dr. H.F. Vischer

dr.

19972019
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Personal profile

Personal information

Henry Vischer studied biology at the Utrecht University. He then joined the Neurobiology department at the Mount Sinai School of Medicine in New York (1997-1998) to investigate ligand-binding pockets of G protein-coupled receptors (GPCRs). His PhD project (1998-2003) at the Utrecht University focused on cloning, profiling, and ligand-receptor interactions between gonadotropins and their cognate GPCRs. He was awarded the Organon Research Prize for Endocrinology (2003). As postdoctoral fellow (2003-2008) in the Department Medicinal Chemistry at the Vrije Universiteit Amsterdam he was involved in molecular GPCR pharmacology, signaling and receptor-receptor interactions of (viral) chemokine receptors. He obtained a Netherlands Organisation for Scientific Research (NWO) Veni (2005), Netherlands Genomics Initiative (NGI) Horizon Breakthrough (2008), and NWO ECHO (2012) grant. In 2009 he was appointed assistant professor in the same department and currently focuses on molecular GPCR pharmacology, and in particular on biased signaling, receptor residence time and multiplex biosensor assay development. 

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Research Output 1997 2019

  • 82 Article
  • 6 Review article
  • 5 Chapter
  • 4 PhD Thesis - Research VU, graduation VU

4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H3 Receptor Agonists with in Vivo Central Nervous System Activity

Wágner, G., Mocking, T. A. M., Arimont, M., Provensi, G., Rani, B., Silva-Marques, B., Latacz, G., Da Costa Pereira, D., Karatzidou, C., Vischer, H. F., Wijtmans, M., Kieć-Kononowicz, K., De Esch, I. J. P. & Leurs, R., 1 Nov 2019, In : Journal of Medicinal Chemistry. 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine H3 Receptors
Histamine Agonists
Amines
Central Nervous System
Cytochrome P-450 Enzyme System

A Photoswitchable Agonist for the Histamine H 3 Receptor, a Prototypic Family A G-Protein-Coupled Receptor

Hauwert, N. J., Mocking, T. A. M., Da Costa Pereira, D., Lion, K., Huppelschoten, Y., Vischer, H. F., De Esch, I. J. P., Wijtmans, M. & Leurs, R., 26 Mar 2019, In : Angewandte Chemie - International Edition. 58, 14, p. 4531-4535 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine Agonists
G-Protein-Coupled Receptors
Histamine
Proteins
Chemical activation

A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light

Gómez-Santacana, X., De Munnik, S. M., Mocking, T. A. M., Hauwert, N. J., Sun, S., Vijayachandran, P., De Esch, I. J. P., Vischer, H. F., Wijtmans, M. & Leurs, R., 23 Oct 2019, In : Beilstein Journal of Organic Chemistry. 15, p. 2509-2523 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chemokine Receptors
Switches
Ligands
Halogens
Chemokines
Open Access
Histamine H3 Receptors
histamines
Bioluminescence
bioluminescence
Energy Transfer

Covalent inhibition of the histamine H3 receptor

Wágner, G., Mocking, T. A. M., Kooistra, A. J., Slynko, I., Ábrányi-Balogh, P., Keser u, G. M., Wijtmans, M., Vischer, H. F., de Esch, I. J. P. & Leurs, R., 11 Dec 2019, In : Molecules. 24, 24, p. 1-19 19 p., 4541.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine H3 Receptors
histamines
Scaffolds
Ligands
reactivity