H.F. Vischer

dr.

19972019
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Personal profile

Personal information

Henry Vischer studied biology at the Utrecht University. He then joined the Neurobiology department at the Mount Sinai School of Medicine in New York (1997-1998) to investigate ligand-binding pockets of G protein-coupled receptors (GPCRs). His PhD project (1998-2003) at the Utrecht University focused on cloning, profiling, and ligand-receptor interactions between gonadotropins and their cognate GPCRs. He was awarded the Organon Research Prize for Endocrinology (2003). As postdoctoral fellow (2003-2008) in the Department Medicinal Chemistry at the Vrije Universiteit Amsterdam he was involved in molecular GPCR pharmacology, signaling and receptor-receptor interactions of (viral) chemokine receptors. He obtained a Netherlands Organisation for Scientific Research (NWO) Veni (2005), Netherlands Genomics Initiative (NGI) Horizon Breakthrough (2008), and NWO ECHO (2012) grant. In 2009 he was appointed assistant professor in the same department and currently focuses on molecular GPCR pharmacology, and in particular on biased signaling, receptor residence time and multiplex biosensor assay development. 

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Research Output 1997 2019

  • 79 Article
  • 6 Review article
  • 5 Chapter
  • 4 PhD Thesis - Research VU, graduation VU

A Photoswitchable Agonist for the Histamine H 3 Receptor, a Prototypic Family A G-Protein-Coupled Receptor

Hauwert, N. J., Mocking, T. A. M., Da Costa Pereira, D., Lion, K., Huppelschoten, Y., Vischer, H. F., De Esch, I. J. P., Wijtmans, M. & Leurs, R., 26 Mar 2019, In : Angewandte Chemie - International Edition. 58, 14, p. 4531-4535 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine Agonists
G-Protein-Coupled Receptors
Histamine
Proteins
Chemical activation
Open Access
Histamine H3 Receptors
histamines
Bioluminescence
bioluminescence
Energy Transfer

Drug-receptor binding kinetics in drug discovery: Sticking around at the histamine H1 receptor

Bosma, R., 2019, 177 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Identification of Key Structural Motifs Involved in 7 Transmembrane Signaling of Adhesion GPCRs

Arimont Segura, M., van der Woude, M., Leurs, R., Vischer, H. F., de Graaf, C. & Nijmeijer, S., 21 Jan 2019, In : ACS Pharmacology & Translational Science. 2, 2, p. 101-113 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

G-Protein-Coupled Receptors
Physiological Phenomena
Drug Design
Molecular Dynamics Simulation
Site-Directed Mutagenesis

Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor

Bosma, R., Stoddart, L. A., Georgi, V., Bouzo-Lorenzo, M., Bushby, N., Inkoom, L., Waring, M. J., Briddon, S. J., Vischer, H. F., Sheppard, R. J., Fernández-Montalván, A., Hill, S. J. & Leurs, R., 1 Dec 2019, In : Scientific Reports. 9, 1, 7906.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
G-Protein-Coupled Receptors
Rate constants
Ligands
Kinetics
Kinetic parameters