Henk Lingeman

dr.

19952014
If you made any changes in Pure these will be visible here soon.

Research Output 1995 2014

  • 113 Article
  • 13 PhD Thesis - Research VU, graduation VU
  • 2 Chapter
2014

Chromatography-mass spectrometry based analysis of biologically active endogenous carboxylic acids

Kloos, D., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In : TrAC. Trends in Analytical Chemistry. 61, p. 17-28

Research output: Contribution to JournalArticleAcademicpeer-review

Carboxylic Acids
Chromatography
Mass spectrometry
Eicosanoids
Liquid chromatography

Comprehensive GC–MS analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis

Kloos, D., Gay, E., Lingeman, H., Bracher, F., Müller, C., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2014, In : RCM. Rapid Communications in Mass Spectrometry. 28, p. 1507-1504

Research output: Contribution to JournalArticleAcademicpeer-review

Sterols
Gas chromatography
Gas Chromatography
Gas Chromatography-Mass Spectrometry
Ionization
2013

Advances in drug-protein adduct analysis Using LC-MS based proteomics

Switzar, L., 2013

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

An efficient analytical platform for on line microfluidic profiling of neurotoxic snake venoms towards nicotinic receptor like affinity.

Heus, F. A. H., Vonk, F., Otvos, R. A., Bruyneel, B., Smit, A. B., Lingeman, H., Richardson, M., Niessen, W. M. A. & Kool, J., 2013, In : Toxicon. 61, p. 112-124

Research output: Contribution to JournalArticleAcademicpeer-review

Snake Venoms
Microfluidics
Venoms
Nicotinic Receptors
Elapidae

EC–SPE–stripline-NMR analysis of reactive products: A feasibility study.

Falck, D., Oosthoek-de Vries, A. J., Kolkman, A. J., Lingeman, H., Honing, M., Wijmenga, S. S., Kentgens, A. P. M. & Niessen, W. M. A., 2013, In : Analytical and Bioanalytical Chemistry. 405, p. 6711-6720

Research output: Contribution to JournalArticleAcademicpeer-review

Feasibility Studies
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Solid Phase Extraction
p38 Mitogen-Activated Protein Kinases

Evaluation of different column chemistries for fast urinary metabolic profiling.

Kloos, D., Lingeman, H., Niessen, W. M. A., Deelder, A. M., Giera, M. & Mayboroda, O. A., 2013, In : Journal of Chromatography B. 927, p. 90-96

Research output: Contribution to JournalArticleAcademicpeer-review

Porous materials

Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice

Switzar, L., Kwast, L. M., Lingeman, H., Giera, M., Pieters, R. H. H. & Niessen, W. M. A., 2013, In : Journal of Chromatography B. 917-918, p. 53-61

Research output: Contribution to JournalArticleAcademicpeer-review

Albumins
Serum Albumin
Serum
Cysteine
Pharmaceutical Preparations
2012

Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction–liquid chromatography–mass spectrometry with positive-ion electrospray ionization

Kloos, D., Derks, R. J. E., Wijtmans, M., Lingeman, H., Mayboroda, O. A., Deelder, A. M., Niessen, W. M. A. & Giera, M., 2012, In : Journal of Chromatography A. 1232, p. 19-26

Research output: Contribution to JournalArticleAcademicpeer-review

Electrospray ionization
Citric Acid Cycle
Spectrometry
Spectrum Analysis
Positive ions

Recent advancements in the LC- and GC-based analysis of malondialdehyde (MDA) – a brief overview.

Giera, M., Lingeman, H. & Niessen, W. M. A., 2012, In : Chromatographia. 75, p. 433-440

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Thromboxanes
Malondialdehyde
Lipid Peroxidation
Lipids
2011

Analysis and biochemical characterization of degradation products of anti-Alzheimer's drugs

de Azevedo Marques, L., 2011

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Analysis of acetylcholinesterase inhibitors: bioanalysis, degradation and metabolism

de Azevedo Marques, L., Giera, M. A., Lingeman, H. & Niessen, W. M. A., 2011, In : Biomedical Chromatography. 25, 1-2, p. 278-299

Research output: Contribution to JournalArticleAcademicpeer-review

Cholinesterase Inhibitors
Metabolism
Degradation
Pharmaceutical Preparations
Metabolites

Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI-MS(/MS) applied for the analysis of prostanoids and NSAID in urine

Kretschmer, A., Giera, M. A., Wijtmans, M., de Vries, L., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In : Journal of Chromatography B. 879, 17-18, p. 1393-1401

Research output: Contribution to JournalArticleAcademicpeer-review

Carboxylic Acids
Prostaglandins
Anti-Inflammatory Agents
Positive ions
Urine
Fractionation
Bioactivity
Acetylcholine
Carrier Proteins
Technology

Mild and selective labeling of malondialdehyde with 2-Aminoacridone: assessment of urinary malondialdehyde levels.

Giera, M., Kloos, D-P., Raaphorst, A., Mayboroda, O. A., Deelder, A. M., Lingeman, H. & Niessen, W. M. A., 2011, In : Analyst. 136, p. 2763-2769

Research output: Contribution to JournalArticleAcademicpeer-review

Oxidative stress
Biomarkers
Malondialdehyde
urine
Labeling

Nanofractionation Spotter Technology for Rapid Contact less and High-Resolution Deposition of LC Eluent for Further Off-Line Analysis

Kool, J., de Kloe, G. E., Denker, A. D., van Altena, K., Smoluch, M. T., van Iperen, D., Nahar, T. T., Limburg, R. J., Niessen, W. M. A., Lingeman, H., Leurs, R., de Esch, I. J. P., Smit, A. B. & Irth, H., 2011, In : Analytical Chemistry. 83, 1, p. 125-132

Research output: Contribution to JournalArticleAcademicpeer-review

Fractionation
Chemical detection
Fluorescein
Acetylcholine
Mass spectrometry

Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands

Pochet, L., Heus, F. A. H., Jonker, N., Lingeman, H., Smit, A. B., Niessen, W. M. A. & Kool, J., 2011, In : Journal of Chromatography B. 879, 20, p. 1781-1788

Research output: Contribution to JournalArticleAcademicpeer-review

Acetylcholine
Carrier Proteins
Screening
Ligands
Proteins

Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors.

de Kloe, G. E., Kool, J., van Elk, R., van Muijlwijk-Koezen, J. E., Smit, A. B., Lingeman, H., Irth, H., Niessen, W. M. A. & de Esch, I. J. P., 2011, In : MedChemComm. 2, p. 590-595

Research output: Contribution to JournalArticleAcademicpeer-review

Nicotinic Receptors
Screening
Proteins
Throughput
Injections

Protein digestion optimization for characterization of drug-protein adducts using response surface modeling

Switzar, L., Giera, M. A., Lingeman, H., Irth, H. & Niessen, W. M. A., 2011, In : Journal of Chromatography A. 1218, 13, p. 1715-1723

Research output: Contribution to JournalArticleAcademicpeer-review

Proteolysis
Digestion
Pharmaceutical Preparations
Proteins
Serum Albumin

Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide

de Azevedo Marques, L., Maada, I., De Kanter, F. J. J., Lingeman, H., Irth, H., Niessen, W. M. A. & Giera, M. A., 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 55, 1, p. 85-92

Research output: Contribution to JournalArticleAcademicpeer-review

Galantamine
Degradation
Acetylcholinesterase
Dehydration
Pharmaceutical Preparations
2010

Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays

Heus, F., Giera, M. A., de Kloe, G. E., van Iperen, D., Buijs, J. B., Nahar, T. T., Smit, A. B., Lingeman, H., de Esch, I. J. P., Niessen, W. M. A., Irth, H. & Kool, J., 2010, In : Analytical and Bioanalytical Chemistry. 398, 7-8, p. 3023-3032

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Microfluidics
Liquid chromatography
Liquid Chromatography
Assays
Fluorescence

Direct Dynamic Protein-Affinity Selection Mass-Spectrometry

Jonker, N., Lingeman, H. & Irth, H., 2010, In : Chromatographia. 72, 1-2, p. 7-13 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Mass spectrometry
Mass Spectrometry
Ligands
Proteins
Immobilized Proteins

Dynamic Protein Affinity Selection Mass Spectrometry

Jonker, N., 2010, 121 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
Assays
Screening
Throughput
Pharmaceutical Preparations
Ligands

Identification of the Biotransformation Products of 2-Ethylhexyl 4-(N,N-Dimethylamino)benzoate

Leon, Z., de Vlieger, J., Chisvert, A., Salvador, A., Lingeman, H., Irth, H. & Giera, M. A., 2010, In : Chromatographia. 71, 1-2, p. 55-63

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
4-Aminobenzoic Acid
Benzoates
Biotransformation
Liver
Rats

Online Fluorescence Enhancement Assay for the Acetylcholine Binding Protein with Parallel Mass Spectrometric Identification

Kool, J., de Kloe, G. E., Bruyneel, B., de Vlieger, J. S. B., Retra, K., Wijtmans, M., van Elk, R., Smit, A. B., Leurs, R., Lingeman, H., de Esch, I. J. P. & Irth, H., 2010, In : Journal of Medicinal Chemistry. 53, 12, p. 4720-4730 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Acetylcholine
Carrier Proteins
Fluorescence
Ligands
Nicotinic Receptors

Photohuperzine A-A new photoisomer of huperzine A: Structure elucidation, formation kinetics and activity assessment

de Azevedo Marques, L., Giera, M., de Kanter, F. J. J., Niessen, W. M. A., Lingeman, H. & Irth, H., 2010, In : Journal of Pharmaceutical and Biomedical Analysis. 52, 2, p. 190-194 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Photoisomerization
Kinetics
Pharmaceutical Preparations
photohuperzine A
huperzine A

Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine

de Azevedo Marques, L., Kool, J., de Kanter, F. J. J., Lingeman, H., Niessen, W. M. A. & Irth, H., 2010, In : Journal of Pharmaceutical and Biomedical Analysis. 53, 3, p. 609-616 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Tacrine
Acetylcholinesterase
Bioactivity
Degradation
Liquid Chromatography

Selective Derivatization Reagents for the Determination of Oxidative Stress Biomarkers by Liquid Chromatography-Mass Spectrometry

Eggink, M., 2010

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
Neomycin
Liquid chromatography
Liquid Chromatography
Mass spectrometry
Mass Spectrometry

Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA

Eggink, M., Wijtmans, M., Kretschmer, A., Kool, J., Lingeman, H., de Esch, I. J. P., Niessen, W. M. A. & Irth, H., 2010, In : Analytical and Bioanalytical Chemistry. 397, 2, p. 665-675 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Carboxylic Acids
Aldehydes
Screening
Ethyldimethylaminopropyl Carbodiimide
Derivatives
2009

Determination of Flavonoids and Resveratrol in Wine by Turbulent-Flow Chromatography-LC-MS

Presta, M. A., Bruyneel, B., Zanella, R., Kool, J., Krabbe, J. G. & Lingeman, H., 2009, In : Chromatographia. 69, Suppl 2, p. 167-173

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Wine
Liquid chromatography
Flavonoids
Liquid Chromatography
Turbulent flow

Development of an on-line weak-cation exchange liquid chromatography-tandem mass spectrometric method for screening aldehyde products in biological matrices

Eggink, M., Charret, S., Wijtmans, M., Lingeman, H., Kool, J., Niessen, W. M. & Irth, H., 2009, In : Journal of Chromatography B. 877, 31, p. 3937-45

Research output: Contribution to JournalArticleAcademicpeer-review

Liquid chromatography
Aldehydes
Liquid Chromatography
Cations
Screening

Microfractionation revisited: a 1536 well high resolution screening assay

Giera, M. A., Heus, F., Janssen, L., Kool, J., Lingeman, H. & Irth, H., 2009, In : Analytical Chemistry. 81, 13, p. 5460-6

Research output: Contribution to JournalArticleAcademicpeer-review

Assays
Screening
Online systems
High performance liquid chromatography
Cyclic AMP-Dependent Protein Kinases

Novel Analytical Methods for the Discovery and Trace Analysis of Biochemically Active Compounds

Kool, J., Lingeman, H., Niessen, W. & Irth, H., 2009, In : LC GC Europe. 22, 6, p. 292-+

Research output: Contribution to JournalArticleAcademicpeer-review

Online magnetic bead dynamic protein-affinity selection coupled to LC-MS for the screening of pharmacologically active compounds

Jonker, N., Kretschmer, A., Kool, J., Fernandez, A., Kloos, D., Krabbe, J. G., Lingeman, H. & Irth, H., 2009, In : Analytical Chemistry. 81, 11, p. 4263-70

Research output: Contribution to JournalArticleAcademicpeer-review

Liquid chromatography
Mass spectrometry
Screening
Ligands
Proteins
2008

Densitometric determination of zinc bacitracin and nystatin in animal feed

Injac, R., Strukej, B., Djordjevic-Milic, V., Karjikovic-Rajic, K. & Lingeman, H., 2008, In : Journal of the Science of Food and Agriculture. 88, 9, p. 1576-1581

Research output: Contribution to JournalArticleAcademicpeer-review

nystatin
Bacitracin
Nystatin
bacitracin
zinc
Liquid chromatography
Liquid Chromatography
Automation
Calibration
Cations
Aldehydes
Derivatives
Biomarkers
Malondialdehyde
Ammonium Compounds

Screening of protein-ligand interactions using dynamic protein-affinity chromatography solid-phase extraction-liquid chromatography-mass spectrometry

Jonker, N., Kool, J., Krabbe, J. G., Retra, K., Lingeman, H. & Irth, H., 2008, In : Journal of Chromatography A. 1205, 1-2, p. 71-7

Research output: Contribution to JournalArticleAcademicpeer-review

Affinity chromatography
Solid Phase Extraction
Liquid chromatography
Affinity Chromatography
Liquid Chromatography
2007

Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography-mass spectrometry

Hoos, J. S., Damsten, M. C., de Vlieger, J. S. B., Commandeur, J. N. M., Vermeulen, N. P. E., Niessen, W. M. A., Lingeman, H. & Irth, H., 2007, In : Journal of Chromatography B. 859, 2, p. 147-56

Research output: Contribution to JournalArticleAcademicpeer-review

Liquid chromatography
Chromatography
Serum Albumin
Liquid Chromatography
Mass spectrometry

Chromatography in Turkey

Ozkan, S. A. & Lingeman, H., 2007, In : Chromatographia. 66, p. S1-S1

Research output: Contribution to JournalArticleAcademicpeer-review

Determination of abacavir, lamivudine and zidovudine in pharmaceutical tablets, human serum and in drug dissolution studies by HPLC

Savaser, A., Goraler, S., Tasoz, A., Uslu, B., Lingeman, H. & Ozkan, S. A., 2007, In : Chromatographia. 65, 5-6, p. 259-265

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Zidovudine
Tablets
Dissolution
High Pressure Liquid Chromatography
Serum

LC determination of propylene glycol in human plasma after pre-column derivatization with benzoyl chloride

Sinjewel, A., Swart, E. L., Lingeman, H. & Wilhelm, A. J., 2007, In : Chromatographia. 66, 1-2, p. 103-105

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Plasma (human)
Propylene Glycol
Ethylene Glycol
Photodiodes
Calibration

Ligand-Exchange and Metal Complexation studied by Mass Spectrometry. Fundamentals and applications in analytical chemistry

Krabbe, J. G., 2007

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Mass spectrometry-based biochemical assays for enzymeinhibitor screening

de Boer, A. R., Lingeman, H., Niessen, W. M. A. & Irth, H., 2007, In : TrAC. Trends in Analytical Chemistry. 26, 9, p. 867-883

Research output: Contribution to JournalArticleAcademicpeer-review

Mass spectrometry
Assays
Screening
Enzyme Inhibitors
Throughput

Mass Spectrometry-Based Biochemical Assays for the Screening of Enzyme Inhibitors

de Boer, A. R., 2007

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Metal-complex formation in continuous-flow ligand-exchange reactors studied by electrospray mass spectrometry

Krabbe, J. G., den Boer, A. V., van der Zwan, G., Lingeman, H., Niessen, W. M. A. & Irth, H., 2007, In : Journal of the American Society for Mass Spectrometry. 18, 4, p. 707-13

Research output: Contribution to JournalArticleAcademicpeer-review

Coordination Complexes
Mass spectrometry
Mass Spectrometry
Ligands
Metal ions

On-line Digestion Methodologies for the Automated HPLC-MS based Bioanalysis of Proteins

Hoos, S. J., 2007

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Trace analysis of proteins using postseparation solution-phase digestion and electrospray mass spectrometric detection of marker peptides

Bruyneel, B., Hoos, J. S., Smoluch, M. T., Lingeman, H., Niessen, W. M. A. & Irth, H., 2007, In : Analytical Chemistry. 79, 4, p. 1591-8

Research output: Contribution to JournalArticleAcademicpeer-review

Trace analysis
Peptides
Proteins
Peptide Hydrolases
Pepsin A
2006

Biochemical assays using mass spectrometry for detection and identification of bioactive compounds

Derks, R. J. E., 2006

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic