Mbarek, H., Willemsen, G., Dolan, C. V., Fedko, I. O., Abdellaoui, A., de Geus, E. J. C., Boomsma, D. I. & Hottenga, J. J., 2015, In : Genes. 6, 3, p. 559-576 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Hair Color
Genome-Wide Association Study
Light
Single Nucleotide Polymorphism
Netherlands

Multicohort analysis of the maternal age effect on recombination

Martin, H. C., Christ, R., Hussin, J. G., O'Connell, J., Gordon, S., Mbarek, H., Hottenga, J. J., McAloney, K., Willemsen, G., Gasparini, P., Pirastu, N., Montgomery, G. W., Navarro, P., Soranzo, N., Toniolo, D., Vitart, V., Wilson, J. F., Marchini, J., Boomsma, D. I., Martin, N. G. & 1 othersDonnelly, P., 2015, In : Nature Communications. 6, 10 p., 7846.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Maternal Age
Polymorphism
Genetic Recombination
Nucleotides
Cohort Effect

The Genetics of Alcohol Dependence: Twin and SNP-Based Heritability, and Genome-Wide Association Study Based on AUDIT Scores

Mbarek, H., Milaneschi, Y., Fedko, I. O., Hottenga, J. J., de Moor, M. H. M., Jansen, R., Gelernter, J., Sherva, R., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H. & Vink, J. M., 2015, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 168, 8, p. 739-748 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Alcoholism
Single Nucleotide Polymorphism
Alcohols
Netherlands
2014

Further confirmation of the association between anxiety and CTNND2: replication in humans

Nivard, M. G., Mbarek, H., Hottenga, J. J., Smit, J. H., Penninx, B. W. J. H., Middeldorp, C. M. & Boomsma, D. I., 2014, In : Genes, Brain and Behavior. 13, 2, p. 195-201 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Anxiety
Agoraphobia
Catenins
Chromosome Mapping
Panic Disorder

Role of Nicotine Dependence in the Association between the Dopamine Receptor Gene DRD3 and Major Depressive Disorder

Korhonen, T., Loukola, A., Wedenoja, J., Nyman, E., Latvala, A., Broms, U., Häppölä, A., Paunio, T., Schrage, A. J., Vink, J. M., Mbarek, H., Boomsma, D. I., Penninx, B. W. J. H., Pergadia, M. L., Madden, P. A. F. & Kaprio, J., 2014, In : PLoS ONE. 9, 6, p. e98199 10 p., e98199.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Tobacco Use Disorder
nicotine
Dopamine Receptors
Major Depressive Disorder
Nicotine

Sex differences in the human peripheral blood transcriptome

Jansen, R., Batista, S., Brooks, A. I., Tischfield, J. A., Willemsen, G., Grootheest, G., Hottenga, J. J., Milaneschi, Y., Mbarek, H., Madar, V., Peyrot, W., Vink, J. M., Verweij, C. L., de Geus, E. J. C., Smit, J. H., Wright, F. A., Sullivan, P. F., Boomsma, D. I. & Penninx, B. W. J. H., 2014, In : BMC Genomics. 15, p. 33 12 p., 33.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Transcriptome
Sex Characteristics
Genes
Contraceptive Agents
Gene Expression

The Contribution of the Functional IL6R Polymorphism rs2228145, eQTLs and Other Genome-Wide SNPs to the Heritability of Plasma sIL-6R Levels

van Dongen, J., Jansen, R., Smit, D. J. A., Hottenga, J. J., Mbarek, H., Willemsen, G., Kluft, C., Penninx, B. W. J. H., Ferreira, M. A., Boomsma, D. I. & de Geus, E. J. C., 2014, In : Behavior Genetics. 44, 4, p. 368-382 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

heritability
Single Nucleotide Polymorphism
polymorphism
genome
genetic polymorphism

The effect of FTO rs9939609 on major depression differs across MDD subtypes

Milaneschi, Y., Lamers, F., Mbarek, H., Hottenga, J. J., Boomsma, D. I. & Penninx, B. W. J. H., 2014, In : Molecular Psychiatry. 19, 9, p. 960-962 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2013

The Adult Netherlands Twin Register: Twenty-Five Years of Survey and Biological Data Collection

Willemsen, G., Vink, J. M., Abdellaoui, A., den Braber, A., van Beek, J. H. D. A., Draisma, H. H. M., van Dongen, J., van t Ent, D., Geels, L. M., van Lien, R., Ligthart, R. S. L., Kattenberg, V. M., Mbarek, H., de Moor, M. H. M., Neijts, M., Pool, R., Stroo, N., Kluft, C., Suchiman, H. E. D., Slagboom, P. E. & 2 othersde Geus, E. J. C. & Boomsma, D. I., 2013, In : Twin Research and Human Genetics. 16, 1, p. 271-281

Research output: Contribution to JournalArticleAcademicpeer-review

Netherlands
Life Style
RNA Sequence Analysis
Gene-Environment Interaction
Metabolomics
2012

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

Sawai, H., Nishida, N., Mbarek, H., Matsuda, K., Mawatari, Y., Yamaoka, M., Hige, S., Kang, J-H., Abe, K., Mochida, S., Watanabe, M., Kurosaki, M., Asahina, Y., Izumi, N., Honda, M., Kaneko, S., Tanaka, E., Matsuura, K., Itoh, Y., Mita, E. & 15 othersKorenaga, M., Hino, K., Murawaki, Y., Hiasa, Y., Ide, T., Ito, K., Sugiyama, M., Ahn, S. H., Han, K-H., Park, J. Y., Yuen, M-F., Nakamura, Y., Tanaka, Y., Mizokami, M. & Tokunaga, K., 19 Jun 2012, In : BMC Medical Genetics. 13, p. 47

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Hepatitis B virus
Single Nucleotide Polymorphism
Hepatocellular Carcinoma
Population
Chronic Hepatitis B
2011

A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population

Mbarek, H., Ochi, H., Urabe, Y., Kumar, V., Kubo, M., Hosono, N., Takahashi, A., Kamatani, Y., Miki, D., Abe, H., Tsunoda, T., Kamatani, N., Chayama, K., Nakamura, Y. & Matsuda, K., 1 Oct 2011, In : Human Molecular Genetics. 20, 19, p. 3884-92 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Chronic Hepatitis B
HLA-DP Antigens
HLA-DQ Antigens
Single Nucleotide Polymorphism
2010

Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers

Plant, D., Flynn, E., Mbarek, H., Dieudé, P., Cornelis, F., Arlestig, L., Dahlqvist, S. R., Goulielmos, G., Boumpas, D. T., Sidiropoulos, P., Johansen, J. S., Ørnbjerg, L. M., Hetland, M. L., Klareskog, L., Filer, A., Buckley, C. D., Raza, K., Witte, T., Schmidt, R. E. & Worthington, J., Aug 2010, In : Annals of the Rheumatic Diseases. 69, 8, p. 1548-53 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Rheumatoid Arthritis
Polymorphism
TNF Receptor-Associated Factor 1
Nucleotides
DNA
2009

TRAF1/C5 polymorphism is not associated with pemphigus

Mejri, K., Mbarek, H., Kallel-Sellami, M., Petit-Teixeira, E., Zerzeri, Y., Abida, O., Zitouni, M., Ben Ayed, M., Mokni, M., Fezza, B., Turki, H., Tron, F., Gilbert, D., Masmoudi, H., Prum, B., Cornelis, F. & Makni, S., Jun 2009, In : British Journal of Dermatology. 160, 6, p. 1348-50 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2007

PTPN22 R620W polymorphism is not associated with pemphigus

Mejri, K., Kallel-Sellami, M., Petit-Teixeira, E., Abida, O., Mbarek, H., Zitouni, M., Ben Ayed, M., Teixeira, V. H., Mokni, M., Fazza, B., Turki, H., Tron, F., Gilbert, D., Masmoudi, H., Cornelis, F. & Makni, S., Nov 2007, In : British Journal of Dermatology. 157, 5, p. 1068-9 2 p.

Research output: Contribution to JournalArticleAcademicpeer-review