20022020
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Research Output 2002 2020

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Article
2019

Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength

Price, C. E., Branco Dos Santos, F., Hesseling, A., Uusitalo, J. J., Bachmann, H., Benavente, V., Goel, A., Berkhout, J., Bruggeman, F. J., Marrink, S. J., Montalban-Lopez, M., De Jong, A., Kok, J., Molenaar, D., Poolman, B., Teusink, B. & Kuipers, O. P., 10 Jan 2019, In : BMC Evolutionary Biology. 19, 1, p. 1-15 15 p., 15.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
strength (mechanics)
glucose
mutation
chemostat
fitness

Ampicillin-treated Lactococcus lactis MG1363 populations contain persisters as well as viable but non-culturable cells

van Tatenhove-Pel, R. J., Zwering, E., Solopova, A., Kuipers, O. P. & Bachmann, H., 1 Dec 2019, In : Scientific Reports. 9, 1, 9867.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
ampicillin
antibiotics
viability
cells

Comparative genome analysis of Lactococcus lactis indicates niche adaptation and resolves genotype/phenotype disparity

Wels, M., Siezen, R., Van Hijum, S., Kelly, W. J. & Bachmann, H., 31 Jan 2019, In : Frontiers in Microbiology. 10, January, p. 1-18 18 p., 4.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
Genotype
Genome
Phenotype
Dairying
2018

Altering textural properties of fermented milk by using surface-engineered Lactococcus lactis

Tarazanova, M., Huppertz, T., Kok, J. & Bachmann, H., 9 May 2018, In : Microbial Biotechnology.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Fermented milk
Lactococcus lactis
Milk
Dairy products
Hydrophobicity

Further elucidation of galactose utilization in Lactococcus lactis MG1363

Solopova, A., Bachmann, H., Teusink, B., Kok, J. & Kuipers, O. P., 3 Aug 2018, In : Frontiers in Microbiology. 9, AUGUST, p. 1-9 9 p., 1803.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
Galactose
Lactose
Lactococcus
Membrane Transport Proteins

Influence of lactococcal surface properties on cell retention and distribution in cheese curd

Tarazanova, M., Huppertz, T., Kok, J. & Bachmann, H., Oct 2018, In : International Dairy Journal. 85, p. 73-78 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Surface Properties
milk curds
Cheese
cheeses
cells
2017

Cell surface properties of Lactococcus lactis reveal milk protein binding specifically evolved in dairy isolates

Tarazanova, M., Huppertz, T., Beerthuyzen, M., van Schalkwijk, S., Janssen, P. W. M., Wels, M., Kok, J. & Bachmann, H., 7 Sep 2017, In : Frontiers in Microbiology. 8, SEP

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
Surface Properties
Milk Proteins
Protein Binding
Hydrophobic and Hydrophilic Interactions

Draft genome Sequences of 11 Lactococcus lactis subsp. cremoris strains

Wels, M., Backus, L., Boekhorst, J., Dijkstra, A., Beerthuyzen, M., Siezen, R. J., Bachmann, H. & van Hijum, S. A. F. T., 2017, In : Genome Announcements. p. e01739-16

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
Genome
Dairy Products
Fermentation
Lactic Acid

Draft genome sequences of 24 Lactococcus lactis strains

Backus, L., Wels, M., Boekhorst, J., Dijkstra, A. R., Beerthuyzen, M., Kelly, W. J., Siezen, R. J., van Hijum, S. A. F. T. & Bachmann, H., 2017, In : Genome Announcements. p. e01737-16

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
Genome
Cultured Milk Products
Geographic Locations
Lactic Acid

Experimental evolution and the adjustment of metabolic strategies in lactic acid bacteria

Bachmann, H., Molenaar, D., Branco dos Santos, F. & Teusink, B., 1 Aug 2017, In : FEMS Microbiology Reviews. 41, Supp_1, p. S201-S219

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactic Acid
Bacteria
Resource Allocation
Population Dynamics
Research Design
2016

Non-hierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp PCC6803.

Du, W., Angermayr, S. A., Jongbloets, J. A., Molenaar, D., Bachmann, H., Hellingwerf, K. J. & Santos, F., 2016, In : ACS synthetic biology. 2016/12/12

Research output: Contribution to JournalArticleAcademicpeer-review

Plasmid Complement of Lactococcus lactis NCDO712 Reveals a Novel Pilus Gene Cluster

Tarazanova, M., Beerthuyzen, M., Siezen, R. J., Fernandez-Gutierrez, M. M., De Jong, A., Van Der Meulen, S., Kok, J. & Bachmann, H., 1 Dec 2016, In : PLoS ONE. 11, 12

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lactococcus lactis
fimbriae
Multigene Family
multigene family
plasmids

Public goods and metabolic strategies

Bachmann, H., Bruggeman, F. J., Molenaar, D., Santos, F. & Teusink, B., Jun 2016, In : Current Opinion in Microbiology. 31, p. 109-115

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2015

Evolutionary engineering to enhance starter culture performance in food fermentations.

Bachmann, H., Pronk, J. T., Kleerebezem, M. & Teusink, B., 2015, In : Current Opinion in Biotechnology. p. 1-7 32.

Research output: Contribution to JournalArticleAcademicpeer-review

Starters
Fermentation
Phenotype
Food
Flavors

Metabolism at Evolutionary Optimal States.

Rabbers, I., van Heerden, J. H., Nordholt, N., Bachmann, H., Teusink, B. & Bruggeman, F. J., 2015, In : Metabolites. 5, 2, p. 311-343

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2014

Bethedging during bacterial diauxic shift.

Solopova, A., van Gestel, J., Weissing, F. J., Bachmann, H., Teusink, B., Kok, J. & Kuipers, O. P., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. p. 7427-7432

Research output: Contribution to JournalArticleAcademicpeer-review

sugars
phenotype
Lactococcus lactis
bacteria
microbiology

Development of the recombinase-based in vivo expression technology in Streptococcus thermophilus and validation using the lactose operon promoter

Junjua, M., Galia, W., Gaci, N., Uriot, O., Genay, M., Bachmann, H., Kleerebezem, M., Dary, A. & Roussel, Y., 2014, In : Journal of Applied Microbiology. 116, 3, p. 620-631 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Streptococcus thermophilus
Recombinases
Lac Operon
Technology
Spectinomycin
2013

Availability of public goods shapes the evolution of competing metabolic strategies.

Bachmann, H., Fischlechner, M., Rabbers, I., Barfa, N., Branco dos Santos, F., Molenaar, D. & Teusink, B., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, p. 14302-14307

Research output: Contribution to JournalArticleAcademicpeer-review

biomass
emulsions
organisms
privatization
Lactococcus lactis
2012

A specific mutation in the promoter region of the silent cel clusteraccounts for the appearance of lactose-utilizingLactococcus lactisMG1363.

Solopova, A., Bachmann, H., Teusink, B., Kok, J., Rute Neves, A. & Kuipers, O. P., 2012, In : Applied and Environmental Microbiology. 78, p. 5612-5621

Research output: Contribution to JournalArticleAcademicpeer-review

Lactococcus lactis
Lactose
Genetic Promoter Regions
lactose
mutation

Microbial domestication signatures of Lactococcus lactis can be reproduced by experimental evolution.

Bachmann, H., Starrenburg, M. J., Molenaar, D., Kleerebezem, M. & van Hylckama Vlieg, J. E. T., 2012, In : Genome Research. 22, p. 115-124

Research output: Contribution to JournalArticleAcademicpeer-review

Lactococcus lactis
Milk
Plasmids
Growth
Genome
2011

High local substrate availability stabilizes a cooperative trait.

Bachmann, H., Molenaar, D., Kleerebezem, M. & van Hylckama Vlieg, J. E. T., 2011, In : ISME Journal. 5, p. 929-932

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
peptide
milk
cooperatives
Peptide Hydrolases
proteinases

Systems Biology of lactic acid bacteria: a critical review.

Teusink, B., Bachmann, H. & Molenaar, D., 2011, In : Microbial Cell Factories. 10, A11, 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Systems Biology
Lactic acid
Systems Analysis
Lactic Acid
Bacteria
2010

Time-resolved genetic responses of Lactococcus lactis to a dairy environment

Bachmann, H., de Wilt, L., Kleerebezem, M. & van Hylckama Vlieg, J. E. T., May 2010, In : Environmental Microbiology. 12, 5, p. 1260-1270 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Lactococcus lactis
cheesemaking
Cheese
cheeses
dairies
2009

A high-throughput cheese manufacturing model for effective cheese starter screening.

Bachmann, H., Kruijswijk, Z., Molenaar, D., Kleerebezem, M. & van Hylckama Vlieg, J. E. T., 2009, In : Journal of Dairy Science. 92, p. 5868-5882

Research output: Contribution to JournalArticleAcademicpeer-review

cheese starters
cheesemaking
Cheese
cheeses
screening

Regulatory phenotyping reveals important diversity within the species Lactococcus lactis.

Bachmann, H., Starrenburg, M. J. C., Dijkstra, A., Molenaar, D., Kleerebezem, M., Rademaker, J. L. W. & van Hylckama Vlieg, J. E. T., 2009, In : Applied and Environmental Microbiology. 75, p. 5687-5694

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Lactococcus lactis
enzyme activity
phenotype
Lactococcus lactis subsp. lactis bv. diacetylactis
Lactococcus lactis subsp. cremoris
2008

Genomics of dairy fermentations

Siezen, R. J. & Bachmann, H., Nov 2008, In : Microbial Biotechnology. 1, 6, p. 435-42 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

High-throughput identification and validation of in situ-expressed genes of Lactococcus lactis

Bachmann, H., Kleerebezem, M. & van Hylckama Vlieg, J. E. T., Aug 2008, In : Applied and Environmental Microbiology. 74, 15, p. 4727-36 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Lactococcus lactis
Recombinases
gene
Technology
Genes
2007

Luciferase detection during stationary phase in Lactococcus lactis

Bachmann, H., dos Santos, F. B., Kleerebezem, M. & Van Hylckama Vlieg, J. E. T., Jul 2007, In : Applied and Environmental Microbiology. p. 4704-4706 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Lactococcus lactis
luciferase
luminescence
Luciferases
Flavin Mononucleotide
2006

Heterologous expression of Arabidopsis UDP-glucosyltransferases in Saccharomyces cerevisiae for production of zearalenone-4-O-glucoside

Poppenberger, B., Berthiller, F., Bachmann, H., Lucyshyn, D., Peterbauer, C., Mitterbauer, R., Schuhmacher, R., Krska, R., Glössl, J. & Adam, G., Jun 2006, In : Applied and Environmental Microbiology. p. 4404-4410 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Zearalenone
Glucosyltransferases
glucosyltransferases
Uridine Diphosphate
zearalenone

Natural diversity and adaptive responses of Lactococcus lactis

Vlieg, JETV., Rademaker, J. L. W., Bachmann, H., Molenaar, D., Kelly, WJ. & Siezen, R. J., Apr 2006, In : Current Opinion in Biotechnology. 17, 2, p. 183-190

Research output: Contribution to JournalArticleAcademicpeer-review

2002

Comparison of organic matter degradation in several feedstuffs in the rumen as determined with the nylon bag and gas production techniques

Cone, J. W., Van Gelder, A. H., Bachmann, H. & Hindle, V. A., 29 Mar 2002, In : Animal Feed Science and Technology. 96, 1-2, p. 55-67 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

gas production (biological)
nylon
bags
rumen
organic matter

Influence of inoculum source on gas production profiles

Cone, J. W., Van Gelder, A. H. & Bachmann, H., 30 Aug 2002, In : Animal Feed Science and Technology. p. 221-231 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

gas production (biological)
rumen fluids
inoculum
cows
sheep